-
1
-
-
0347664057
-
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
-
Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y (2003). IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature, 421: 182-187
-
(2003)
Nature
, vol.421
, pp. 182-187
-
-
Holzenberger, M.1
Dupont, J.2
Ducos, B.3
Leneuve, P.4
Geloen, A.5
Even, P.C.6
Cervera, P.7
Le Bouc, Y.8
-
2
-
-
13944276264
-
Life extension in the dwarf mouse
-
Bartke A, Brown-Borg H (2004). Life extension in the dwarf mouse. Curr Top Dev Biol, 63:189-225
-
(2004)
Curr Top Dev Biol
, vol.63
, pp. 189-225
-
-
Bartke, A.1
Brown-Borg, H.2
-
3
-
-
27844561111
-
Regulation of oxidative stress by the anti-aging hormone klotho
-
Yamamoto M, Clark JD, Pastor JV, Gurnani P, Nandi A, Kurosu H, Miyoshi M, Ogawa Y, Castrillon DH, Rosenblatt KP and Kuro-o M (2005). Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem, 280: 38029-38034
-
(2005)
J Biol Chem
, vol.280
, pp. 38029-38034
-
-
Yamamoto, M.1
Clark, J.D.2
Pastor, J.V.3
Gurnani, P.4
Nandi, A.5
Kurosu, H.6
Miyoshi, M.7
Ogawa, Y.8
Castrillon, D.H.9
Rosenblatt, K.P.10
Kuro-o, M.11
-
4
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, Pandolfi PP, Lanfrancone L, Pelicci PG (1999). The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature, 402:309-313
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reboldi, P.5
Pandolfi, P.P.6
Lanfrancone, L.7
Pelicci, P.G.8
-
5
-
-
67649243697
-
The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury
-
Carpi A, Menabo R, Kaludercic N, Pelicci P, Di Lisa F, Giorgio M (2009). The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta, 1787:774-780
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 774-780
-
-
Carpi, A.1
Menabo, R.2
Kaludercic, N.3
Pelicci, P.4
Di Lisa, F.5
Giorgio, M.6
-
6
-
-
77956379343
-
The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing
-
Fadini GP, Albiero M, Menegazzo L, Boscaro E, Pagnin E, Iori E, Cosma C, Lapolla A, Pengo V, Stendardo M, Agostini C, Pelicci PG, Giorgio M, Avogaro A (2010). The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.Diabetes, 59:2306-2314
-
(2010)
Diabetes
, vol.59
, pp. 2306-2314
-
-
Fadini, G.P.1
Albiero, M.2
Menegazzo, L.3
Boscaro, E.4
Pagnin, E.5
Iori, E.6
Cosma, C.7
Lapolla, A.8
Pengo, V.9
Stendardo, M.10
Agostini, C.11
Pelicci, P.G.12
Giorgio, M.13
Avogaro, A.14
-
7
-
-
84878708811
-
The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration
-
Savino C, Pelicci P, Giorgio M (2013). The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration. Oxid Med Cell Longev, 2013:719407.
-
(2013)
Oxid Med Cell Longev
, vol.2013
-
-
Savino, C.1
Pelicci, P.2
Giorgio, M.3
-
8
-
-
0019644298
-
The aging process
-
Harman D (1981). The aging process. Proc Natl Acad Sci USA,78:7124-7128
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 7124-7128
-
-
Harman, D.1
-
9
-
-
22344456832
-
Mitochondrial DNA mutations, oxidative stress and apoptosis in mammalian aging
-
Kujoth GC, Hiona A, Pugh TD, et al (2005). Mitochondrial DNA mutations, oxidative stress and apoptosis in mammalian aging. Science 309:481-484
-
(2005)
Science
, vol.309
, pp. 481-484
-
-
Kujoth, G.C.1
Hiona, A.2
Pugh, T.D.3
-
10
-
-
84871302192
-
Senescent cells: a novel therapeutic target for aging and age-related diseases
-
Naylor RM, Baker DJ, van Deursen JM (2013). Senescent cells: a novel therapeutic target for aging and age-related diseases.Clin Pharmacol Ther, 93:105-116
