Biophysical analysis of kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPXY motif

Journal of Biological Chemistry

Volumn 287, Issue 45, 2012, Pages 37715-37731

  Yates, Luke A ^a   Füzéry, Anna K ^b,c   Bonet, Roman ^b   Campbell, Iain D ^b   Gilbert, Robert J C ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPHYSICAL ANALYSIS; COACTIVATORS; ELONGATED STRUCTURES; INTEGRIN BINDING; INTEGRINS; SOLUTION STRUCTURES; TERNARY COMPLEX;

BIOCHEMISTRY;

BIOLOGY;

BETA INTEGRIN; BINDING PROTEIN; ISOPROTEIN; KINDLIN 3; RECOMBINANT PROTEIN; SERINE; TALIN; THREONINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BACULOVIRUS; COMPLEX FORMATION; CONTROLLED STUDY; MOLECULAR CLONING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN QUATERNARY STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; ULTRACENTRIFUGATION; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD29; BIOPHYSICAL PHENOMENA; CYTOSKELETAL PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE PROTEINS; MICE; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; SF9 CELLS; TALIN; X-RAY DIFFRACTION;

EID: 84868306936     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.415208     Document Type: Article

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