A small molecule agonist of an integrin, αLβ 2

Journal of Biological Chemistry

Volumn 281, Issue 49, 2006, Pages 37904-37912

  Yang, Wei ^a   Carman, Christopher V ^a   Kim, Minsoo ^a,b   Salas, Azucena ^a,c   Shimaoka, Motomu ^a   Springer, Timothy A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROWN UNIVERSITY   (United States)

^c INST D INVESTIGACIONS B   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI INFLAMMATORY DRUGS; INTEGRIN; LEUKOCYTES; LYMPHOCYTES;

ANTIGEN-ANTIBODY REACTIONS; BLOOD; CALCIUM; CHEMICAL ACTIVATION; MANGANESE; POSITIVE IONS;

DRUG PRODUCTS;

BIRT 377; CALCIUM; INTEGRIN; LFA 703; MAGNESIUM; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LIGAND BINDING; LYMPHOCYTE; PRIORITY JOURNAL;

ALLOSTERIC REGULATION; ANTIBODIES, MONOCLONAL; CATIONS, DIVALENT; CELL ADHESION; CELL MOVEMENT; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; K562 CELLS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; LYMPHOCYTES; MOLECULAR STRUCTURE; MUTATION; PROTEIN BINDING; RECOMBINANT PROTEINS; TRANSFECTION;

UROPODA;

EID: 33845989911     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606888200     Document Type: Article

References (54)

