메뉴 건너뛰기




Volumn 89, Issue 1, 2015, Pages 3-14

Perspectives of CD44 targeting therapies

Author keywords

CD44; Hyaluronan; Receptor tyrosine kinases; Therapy

Indexed keywords

APTAMER; CD44V6 ANTIGEN; HERMES ANTIGEN; MONOCLONAL ANTIBODY; ANTINEOPLASTIC AGENT; HYALURONIC ACID;

EID: 84935138318     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1424-2     Document Type: Review
Times cited : (93)

References (127)
  • 1
    • 0035821780 scopus 로고    scopus 로고
    • Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid
    • COI: 1:CAS:528:DC%2BD3MXltVSqtr0%3D, PID: 11423990
    • Ahrens T, Sleeman JP, Schempp CM et al (2001) Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene 20(26):3399–3408
    • (2001) Oncogene , vol.20 , Issue.26 , pp. 3399-3408
    • Ahrens, T.1    Sleeman, J.P.2    Schempp, C.M.3
  • 2
    • 9344229753 scopus 로고    scopus 로고
    • Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity
    • COI: 1:CAS:528:DyaK28XksVGjsr0%3D, PID: 8798873
    • Akima K, Ito H, Iwata Y et al (1996) Evaluation of antitumor activities of hyaluronate binding antitumor drugs: synthesis, characterization and antitumor activity. J Drug Target 4(1):1–8. doi:10.3109/10611869609046255
    • (1996) J Drug Target , vol.4 , Issue.1 , pp. 1-8
    • Akima, K.1    Ito, H.2    Iwata, Y.3
  • 3
    • 0025282411 scopus 로고
    • CD44 is the principal cell surface receptor for hyaluronate
    • COI: 1:CAS:528:DyaK3cXkslGgtbc%3D, PID: 1694723
    • Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell 61(7):1303–1313
    • (1990) Cell , vol.61 , Issue.7 , pp. 1303-1313
    • Aruffo, A.1    Stamenkovic, I.2    Melnick, M.3    Underhill, C.B.4    Seed, B.5
  • 4
    • 11144358161 scopus 로고    scopus 로고
    • CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow
    • COI: 1:CAS:528:DC%2BD2cXjsVagsr8%3D, PID: 15070674
    • Avigdor A, Goichberg P, Shivtiel S et al (2004) CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 103(8):2981–2989
    • (2004) Blood , vol.103 , Issue.8 , pp. 2981-2989
    • Avigdor, A.1    Goichberg, P.2    Shivtiel, S.3
  • 5
    • 0028216487 scopus 로고
    • Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development
    • COI: 1:CAS:528:DyaK2cXktlahsLc%3D, PID: 7516417
    • Bartolazzi A, Peach R, Aruffo A, Stamenkovic I (1994) Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med 180(1):53–66
    • (1994) J Exp Med , vol.180 , Issue.1 , pp. 53-66
    • Bartolazzi, A.1    Peach, R.2    Aruffo, A.3    Stamenkovic, I.4
  • 6
    • 0345357073 scopus 로고    scopus 로고
    • Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery
    • COI: 1:CAS:528:DC%2BD3sXos1Cjur0%3D, PID: 14624625
    • Bellocq NC, Pun SH, Jensen GS, Davis ME (2003) Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery. Bioconjug Chem 14(6):1122–1132. doi:10.1021/bc034125f
    • (2003) Bioconjug Chem , vol.14 , Issue.6 , pp. 1122-1132
    • Bellocq, N.C.1    Pun, S.H.2    Jensen, G.S.3    Davis, M.E.4
  • 7
    • 0028985177 scopus 로고
    • CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor
    • COI: 1:CAS:528:DyaK2MXjs1ehu7w%3D, PID: 7532176
    • Bennett KL, Jackson DG, Simon JC et al (1995) CD44 isoforms containing exon v3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol 128:687–698
    • (1995) J Cell Biol , vol.128 , pp. 687-698
    • Bennett, K.L.1    Jackson, D.G.2    Simon, J.C.3
  • 8
    • 10844290511 scopus 로고    scopus 로고
    • Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma
    • PID: 14506195
    • Borjesson PK, Postema EJ, Roos JC et al (2003) Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clin Cancer Res 9(10 Pt 2):3961S–3972S