-
(2013)
Clin Pharmacol Ther
, vol.93
, pp. 105-116
-
-
Naylor, R.M.1
Baker, D.J.2
van Deursen, J.M.3
-
11
-
-
0026777369
-
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
-
Pelicci G, Lanfrancone L, Grignani F, et al (1992). A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70:93-104
-
(1992)
Cell
, vol.70
, pp. 93-104
-
-
Pelicci, G.1
Lanfrancone, L.2
Grignani, F.3
-
12
-
-
0030199613
-
Not all Shc's roads lead to Ras
-
Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L, Pelicci PG (1996). Not all Shc's roads lead to Ras. Trends Biochem Sci, 21:257-261
-
(1996)
Trends Biochem Sci
, vol.21
, pp. 257-261
-
-
Bonfini, L.1
Migliaccio, E.2
Pelicci, G.3
Lanfrancone, L.4
Pelicci, P.G.5
-
13
-
-
0031056755
-
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
-
Migliaccio E, Mele S, Salcini AE, et al (1997).Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J, 16:706-716
-
(1997)
EMBO J
, vol.16
, pp. 706-716
-
-
Migliaccio, E.1
Mele, S.2
Salcini, A.E.3
-
14
-
-
0033669885
-
Evolution of Shc functions from nematode to human
-
Luzi L,Confalonieri S,Di Fiore PP, Pelicci PG (2000).Evolution of Shc functions from nematode to human.Curr Opin Genet Dev,10:668-674
-
(2000)
Curr Opin Genet Dev
, vol.10
, pp. 668-674
-
-
Luzi, L.1
Confalonieri, S.2
Di Fiore, P.P.3
Pelicci, P.G.4
-
15
-
-
85047695800
-
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis
-
Trinei M, Giorgio M, Cicalese A, et al (2002). A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene,21:3872-3878
-
(2002)
Oncogene
, vol.21
, pp. 3872-3878
-
-
Trinei, M.1
Giorgio, M.2
Cicalese, A.3
-
17
-
-
77953953488
-
P66Shc signals to age
-
Trinei M, Berniakovich I, Beltrami E, Migliaccio E, Fassina A, Pelicci P, Giorgio M (2009). P66Shc signals to age. Aging, 1(6): 503-510
-
(2009)
Aging
, vol.1
, Issue.6
, pp. 503-510
-
-
Trinei, M.1
Berniakovich, I.2
Beltrami, E.3
Migliaccio, E.4
Fassina, A.5
Pelicci, P.6
Giorgio, M.7
-
19
-
-
2942584910
-
The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential
-
Orsini F, Migliaccio E, Moroni M, et al (2004). The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential. J Biol Chem, 279:25689-25695
-
(2004)
J Biol Chem
, vol.279
, pp. 25689-25695
-
-
Orsini, F.1
Migliaccio, E.2
Moroni, M.3
-
20
-
-
22744447211
-
Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
-
Giorgio M, Migliaccio E,Orsini F, et al (2005). Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell, 122:221-233
-
(2005)
Cell
, vol.122
, pp. 221-233
-
-
Giorgio, M.1
Migliaccio, E.2
Orsini, F.3
-
21
-
-
80053007221
-
The Regulation of Aging and Longevity: A New and Complex Role of p53
-
Feng Z, Lin M, Wu R (2011). The Regulation of Aging and Longevity: A New and Complex Role of p53. Genes Cancer, 2:443-452
-
(2011)
Genes Cancer
, vol.2
, pp. 443-452
-
-
Feng, Z.1
Lin, M.2
Wu, R.3
-
22
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B, Gluba W, Bernier B, et al (2004). Modulation of mammalian life span by the short isoform of p53. Genes Dev, 18:306-319
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
-
23
-
-
84877806331
-
Oxidative stress activates a specific p53 transcriptionalresponse that regulates cellular senescence and aging
-
Gambino V, De Michele G, Venezia O, et al (2013). Oxidative stress activates a specific p53 transcriptionalresponse that regulates cellular senescence and aging. Aging Cell, 1 2:435-45.
