The influence of Shc proteins on life span in mice

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69, Issue 10, 2014, Pages 1177-1185

  Ramsey, Jon J ^a   Tran, Dianna ^a   Giorgio, Marco ^b   Griffey, Stephen M ^c   Koehne, Amanda ^c   Laing, Steven T ^c   Taylor, Sandra L ^d   Kim, Kyoungmi ^d   Cortopassi, Gino A ^a   Lloyd, K C Kent ^e   Hagopian, Kevork ^a   Tomilov, Alexey A ^a   Migliaccio, Enrica ^b   Pelicci, Pier Giuseppe ^b   McDonald, Roger B ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Department of Public Health Sciences ^*  (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; Longevity; Pathology; Shc

Indexed keywords

PROTEIN SHC; SHC1 PROTEIN, MOUSE;

ANIMAL; ANIMAL HUSBANDRY; C57BL MOUSE; CALORIC RESTRICTION; FEMALE; KNOCKOUT MOUSE; LONGEVITY; MALE; MOUSE; PHYSIOLOGY; SPECIES DIFFERENCE;

ANIMAL HUSBANDRY; ANIMALS; CALORIC RESTRICTION; FEMALE; LONGEVITY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SHC SIGNALING ADAPTOR PROTEINS; SPECIES SPECIFICITY;

EID: 84903530541     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt198     Document Type: Article

References (29)

1. Pelicci G, Lanfrancone L, Grignani F, et al. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. 1992;70:93-104.
2. Giorgio M, Migliaccio E, Orsini F, et al. Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis. Cell. 2005;122:221-233.
3. Migliaccio E, Giorgio M, Mele S, et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature. 1999;402:309-313.
4. Pacini S, Pellegrini M, Migliaccio E, et al. p66SHC promotes apoptosis and antagonizes mitogenic signaling in T cells. Mol Cell Biol. 2004;24:1747-1757.
5. Trinei M, Giorgio M, Cicalese A, et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidationdamaged DNA and oxidative stress-induced apoptosis. Oncogene. 2002;21:3872-3878.
6. Tomilov AA, Ramsey JJ, Hagopian K, et al. The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 2011;10:55-65.
7. Raffaello A, Rizzuto R. Mitochondrial longevity pathways. Biochim Biophys Acta. 2011;1813:260-268.
8. Hagopian K, Tomilov AA, Tomilova N, et al. Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. 2012.
9. Nicklas W, Baneux P, Boot R, Decelle T, Deeny AA, Fumanelli M, et al. Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Laboratory Animals. 2002;36:20-42.
10. Sprent P. Applied Non-parametric Statistical Methods. 2nd ed. London: Chapman and Hall; 1993.
11. Kleinbaum DG, Klein M. Survival Analysis. New York, NY: Springer; 2005.
12. Ikeno Y, Hubbard GB, Lee SR et al. Housing density does not influence the longevity effect of calorie restriction. J Gerontol A Biol Sci Med Sci. 2005;60:1510-1517.
13. Pearson KJ, Baur JA, Lewis KN, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 2008;8:157-168.
14. Yuan R, Tsaih SW, Petkova SB, et al. Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell. 2009;8:277-287.
15. Zhang Y, Bokov A, Gelfond J, et al. Rapamycin Extends Life and Health in C57BL/6 Mice. J Gerontol A Biol Sci Med Sci. 2013.
16. Pellegrini M, Pacini S, Baldari CT. p66SHC: the apoptotic side of Shc proteins. Apoptosis. 2005;10:13-18.
17. Trinei M, Berniakovich I, Beltrami E, et al. P66Shc signals to age. Aging (Albany NY). 2009;1:503-510.
18. Wills MK, Jones N. Teaching an old dogma new tricks: twenty years of Shc adaptor signalling. Biochem J. 2012;447:1-16.
19. Liang H, Masoro EJ, Nelson JF, Strong R, McMahan CA, Richardson A. Genetic mouse models of extended lifespan. Exp Gerontol. 2003;38:1353-1364.
20. Giorgio M, Berry A, Berniakovich I, et al. The p66Shc knocked out mice are short lived under natural condition. Aging Cell. 2012;11:162-168.
21. Pandolfi S, Bonafe M, Di Tella L, et al. p66 (shc) is highly expressed in fibroblasts from centenarians. Mech Ageing Dev. 2005;126:839-844.
22. Berniakovich I, Trinei M, Stendardo M, et al. p66Shc-generated oxidative signal promotes fat accumulation. J Biol Chem. 2008;283:34283-34293.
23. Natalicchio A, De Stefano F, Perrini S, et al. Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts. Am J Physiol Endocrinol Metab. 2009;296:E228-237.
24. Nemoto S, Combs CA, French S, et al. The mammalian longevityassociated gene product p66shc regulates mitochondrial metabolism. J Biol Chem. 2006;281:10555-10560.
25. Ranieri SC, Fusco S, Panieri EL et al. Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance. Proc Natl Acad Sci USA. 2010;107:13420-13425.
26. Napoli C, Martin-Padura I, De Nigris F, et al. Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet. Proc Natl Acad Sci USA. 2003;100:2112-2116.
27. Pinton P, Rimessi A, Marchi S, et al. Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc. Science. 2007;315:659-663.
28. Carpi A, Menabo R, Kaludercic N, Pelicci P, Di Lisa F, Giorgio M. The cardioprotective effects elicited by p66 (Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta. 2009;1787:774-780.
29. Blackwell BN, Bucci TJ, Hart RW, Turturro A. Longevity, body weight, and neoplasia in ad libitum-fed and diet-restricted C57BL6 mice fed NIH-31 open formula diet. Toxicol Pathol. 1995;23:570-582.