    • (2003) Clin Cancer Res , vol.9 , pp. 3961S-3972S
    • Borjesson, P.K.1    Postema, E.J.2    Roos, J.C.3
  • 9
    • 33646241548 scopus 로고    scopus 로고
    • Performance of immuno-positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients
    • PID: 16609026
    • Borjesson PK, Jauw YW, Boellaard R et al (2006) Performance of immuno-positron emission tomography with zirconium-89-labeled chimeric monoclonal antibody U36 in the detection of lymph node metastases in head and neck cancer patients. Clin Cancer Res 12(7 Pt 1):2133–2140. doi:10.1158/1078-0432.CCR-05-2137
    • (2006) Clin Cancer Res , vol.12 , pp. 2133-2140
    • Borjesson, P.K.1    Jauw, Y.W.2    Boellaard, R.3
  • 10
    • 0037289755 scopus 로고    scopus 로고
    • A urokinase-derived peptide (A6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis
    • COI: 1:CAS:528:DC%2BD3sXhtlKqsrw%3D, PID: 12547719
    • Boyd DD, Kim SJ, Wang H, Jones TR, Gallick GE (2003) A urokinase-derived peptide (A6) increases survival of mice bearing orthotopically grown prostate cancer and reduces lymph node metastasis. Am J Pathol 162(2):619–626. doi:10.1016/S0002-9440(10)63855-2
    • (2003) Am J Pathol , vol.162 , Issue.2 , pp. 619-626
    • Boyd, D.D.1    Kim, S.J.2    Wang, H.3    Jones, T.R.4    Gallick, G.E.5
  • 11
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • COI: 1:CAS:528:DC%2BD28XhtFWhs7fM, PID: 17060945
    • Calin GA, Croce CM (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 6(11):857–866. doi:10.1038/nrc1997
    • (2006) Nat Rev Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 12
    • 84888270638 scopus 로고    scopus 로고
    • CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXhvVehsr7E, PID: 24016461
    • Casucci M, Nicolis di Robilant B, Falcone L et al (2013) CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma. Blood 122(20):3461–3472. doi:10.1182/blood-2013-04-493361
    • (2013) Blood , vol.122 , Issue.20 , pp. 3461-3472
    • Casucci, M.1    Nicolis di Robilant, B.2    Falcone, L.3
  • 13
    • 84903388427 scopus 로고    scopus 로고
    • MicroRNA-328 inhibits renal tubular cell epithelial-to-mesenchymal transition by targeting the CD44 in pressure-induced renal fibrosis
    • PID: 24919189
    • Chen CH, Cheng CY, Chen YC et al (2014) MicroRNA-328 inhibits renal tubular cell epithelial-to-mesenchymal transition by targeting the CD44 in pressure-induced renal fibrosis. PLoS One 9(6):e99802. doi:10.1371/journal.pone.0099802
    • (2014) PLoS One , vol.9 , Issue.6 , pp. 99802
    • Chen, C.H.1    Cheng, C.Y.2    Chen, Y.C.3
  • 14
    • 84863866947 scopus 로고    scopus 로고
    • Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer
    • COI: 1:CAS:528:DC%2BC38XhtVCjsr7F
    • Choi KY, Saravanakumar G, Park JH, Park K (2012) Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer. Coll Surf B Biointerfaces 99:82–94. doi:10.1016/j.colsurfb.2011.10.029
    • (2012) Coll Surf B Biointerfaces , vol.99 , pp. 82-94
    • Choi, K.Y.1    Saravanakumar, G.2    Park, J.H.3    Park, K.4
  • 15
    • 0034519646 scopus 로고    scopus 로고
    • Phase I therapy study of 186Re-labeled chimeric monoclonal antibody U36 in patients with squamous cell carcinoma of the head and neck
    • COI: 1:CAS:528:DC%2BD3MXkvFSmtQ%3D%3D, PID: 11138685
    • Colnot DR, Quak JJ, Roos JC et al (2000) Phase I therapy study of 186Re-labeled chimeric monoclonal antibody U36 in patients with squamous cell carcinoma of the head and neck. J Nucl Med 41(12):1999–2010
    • (2000) J Nucl Med , vol.41 , Issue.12 , pp. 1999-2010