-
(2013)
Aging Cell
, vol.1
, pp. 435-445
-
-
Gambino, V.1
De Michele, G.2
Venezia, O.3
-
24
-
-
79952706223
-
The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias
-
Di Cicco E, Tozzini ET, Rossi G, Cellerino A (2011). The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias. Exp Gerontol, 46:249-256
-
(2011)
Exp Gerontol
, vol.46
, pp. 249-256
-
-
Di Cicco, E.1
Tozzini, E.T.2
Rossi, G.3
Cellerino, A.4
-
25
-
-
0242574697
-
Extremely short lifespan in the annual fish Nothobranchius furzeri
-
Valdesalici S, Cellerino A (2003). Extremely short lifespan in the annual fish Nothobranchius furzeri. Proc Biol Sci, 270 Suppl 2S189-191
-
(2003)
Proc Biol Sci
, vol.270
, pp. S189-191
-
-
Valdesalici, S.1
Cellerino, A.2
-
26
-
-
0030033436
-
Ponce d'elegans: genetic quest for the fountain of youth
-
Kenyon C (1996). Ponce d'elegans: genetic quest for the fountain of youth. Cell, 84:501-504
-
(1996)
Cell
, vol.84
, pp. 501-504
-
-
Kenyon, C.1
-
27
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L, Kenyon C (2000). Genetic pathways that regulate ageing in model organisms. Nature, 408:255-262
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
28
-
-
67651163661
-
Lifespan extension in genetically modified mice
-
Ladiges W, Van Remmen H, Strong R, Ikeno Y, Treuting P, Rabinovitch P, Richardson A (2009). Lifespan extension in genetically modified mice. Aging Cell, 8:346-352
-
(2009)
Aging Cell
, vol.8
, pp. 346-352
-
-
Ladiges, W.1
Van Remmen, H.2
Strong, R.3
Ikeno, Y.4
Treuting, P.5
Rabinovitch, P.6
Richardson, A.7
-
29
-
-
79961130736
-
Phylogeny, genetic variability and colour polymorphism of an emerging animal model: the short-lived annual Nothobranchius fishes from southern Mozambique
-
Dorn A, Ng'oma E, Janko K, Reichwald K, Polacik M, Platzer M, Cellerino A, Reichard M (2011). Phylogeny, genetic variability and colour polymorphism of an emerging animal model: the short-lived annual Nothobranchius fishes from southern Mozambique. Mol Phylogenet Evol, 61:739-749
-
(2011)
Mol Phylogenet Evol
, vol.61
, pp. 739-749
-
-
Dorn, A.1
Ng'oma, E.2
Janko, K.3
Reichwald, K.4
Polacik, M.5
Platzer, M.6
Cellerino, A.7
Reichard, M.8
-
30
-
-
57349135308
-
Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri
-
Terzibasi E, Valenzano DR, Benedetti M, Roncaglia P, Cattaneo A, Domenici L, Cellerino A (2008). Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri. PLoS One, 3:e3866
-
(2008)
PLoS One
, vol.3
-
-
Terzibasi, E.1
Valenzano, D.R.2
Benedetti, M.3
Roncaglia, P.4
Cattaneo, A.5
Domenici, L.6
Cellerino, A.7
-
31
-
-
27744540845
-
Annual fishes of the genus Nothobranchius as a model system for aging research
-
Genade T, Benedetti M, Terzibasi E, et al (2005). Annual fishes of the genus Nothobranchius as a model system for aging research. Aging Cell, 4:223-233
-
(2005)
Aging Cell
, vol.4
, pp. 223-233
-
-
Genade, T.1
Benedetti, M.2
Terzibasi, E.3
-
32
-
-
31944450272
-
Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
-
Valenzano DR, Terzibasi E, Genade T, et al (2006). Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol, 16:296-300
-
(2006)
Curr Biol
, vol.16
, pp. 296-300
-
-
Valenzano, D.R.1
Terzibasi, E.2
Genade, T.3
-
33
-
-
84858343507
-
Mapping of quantitative trait loci controlling lifespan in the shortlived fish Nothobranchius furzeri--a new vertebrate model for age research
-
Kirschner J, Weber D, Neuschl C, et al (2012). Mapping of quantitative trait loci controlling lifespan in the shortlived fish Nothobranchius furzeri--a new vertebrate model for age research. Aging Cell, 11:252-61.
-
(2012)
Aging Cell
, vol.11
, pp. 252-261
-
-
Kirschner, J.1
Weber, D.2
Neuschl, C.3
-
35
-
-
84874939976
-
The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into agedependent changes of mRNA levels
-
Petzold A, Reichwald K, Groth M, et al (2013). The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into agedependent changes of mRNA levels. BMC Genomics, 14: 185-201
-
(2013)
BMC Genomics
, vol.14
, pp. 185-201
-
-
Petzold, A.1
Reichwald, K.2
Groth, M.3
-
36
-
-
79958088926
-
Zebrafish kruppellike factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages
-
Li IC, Chan CT, Lu YF, et al. (2011) Zebrafish kruppellike factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. PLoS One, 6:e20974.
-
(2011)
PLoS One
, vol.6
-
-
Li, I.C.1
Chan, C.T.2
Lu, Y.F.3
-
38
-
-
67649884353
-
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells
-
Santoriello C, Deflorian G, Pezzimenti F, et al (2009) Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells. Dis Model Mech, 2:56-67.
