Kindlin: Helper, co-activator, or booster of talin in integrin activation?

Current Opinion in Hematology

Volumn 18, Issue 5, 2011, Pages 356-360

  Ye, Feng ^a   Petrich, Brian G ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

integrin; kindlin; talin

Indexed keywords

INTEGRIN; INTEGRIN ALPHA2B BETA3; PHOSPHOPROTEIN; PROTEIN KINDLIN; PROTEIN KINDLIN 1; PROTEIN KINDLIN 2; PROTEIN KINDLIN 3; SCAFFOLD PROTEIN; TALIN; UNCLASSIFIED DRUG;

BINDING AFFINITY; CELL FUNCTION; GENE DELETION; GENE INTERACTION; HEMOSTASIS; HUMAN; LEUKOCYTE ADHERENCE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE ADHESION;

ANIMALS; BLOOD PLATELETS; CYTOSKELETAL PROTEINS; HEMOSTASIS; HUMANS; INTEGRINS; MEMBRANE PROTEINS; MICE; PROTEIN BINDING; TALIN;

EID: 80051802621     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e3283497f09     Document Type: Review

References (44)

1. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell 2002;110:673-687. (Pubitemid 35283958)
2. Wagner CL, Mascelli MA, Neblock DS, et al. Analysis of GPIIb/IIIa receptor number by quantification of 7E3 binding to human platelets. Blood 1996;88:907-914. (Pubitemid 26333313)
3. Coller BS, Shattil SJ. The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood 2008;112:3011-3025.
4. Shattil SJ, Kashiwagi H, Pampori N. Integrin signaling: the platelet paradigm. Blood 1998;91:2645-2657. (Pubitemid 28227512)
5. Shattil SJ, Newman PJ. Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood 2004;104:1606-1615. (Pubitemid 39202265)
6. Moser M, Legate KR, Zent R, Fassler R. The tail of integrins, talin, and kindlins. Science 2009;324:895-899.
7. Shattil SJ, Kim C, Ginsberg MH. The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol 2010;11:288-300.
8. Critchley DR. Biochemical and structural properties of the integrin-associated cytoskeletal protein talin. Annu Rev Biophys 2009;38:235-254.
9. Bouaouina M, Lad Y, Calderwood DA. The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins. J Biol Chem 2008;283:6118-6125.
10. Calderwood DA, Zent R, Grant R, et al. The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation. J Biol Chem 1999;274:28071-28074.
11. Kim M, Carman CV, Springer TA. Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins. Science 2003;301:1720-1725. (Pubitemid 37174365)
12. Monkley SJ, Zhou XH, Kinston SJ, et al. Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn 2000;219:560-574.
13. Nieswandt B, Moser M, Pleines I, et al. Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo. J Exp Med 2007;204:3113-3118.
14. Petrich BG, Marchese P, Ruggeri ZM, et al. Talin is required for integrinmediated platelet function in hemostasis and thrombosis. J Exp Med 2007;204:3103-3111.
15. Haling JR, Monkley SJ, Critchley DR, Petrich BG. Talin-dependent integrin activation is required for fibrin clot retraction by platelets. Blood 2011;117:1719-1722.
16. Petrich BG, Fogelstrand P, Partridge AW, et al. The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest 2007;117:2250-2259. (Pubitemid 47219570)
17. Lim J, Wiedemann A, Tzircotis G, et al. An essential role for talin during alpha (M) beta (2)-mediated phagocytosis. Mol Biol Cell 2007;18:976-985. (Pubitemid 46399501)
18. Harburger DS, Bouaouina M, Calderwood DA. Kindlin-1 and-2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrinspecific activation effects. J Biol Chem 2009;284:11485-11497. This article recognized that over-expressed kindlin is inhibitory for β1 integrin and for β3 integrin in some circumstances. The authors suggested a possible scaffold role for kindlin.
19. Moser M, Nieswandt B, Ussar S, et al. Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 2008;14:325-330. This is the first article to recognize and establish the role of kindlin in integrin regulation. (Pubitemid 351347914)
20. Ma YQ, Qin J, Wu C, Plow EF. Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J Cell Biol 2008;181:439-446. This article established that kindlin can synergize with THD in activating integrin aIIbb3. (Pubitemid 351645034)
