Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 98, Issue 11, 2001, Pages 6009-6014

  Shimaoka, Motomu ^a   Lu, Chafen ^a,b   Palframan, Roger T ^a   Von Andrian, Ulrich H ^a   McCormack, Alison ^a   Takagi, Junichi ^a   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; DISULFIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTEGRIN; INTEGRIN ALPHAL I; INTEGRIN ALPHALBETA2; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; INTERCELLULAR ADHESION MOLECULE 3; LIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; CONFORMATION; CRYSTALLIZATION; DISULFIDE BOND; LIGAND BINDING; LYMPHOCYTE HOMING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; REDUCTION;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CELL ADHESION MOLECULES; DISULFIDES; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; K562 CELLS; KINETICS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 0035932996     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.101130498     Document Type: Article

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