    • Colnot, D.R.1    Quak, J.J.2    Roos, J.C.3
  • 16
    • 0036845695 scopus 로고    scopus 로고
    • Reinfusion of unprocessed, granulocyte colony-stimulating factor-stimulated whole blood allows dose escalation of 186Relabeled chimeric monoclonal antibody U36 radioimmunotherapy in a phase I dose escalation study
    • COI: 1:CAS:528:DC%2BD38XpsVCgt70%3D, PID: 12429627
    • Colnot DR, Ossenkoppele GJ, Roos JC et al (2002) Reinfusion of unprocessed, granulocyte colony-stimulating factor-stimulated whole blood allows dose escalation of 186Relabeled chimeric monoclonal antibody U36 radioimmunotherapy in a phase I dose escalation study. Clin Cancer Res 8(11):3401–3406
    • (2002) Clin Cancer Res , vol.8 , Issue.11 , pp. 3401-3406
    • Colnot, D.R.1    Ossenkoppele, G.J.2    Roos, J.C.3
  • 17
    • 0041854151 scopus 로고    scopus 로고
    • Safety, biodistribution, pharmacokinetics, and immunogenicity of (99 m)Tc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck
    • COI: 1:CAS:528:DC%2BD3sXls1ynsrw%3D, PID: 14627130
    • Colnot DR, Roos JC, De Bree R et al (2003) Safety, biodistribution, pharmacokinetics, and immunogenicity of (99 m)Tc-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with squamous cell carcinoma of the head and neck. Cancer Immunol Immunother 52:576–582
    • (2003) Cancer Immunol Immunother , vol.52 , pp. 576-582
    • Colnot, D.R.1    Roos, J.C.2    De Bree, R.3
  • 18
    • 0034852021 scopus 로고    scopus 로고
    • Automated selection of anti-protein aptamers
    • COI: 1:CAS:528:DC%2BD3MXms1Ogsr8%3D, PID: 11557339
    • Cox JC, Ellington AD (2001) Automated selection of anti-protein aptamers. Bioorg Med Chem 9(10):2525–2531
    • (2001) Bioorg Med Chem , vol.9 , Issue.10 , pp. 2525-2531
    • Cox, J.C.1    Ellington, A.D.2
  • 19
    • 0026531648 scopus 로고
    • The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan
    • COI: 1:CAS:528:DyaK38XhtVCgsr0%3D, PID: 1370836
    • Culty M, Nguyen HA, Underhill CB (1992) The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan. J Cell Biol 116(4):1055–1062
    • (1992) J Cell Biol , vol.116 , Issue.4 , pp. 1055-1062
    • Culty, M.1    Nguyen, H.A.2    Underhill, C.B.3
  • 20
    • 0028109048 scopus 로고
    • Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: correlation with invasive potential
    • COI: 1:CAS:528:DyaK2cXltlWrurs%3D, PID: 7518822
    • Culty M, Shizari M, Thompson EW, Underhill CB (1994) Binding and degradation of hyaluronan by human breast cancer cell lines expressing different forms of CD44: correlation with invasive potential. J Cell Physiol 160(2):275–286
    • (1994) J Cell Physiol , vol.160 , Issue.2 , pp. 275-286
    • Culty, M.1    Shizari, M.2    Thompson, E.W.3    Underhill, C.B.4
  • 21
    • 0028979238 scopus 로고
    • Radioimmunoscintigraphy and biodistribution of technetium-99 m-labeled monoclonal antibody U36 in patients with head and neck cancer
    • PID: 9816020
    • de Bree R, Roos JC, Quak JJ, den Hollander W, Snow GB, van Dongen GA (1995) Radioimmunoscintigraphy and biodistribution of technetium-99 m-labeled monoclonal antibody U36 in patients with head and neck cancer. Clin Cancer Res 1(6):591–598
    • (1995) Clin Cancer Res , vol.1 , Issue.6 , pp. 591-598
    • de Bree, R.1    Roos, J.C.2    Quak, J.J.3    den Hollander, W.4    Snow, G.B.5    van Dongen, G.A.6
  • 22
    • 0029966274 scopus 로고    scopus 로고
    • CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte–endothelial cell primary adhesion pathway
    • COI: 1:CAS:528:DyaK28XhvV2qsL8%3D, PID: 8642254
