NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 10, 2000, Pages 5231-5236

  Huth, Jeffrey R ^a   Olejniczak, Edward T ^a   Mendoza, Renaldo ^a   Liang, Heng ^a   Harris, Edith A S ^b   Lupher Jr , Mark L ^b   Wilson, Amy E ^b   Fesik, Stephen W ^a   Staunton, Donald E ^b  

^a ABBOTT LABORATORIES   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BINDING SITE; CELL ADHESION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; LIGAND BINDING; MUTAGENESIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE;

ALLOSTERIC SITE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIGENS, CD18; BINDING SITES; CELL ADHESION; COS CELLS; CRYSTALLOGRAPHY, X-RAY; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LIGANDS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; TRANSFECTION;

ANIMALIA; IDAS;

EID: 0034625083     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.10.5231     Document Type: Article

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