Kindlin-1 and -2 directly bind the C-terminal region of β integrin cytoplasmic tails and exert integrin-specific activation effects

Journal of Biological Chemistry

Volumn 284, Issue 17, 2009, Pages 11485-11497

  Harburger, David S ^a   Bouaouina, Mohamed ^a   Calderwood, David A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION EFFECT; ADAPTOR PROTEINS; ADHESION RECEPTORS; BINDING ASSAYS; BINDING PROTEINS; C-TERMINAL REGIONS; CHINESE HAMSTER OVARY CELLS; COACTIVATORS; CYTOPLASMIC TAIL; DIRECT INTERACTIONS; EXPRESSION LEVELS; FLUORESCENCE ACTIVATED CELL SORTING; INTEGRIN; INTEGRIN ACTIVATION; INTEGRIN BINDING; INTEGRIN-BINDING SITE; INTEGRINS; INTRACELLULAR SIGNALS; LOW-TO-HIGH; MUTATIONAL ANALYSIS; RAPID CONVERSION; SPECIFIC EFFECTS; SUBDOMAIN; TALIN BINDING; TRANSIENT EXPRESSION;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; CHEMICAL ACTIVATION; GLYCOPROTEINS; PROTEINS;

ACTIVATION ANALYSIS;

ADAPTOR PROTEIN; ALPHA2B BETA3 INTEGRIN; BETA INTEGRIN; BETA3 INTEGRIN; INTEGRIN; KINDLIN 1; KINDLIN 2; TALIN; THREONINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; FERMT1 PROTEIN, HUMAN; FIBRINOGEN RECEPTOR; MEMBRANE PROTEIN; MIG2B PROTEIN, HUMAN; TUMOR PROTEIN;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTING; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; ANIMAL; CELL STRAIN 3T3; CHEMISTRY; CRICETULUS; CYTOPLASM; HAMSTER; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE;

CRICETULUS GRISEUS;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; CYTOPLASM; HUMANS; INTEGRIN BETA CHAINS; MEMBRANE PROTEINS; MICE; NEOPLASM PROTEINS; NIH 3T3 CELLS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN STRUCTURE, TERTIARY;

EID: 66449119343     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M809233200     Document Type: Article

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