Necroptosis drives motor neuron death in models of both sporadic and familial ALS

Neuron

Volumn 81, Issue 5, 2014, Pages 1001-1008

  Re, Diane B ^a,b   Le Verche, Virginia ^a,b   Yu, Changhao ^a,b   Amoroso, Mackenzie W ^a,b,c,e   Politi, Kristin A ^a,b   Phani, Sudarshan ^a,b   Ikiz, Burcin ^a,b   Hoffmann, Lucas ^a   Koolen, Martijn ^a,d   Nagata, Tetsuya ^a,b   Papadimitriou, Dimitra ^a,b   Nagy, Peter ^a,b   Mitsumoto, Hiroshi ^a   Kariya, Shingo ^a,b   Wichterle, Hynek ^a,b,c   Henderson, Christopher E ^a,b,c   Przedborski, Serge ^a,b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c Project ALS/Jenifer Estess Laboratory for Stem Cell Research   (United States)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; MIXED LINEAGE KINASE; NUCLEAR PROTEIN; RECEPTOR INTERACTING PROTEIN 1; SHORT HAIRPIN RNA; TAR DNA BINDING PROTEIN; UNCLASSIFIED DRUG;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; ASTROCYTE; CELL FUNCTION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ACTIVITY; DISEASE ASSOCIATION; FAMILIAL DISEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NECROPTOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; BIOLOGICAL MODEL; EMBRYO; EMBRYONIC STEM CELL; GENE EXPRESSION; GENE MUTATION; HUMAN TISSUE; MOTONEURON; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTOXICITY; PROTEIN EXPRESSION; PROTEIN FOLDING; SOD1 GENE;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ASTROCYTES; CELL COMMUNICATION; CELL DEATH; COCULTURE TECHNIQUES; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MOTOR NEURONS; NECROSIS; PRIMARY CELL CULTURE; PROTEIN KINASES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SPINAL CORD; SUPEROXIDE DISMUTASE;

EID: 84895508213     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.01.011     Document Type: Article

References (23)

1. Amoroso M.W., Croft G.F., Williams D.J., O'Keeffe S., Carrasco M.A., Davis A.R., Roybon L., Oakley D.H., Maniatis T., Henderson C.E., Wichterle H. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. J. Neurosci. 2013, 33:574-586.
2. Artus C., Boujrad H., Bouharrour A., Brunelle M.-N., Hoos S., Yuste V.J., Lenormand P., Rousselle J.-C., Namane A., England P., et al. AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010, 29:1585-1599.
3. Bates D.M., Watts D.G. Nonlinear Regression Analysis and Its Applications 1988, John Wiley & Sons, Inc., Hoboken.
4. Bosco D.A., Morfini G., Karabacak N.M., Song Y., Gros-Louis F., Pasinelli P., Goolsby H., Fontaine B.A., Lemay N., McKenna-Yasek D., et al. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat. Neurosci. 2010, 13:1396-1403.
5. Cassina P., Pehar M., Vargas M.R., Castellanos R., Barbeito A.G., Estévez A.G., Thompson J.A., Beckman J.S., Barbeito L. Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J. Neurochem. 2005, 93:38-46.
6. De Groot C.J., Langeveld C.H., Jongenelen C.A., Montagne L., Van Der Valk P., Dijkstra C.D. Establishment of human adult astrocyte cultures derived from postmortem multiple sclerosis and control brain and spinal cord regions: immunophenotypical and functional characterization. J. Neurosci. Res. 1997, 49:342-354.
7. Degterev A., Huang Z., Boyce M., Li Y., Jagtap P., Mizushima N., Cuny G.D., Mitchison T.J., Moskowitz M.A., Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. 2005, 1:112-119.
8. Degterev A., Hitomi J., Germscheid M., Ch'en I.L., Korkina O., Teng X., Abbott D., Cuny G.D., Yuan C., Wagner G., et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 2008, 4:313-321.
9. Di Giorgio F.P., Carrasco M.A., Siao M.C., Maniatis T., Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 2007, 10:608-614.
10. Di Giorgio F.P., Boulting G.L., Bobrowicz S., Eggan K.C. Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 2008, 3:637-648.
11. Guareschi S., Cova E., Cereda C., Ceroni M., Donetti E., Bosco D.A., Trotti D., Pasinelli P. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1. Proc. Natl. Acad. Sci. USA 2012, 109:5074-5079.
12. Haidet-Phillips A.M., Hester M.E., Miranda C.J., Meyer K., Braun L., Frakes A., Song S., Likhite S., Murtha M.J., Foust K.D., et al. Astrocytes from familial and sporadic ALS patients are toxic to motor neurons. Nat. Biotechnol. 2011, 29:824-828.
13. Ilieva H., Polymenidou M., Cleveland D.W. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J. Cell Biol. 2009, 187:761-772.
14. Kanning K.C., Kaplan A., Henderson C.E. Motor neuron diversity in development and disease. Annu. Rev. Neurosci. 2010, 33:409-440.
15. Krysko D.V., D'Herde K., Vandenabeele P. Clearance of apoptotic and necrotic cells and its immunological consequences. Apoptosis 2006, 11:1709-1726.
16. Marchetto M.C., Muotri A.R., Mu Y., Smith A.M., Cezar G.G., Gage F.H. Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 2008, 3:649-657.
17. Nagai M., Re D.B., Nagata T., Chalazonitis A., Jessell T.M., Wichterle H., Przedborski S. Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat. Neurosci. 2007, 10:615-622.
18. Ofengeim D., Yuan J. Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat. Rev. Mol. Cell Biol. 2013, 14:727-736.
19. Papadeas S.T., Kraig S.E., O'Banion C., Lepore A.C., Maragakis N.J. Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo. Proc. Natl. Acad. Sci. USA 2011, 108:17803-17808.
20. Sheridan C., Delivani P., Cullen S.P., Martin S.J. Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Mol. Cell 2008, 31:570-585.
21. Sun L., Wang H., Wang Z., He S., Chen S., Liao D., Wang L., Yan J., Liu W., Lei X., Wang X. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012, 148:213-227.
22. Wang Z., Jiang H., Chen S., Du F., Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012, 148:228-243.
23. Zhang D.W., Shao J., Lin J., Zhang N., Lu B.J., Lin S.C., Dong M.Q., Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336.