-
(2009)
Dis Model Mech
, vol.2
, pp. 56-67
-
-
Santoriello, C.1
Deflorian, G.2
Pezzimenti, F.3
-
40
-
-
1042266548
-
Modulation of mammalian life span by the short isoform of p53
-
Maier B, Gluba W, Bernier B, et al (2004). Modulation of mammalian life span by the short isoform of p53. Genes Dev, 18:306-319
-
(2004)
Genes Dev
, vol.18
, pp. 306-319
-
-
Maier, B.1
Gluba, W.2
Bernier, B.3
-
41
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, et al (2002). p53 mutant mice that display early ageing-associated phenotypes. Nature, 415:45-53
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
-
42
-
-
0037112844
-
Super p53 mice exhibit enhanced DNA damage response, are tumor resistant and age normally
-
Garcia-Cao I, Garcia-Cao M, Martin-Caballero J, et al (2002). "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally. EMBO J, 21:6225-6235
-
(2002)
EMBO J
, vol.21
, pp. 6225-6235
-
-
Garcia-Cao, I.1
Garcia-Cao, M.2
Martin-Caballero, J.3
-
44
-
-
84875297605
-
Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death
-
Jeon HY and Lee H (2013). Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. FEBS J 280:1518-1530
-
(2013)
FEBS J
, vol.280
, pp. 1518-1530
-
-
Jeon, H.Y.1
Lee, H.2
-
45
-
-
0037442760
-
Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis
-
Gunther EJ, Moody SE, Belka GK, et al (2003). Impact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesis. Genes Dev, 17: 488-501
-
(2003)
Genes Dev
, vol.17
, pp. 488-501
-
-
Gunther, E.J.1
Moody, S.E.2
Belka, G.K.3
-
46
-
-
0042284839
-
Data mining the p53 pathway in the Fugu genome: evidence for strong conservation of the apoptotic pathway
-
Le Bras M, Bensaad K, Soussi T (2003). Data mining the p53 pathway in the Fugu genome: evidence for strong conservation of the apoptotic pathway. Oncogene, 22:5082-5090
-
(2003)
Oncogene
, vol.22
, pp. 5082-5090
-
-
Le Bras, M.1
Bensaad, K.2
Soussi, T.3
-
47
-
-
84870497243
-
Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes)
-
Yasuda T, Oda S, Li Z, Kimori Y, Kamei Y, Ishikawa T, Todo T, Mitani H (2012). Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in the testis of p53-deficient medaka (Oryzias latipes). Cell Death Dis, 3e395
-
(2012)
Cell Death Dis
, vol.3
-
-
Yasuda, T.1
Oda, S.2
Li, Z.3
Kimori, Y.4
Kamei, Y.5
Ishikawa, T.6
Todo, T.7
Mitani, H.8
-
48
-
-
78049302116
-
p53 post-translational modification: deregulated in tumorigenesis
-
Dai C, Gu W (2010). p53 post-translational modification: deregulated in tumorigenesis. Trends Mol Med, 16:528-536
-
(2010)
Trends Mol Med
, vol.16
, pp. 528-536
-
-
Dai, C.1
Gu, W.2
-
49
-
-
34047194383
-
Crippling p53 activities via knock-in mutations in mouse models
-
Iwakuma T, Lozano G (2007). Crippling p53 activities via knock-in mutations in mouse models. Oncogene, 26; 2177-2184.
-
(2007)
Oncogene
, vol.26
, pp. 2177-2184
-
-
Iwakuma, T.1
Lozano, G.2
-
50
-
-
33845668241
-
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
-
Tang Y, Luo J, Zhang W, Gu W (2006). Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis. Mol Cell, 24:827-839
-
(2006)
Mol Cell
, vol.24
, pp. 827-839
-
-
Tang, Y.1
Luo, J.2
Zhang, W.3
Gu, W.4
-
51
-
-
33745752959
-
Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
-
Chao C, Herr D, Chun J, Xu Y (2006). Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J, 25:2615-2622
-
(2006)
EMBO J
, vol.25
, pp. 2615-2622
-
-
Chao, C.1
Herr, D.2
Chun, J.3
Xu, Y.4
-
52
-
-
43049163953
-
Acetylation is indispensable for p53 activation
-
Tang Y, Zhao W, Chen Y, Zhao Y, Gu W (2008). Acetylation is indispensable for p53 activation. Cell, 133: 612-626.
