메뉴 건너뛰기




Volumn 312, Issue 5, 2006, Pages 651-658

Integrins and angiogenesis: A sticky business

Author keywords

Angiogenesis; Growth factors; Integrins; Semaphorins

Indexed keywords

ALPHA6BETA4 INTEGRIN; CD51 ANTIGEN; COLLAGEN TYPE 4; FIBRONECTIN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN; KALININ; LAMININ RECEPTOR; MATRIX METALLOPROTEINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN; VERY LATE ACTIVATION ANTIGEN 5; VITRONECTIN; VITRONECTIN RECEPTOR;

EID: 33344461837     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2005.10.020     Document Type: Review
Times cited : (175)

References (96)
  • 2
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • R.K. Jain Molecular regulation of vessel maturation Nat. Med. 9 2003 685 693
    • (2003) Nat. Med. , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 3
    • 0034710157 scopus 로고    scopus 로고
    • The evolution of cell adhesion
    • R.O. Hynes, and Q. Zhao The evolution of cell adhesion J. Cell Biol. 150 2000 F89 F96
    • (2000) J. Cell Biol. , vol.150
    • Hynes, R.O.1    Zhao, Q.2
  • 4
    • 0031459892 scopus 로고    scopus 로고
    • Angiogenesis promoted by vascular endothelial growth factor: Regulation through alpha1beta1 and alpha2beta1 integrins
    • D.R. Senger, K.P. Claffey, J.E. Benes, C.A. Perruzzi, A.P. Sergiou, and M. Detmar Angiogenesis promoted by vascular endothelial growth factor: regulation through alpha1beta1 and alpha2beta1 integrins Proc. Natl. Acad. Sci. U. S. A. 94 1997 13612 13617
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 13612-13617
    • Senger, D.R.1    Claffey, K.P.2    Benes, J.E.3    Perruzzi, C.A.4    Sergiou, A.P.5    Detmar, M.6
  • 5
    • 0036142782 scopus 로고    scopus 로고
    • The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis
    • D.R. Senger, C.A. Perruzzi, M. Streit, V.E. Koteliansky, A.R. de Fougerolles, and M. Detmar The alpha(1)beta(1) and alpha(2)beta(1) integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis Am. J. Pathol. 160 2002 195 204
    • (2002) Am. J. Pathol. , vol.160 , pp. 195-204
    • Senger, D.R.1    Perruzzi, C.A.2    Streit, M.3    Koteliansky, V.E.4    De Fougerolles, A.R.5    Detmar, M.6
  • 6
    • 0037414766 scopus 로고    scopus 로고
    • Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase a
    • M.C. Whelan, and D.R. Senger Collagen I initiates endothelial cell morphogenesis by inducing actin polymerization through suppression of cyclic AMP and protein kinase A J. Biol. Chem. 278 2003 327 334
    • (2003) J. Biol. Chem. , vol.278 , pp. 327-334
    • Whelan, M.C.1    Senger, D.R.2
  • 7
    • 20444483652 scopus 로고    scopus 로고
    • Integrin alpha(4)beta(1)-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation
    • B. Garmy-Susini, H. Jin, Y. Zhu, R.J. Sung, R. Hwang, and J. Varner Integrin alpha(4)beta(1)-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation J. Clin. Invest. 115 2005 1542 1551
    • (2005) J. Clin. Invest. , vol.115 , pp. 1542-1551
    • Garmy-Susini, B.1    Jin, H.2    Zhu, Y.3    Sung, R.J.4    Hwang, R.5    Varner, J.6
  • 8
    • 0027371908 scopus 로고
    • Embryonic mesodermal defects in alpha 5 integrin-deficient mice
    • J.T. Yang, H. Rayburn, and R.O. Hynes Embryonic mesodermal defects in alpha 5 integrin-deficient mice Development 119 1993 1093 1105
    • (1993) Development , vol.119 , pp. 1093-1105
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 9
    • 0030700763 scopus 로고    scopus 로고
    • Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
    • K.L. Goh, J.T. Yang, and R.O. Hynes Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos Development 124 1997 4309 4319
    • (1997) Development , vol.124 , pp. 4309-4319
    • Goh, K.L.1    Yang, J.T.2    Hynes, R.O.3
  • 11
    • 0033843942 scopus 로고    scopus 로고
    • Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin
