Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

Journal of Cell Biology

Volumn 156, Issue 5, 2002, Pages 879-892

  Woodring, Pamela J ^a   David Litwack, E ^a   O'Leary, Dennis D M ^a   Lucero, Ginger R ^a   Wang, Jean Y J ^b   Hunter, Tony ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Abl Arg fibroblasts; F actin microspikes; Fibronectin cell spreading; Latrunculin; STI571

Indexed keywords

ABELSON KINASE; ACTIN BINDING PROTEIN; F ACTIN; GUANOSINE TRIPHOSPHATASE; MUTANT PROTEIN; NEURITE PROMOTING FACTOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL ADHESION; CELL SPREADING; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GENETIC CODE; MOLECULAR DYNAMICS; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; CELL ADHESION; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SIZE; CEREBRAL CORTEX; CYTOSKELETON; EXTRACELLULAR MATRIX; FIBRONECTINS; FLUORESCENT ANTIBODY TECHNIQUE; MICE; NEURITES; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES; RATS; RHO GTP-BINDING PROTEINS;

ANIMALIA;

EID: 0037018155     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200110014     Document Type: Article

References (68)

1. Proteins of the ADF/cofilin family: Essential regulators of actin dynamics
2. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor
3. Identification of a binding site in c-Abl tyrosine kinase for the C-terminal repeated domain of RNA polymerase II
4. Tyrosine phosphorylation of mammalian RNA polymerase II carboxyl-terminal domain
5. Dynamics of target recognition by interstitial axon branching along developing cortical axons
6. Regulating cellular actin assembly
7. Negative regulation of fibroblast motility by Ena/VASP proteins
8. SU6656, a selective Src family kinase inhibitor, used to probe growth factor signaling
9. p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation
10. Integrin-mediated signals regulated by members of the Rho family of GTPases
11. Remodeling of synaptic actin induced by photoconductive stimulation
12. Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled
13. Activated c-Abl is degraded by the ubiquitin-dependent proteosome pathway
14. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis
15. Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor
16. Rapid actin-based plasticity in dendritic spines
17. Enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties
18. Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog
19. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. 1996
20. Drosophila Abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled
21. The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
22. Rho GTPases and the actin cytoskeleton
23. A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization
24. Regulation of actin filament network formation through Arp2/3 complex: Activation by a diverse array of proteins
25. Genetic interactions between the Drosophila Abelson (Abl) tyrosine kinase and failed axon connections (fax), a novel protein in axon bundles
26. Reelin-induced tryosine phosphorylation of disabled 1 during neuronal positioning
27. Integrins: Versatility, modulation and signaling in cell adhesion
28. Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes
29. Common mechanisms underlying growth cone guidance and axon branching
30. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism
31. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration
32. Essential roles for the Abl and Arg tyrosine kinases in neurulation
33. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
34. Mena is required for neurulation and commissure formation
35. From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility
36. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic-nuclear transport
37. Integrins regulate the association and phosphorylation of paxillin by c-Abl
38. Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding
39. Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases
40. Cofilin changes the twist of F-actin: Implications for actin filament dynamics and cellular function
41. Activation of tyrosine kinase and microfilament-binding functions of c-Abl by Bcr sequences in Bcr/Abl fusion proteins
42. An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias
43. A complex of N-WASP and WIP integrates signaling cascades that lead to actin polymerization
44. Latrunculin alters the actinmonomer subunit interface to prevent polymerization
45. Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells
46. The functional role of CrkII in actin cytoskeleton organization and mitogenesis
47. Integrin signaling: A new Cas(t) of characters enters the stage
48. Production of high-titer helper-free retroviruses by transient transfection
49. c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF
50. Molecular mechanisms controlling actin filament dynamics in nonmuscle cells
51. Action of a diffusible target-derived chemoattractant on cortical axon branch induction and directed growth
52. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: Involvement of the Grb2, p130cas, and Nck adaptor proteins
53. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics
54. The Abl interactor proteins localize to sites of actin polymerization at the tips of lamellipodia and filopodia
55. Interstitial branches develop from active regions of the axon demarcated by the primary growth cone during pausing behaviors
56. Paxillin interactions
57. Activation of Arp2/3 complex-mediated actin polymerization by cortactin
58. Cycling, stressed-out and nervous: Cellular functions of c-Abl
59. The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity
60. Regulation of cell death by the Abl tyrosine kinase
61. Cortactin: Coupling membrane dynamics to cortical actin networks
62. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold
63. The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance
64. Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo
65. Inhibition of c-Abl tyrosine kinase by filamentous-actin
66. The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
67. Signal transduction and actin filament organization
68. Cables links Cdk5 and c-Abl and facilitates Cdk tyrosine phosphorylation, kinase upregulation, and neurite outgrowth