-
(2008)
Cell
, vol.133
, pp. 612-626
-
-
Tang, Y.1
Zhao, W.2
Chen, Y.3
Zhao, Y.4
Gu, W.5
-
53
-
-
0029013621
-
Role of cysteine residues in regulation of p53 function
-
Rainwater R, Parks D, Anderson ME, Tegtmeyer P, Mann K (1995). Role of cysteine residues in regulation of p53 function. Mol Cell Biol, 15:3892-3903
-
(1995)
Mol Cell Biol
, vol.15
, pp. 3892-3903
-
-
Rainwater, R.1
Parks, D.2
Anderson, M.E.3
Tegtmeyer, P.4
Mann, K.5
-
54
-
-
70349758334
-
Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wildtype and thioredoxin reductase null yeast
-
Stoner CS, Pearson GD, Koc A, Merwin JR, Lopez NI, Merrill GF (2009). Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wildtype and thioredoxin reductase null yeast. Biochemistry, 48: 9156-9169
-
(2009)
Biochemistry
, vol.48
, pp. 9156-9169
-
-
Stoner, C.S.1
Pearson, G.D.2
Koc, A.3
Merwin, J.R.4
Lopez, N.I.5
Merrill, G.F.6
-
55
-
-
84862197806
-
Aurora B kinase phosphorylates and instigates degradation of p53
-
Gully CP, Velazquez-Torres G, Shin JH, et al (2012). Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A, 109:E1513-1522
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E1513-1522
-
-
Gully, C.P.1
Velazquez-Torres, G.2
Shin, J.H.3
-
56
-
-
10644227569
-
Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215
-
Liu Q, Kaneko S, Yang L, et al (2004). Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215. J Biol Chem, 279: 52175-52182
-
(2004)
J Biol Chem
, vol.279
, pp. 52175-52182
-
-
Liu, Q.1
Kaneko, S.2
Yang, L.3
-
57
-
-
33750036122
-
Posttranslational phosphorylation of mutant p53 protein in tumor development
-
Matsumoto M, Furihata M, Ohtsuki Y (2006) Posttranslational phosphorylation of mutant p53 protein in tumor development. Med Mol Morphol 39:79-87
-
(2006)
Med Mol Morphol
, vol.39
, pp. 79-87
-
-
Matsumoto, M.1
Furihata, M.2
Ohtsuki, Y.3
-
58
-
-
0038491354
-
Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305
-
Wang YH, Tsay YG, Tan BC, Lo WY, Lee SC (2003) Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305. J Biol Chem, 278:25568-25576
-
(2003)
J Biol Chem
, vol.278
, pp. 25568-25576
-
-
Wang, Y.H.1
Tsay, Y.G.2
Tan, B.C.3
Lo, W.Y.4
Lee, S.C.5
-
59
-
-
43949107925
-
SnapShot: p53 posttranslational modifications
-
Kruse JP, Gu W (2008). SnapShot: p53 posttranslational modifications. Cell 133, 930-930 e931.
-
(2008)
Cell
, vol.133
, pp. 930-930
-
-
Kruse, J.P.1
Gu, W.2
-
60
-
-
0028968362
-
Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit
-
Lanfrancone L, Pelicci G, Brizzi MF, et al (1995). Overexpression of Shc proteins potentiates the proliferative response to the granulocyte-macrophage colony-stimulating factor and recruitment of Grb2/SoS and Grb2/p140 complexes to the beta receptor subunit. Oncogene, 10:907-917
-
(1995)
Oncogene
, vol.10
, pp. 907-917
-
-
Lanfrancone, L.1
Pelicci, G.2
Brizzi, M.F.3
-
61
-
-
57749091893
-
p66Shc-generated oxidative signal promotes fat accumulation
-
Berniakovich I, Trinei M, Stendardo M, et al (2008). p66Shc-generated oxidative signal promotes fat accumulation. J Biol Chem 283:34283-34293
-
(2008)
J Biol Chem
, vol.283
, pp. 34283-34293
-
-
Berniakovich, I.1
Trinei, M.2
Stendardo, M.3
-
62
-
-
77955798757
-
Mammalian life-span determinant p66shcA mediates obesityinduced insulin resistance
-
Ranieri SC, Fusco S, Panieri E, et al (2010). Mammalian life-span determinant p66shcA mediates obesityinduced insulin resistance. Proc Natl Acad Sci U S A, 107:13420-13425
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 13420-13425
-
-
Ranieri, S.C.1
Fusco, S.2
Panieri, E.3
-
63
-
-
33748288148
-
Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress
-
Menini S, Amadio L, Oddi G, et al (2006). Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress. Diabetes 55:1642-1650
-
(2006)
Diabetes
, vol.55
, pp. 1642-1650
-
-
Menini, S.1
Amadio, L.2
Oddi, G.3
-
64
-
-
77956379343
-