    • S. Kim, K. Bell, S.A. Mousa, and J.A. Varner Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin Am. J. Pathol. 156 2000 1345 1362
    • (2000) Am. J. Pathol. , vol.156 , pp. 1345-1362
    • Kim, S.1    Bell, K.2    Mousa, S.A.3    Varner, J.A.4
  • 15
    • 0032514841 scopus 로고    scopus 로고
    • Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins
    • B.L. Bader, H. Rayburn, D. Crowley, and R.O. Hynes Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins Cell 95 1998 507 519
    • (1998) Cell , vol.95 , pp. 507-519
    • Bader, B.L.1    Rayburn, H.2    Crowley, D.3    Hynes, R.O.4
  • 21
    • 0035984003 scopus 로고    scopus 로고
    • Beta8 integrins are required for vascular morphogenesis in mouse embryos
    • J. Zhu, K. Motejlek, D. Wang, K. Zang, A. Schmidt, and L.F. Reichardt beta8 integrins are required for vascular morphogenesis in mouse embryos Development 129 2002 2891 2903
    • (2002) Development , vol.129 , pp. 2891-2903
    • Zhu, J.1    Motejlek, K.2    Wang, D.3    Zang, K.4    Schmidt, A.5    Reichardt, L.F.6
  • 22
    • 13444249941 scopus 로고    scopus 로고
    • Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    • J.H. McCarty, A. Lacy-Hulbert, A. Charest, R.T. Bronson, D. Crowley, D. Housman, J. Savill, J. Roes, and R.O. Hynes Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death Development 132 2005 165 176
    • (2005) Development , vol.132 , pp. 165-176
    • McCarty, J.H.1    Lacy-Hulbert, A.2    Charest, A.3    Bronson, R.T.4    Crowley, D.5    Housman, D.6    Savill, J.7    Roes, J.8    Hynes, R.O.9
  • 23
    • 0141725517 scopus 로고    scopus 로고
    • Endothelial expression of the alpha6beta4 integrin is negatively regulated during angiogenesis
    • T.S. Hiran, J.E. Mazurkiewicz, P. Kreienberg, F.L. Rice, and S.E. LaFlamme Endothelial expression of the alpha6beta4 integrin is negatively regulated during angiogenesis J. Cell Sci. 116 2003 3771 3781
    • (2003) J. Cell Sci. , vol.116 , pp. 3771-3781
    • Hiran, T.S.1    Mazurkiewicz, J.E.2    Kreienberg, P.3    Rice, F.L.4    Laflamme, S.E.5
  • 25
    • 0028362876 scopus 로고
    • Requirement of vascular integrin alpha v beta 3 for angiogenesis
    • P.C. Brooks, R.A. Clark, and D.A. Cheresh Requirement of vascular integrin alpha v beta 3 for angiogenesis Science 264 1994 569 571
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 26
    • 0028670833 scopus 로고
    • Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • P.C. Brooks, A.M. Montgomery, M. Rosenfeld, R.A. Reisfeld, T. Hu, G. Klier, and D.A. Cheresh Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels Cell 79 1994 1157 1164
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1    Montgomery, A.M.2    Rosenfeld, M.3    Reisfeld, R.A.4    Hu, T.5    Klier, G.6    Cheresh, D.A.7
  • 28
    • 0042165831 scopus 로고    scopus 로고
    • Alpha v integrin inhibitors and cancer therapy
    • G.C. Tucker Alpha v integrin inhibitors and cancer therapy Curr. Opin. Investig. Drugs 4 2003 722 731
    • (2003) Curr. Opin. Investig. Drugs , vol.4 , pp. 722-731
    • Tucker, G.C.1
  • 29
    • 0027379724 scopus 로고
    • Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin
    • E.L. George, E.N. Georges-Labouesse, R.S. Patel-King, H. Rayburn, and R.O. Hynes Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin Development 119 1993 1079 1091
    • (1993) Development , vol.119 , pp. 1079-1091
    • George, E.L.1    Georges-Labouesse, E.N.2    Patel-King, R.S.3    Rayburn, H.4    Hynes, R.O.5
  • 30
    • 0030818072 scopus 로고    scopus 로고
    • Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells
    • E.L. George, H.S. Baldwin, and R.O. Hynes Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells Blood 90 1997 3073 3081
    • (1997) Blood , vol.90 , pp. 3073-3081
    • George, E.L.1    Baldwin, H.S.2    Hynes, R.O.3
  • 34
    • 19544368642 scopus 로고    scopus 로고
    • Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: An angiogenic control switch
