Aurora B kinase phosphorylates and instigates degradation of p53

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 24, 2012, Pages

  Gully, Chris P ^a,b   Velazquez Torres, Guermarie ^a,b   Shin, Ji Hyun ^a,b   Fuentes Mattei, Enrique ^b   Wang, Edward ^a,b   Carlock, Colin ^a,b   Chen, Jian ^b   Rothenberg, Daniel ^b   Adams, Henry P ^b   Choi, Hyun Ho ^a,b   Guma, Sergei ^a,b   Phan, Liem ^a,b   Chou, Ping Chieh ^a,b   Su, Chun Hui ^a,b   Zhang, Fanmao ^a,b   Chen, Jiun Sheng ^b   Yang, Tsung Ying ^b   Yeung, Sai Ching J ^a,b   Lee, Mong Hong ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

AZD1152; Centromere protein A; Chromosome passenger complex; DNA damage

Indexed keywords

AURORA B KINASE; PROTEIN P53; SURVIVIN;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; TUMOR GROWTH; UBIQUITINATION;

HUMANS; INTERPHASE; MITOSIS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; SUBCELLULAR FRACTIONS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 84862197806     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110287109     Document Type: Article

References (51)

1. Carmena M, Earnshaw WC (2003) The cellular geography of aurora kinases. Nat Rev Mol Cell Biol 4:842-854. (Pubitemid 37411723)
2. Ruchaud S, Carmena M, Earnshaw WC (2007) Chromosomal passengers: Conducting cell division. Nat Rev Mol Cell Biol 8:798-812. (Pubitemid 47462135)
3. Lindqvist A, Rodríguez-Bravo V, Medema RH (2009) The decision to enter mitosis: Feedback and redundancy in the mitotic entry network. J Cell Biol 185:193-202.
4. Fu J, Bian M, Jiang Q, Zhang C (2007) Roles of Aurora kinases in mitosis and tumorigenesis. Mol Cancer Res 5:1-10.
5. Ducat D, Zheng Y (2004) Aurora kinases in spindle assembly and chromosome segregation. Exp Cell Res 301:60-67. (Pubitemid 39388897)
6. Katayama H, Brinkley WR, Sen S (2003) The Aurora kinases: Role in cell transformation and tumorigenesis. Cancer Metastasis Rev 22:451-464. (Pubitemid 36791899)
7. Lens SM, Voest EE, Medema RH (2010) Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nat Rev Cancer 10:825-841.
8. Slattery SD, Moore RV, Brinkley BR, Hall RM (2008) Aurora-C and Aurora-B share phosphorylation and regulation of CENP-A and Borealin during mitosis. Cell Cycle 7:787-795. (Pubitemid 351520043)
9. Schwartz D, Rotter V (1998) p53-dependent cell cycle control: Response to genotoxic stress. Semin Cancer Biol 8:325-336. (Pubitemid 29131354)
10. Cross SM, et al. (1995) A p53-dependent mouse spindle checkpoint. Science 267:1353-1356.
11. Toledo F, Wahl GM (2006) Regulating the p53 pathway: In vitro hypotheses, in vivo veritas. Nat Rev Cancer 6:909-923. (Pubitemid 44862676)
12. Yeung SC, Gully C, Lee MH (2008) Aurora-B kinase inhibitors for cancer chemotherapy. Mini Rev Med Chem 8:1514-1525.
13. Keen N, Taylor S (2004) Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 4:927-936. (Pubitemid 39626216)
14. Wilkinson RW, et al. (2007) AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis. Clin Cancer Res 13:3682-3688. (Pubitemid 46955132)
15. Yang J, et al. (2007) AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 110:2034-2040. (Pubitemid 47443920)
16. Gully CP, et al. (2010) Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer, 10.1186/1476-4598-9-42.
17. Wu L, Ma CA, Zhao Y, Jain A (2011) Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. J Biol Chem 286:2236-2244.
18. Hsu JY, et al. (2000) Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102:279-291.
19. Hirota T, Lipp JJ, Toh BH, Peters JM (2005) Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature 438:1176-1180. (Pubitemid 41831689)
20. Nagai T, et al. (2002) A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol 20:87-90. (Pubitemid 34044921)