The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing
-
Fadini GP, Albiero M, Menegazzo L, et al (2010). The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing. Diabetes, 59: 2306-2314
-
(2010)
Diabetes
, vol.59
, pp. 2306-2314
-
-
Fadini, G.P.1
Albiero, M.2
Menegazzo, L.3
-
65
-
-
0037452461
-
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high fat diet
-
Napoli C, Martin-Padura I, de Nigris F, et al (2003). Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high fat diet. Proc Natl Acad Sci U S A, 100:2112-2116
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 2112-2116
-
-
Napoli, C.1
Martin-Padura, I.2
de Nigris, F.3
-
66
-
-
23244434000
-
Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage
-
Graiani G, Lagrasta C, Migliaccio E, et al (2005). Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage. Hypertension, 46:433-440
-
(2005)
Hypertension
, vol.46
, pp. 433-440
-
-
Graiani, G.1
Lagrasta, C.2
Migliaccio, E.3
-
67
-
-
16544365687
-
p66ShcA modulates tissue response to hindlimb ischemia
-
Zaccagnini G, Martelli F, Fasanaro P, et al (2004). p66ShcA modulates tissue response to hindlimb ischemia. Circulation, 109: 2917-2923
-
(2004)
Circulation
, vol.109
, pp. 2917-2923
-
-
Zaccagnini, G.1
Martelli, F.2
Fasanaro, P.3
-
68
-
-
67649243697
-
The cardioprotective effects elicited by p66 (Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury
-
Carpi A, Menabo R, Kaludercic N, et al (2009). The cardioprotective effects elicited by p66 (Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta, 1787: 774-780
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 774-780
-
-
Carpi, A.1
Menabo, R.2
Kaludercic, N.3
-
69
-
-
0032213730
-
Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain
-
Cattaneo E, Pelicci PG (1998). Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain. Trends Neurosci, 21:476-481
-
(1998)
Trends Neurosci
, vol.21
, pp. 476-481
-
-
Cattaneo, E.1
Pelicci, P.G.2
-
70
-
-
0034809342
-
Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135
-
Kojima T, Yoshikawa Y, Takada S, et al (2001). Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135. Biochem Biophys Res Commun, 284:1039-1047
-
(2001)
Biochem Biophys Res Commun
, vol.284
, pp. 1039-1047
-
-
Kojima, T.1
Yoshikawa, Y.2
Takada, S.3
-
71
-
-
34248144306
-
RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas
-
Fagiani E, Giardina G, Luzi L, et al (2007). RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas. Cancer Res, 67:3064-3073
-
(2007)
Cancer Res
, vol.67
, pp. 3064-3073
-
-
Fagiani, E.1
Giardina, G.2
Luzi, L.3
-
72
-
-
0033542136
-
"A 58-kDa Shc protein is present in Xenopus eggs and is phosphorylated on tyrosine residues upon egg activation
-
Aoto M, Sato K, Takeba S, et al (1999). "A 58-kDa Shc protein is present in Xenopus eggs and is phosphorylated on tyrosine residues upon egg activation." Biochem Biophys Res Commun, 258:265-70.
-
(1999)
" Biochem Biophys Res Commun
, vol.258
, pp. 265-270
-
-
Aoto, M.1
Sato, K.2
Takeba, S.3
-
73
-
-
0035118037
-
Hydrogen peroxide induces Src family tyrosine kinase-dependent activation of Xenopus eggs
-
Sato K, Ogawa K, Tokmakov AA, Iwasaki T, Fukami Y (2001). Hydrogen peroxide induces Src family tyrosine kinase-dependent activation of Xenopus eggs. Dev Growth Differ, 43:55-72
-
(2001)
Dev Growth Differ
, vol.43
, pp. 55-72
-
-
Sato, K.1
Ogawa, K.2
Tokmakov, A.A.3
Iwasaki, T.4
Fukami, Y.5
-
74
-
-
0042329686
-
Molecular cloning and characterization of an adaptor protein Shc isoform from Xenopus laevis oocytes
-
Chesnel F, Heligon C, Richard-Parpaillon L, Boujard D (2003). Molecular cloning and characterization of an adaptor protein Shc isoform from Xenopus laevis oocytes. Biol Cell, 95:311-320
-
(2003)
Biol Cell
, vol.95
, pp. 311-320
-
-
Chesnel, F.1
Heligon, C.2
Richard-Parpaillon, L.3
Boujard, D.4
-
75
-
-
0032858110
-