    • S. Cambier, S. Gline, D. Mu, R. Collins, J. Araya, G. Dolganov, S. Einheber, N. Boudreau, and S.L. Nishimura Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch Am. J. Pathol. 166 2005 1883 1894
    • (2005) Am. J. Pathol. , vol.166 , pp. 1883-1894
    • Cambier, S.1    Gline, S.2    Mu, D.3    Collins, R.4    Araya, J.5    Dolganov, G.6    Einheber, S.7    Boudreau, N.8    Nishimura, S.L.9
  • 36
    • 0034604650 scopus 로고    scopus 로고
    • Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties
    • Y. Maeshima, P.C. Colorado, and R. Kalluri Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties J. Biol. Chem. 275 2000 23745 23750
    • (2000) J. Biol. Chem. , vol.275 , pp. 23745-23750
    • Maeshima, Y.1    Colorado, P.C.2    Kalluri, R.3
  • 40
    • 0037446897 scopus 로고    scopus 로고
    • Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    • A. Sudhakar, H. Sugimoto, C. Yang, J. Lively, M. Zeisberg, and R. Kalluri Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins Proc. Natl. Acad. Sci. U. S. A. 100 2003 4766 4771
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 4766-4771
    • Sudhakar, A.1    Sugimoto, H.2    Yang, C.3    Lively, J.4    Zeisberg, M.5    Kalluri, R.6
  • 41
    • 10744223801 scopus 로고    scopus 로고
    • Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin
    • Y. Hamano, M. Zeisberg, H. Sugimoto, J.C. Lively, Y. Maeshima, C. Yang, R.O. Hynes, Z. Werb, A. Sudhakar, and R. Kalluri Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin Cancer Cell 3 2003 589 601
    • (2003) Cancer Cell , vol.3 , pp. 589-601
    • Hamano, Y.1    Zeisberg, M.2    Sugimoto, H.3    Lively, J.C.4    Maeshima, Y.5    Yang, C.6    Hynes, R.O.7    Werb, Z.8    Sudhakar, A.9    Kalluri, R.10
  • 42
    • 20144379162 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis
    • P. Nyberg, L. Xie, and R. Kalluri Endogenous inhibitors of angiogenesis Cancer Res. 65 2005 3967 3979
    • (2005) Cancer Res. , vol.65 , pp. 3967-3979
    • Nyberg, P.1    Xie, L.2    Kalluri, R.3
  • 43
    • 0033558087 scopus 로고    scopus 로고
    • Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2
    • R. Soldi, S. Mitola, M. Strasly, P. Defilippi, G. Tarone, and F. Bussolino Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2 EMBO J. 18 1999 882 892
    • (1999) EMBO J. , vol.18 , pp. 882-892
    • Soldi, R.1    Mitola, S.2    Strasly, M.3    Defilippi, P.4    Tarone, G.5    Bussolino, F.6
  • 44
    • 0034704174 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain
    • E. Borges, Y. Jan, and E. Ruoslahti Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain J. Biol. Chem. 275 2000 39867 39873
    • (2000) J. Biol. Chem. , vol.275 , pp. 39867-39873
    • Borges, E.1    Jan, Y.2    Ruoslahti, E.3
  • 46
  • 47
    • 0033813105 scopus 로고    scopus 로고
    • Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion
    • B.P. Nguyen, M.C. Ryan, S.G. Gil, and W.G. Carter Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion Curr. Opin. Cell Biol. 12 2000 554 562
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 554-562
    • Nguyen, B.P.1    Ryan, M.C.2    Gil, S.G.3    Carter, W.G.4
  • 48
    • 0032514156 scopus 로고    scopus 로고
    • Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180
    • R.Q. Schaapveld, L. Borradori, D. Geerts, M.R. van Leusden, I. Kuikman, M.G. Nievers, C.M. Niessen, R.D. Steenbergen, P.J. Snijders, and A. Sonnenberg Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180 J. Cell Biol. 142 1998 271 284
    • (1998) J. Cell Biol. , vol.142 , pp. 271-284
    • Schaapveld, R.Q.1    Borradori, L.2    Geerts, D.3    Van Leusden, M.R.4    Kuikman, I.5    Nievers, M.G.6    Niessen, C.M.7    Steenbergen, R.D.8    Snijders, P.J.9    Sonnenberg, A.10
  • 49
    • 0035851913 scopus 로고    scopus 로고
    • EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: Role in epithelial cell migration and carcinoma invasion