    • DeGrendele HC, Estess P, Picker LJ, Siegelman MH (1996) CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte–endothelial cell primary adhesion pathway. J Exp Med 183(3):1119–1130
    • (1996) J Exp Med , vol.183 , Issue.3 , pp. 1119-1130
    • DeGrendele, H.C.1    Estess, P.2    Picker, L.J.3    Siegelman, M.H.4
  • 23
    • 0030690228 scopus 로고    scopus 로고
    • Requirement for CD44 in activated T cell extravasation into an inflammatory site
    • COI: 1:CAS:528:DyaK2sXmvVygurk%3D, PID: 9381175
    • DeGrendele HC, Estess P, Siegelman MH (1997) Requirement for CD44 in activated T cell extravasation into an inflammatory site. Science 278(5338):672–675
    • (1997) Science , vol.278 , Issue.5338 , pp. 672-675
    • DeGrendele, H.C.1    Estess, P.2    Siegelman, M.H.3
  • 24
    • 0035866799 scopus 로고    scopus 로고
    • Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells
    • COI: 1:CAS:528:DC%2BD3MXisVSks7s%3D, PID: 11289136
    • Eliaz RE, Szoka FC Jr (2001) Liposome-encapsulated doxorubicin targeted to CD44: a strategy to kill CD44-overexpressing tumor cells. Cancer Res 61(6):2592–2601
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2592-2601
    • Eliaz, R.E.1    Szoka, F.C.2
  • 25
    • 1642475114 scopus 로고    scopus 로고
    • Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes
    • COI: 1:CAS:528:DC%2BD2cXmsVantg%3D%3D, PID: 14744789
    • Eliaz RE, Nir S, Marty C, Szoka FC Jr (2004) Determination and modeling of kinetics of cancer cell killing by doxorubicin and doxorubicin encapsulated in targeted liposomes. Cancer Res 64(2):711–718
    • (2004) Cancer Res , vol.64 , Issue.2 , pp. 711-718
    • Eliaz, R.E.1    Nir, S.2    Marty, C.3    Szoka, F.C.4
  • 26
    • 34548174214 scopus 로고    scopus 로고
    • Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies
    • COI: 1:CAS:528:DC%2BD2sXpsVaruro%3D, PID: 17277931
    • Fortin MA, Salnikov AV, Nestor M, Heldin NE, Rubin K, Lundqvist H (2007) Immuno-PET of undifferentiated thyroid carcinoma with radioiodine-labelled antibody cMAb U36: application to antibody tumour uptake studies. Eur J Nucl Med Mol Imaging 34(9):1376–1387. doi:10.1007/s00259-006-0346-5
    • (2007) Eur J Nucl Med Mol Imaging , vol.34 , Issue.9 , pp. 1376-1387
    • Fortin, M.A.1    Salnikov, A.V.2    Nestor, M.3    Heldin, N.E.4    Rubin, K.5    Lundqvist, H.6
  • 27
    • 84887491236 scopus 로고    scopus 로고
    • Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44
    • COI: 1:CAS:528:DC%2BC3sXhsF2gu7vK, PID: 24091662
    • Fuchs K, Hippe A, Schmaus A, Homey B, Sleeman JP, Orian-Rousseau V (2013) Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44. Cell Death Dis 4:e819. doi:10.1038/cddis.2013.364
    • (2013) Cell Death Dis , vol.4 , pp. 819
    • Fuchs, K.1    Hippe, A.2    Schmaus, A.3    Homey, B.4    Sleeman, J.P.5    Orian-Rousseau, V.6
  • 28
    • 0021751193 scopus 로고
    • In vitro studies on the cell-mediated immune response to human brain tumors. II. Leukocyte-induced coats of glycosaminoglycan increase the resistance of glioma cells to cellular immune attack
    • COI: 1:CAS:528:DyaL2MXit1Krtg%3D%3D, PID: 6238097
    • Gately CL, Muul LM, Greenwood MA et al (1984) In vitro studies on the cell-mediated immune response to human brain tumors. II. Leukocyte-induced coats of glycosaminoglycan increase the resistance of glioma cells to cellular immune attack. J Immunol 133(6):3387–3395
    • (1984) J Immunol , vol.133 , Issue.6 , pp. 3387-3395
    • Gately, C.L.1    Muul, L.M.2    Greenwood, M.A.3
  • 29
    • 52049127235 scopus 로고    scopus 로고
    • A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer
