Kindlin-2 inhibited the growth and migration of colorectal cancer cells

Tumor Biology

Volumn 36, Issue 6, 2015, Pages 4107-4114

  Ren, Yuanyuan ^a   Jin, Hongsong ^a   Xue, Zhidong ^a   Xu, Qianlang ^a   Wang, Songhua ^a   Zhao, Guojun ^a   Huang, Junxing ^b   Huang, He ^b  

^a People's Hospital of Taizhou   (China)

^b The Institute of Cancer Research   (China)

Author keywords

Beta catenin; Cell proliferation and migration; CRC; Kindlin 2

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN KINDLIN 2; REGULATOR PROTEIN; SERINE; UNCLASSIFIED DRUG; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MEMBRANE PROTEIN; MIG2B PROTEIN, HUMAN; TUMOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; CELL PROLIFERATION; COLON MUCOSA; COLORECTAL CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MIGRATION INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UBIQUITINATION; ANIMAL; BIOSYNTHESIS; CARCINOGENESIS; COLORECTAL TUMOR; GENE EXPRESSION REGULATION; GENETICS; HCT116 CELL LINE; METABOLISM; PATHOLOGY; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; CARCINOGENESIS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HCT116 CELLS; HUMANS; MEMBRANE PROTEINS; MICE; NEOPLASM PROTEINS; WNT SIGNALING PATHWAY;

EID: 84938997534     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3044-8     Document Type: Article

References (16)

1. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64(1):9–29.
2. Abdel-Magid AF. Wnt/beta-catenin signaling pathway inhibitors: a promising cancer therapy. ACS Med Chem Lett. 2014;5(9):956–7.
3. Tian J, He H, Lei G. Wnt/beta-catenin pathway in bone cancers. Tumour Biol. 2014;35(10):9439–45.
4. Ali RH, Khan AA. Tracing the evolution of FERM domain of Kindlins. Mol Phylogenet Evol. 2014;80:193–204.
5. Lai-Cheong JE, Parsons M, McGrath JA. The role of kindlins in cell biology and relevance to human disease. Int J Biochem Cell Biol. 2010;42(5):595–603.
6. Sin S, Bonin F, Petit V, et al. Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis. J Natl Cancer Inst. 2011;103(17):132313–37.
7. Mahawithitwong P, Ohuchida K, Ikenaga N, et al. Kindlin-1 expression is involved in migration and invasion of pancreatic cancer. Int J Oncol. 2013;42(4):1360–6.
8. Zhao T, Guan L, Yu Y, et al. Kindlin-2 promotes genome instability in breast cancer cells. Cancer Lett. 2013;330(2):208–16.
9. Konsavage Jr WM, Jin G, Yochum GS. The Myc 3’ Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol. 2012;32(19):3891–902.
10. Fodde R, Brabletz T. Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol. 2007;19(2):150–8.
11. Kaler P, Augenlicht L, Klampfer L. Activating mutations in beta-catenin in colon cancer cells alter their interaction with macrophages; the role of snail. PLoS One. 2012;7(9):e45462.
12. Kapitanovic S, Cacev T, Radosevic S, Spaventi S, Spaventi R, Pavelic K. APC gene loss of heterozygosity, mutations, E1317Q, and I1307K germ-line variants in sporadic colon cancer in Croatia. Exp Mol Pathol. 2004;77(3):193–200.
13. Xie D, Yin D, Tong X, et al. Cyr61 is overexpressed in gliomas and involved in integrin-linked kinase-mediated Akt and beta-catenin-TCF/Lef signaling pathways. Cancer Res. 2004;64(6):1987–96.
14. Fukuda K, Bledzka K, Yang J, Perera HD, Plow EF, Qin J. Molecular basis of Kindlin-2 binding to integrin-linked kinase pseudokinase for regulating cell adhesion. J Biol Chem. 2014;289(41):28363–75.
15. Dowling JJ, Vreede AP, Kim S, Golden J, Feldman EL. Kindlin-2 is required for myocyte elongation and is essential for myogenesis. BMC Cell Biol. 2008;9:36.
16. Rognoni E, Widmaier M, Jakobson M, et al. Kindlin-1 controls Wnt and TGF-beta availability to regulate cutaneous stem cell proliferation. Nat Med. 2014;20(4):350–9.