21. Kloeker S, Major MB, Calderwood DA, et al. The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrinmediated adhesion. J Biol Chem 2004;279:6824-6833. (Pubitemid 38248824)
22. Moser M, Bauer M, Schmid S, et al. Kindlin-3 is required for beta2 integrin mediated leukocyte adhesion to endothelial cells. Nat Med 2009;15:300-305.
23. Schmidt S, Nakchbandi I, Ruppert R, et al. Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol 2011;192:883-897.
24. Kuijpers TW, van de Vijver E, Weterman MA, et al. LAD-1/variant syndrome is caused by mutations in FERMT3. Blood 2009;113:4740-4746.
25. *] was the first to show that mutations in kindlin-3 caused integrin activation defects in human patients with leukocyte adhesion deficiency-III.
26. McDowall A, Svensson L, Stanley P, et al. Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency III patient reveal distinct effects on leukocyte function in vitro. Blood 2010;115:4834-4842.
27. *] was the first to show that mutations in kindlin-3 caused integrin activation defects in human patients with leukocyte adhesion deficiency-III.
28. Robert P, Canault M, Farnarier C, et al. A novel leukocyte adhesion deficiency-III variant: kindlin-3 deficiency results in integrin and nonintegrin-related defects in different steps of leukocyte adhesion. J Immunol 2011;186:5273-5283.
29. Ussar S, Moser M, Widmaier M, et al. Loss of Kindlin-1 causes skin atrophy and lethal neonatal intestinal epithelial dysfunction. PLoS Genet 2008;4:e1000289.
30. Montanez E, Ussar S, Schifferer M, et al. Kindlin-2 controls bidirectional signaling of integrins. Genes Dev 2008;22:1325-1330. (Pubitemid 351717522)
31. Manevich-Mendelson E, Feigelson SW, Pasvolsky R, et al. Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. Blood 2009;114:2344-2353.
32. Calderwood DA, Yan B, de Pereda JM, et al. Thephosphotyrosine binding-like domain of talin activates integrins. J Biol Chem 2002;277:21749-21758. (Pubitemid 34952326)
33. Ye F, Hu G, Taylor D, et al. Recreation of the terminal events in physiological integrin activation. J Cell Biol 2010;188:157-173. This study utilizes monomeric integrins embedded in phospholipid nanodiscs to show that the THD alone is sufficient to activate integrins and does not require integrin clustering.
34. Shi X, Ma YQ, Tu Y, et al. The MIG-2/integrin interaction strengthens cellmatrix adhesion and modulates cell motility. J Biol Chem 2007;282:20455-20466. (Pubitemid 47100027)
35. Qu H, Tu Y, Shi X, et al. Kindlin-2 regulates podocyte adhesion andfibronectin matrix deposition through interactions with phosphoinositides and integrins. J Cell Sci 2011;124(Pt 6):879-891.
36. Loer B, Bauer R, Bornheim R, et al. The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nat Cell Biol 2008;10:422-428.
37. Metcalf DG, Moore DT, Wu Y, et al. NMR analysis of the alphaIIb beta3 cytoplasmic interaction suggests a mechanism for integrin regulation. Proc Natl Acad Sci USA 2011;107:22481-22486.
38. Bialkowska K, Ma YQ, Bledzka K, et al. The integrin co-activator Kindlin-3 is expressed and functional in a nonhematopoietic cell, the endothelial cell. J Biol Chem 2010;285:18640-18649. This article showed that kindlin-2 and kindlin-3 might localize differently in cells and display some integrin specificity.
39. Saltel F, Mortier E, Hytonen VP, et al. New PI (4, 5) P2-and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering. J Cell Biol 2009;187:715-731.
40. Kim C, Lau TL, Ulmer TS, Ginsberg MH. Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood 2009;113:4747-4753.
41. Gingras AR, Bate N, Goult BT, et al. The structure of the C-terminal actinbinding domain of talin. Embo J 2008;27:458-469. (Pubitemid 351161654)
42. Tremuth L, Kreis S, Melchior C, et al. A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain. J Biol Chem 2004;279:22258-22266. (Pubitemid 38679422)
43. Xing B, Jedsadayanmata A, Lam SC. Localization of an integrin binding site to the C terminus of talin. J Biol Chem 2001;276:44373-44378.
44. Abrams C, Deng YJ, Steiner B, et al. Determinants ofspecificity of a baculovirusexpressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3. J Biol Chem 1994;269:18781-18788.