Molecular cloning of EDG-3 and N-Shc genes from the puffer fish, Fugu rubripes, and conservation of synteny with the human genome
-
Yamaguchi F, Yamaguchi K, Tokuda M, Brenner S (1999). Molecular cloning of EDG-3 and N-Shc genes from the puffer fish, Fugu rubripes, and conservation of synteny with the human genome. FEBS Lett, 459:105-110
-
(1999)
FEBS Lett
, vol.459
, pp. 105-110
-
-
Yamaguchi, F.1
Yamaguchi, K.2
Tokuda, M.3
Brenner, S.4
-
76
-
-
84863145282
-
The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis
-
Sweet DT, Chen Z, Wiley DM, Bautch VL, Tzima E (2011). The adaptor protein Shc integrates growth factor and ECM signaling during postnatal angiogenesis. Blood 119:1946-1955
-
(2011)
Blood
, vol.119
, pp. 1946-1955
-
-
Sweet, D.T.1
Chen, Z.2
Wiley, D.M.3
Bautch, V.L.4
Tzima, E.5
-
77
-
-
33846817351
-
Protein kinase C beta and prolyl isomerase 1 regulates mitochondrial effects of the life-span determinant p66Shc
-
Pinton P, Rimessi A, Marchi S, et al (2007). Protein kinase C beta and prolyl isomerase 1 regulates mitochondrial effects of the life-span determinant p66Shc. Science, 315: 659-663
-
(2007)
Science
, vol.315
, pp. 659-663
-
-
Pinton, P.1
Rimessi, A.2
Marchi, S.3
-
78
-
-
0035854682
-
Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells
-
Foschi M, Franchi F, Han J, La Villa G, Sorokin A (2001). Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells. J Biol Chem, 276:26640-26647
-
(2001)
J Biol Chem
, vol.276
, pp. 26640-26647
-
-
Foschi, M.1
Franchi, F.2
Han, J.3
La Villa, G.4
Sorokin, A.5
-
79
-
-
0029744885
-
Sounding the alarm: protein kinase cascades activated by stress and inflammation
-
Kyriakis JM, Avruch J (1996). Sounding the alarm: protein kinase cascades activated by stress and inflammation. J Biol Chem, 4:24313-6.
-
(1996)
J Biol Chem
, vol.4
, pp. 24313-24316
-
-
Kyriakis, J.M.1
Avruch, J.2
-
80
-
-
0033458831
-
Scaffolding and protein interactions in MAP kinase modules
-
Karandikar M, Cobb MH (1999) Scaffolding and protein interactions in MAP kinase modules." Cell Calcium, 26:219-26
-
(1999)
" Cell Calcium
, vol.26
, pp. 219-226
-
-
Karandikar, M.1
Cobb, M.H.2
-
81
-
-
23044441390
-
ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress
-
Hu Y, Wang X, Zeng L, Cai DY, Sabapathy K, Goff SP, Firpo EJ, Li B (2005). ERK phosphorylates p66shcA on Ser36 and subsequently regulates p27kip1 expression via the Akt-FOXO3a pathway: implication of p27kip1 in cell response to oxidative stress. Mol Biol Cell, 16:3705-18.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 3705-3718
-
-
Hu, Y.1
Wang, X.2
Zeng, L.3
Cai, D.Y.4
Sabapathy, K.5
Goff, S.P.6
Firpo, E.J.7
Li, B.8
-
82
-
-
0035930534
-
c-Jun Nterminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation
-
Le S, Connors TJ, Maroney AC (2001). c-Jun Nterminal kinase specifically phosphorylates p66ShcA at serine 36 in response to ultraviolet irradiation. J Biol Chem, 276:48332-6.
-
(2001)
J Biol Chem
, vol.276
, pp. 48332-48336
-
-
Le, S.1
Connors, T.J.2
Maroney, A.C.3
-
83
-
-
0033621394
-
Definition of the interaction domain for cytochrome c on cytochrome c oxidase. I. Biochemical, spectral, and kinetic characterization of surface mutants in subunit ii of Rhodobacter sphaeroides cytochrome aa
-
Zhen Y, Hoganson CW, Babcock GT, Ferguson-Miller S (1999). Definition of the interaction domain for cytochrome c on cytochrome c oxidase. I. Biochemical, spectral, and kinetic characterization of surface mutants in subunit ii of Rhodobacter sphaeroides cytochrome aa. J Biol Chem, 274:38032-38041
-
(1999)
J Biol Chem
, vol.274
, pp. 38032-38041
-
-
Zhen, Y.1
Hoganson, C.W.2
Babcock, G.T.3
Ferguson-Miller, S.4
-
84
-
-
84880314780
-
p66Shc, mitochondria, and the generation of reactive oxygen species
-
99-11
-
Trinei M, Migliaccio E, Bernardi P, Paolucci F, Pelicci P, Giorgio M (2013). p66Shc, mitochondria, and the generation of reactive oxygen species. Methods Enzymol, 528: 99-11
