Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 30, 2010, Pages 13420-13425

  Ranieri, Sofia Chiatamone ^a   Fusco, Salvatore ^a   Panieri, Emiliano ^a   Labate, Valentina ^a   Mele, Marina ^a   Tesori, Valentina ^a   Ferrara, Anna Maria ^a   Maulucci, Giuseppe ^a   De Spirito, Marco ^a   Martorana, Giuseppe Ettore ^a   Galeotti, Tommaso ^a   Pani, Giovambattista ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Diabetes; Longevity; mTOR S6K; Nutrients; p66shc

Indexed keywords

COLLAGEN; FATTY ACID; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P66; ANTIDIABETIC AGENT; INSULIN; LEPTIN; PROTEIN SHC; S6 KINASE; SHC1 PROTEIN, MOUSE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BODY WEIGHT; CONTROLLED STUDY; DEATH; DESENSITIZATION; FEMALE; GENETIC MODEL; GLUCOSE TOLERANCE; HYPERINSULINEMIA; IN VITRO STUDY; INSULIN RESISTANCE; LIFESPAN; LIPID STORAGE; MALE; MAMMAL; MOLECULAR INTERACTION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN PHOSPHORYLATION; SRC HOMOLOGY DOMAIN; TRANSDUCER; UPREGULATION; WILD TYPE; 3T3 CELL LINE; ADIPOCYTE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; GLUCOSE INTOLERANCE; HYPERINSULINISM; IMMUNOBLOTTING; INBRED MOUSE STRAIN; KNOCKOUT MOUSE; LONGEVITY; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RNA INTERFERENCE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; FLOW CYTOMETRY; GLUCOSE INTOLERANCE; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; IMMUNOBLOTTING; INSULIN; INSULIN RESISTANCE; LEPTIN; LONGEVITY; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, OBESE; OBESITY; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA INTERFERENCE; SHC SIGNALING ADAPTOR PROTEINS;

EID: 77955798757     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008647107     Document Type: Article

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