    • A. Mariotti, P.A. Kedeshian, M. Dans, A.M. Curatola, L. Gagnoux-Palacios, and F.G. Giancotti EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion J. Cell Biol. 155 2001 447 458
    • (2001) J. Cell Biol. , vol.155 , pp. 447-458
    • Mariotti, A.1    Kedeshian, P.A.2    Dans, M.3    Curatola, A.M.4    Gagnoux-Palacios, L.5    Giancotti, F.G.6
  • 50
    • 0035847016 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes
    • M. Dans, L. Gagnoux-Palacios, P. Blaikie, S. Klein, A. Mariotti, and F.G. Giancotti Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes J. Biol. Chem. 276 2001 1494 1502
    • (2001) J. Biol. Chem. , vol.276 , pp. 1494-1502
    • Dans, M.1    Gagnoux-Palacios, L.2    Blaikie, P.3    Klein, S.4    Mariotti, A.5    Giancotti, F.G.6
  • 51
    • 0029666420 scopus 로고    scopus 로고
    • Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
    • J. Dowling, Q.C. Yu, and E. Fuchs Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival J. Cell Biol. 134 1996 559 572
    • (1996) J. Cell Biol. , vol.134 , pp. 559-572
    • Dowling, J.1    Yu, Q.C.2    Fuchs, E.3
  • 52
  • 53
    • 0036303033 scopus 로고    scopus 로고
    • Mechanisms and functions of eph and ephrin signalling
    • K. Kullander, and R. Klein Mechanisms and functions of eph and ephrin signalling Nat. Rev., Mol. Cell Biol. 3 2002 475 486
    • (2002) Nat. Rev., Mol. Cell Biol. , vol.3 , pp. 475-486
    • Kullander, K.1    Klein, R.2
  • 54
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • R.O. Hynes Integrins: bidirectional, allosteric signaling machines Cell 110 2002 673 687
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 55
    • 0141756175 scopus 로고    scopus 로고
    • Integrin avidity regulation: Are changes in affinity and conformation underemphasized?
    • C.V. Carman, and T.A. Springer Integrin avidity regulation: are changes in affinity and conformation underemphasized? Curr. Opin. Cell Biol. 15 2003 547 556
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 547-556
    • Carman, C.V.1    Springer, T.A.2
  • 57
    • 16644368209 scopus 로고    scopus 로고
    • Integrin bidirectional signaling: A molecular view
    • J. Qin, O. Vinogradova, and E.F. Plow Integrin bidirectional signaling: a molecular view PLoS Biol. 2 2004 e169
    • (2004) PLoS Biol. , vol.2 , pp. 169
    • Qin, J.1    Vinogradova, O.2    Plow, E.F.3
  • 59
    • 4043057284 scopus 로고    scopus 로고
    • The talin-tail interaction places integrin activation on FERM ground
    • I.D. Campbell, and M.H. Ginsberg The talin-tail interaction places integrin activation on FERM ground Trends Biochem. Sci. 29 2004 429 435
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 429-435
    • Campbell, I.D.1    Ginsberg, M.H.2
  • 60
    • 0042490495 scopus 로고    scopus 로고
    • RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
    • K. Katagiri, A. Maeda, M. Shimonaka, and T. Kinashi RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1 Nat. Immunol. 4 2003 741 748
    • (2003) Nat. Immunol. , vol.4 , pp. 741-748
    • Katagiri, K.1    Maeda, A.2    Shimonaka, M.3    Kinashi, T.4
  • 62
    • 5444228893 scopus 로고    scopus 로고
    • RAPL: Taking the Rap in immunity
    • L.S. Price, and J.L. Bos RAPL: taking the Rap in immunity Nat. Immunol. 5 2004 1007 1008
    • (2004) Nat. Immunol. , vol.5 , pp. 1007-1008
    • Price, L.S.1    Bos, J.L.2
  • 63
    • 0030602819 scopus 로고    scopus 로고
    • Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule
    • W. Kolanus, W. Nagel, B. Schiller, L. Zeitlmann, S. Godar, H. Stockinger, and B. Seed Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule Cell 86 1996 233 242
    • (1996) Cell , vol.86 , pp. 233-242
    • Kolanus, W.1    Nagel, W.2    Schiller, B.3    Zeitlmann, L.4    Godar, S.5    Stockinger, H.6    Seed, B.7
  • 65
    • 0035846547 scopus 로고    scopus 로고
    • Cytohesin-1 is a dynamic regulator of distinct LFA-1 functions in leukocyte arrest and transmigration triggered by chemokines
