Structural basis of blocking integrin activation and deactivation for anti-inflammation

Journal of Biomedical Science

Volumn 22, Issue 1, 2015, Pages

  Park, Eun Jeong ^a,b   Yuki, Yoshikazu ^b   Kiyono, Hiroshi ^b   Shimaoka, Motomu ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Activation; Affinity; Deactivation; Inflammation; Integrin; Kindlin; Leukocyte; Talin

Indexed keywords

ALPHA INTEGRIN; BETA INTEGRIN; CALPAIN; DOCKING PROTEIN; G PROTEIN COUPLED RECEPTOR; GELATINASE A; INTEGRIN; INTEGRIN CYTOPLASMIC DOMAIN ASSOCIATED PROTEIN 1; INTERCELLULAR ADHESION MOLECULE 1; ISOLEUCINE; KINDLIN 1; KINDLIN 2; KINDLIN 3; MEMBRANE PROTEIN; PHOSPHOTYROSINE; RAP1 PROTEIN; SHANK ASSOCIATED RH DOMAIN INTERACTING PROTEIN; TALIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4; BETA1 INTEGRIN;

AMINO TERMINAL SEQUENCE; ANTIINFLAMMATORY ACTIVITY; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL INTERACTION; CONFORMATIONAL TRANSITION; HUMAN; INTRACELLULAR SIGNALING; LEUKOCYTE MIGRATION; LIGAND BINDING; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; REVIEW; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE ACTIVATION; CELL MOTION; CHEMISTRY; GENETICS; INFLAMMATION; LEUKOCYTE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTIGENS, CD29; CELL MOVEMENT; HUMANS; INFLAMMATION; INTEGRIN ALPHA CHAINS; LEUKOCYTES; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84935418112     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/s12929-015-0159-6     Document Type: Review

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