21. Tsukahara T, Tanno Y, Watanabe Y (2010) Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Nature 467:719-723.
22. Wang F, et al. (2010) Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science 330:231-235.
23. Rosasco-Nitcher SE, LanW, Khorasanizadeh S, Stukenberg PT (2008) CentromericAurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation. Science 319:469-472. (Pubitemid 351160581)
24. Vong QP, Cao K, Li HY, Iglesias PA, Zheng Y (2005) Chromosome alignment and segregation regulated by ubiquitination of survivin. Science 310:1499-1504. (Pubitemid 41746347)
25. Kelly AE, et al. (2010) Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B. Science 330:235-239.
26. Banin S, et al. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281:1674-1677.
27. Khanna KK, et al. (1998) ATM associates with and phosphorylates p53: Mapping the region of interaction. Nat Genet 20:398-400. (Pubitemid 28541643)
28. Hirao A, et al. (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287:1824-1827.
29. Zhou BP, et al. (2001) HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 3:973-982. (Pubitemid 34428742)
30. Yang H, et al. (2006) DNA damage-induced protein 14-3-3 sigma inhibits protein kinase B/Akt activation and suppresses Akt-activated cancer. Cancer Res 66:3096-3105.
31. Lozano G, Montes de Oca Luna R (1998) MDM2 function. Biochim Biophys Acta 1377:M55-M59.
32. Lee MH, Lozano G (2006) Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins. Semin Cancer Biol 16:225-234.
33. Dornan D, et al. (2006) ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage. Science 313:1122-1126. (Pubitemid 44300238)
34. Su CH, et al. (2010) Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage. Mol Cancer 9:243.
35. Su CH, et al. (2011) 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res 71:884-894.
36. Zhao R, et al. (2011) Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 121:851-865.
37. Katayama H, et al. (2004) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet 36:55-62. (Pubitemid 38056208)
38. el-Deiry WS, et al. (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
39. Bunz F, et al. (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497-1501. (Pubitemid 28538613)
40. Milner J, Cook A, Mason J (1990) p53 is associated with p34cdc2 in transformed cells. EMBO J 9:2885-2889.
41. Innocente SA, Abrahamson JL, Cogswell JP, Lee JM (1999) p53 regulates a G2 checkpoint through cyclin B1. Proc Natl Acad Sci USA 96:2147-2152. (Pubitemid 29117882)
42. Krause K, et al. (2000) The tumour suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res 28:4410-4418.
43. Taylor WR, et al. (1999) Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell 10:3607-3622. (Pubitemid 29534013)
44. Raj D, Liu T, Samadashwily G, Li F, Grossman D (2008) Survivin repression by p53, Rb and E2F2 in normal human melanocytes. Carcinogenesis 29:194-201. (Pubitemid 351201759)
45. Gottesfeld JM, Forbes DJ (1997) Mitotic repression of the transcriptional machinery. Trends Biochem Sci 22:197-202. (Pubitemid 27246634)
46. Martínez-Balbás MA, Dey A, Rabindran SK, Ozato K, Wu C (1995) Displacement of sequence-specific transcription factors from mitotic chromatin. Cell 83:29-38.
47. Gergely F (2008) Mitosis: Cdh1 clears the way for anaphase spindle assembly. Curr Biol 18:R1009-R1012.
48. Stukenberg PT (2004) Triggering p53 after cytokinesis failure. J Cell Biol 165:607-608.
49. Laronga C, Yang HY, Neal C, Lee MH (2000) Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 275:23106-23112. (Pubitemid 30646202)
50. Mortlock AA, et al. (2007) Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J Med Chem 50:2213-2224. (Pubitemid 46683074)
51. Ding Z, et al. (2006) A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci USA 103:15014-15019. (Pubitemid 44583156)