    • K.S. Weber, C. Weber, G. Ostermann, H. Dierks, W. Nagel, and W. Kolanus Cytohesin-1 is a dynamic regulator of distinct LFA-1 functions in leukocyte arrest and transmigration triggered by chemokines Curr. Biol. 11 2001 1969 1974
    • (2001) Curr. Biol. , vol.11 , pp. 1969-1974
    • Weber, K.S.1    Weber, C.2    Ostermann, G.3    Dierks, H.4    Nagel, W.5    Kolanus, W.6
  • 67
    • 3142752573 scopus 로고    scopus 로고
    • Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression
    • T. Kong, H.K. Eltzschig, J. Karhausen, S.P. Colgan, and C.S. Shelley Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression Proc. Natl. Acad. Sci. U. S. A. 101 2004 10440 10445
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10440-10445
    • Kong, T.1    Eltzschig, H.K.2    Karhausen, J.3    Colgan, S.P.4    Shelley, C.S.5
  • 69
    • 16344378769 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression
    • K.D. Cowden Dahl, S.E. Robertson, V.M. Weaver, and M.C. Simon Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression Mol. Biol. Cell 16 2005 1901 1912
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1901-1912
    • Cowden Dahl, K.D.1    Robertson, S.E.2    Weaver, V.M.3    Simon, M.C.4
  • 70
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • N. Tang, L. Wang, J. Esko, F.J. Giordano, Y. Huang, H.P. Gerber, N. Ferrara, and R.S. Johnson Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis Cancer Cell 6 2004 485 495
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.P.6    Ferrara, N.7    Johnson, R.S.8
  • 76
    • 0034745356 scopus 로고    scopus 로고
    • Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration
    • W.B. Kiosses, S.J. Shattil, N. Pampori, and M.A. Schwartz Rac recruits high-affinity integrin alphavbeta3 to lamellipodia in endothelial cell migration Nat. Cell Biol. 3 2001 316 320
    • (2001) Nat. Cell Biol. , vol.3 , pp. 316-320
    • Kiosses, W.B.1    Shattil, S.J.2    Pampori, N.3    Schwartz, M.A.4
  • 77
    • 6944234979 scopus 로고    scopus 로고
    • Intussusceptive angiogenesis: Its emergence, its characteristics, and its significance
    • P.H. Burri, R. Hlushchuk, and V. Djonov Intussusceptive angiogenesis: its emergence, its characteristics, and its significance Dev. Dyn. 231 2004 474 488
    • (2004) Dev. Dyn. , vol.231 , pp. 474-488
    • Burri, P.H.1    Hlushchuk, R.2    Djonov, V.3
  • 78
    • 0035801529 scopus 로고    scopus 로고
    • Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment
    • E. Tzima, M.A. del Pozo, S.J. Shattil, S. Chien, and M.A. Schwartz Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment EMBO J. 20 2001 4639 4647
    • (2001) EMBO J. , vol.20 , pp. 4639-4647
    • Tzima, E.1    Del Pozo, M.A.2    Shattil, S.J.3    Chien, S.4    Schwartz, M.A.5
  • 79
    • 0141613755 scopus 로고    scopus 로고
    • The C-terminal end of R-Ras contains a focal adhesion targeting signal
    • J. Furuhjelm, and J. Peranen The C-terminal end of R-Ras contains a focal adhesion targeting signal J. Cell Sci. 116 2003 3729 3738
    • (2003) J. Cell Sci. , vol.116 , pp. 3729-3738
    • Furuhjelm, J.1    Peranen, J.2
  • 81
    • 0034739854 scopus 로고    scopus 로고
    • Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains
    • A.L. Berrier, A.M. Mastrangelo, J. Downward, M. Ginsberg, and S.E. LaFlamme Activated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains J. Cell Biol. 151 2000 1549 1560
    • (2000) J. Cell Biol. , vol.151 , pp. 1549-1560
    • Berrier, A.L.1    Mastrangelo, A.M.2    Downward, J.3    Ginsberg, M.4    Laflamme, S.E.5
  • 83
    • 0031038131 scopus 로고    scopus 로고
    • R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways
    • B.M. Marte, P. Rodriguez-Viciana, S. Wennstrom, P.H. Warne, and J. Downward R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways Curr. Biol. 7 1997 63 70
    • (1997) Curr. Biol. , vol.7 , pp. 63-70
