Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of als through activation of c-Abl signaling

Frontiers in Cellular Neuroscience

Volumn 9, Issue June, 2015, Pages 1-20

  Rojas, Fabiola ^a   Gonzalez, David ^a   Cortes, Nicole ^a   Ampuero, Estibaliz ^a   Hernández, Diego E ^b   Fritz, Elsa ^a   Abarzua, Sebastián ^a   Martinez, Alexis ^b   Elorza, Alvaro A ^a,c   Alvarez, Alejandra ^b   Court, Felipe ^b   Van Zundert, Brigitte ^a  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c Pontificia Universidad Católica de Chile   (Chile)

Author keywords

ALS; C Abl; Mitochondria; Motor neuron; Non cell autonomous; Reactive oxygen species (ROS)

Indexed keywords

ABELSON KINASE; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOSPORIN A; ESCULETIN; GLIAL FIBRILLARY ACIDIC PROTEIN; IMATINIB; MEXILETINE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; RILUZOLE; SPERMIDINE; TAR DNA BINDING PROTEIN; TETRAMETHYLRHODAMINE METHYL ESTER; TIRON; TROLOX C;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CELL SURVIVAL; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFICACY; ELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; MOTONEURON DEATH; MOUSE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE STRESS; PHOSPHORYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; SIGNAL TRANSDUCTION; SPINAL CORD CELL CULTURE; WESTERN BLOTTING;

EID: 84935850625     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2015.00203     Document Type: Article

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