1. Anderson, D. C., Smith, C. W., and Springer, T. A. (1989) in Metabolic Basis of Inherited Disease (Stanbury, J. B., Wyngaarden, J. B., and Frederickson, D. S., eds) 6th Ed., pp. 2751-2777, McGraw-Hill, New York
2. Springer, T. A. (1990) Nature 346, 425-433
3. Harlan, J. M., Winn, R. K., Vedder, N. B., Doerschuk, C. M., and Rice, C. L. (1992) in Adhesion: Its Role in Inflammatory Disease (Harlan, J. R., and Liu, D., eds) pp. 117-150, W. H. Freeman and Co., New York
4. Giblin, P. A., and Kelly, T. A. (2001) Annu. Rep. Med. Chem. 36, 181-190
5. Yusuf-Makagiansar, H., Anderson, M. E., Yakovleva, T. V., Murray, J. S., and Siahaan, T. J. (2002) Med. Res. Rev. 22, 146-167
6. Gottlieb, A., Krueger, J. G., Bright, R., Ling, M., Lebwohl, M., Kang, S., Feldman, S., Spellman, M., Wittkowski, K., Ochs, H. D., Jardieu, P., Bauer, R., White, M., Dedrick, R., and Garovoy, M. (2000) J. Am. Acad. Dermatol. 42, 428-435
7. Gottlieb, A. B., and Bos, J. D. (2002) Clin. Immunol. 105, 105-116
8. Gottlieb, A. B., Krueger, J. G., Wittkowski, K., Dedrick, R., Walicke, P. A., and Garovoy, M. (2002) Arch. Dermatol. 138, 591-600
9. Cather, J. C., and Menter, A. (2003) Expert Opin. Biol. Ther. 3, 361-370
10. Lebwohl, M., Tyring, S. K., Hamilton, T. K., Toth, D., Glazer, S., Tawfik, N. H., Walicke, P., Dummer, W., Wang, X., Garovoy, M. R., and Pariser, D. (2003) N. Engl. J. Med. 349, 2004-2013
11. Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S., Takada, Y., and Hommel, U. (2001) Nat. Med. 7, 687-692
12. Kallen, J., Welzenbach, K., Ramage, P., Geyl, D., Kriwacki, R., Legge, G., Cottens, S., Weitz-Schmidt, G., and Hommel, U. (1999) J. Mol. Biol. 292, 1-9
13. Last-Barney, K., Davidson, W., Cardozo, M., Frye, L. L., Grygon, C. A., Hopkins, J. L., Jeanfavre, D. D., Pav, S., Qian, C., Stevenson, J. M., Tong, L., Zindell, R., and Kelly, T. A. (2001) J. Am. Chem. Soc. 123, 5643-5650
14. Liu, G., Huth, J. R., Olejniczak, E. T., Mendoza, R., DeVries, P., Leitza, S., Reilly, E. B., Okasinski, G. F., Fesik, S. W., and von Geldern, T. W. (2001) J. Med. Chem. 44, 1202-1210
15. Burdick, D. J. (March 24, 1999) International Patent WO9949856
16. Burdick, D. J., Gadek, T. R., Marsters, J., Oare, D. A., Reynolds, M. E., and Stanley, M. S. (November 26, 2001) International Patent WO02059114
17. Gadek, T. R., Burdick, D. J., McDowell, R. S., Stanley, M. S., Marsters, J. C., Jr., Paris, K. J., Oare, D. A., Reynolds, M. E., Ladner, C., Zioncheck, K. A., Lee, W. P., Gribling, P., Dennis, M. S., Skelton, N. J., Tumas, D. B., Clark, K. R., Keating, S. M., Beresini, M. H., Tilley, J. W., Presta, L. G., and Bodary, S. C. (2002) Science 295, 1086-1089
18. Humphries, M. J. (2000) Biochem. Soc. Trans. 28, 311-339
19. Gahmberg, C. G., Tolvanen, M., and Kotovuori, P. (1997) Eur. J. Biochem. 245, 215-232
20. Shimaoka, M., Takagi, J., and Springer, T. A. (2002) Annu. Rev. Biophys. Biomol. Struct. 31, 485-516
21. Lee, J.-O., Rieu, P., Arnaout, M. A., and Liddington, R. (1995) Cell 80, 631-638
22. Huang, C., Zang, Q., Takagi, J., and Springer, T. A. (2000) J. Biol. Chem. 275, 21514-21524
23. Xiong, J.-P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Goodman, S. L., and Arnaout, M. A. (2001) Science 294, 339-345
24. Song, G., Yang, Y., Liu, J.-h., Casasnovas, J., Shimaoka, M., Springer, T. A., and Wang, J.-h. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 3366-3371
25. Shimaoka, M., Shifman, J. M., Jing, H., Takagi, J., Mayo, S. L., and Springer, T. A. (2000) Nat. Struct. Biol. 7, 674-678
26. Shimaoka, M., Lu, C., Palframan, R., von Andrian, U. H., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 6009-6014
27. Takagi, J., Petre, B. M., Walz, T., and Springer, T. A. (2002) Cell 110, 599-611
28. Luo, B.-H., Takagi, J., and Springer, T. A. (2004) J. Biol. Chem. 279, 10215-10221
29. Yang, W., Shimaoka, M., Chen, J. F., and Springer, T. A. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 2333-2338
30. Xiao, T., Takagi, J., Wang, J.-h., Coller, B. S., and Springer, T. A. (2004) Nature 432, 59-67
31. Semmrich, M., Smith, A., Feterowski, C., Beer, S., Engelhardt, B., Busch, D. H., Bartsch, B., Laschinger, M., Hogg, N., Pfeffer, K., and Holzmann, B. (2005) J. Exp. Med. 201, 1987-1998
32. Alonso, J. L., Essafi, M., Xiong, J. P., Stehle, T., and Arnaout, M. A. (2002) Curr. Biol. 12, 340-342
33. Yang, W., Shimaoka, M., Salas, A., Takagi, J., and Springer, T. A. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 2906-2911
34. Lu, C., Shimaoka, M., Zang, Q., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2393-2398
35. Fotouhi, N., Gillespie, P., Guthrie, R., Pietranico-Cole, S., and Yun, W. (October 12, 1999) International Patent WO0021920
36. Welzenbach, K., Hommel, U., and Weitz-Schmidt, G. (2002) J. Biol. Chem. 277, 10590-10598
37. Shimaoka, M., Salas, A., Yang, W., Weitz-Schmidt, G., and Springer, T. A. (2003) Immunity 19, 391-402
38. Dransfield, I., and Hogg, N. (1989) EMBO J. 8, 3759-3765
39. Robinson, M. K., Andrew, D., Rosen, H., Brown, D., Ortlepp, S., Stephens, P., and Butcher, E. C. (1992) J. Immunol. 148, 1080-1085
40. Lu, C., and Springer, T. A. (1997) J. Immunol. 159, 268-278
41. Carman, C. V., and Springer, T. A. (2004) J. Cell Biol. 167, 377-388
42. Salas, A., Shimaoka, M., Kogan, A. N., Harwood, C., von Andrian, U. H., and Springer, T. A. (2004) Immunity 20, 393-406
43. Kim, M., Carman, C. V., and Springer, T. A. (2003) Science 301, 1720-1725
44. Huth, J. R., Olejniczak, E. T., Mendoza, R., Liang, H., Harris, E. A., Lupher, M. L., Jr., Wilson, A. E., Fesik, S. W., and Staunton, D. E. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5231-5236
45. Lu, C., Shimaoka, M., Ferzly, M., Oxvig, C., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2387-2392
46. Lu, C., Shimaoka, M., Salas, A., and Springer, T. A. (2004) J. Immunol. 173, 3972-3978
47. Keating, S. M., Clark, K. R., Stefanich, L. D., Arellano, F., Edwards, C. P., Bodary, S. C., Spencer, S. A., Gadek, T. R., Marsters, J. C., Jr., and Beresini, M. H. (2006) Protein Sci. 15, 290-303
48. Chen, J. F., Salas, A., and Springer, T. A. (2003) Nat. Struct. Biol. 10, 995-1001
49. Springer, T. A., and Anderson, D. C. (1986) in Biochemistry of Macrophages (Ciba Symposium 118) pp. 102-126, Pitman, London
50. Smith, A., Bracke, M., Leitinger, B., Porter, J. C., and Hogg, N. (2003) J. Cell Sci. 116, 3123-3133
51. Sanchez-Madrid, F., and del Pozo, M. A. (1999) EMBO J. 18, 501-511
52. Kuijpers, T. W., Mul, E. P. J., Blom, M., Kovach, N. L., Gaeta, F. C. A., Tollefson, V., Elices, M. J., and Harlan, J. M. (1993) J. Exp. Med. 178, 279-284
53. Weber, C., Lu, C.-F., Casasnovas, J. M., and Springer, T. A. (1997) J. Immunol. 159, 3968-3975
54. Worthylake, R. A., Lemoine, S., Watson, J. M., and Burridge, K. (2001) J. Cell Biol. 154, 147-160