    • Marte, B.M.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 84
    • 10044256619 scopus 로고    scopus 로고
    • A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters
    • D.M. Roberts, A.L. Anderson, M. Hidaka, R.L. Swetenburg, C. Patterson, W.L. Stanford, and V.L. Bautch A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters Mol. Cell. Biol. 24 2004 10515 10528
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 10515-10528
    • Roberts, D.M.1    Anderson, A.L.2    Hidaka, M.3    Swetenburg, R.L.4    Patterson, C.5    Stanford, W.L.6    Bautch, V.L.7
  • 86
    • 0037904987 scopus 로고    scopus 로고
    • The integrin-actin connection, an eternal love affair
    • C. Brakebusch, and R. Fassler The integrin-actin connection, an eternal love affair EMBO J. 22 2003 2324 2333
    • (2003) EMBO J. , vol.22 , pp. 2324-2333
    • Brakebusch, C.1    Fassler, R.2
  • 89
    • 10444220152 scopus 로고    scopus 로고
    • Common cues in vascular and axon guidance
    • G. Serini, and F. Bussolino Common cues in vascular and axon guidance Physiology (Bethesda) 19 2004 348 354
    • (2004) Physiology (Bethesda) , vol.19 , pp. 348-354
    • Serini, G.1    Bussolino, F.2
  • 90
    • 1642283154 scopus 로고    scopus 로고
    • Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development
    • H. Fujisawa Discovery of semaphorin receptors, neuropilin and plexin, and their functions in neural development J. Neurobiol. 59 2004 24 33
    • (2004) J. Neurobiol. , vol.59 , pp. 24-33
    • Fujisawa, H.1
  • 91
    • 20744434543 scopus 로고    scopus 로고
    • Plexins: Axon guidance and signal transduction
    • M. Negishi, I. Oinuma, and H. Katoh Plexins: axon guidance and signal transduction Cell. Mol. Life Sci. 62 2005 1363 1371
    • (2005) Cell. Mol. Life Sci. , vol.62 , pp. 1363-1371
    • Negishi, M.1    Oinuma, I.2    Katoh, H.3
  • 92
    • 0037080330 scopus 로고    scopus 로고
    • Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse
    • S.M. Zanata, I. Hovatta, B. Rohm, and A.W. Puschel Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse J. Neurosci. 22 2002 471 477
    • (2002) J. Neurosci. , vol.22 , pp. 471-477
    • Zanata, S.M.1    Hovatta, I.2    Rohm, B.3    Puschel, A.W.4
  • 93
    • 10644250013 scopus 로고    scopus 로고
    • Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons
    • I. Oinuma, H. Katoh, and M. Negishi Molecular dissection of the semaphorin 4D receptor plexin-B1-stimulated R-Ras GTPase-activating protein activity and neurite remodeling in hippocampal neurons J. Neurosci. 24 2004 11473 11480
    • (2004) J. Neurosci. , vol.24 , pp. 11473-11480
    • Oinuma, I.1    Katoh, H.2    Negishi, M.3
  • 94
    • 4043105621 scopus 로고    scopus 로고
    • The activity of the plexin-A1 receptor is regulated by Rac
    • L.J. Turner, S. Nicholls, and A. Hall The activity of the plexin-A1 receptor is regulated by Rac J. Biol. Chem. 279 2004 33199 33205
    • (2004) J. Biol. Chem. , vol.279 , pp. 33199-33205
    • Turner, L.J.1    Nicholls, S.2    Hall, A.3
  • 95
    • 3843065433 scopus 로고    scopus 로고
    • The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras
    • I. Oinuma, Y. Ishikawa, H. Katoh, and M. Negishi The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras Science 305 2004 862 865
    • (2004) Science , vol.305 , pp. 862-865
    • Oinuma, I.1    Ishikawa, Y.2    Katoh, H.3    Negishi, M.4
  • 96
    • 22344434300 scopus 로고    scopus 로고
    • Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
    • T.L. Shen, A.Y. Park, A. Alcaraz, X. Peng, I. Jang, P. Koni, R.A. Flavell, H. Gu, and J.L. Guan Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis J. Cell Biol. 169 2005 941 952
    • (2005) J. Cell Biol. , vol.169 , pp. 941-952
    • Shen, T.L.1    Park, A.Y.2    Alcaraz, A.3    Peng, X.4    Jang, I.5    Koni, P.6    Flavell, R.A.7    Gu, H.8    Guan, J.L.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.