    • COI: 1:CAS:528:DC%2BD1cXhtFOgsr%2FP, PID: 18760451
    • Ghamande SA, Silverman MH, Huh W et al (2008) A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol 111(1):89–94. doi:10.1016/j.ygyno.2008.06.028
    • (2008) Gynecol Oncol , vol.111 , Issue.1 , pp. 89-94
    • Ghamande, S.A.1    Silverman, M.H.2    Huh, W.3
  • 30
    • 0037063999 scopus 로고    scopus 로고
    • Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway
    • COI: 1:CAS:528:DC%2BD38Xns1CgtbY%3D, PID: 12145277
    • Ghatak S, Misra S, Toole BP (2002) Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. J Biol Chem 277(41):38013–38020. doi:10.1074/jbc.M202404200
    • (2002) J Biol Chem , vol.277 , Issue.41 , pp. 38013-38020
    • Ghatak, S.1    Misra, S.2    Toole, B.P.3
  • 31
    • 84862539273 scopus 로고    scopus 로고
    • CD44: a validated target for improved delivery of cancer therapeutics
    • COI: 1:CAS:528:DC%2BC38Xos1ajtL0%3D, PID: 22621669
    • Ghosh SC, Neslihan Alpay S, Klostergaard J (2012) CD44: a validated target for improved delivery of cancer therapeutics. Expert opinion on therapeutic targets 16(7):635–650. doi:10.1517/14728222.2012.687374
    • (2012) Expert opinion on therapeutic targets , vol.16 , Issue.7 , pp. 635-650
    • Ghosh, S.C.1    Neslihan Alpay, S.2    Klostergaard, J.3
  • 32
    • 0023609134 scopus 로고
    • The tandemly repeated sequences of cartilage link protein contain the sites for interaction with hyaluronic acid
    • COI: 1:CAS:528:DyaL1cXht1KqsL0%3D, PID: 2445761
    • Goetinck PF, Stirpe NS, Tsonis PA, Carlone D (1987) The tandemly repeated sequences of cartilage link protein contain the sites for interaction with hyaluronic acid. J Cell Biol 105(5):2403–2408
    • (1987) J Cell Biol , vol.105 , Issue.5 , pp. 2403-2408
    • Goetinck, P.F.1    Stirpe, N.S.2    Tsonis, P.A.3    Carlone, D.4
  • 33
    • 84861189808 scopus 로고    scopus 로고
    • A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: a Gynecologic Oncology Group study
    • COI: 1:CAS:528:DC%2BC38XlslSitL0%3D, PID: 22446624
    • Gold MA, Brady WE, Lankes HA et al (2012) A phase II study of a urokinase-derived peptide (A6) in the treatment of persistent or recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 125(3):635–639. doi:10.1016/j.ygyno.2012.03.023
    • (2012) Gynecol Oncol , vol.125 , Issue.3 , pp. 635-639
    • Gold, M.A.1    Brady, W.E.2    Lankes, H.A.3
  • 34
    • 0024517268 scopus 로고
    • A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins
    • COI: 1:CAS:528:DyaK3cXkvFKltQ%3D%3D, PID: 2466576
    • Goldstein LA, Zhou DF, Picker LJ et al (1989) A human lymphocyte homing receptor, the hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell 56(6):1063–1072
    • (1989) Cell , vol.56 , Issue.6 , pp. 1063-1072
    • Goldstein, L.A.1    Zhou, D.F.2    Picker, L.J.3
  • 35
    • 0025825209 scopus 로고
    • A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
    • COI: 1:STN:280:DyaK3M7ptFGmsA%3D%3D, PID: 1707342
    • Gunthert U, Hofmann M, Rudy W et al (1991) A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65(1):13–24. doi:10.1016/0092-8674(91)90403-L
    • (1991) Cell , vol.65 , Issue.1 , pp. 13-24
    • Gunthert, U.1    Hofmann, M.2    Rudy, W.3
  • 36
    • 84899439619 scopus 로고    scopus 로고
    • In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study
    • PID: 24598405
    • Haylock AK, Spiegelberg D, Nilvebrant J, Sandstrom K, Nestor M (2014) In vivo characterization of the novel CD44v6-targeting Fab fragment AbD15179 for molecular imaging of squamous cell carcinoma: a dual-isotope study. EJNMMI Res 4(1):11. doi:10.1186/2191-219X-4-11
