Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 42, 2013, Pages 17005-17010

  Moretti, Federico A ^a   Moser, Markus ^a   Lyck, Ruth ^b   Abadier, Michael ^b   Ruppert, Raphael ^a   Engelhardt, Britta ^b   Fässler, Reinhard ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Eae; Integrin affinity

Indexed keywords

AUTOANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; KINDLIN 3; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; EFFECTOR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EAE; INTEGRIN AFFINITY;

ANIMALS; CELL ADHESION; CYTOSKELETAL PROTEINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; INTEGRIN ALPHA4BETA1; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MICE; T-LYMPHOCYTES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84885806025     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1316032110     Document Type: Article

References (34)

1. McFarland HF, Martin R (2007) Multiple sclerosis: A complicated picture of autoimmunity. Nat Immunol 8(9): 913-919.
2. Engelhardt B (2010) T cell migration into the central nervous system during health and disease: Different molecular keys allow access to different central nervous system compartments. Clin Exp Neuroimmunol 1: 79-93.
3. Steinman L (2005) Blocking adhesion molecules as therapy for multiple sclerosis: Natalizumab. Nat Rev Drug Discov 4(6): 510-518.
4. Hynes RO (2002) Integrins: Bidirectional, allosteric signaling machines. Cell 110(6): 673-687.
5. Kim C, Ye F, Ginsberg MH (2011) Regulation of integrin activation. Annu Rev Cell Dev Biol 27: 321-345.
6. Moser M, Legate KR, Zent R, Fässler R (2009) The tail of integrins, talin, and kindlins. Science 324(5929): 895-899.
7. Kinashi T (2005) Intracellular signalling controlling integrin activation in lymphocytes. Nat Rev Immunol 5(7): 546-559.
8. Paszek MJ, Boettiger D, Weaver VM, Hammer DA (2009) Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. PLOS Comput Biol 5(12):e1000604.
9. Kong F, García AJ, Mould AP, Humphries MJ, Zhu C (2009) Demonstration of catch bonds between an integrin and its ligand. J Cell Biol 185(7): 1275-1284.
10. Marshall BT, et al. (2003) Direct observation of catch bonds involving cell-adhesion molecules. Nature 423(6936): 190-193.
11. Ussar S, Wang HV, Linder S, Fässler R, Moser M (2006) The Kindlins: Subcellular localization and expression during murine development. Exp Cell Res 312(16): 3142-3151.
12. Moser M, et al. (2009) Kindlin-3 is required for beta2 integrin-mediated leukocyte adhesion to endothelial cells. Nat Med 15(3): 300-305.
13. Moser M, Nieswandt B, Ussar S, Pozgajova M, Fässler R (2008) Kindlin-3 is essential for integrin activation and platelet aggregation. Nat Med 14(3): 325-330.
14. Schmidt S, et al. (2011) Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption. J Cell Biol 192(5): 883-897.
15. Kuijpers TW, et al. (2009) LAD-1/variant syndrome is caused by mutations in FERMT3. Blood 113(19): 4740-4746.
16. Malinin NL, et al. (2009) A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans. Nat Med 15(3): 313-318.
17. Svensson L, et al. (2009) Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Nat Med 15(3): 306-312.
18. Stromnes IM, Goverman JM (2006) Passive induction of experimental allergic encephalomyelitis. Nat Protoc 1(4): 1952-1960.
19. Stromnes IM, Goverman JM (2006) Active induction of experimental allergic encephalomyelitis. Nat Protoc 1(4): 1810-1819.
20. Lee PP, et al. (2001) A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15(5): 763-774.
21. Bettelli E, et al. (2003) Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 197(9): 1073-1081.
22. Bergman RK, Munoz JJ, Portis JL (1978) Vascular permeability changes in the central nervous system of rats with hyperacute experimental allergic encephalomyelitis induced with the aid of a substance from Bordetella pertussis. Infect Immun 21(2): 627-637.
23. Steffen BJ, Butcher EC, Engelhardt B (1994) Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am J Pathol 145(1): 189-201.
24. Constantin G, et al. (2000) Chemokines trigger immediate beta2 integrin affinity and mobility changes: Differential regulation and roles in lymphocyte arrest under flow. Immunity 13(6): 759-769.
25. Steiner O, et al. (2010) Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium. J Immunol 185(8): 4846-4855.
26. Coisne C, Lyck R, Engelhardt B (2013) Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo. Fluids Barriers CNS 10(1): 7.
27. Bauer M, et al. (2009) Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity. Proc Natl Acad Sci USA 106(6): 1920-1925.
28. Manevich-Mendelson E, et al. (2009) Loss of Kindlin-3 in LAD-III eliminates LFA-1 but not VLA-4 adhesiveness developed under shear flow conditions. Blood 114(11): 2344-2353.
29. Lefort CT, et al. (2012) Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood 119(18): 4275-4282.
30. Ye F, et al. (2010) Recreation of the terminal events in physiological integrin activation. J Cell Biol 188(1): 157-173.
31. Hao JJ, et al. (2008) Enrichment of distinct microfilament-associated and GTP-binding proteins in membrane/microvilli fractions from lymphoid cells. J Proteome Res 7(7): 2911-2927.
32. Hyduk SJ, et al. (2011) Talin-1 and kindlin-3 regulate alpha4beta1 integrin-mediated adhesion stabilization, but not G protein-coupled receptor-induced affinity up-regulation. J Immunol 187(8): 4360-4368.
33. Feng C, et al. (2012) Kindlin-3 mediates integrin αLβ2 outside-in signaling, and it interacts with scaffold protein receptor for activated-C kinase 1 (RACK1). J Biol Chem 287(14): 10714-10726.
34. Montanez E, et al. (2007) Analysis of integrin functions in peri-implantation embryos, hematopoietic system, and skin. Methods Enzymol 426: 239-289.