Calcium release from intra-axonal endoplasmic reticulum leads to axon degeneration through mitochondrial dysfunction

Journal of Neuroscience

Volumn 34, Issue 21, 2014, Pages 7179-7189

  Villegas, Rosario ^a   Martinez, Nicolas W ^a   Lillo, Jorge ^a   Pihan, Phillipe ^a   Hernandez, Diego ^a   Twiss, Jeffery L ^b   Court, Felipe A ^a,c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

^c NeuroUnion Biomedical Foundation ^*  (Chile)

Author keywords

Axon degeneration; Endoplasmic reticulum; Mitochondria; mPTP; Neurodegeneration

Indexed keywords

CAFFEINE; INOSITOL PHOSPHATE; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; ENDOPLASMIC RETICULUM; FEMALE; GENE SILENCING; IMMUNOFLUORESCENCE TEST; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MOUSE; NERVE FIBER DEGENERATION; NERVE FIBER TRANSECTION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHWANN CELL; SCIATIC NERVE INJURY; SPINAL GANGLION; ULTRAMICROTOMY; WESTERN BLOTTING;

AXON DEGENERATION; ENDOPLASMIC RETICULUM; MITOCHONDRIA; MPTP; NEURODEGENERATION;

ANIMALS; AXONS; CALCIUM; EMBRYO, MAMMALIAN; ENDOPLASMIC RETICULUM; FEMALE; GANGLIA, SPINAL; IMAGING, THREE-DIMENSIONAL; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; MITOCHONDRIAL DISEASES; ORGAN CULTURE TECHNIQUES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SCIATIC NERVE;

EID: 84901049664     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4784-13.2014     Document Type: Article

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