Charcot-marie-tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels

PLoS Genetics

Volumn 7, Issue 12, 2011, Pages

  Motley, William W ^a,b,c   Seburn, Kevin L ^a   Nawaz, Mir Hussain ^d   Miers, Kathy E ^a   Cheng, Jun ^e   Antonellis, Anthony ^e,f   Green, Eric D ^e   Talbot, Kevin ^c   Yang, Xiang Lei ^d   Fischbeck, Kenneth H ^b   Burgess, Robert W ^a  

^a JACKSON LABORATORY   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GAIN OF FUNCTION MUTATION; GENE DOSAGE; GENE FUNCTION; GENE OVEREXPRESSION; GLYCYL TRNA SYNTHASE GENE; HEREDITARY MOTOR SENSORY NEUROPATHY; HETEROZYGOSITY; HISTOPATHOLOGY; HOMOZYGOSITY; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; MOUSE; MUTATOR GENE; NONHUMAN; NULL ALLELE; PHENOTYPE; TRANSGENE; WILD TYPE; ANIMAL; DISEASE MODEL; GENETICS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; METABOLISM; NERVE CELL; NERVE FIBER; PATHOLOGY; PERIPHERAL NERVOUS SYSTEM; SCHWANN CELL; SCIATIC NERVE; TRANSGENIC MOUSE;

LEPISOSTEIDAE; MUS; MUS MUSCULUS;

GLYCINE TRANSFER RNA LIGASE;

ANIMALS; AXONS; CHARCOT-MARIE-TOOTH DISEASE; DISEASE MODELS, ANIMAL; GLYCINE-TRNA LIGASE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; NEURONS; PERIPHERAL NERVOUS SYSTEM; SCHWANN CELLS; SCIATIC NERVE;

EID: 84855289563     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002399     Document Type: Article

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