-
(2013)
Methods Enzymol
, vol.528
-
-
Trinei, M.1
Migliaccio, E.2
Bernardi, P.3
Paolucci, F.4
Pelicci, P.5
Giorgio, M.6
-
85
-
-
44449151542
-
Activation of the lifespan regulator p66Shc through reversible disulfide bond formation
-
Gertz M, Fischer F, Wolters D, Steegborn C (2008). Activation of the lifespan regulator p66Shc through reversible disulfide bond formation. Proc Natl Acad Sci U S A., 105: 5705-9.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 5705-5709
-
-
Gertz, M.1
Fischer, F.2
Wolters, D.3
Steegborn, C.4
-
86
-
-
0037119469
-
Serine/threonine phosphorylation of ShcA Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling
-
Faisal A, el-Shemerly M, Hess D, Nagamine Y (2002). Serine/threonine phosphorylation of ShcA.Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling. J Biol Chem, 277:30144-30152
-
(2002)
J Biol Chem
, vol.277
, pp. 30144-30152
-
-
Faisal, A.1
el-Shemerly, M.2
Hess, D.3
Nagamine, Y.4
-
87
-
-
30044449425
-
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress
-
Khanday FA, Yamamori T, Mattagajasingh I, et al (2006). Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress. Mol Biol Cell, 17:122-129
-
(2006)
Mol Biol Cell
, vol.17
, pp. 122-129
-
-
Khanday, F.A.1
Yamamori, T.2
Mattagajasingh, I.3
-
88
-
-
0027934261
-
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins
-
Salcini AE, McGlade J, Pelicci G, et al (1994). Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene, 9:2827-2836
-
(1994)
Oncogene
, vol.9
, pp. 2827-2836
-
-
Salcini, A.E.1
McGlade, J.2
Pelicci, G.3
-
89
-
-
0030877360
-
Activation of R-Ras by Ras-guanine nucleotide-releasing factor
-
Gotoh T, Niino Y, Tokuda M, Hatase O, Nakamura S, Matsuda M, Hattori S (1997). Activation of R-Ras by Ras-guanine nucleotide-releasing factor. J Biol Chem, 272:18602-18607
-
(1997)
J Biol Chem
, vol.272
, pp. 18602-18607
-
-
Gotoh, T.1
Niino, Y.2
Tokuda, M.3
Hatase, O.4
Nakamura, S.5
Matsuda, M.6
Hattori, S.7
-
90
-
-
34547935761
-
Living with p53, dying of p53
-
Aylon Y, Oren M (2007). Living with p53, dying of p53. Cell, 130:597-600.
-
(2007)
Cell
, vol.130
, pp. 597-600
-
-
Aylon, Y.1
Oren, M.2
-
92
-
-
81155139688
-
Biological functions of p53 isoforms through evolution: lessons from animal and cellular models
-
Marcel V, Dichtel-Danjoy ML, Sagne C, et al (2011). Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ 18:1815-1824
-
(2011)
Cell Death Differ
, vol.18
, pp. 1815-1824
-
-
Marcel, V.1
Dichtel-Danjoy, M.L.2
Sagne, C.3
-
93
-
-
77950346841
-
Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47
-
Bourougaa K, Naski N, Boularan C, et al (2012). Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell, 38:78-88
-
(2012)
Mol Cell
, vol.38
, pp. 78-88
-
-
Bourougaa, K.1
Naski, N.2
Boularan, C.3
-
94
-
-
77957370163
-
Differential regulation of p53 function by the N-terminal DeltaNp53 and Delta113p53 isoforms in zebrafish embryos
-
Davidson WR, Kari C, Ren Q, et al (2010). Differential regulation of p53 function by the N-terminal DeltaNp53 and Delta113p53 isoforms in zebrafish embryos. BMC Dev Biol, 10:102-113
-
(2010)
BMC Dev Biol
, vol.10
, pp. 102-113
-
-
Davidson, W.R.1
Kari, C.2
Ren, Q.3
-
95
-
-
27844596799
-
Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
-
Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL (2005). Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol, 15:2063-2068
-
(2005)
Curr Biol
, vol.15
, pp. 2063-2068
-
-
Bauer, J.H.1
Poon, P.C.2
Glatt-Deeley, H.3
Abrams, J.M.4
Helfand, S.L.5
-
96
-
-
67651174517
-
p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress
-
Ventura N, Rea SL, Schiavi A, Torgovnick A, Testi R, Johnson TE (2009). p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress. Aging Cell, 8:380-393
-
(2009)
Aging Cell
, vol.8
, pp. 380-393
-
-
Ventura, N.1
Rea, S.L.2
Schiavi, A.3
Torgovnick, A.4
Testi, R.5
Johnson, T.E.6
|