    • (2014) EJNMMI Res , vol.4 , Issue.1 , pp. 11
    • Haylock, A.K.1    Spiegelberg, D.2    Nilvebrant, J.3    Sandstrom, K.4    Nestor, M.5
  • 37
    • 0030454435 scopus 로고    scopus 로고
    • Characterization of a high-affinity monoclonal antibody specific for CD44v6 as candidate for immunotherapy of squamous cell carcinomas
    • COI: 1:CAS:528:DyaK2sXotlagtQ%3D%3D, PID: 9003471
    • Heider KH, Sproll M, Susani S et al (1996) Characterization of a high-affinity monoclonal antibody specific for CD44v6 as candidate for immunotherapy of squamous cell carcinomas. Cancer Immunol Immunother 43(4):245–253
    • (1996) Cancer Immunol Immunother , vol.43 , Issue.4 , pp. 245-253
    • Heider, K.H.1    Sproll, M.2    Susani, S.3
  • 38
    • 78649697501 scopus 로고    scopus 로고
    • miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines
    • COI: 1:CAS:528:DC%2BC3cXhsFantb%2FP, PID: 21055388
    • Henry JC, Park JK, Jiang J et al (2010) miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun 403(1):120–125. doi:10.1016/j.bbrc.2010.10.130
    • (2010) Biochem Biophys Res Commun , vol.403 , Issue.1 , pp. 120-125
    • Henry, J.C.1    Park, J.K.2    Jiang, J.3
  • 39
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • COI: 1:CAS:528:DC%2BC3cXjt12jtQ%3D%3D, PID: 19461653
    • Hermeking H (2010) The miR-34 family in cancer and apoptosis. Cell Death Differ 17(2):193–199. doi:10.1038/cdd.2009.56
    • (2010) Cell Death Differ , vol.17 , Issue.2 , pp. 193-199
    • Hermeking, H.1
  • 40
    • 34547763362 scopus 로고    scopus 로고
    • Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury
    • COI: 1:CAS:528:DC%2BD2sXoslagu7o%3D, PID: 17507906
    • Herrera MB, Bussolati B, Bruno S et al (2007) Exogenous mesenchymal stem cells localize to the kidney by means of CD44 following acute tubular injury. Kidney Int 72(4):430–441. doi:10.1038/sj.ki.5002334
    • (2007) Kidney Int , vol.72 , Issue.4 , pp. 430-441
    • Herrera, M.B.1    Bussolati, B.2    Bruno, S.3
  • 41
    • 3142742372 scopus 로고    scopus 로고
    • Identification of an active site on the laminin alpha5 chain globular domain that binds to CD44 and inhibits malignancy
    • COI: 1:CAS:528:DC%2BD2cXls1Omsb0%3D, PID: 15256450
    • Hibino S, Shibuya M, Engbring JA, Mochizuki M, Nomizu M, Kleinman HK (2004) Identification of an active site on the laminin alpha5 chain globular domain that binds to CD44 and inhibits malignancy. Cancer Res 64(14):4810–4816
    • (2004) Cancer Res , vol.64 , Issue.14 , pp. 4810-4816
    • Hibino, S.1    Shibuya, M.2    Engbring, J.A.3    Mochizuki, M.4    Nomizu, M.5    Kleinman, H.K.6
  • 42
    • 0026002788 scopus 로고
    • CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines
    • COI: 1:CAS:528:DyaK38XmtVKis7g%3D, PID: 1717145
    • Hofmann M, Rudy W, Zoller M et al (1991) CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. Cancer Res 51(19):5292–5297
    • (1991) Cancer Res , vol.51 , Issue.19 , pp. 5292-5297
    • Hofmann, M.1    Rudy, W.2    Zoller, M.3
  • 43
    • 84896772168 scopus 로고    scopus 로고
    • DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration
    • PID: 24586375
    • Iida J, Clancy R, Dorchak J et al (2014) DNA aptamers against exon v10 of CD44 inhibit breast cancer cell migration. PLoS ONE 9(2):e88712. doi:10.1371/journal.pone.0088712
    • (2014) PLoS ONE , vol.9 , Issue.2 , pp. 88712
    • Iida, J.1    Clancy, R.2    Dorchak, J.3
  • 44
    • 79952528125 scopus 로고    scopus 로고
    • CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth
    • COI: 1:CAS:528:DC%2BC3MXjtFKisrY%3D, PID: 21397861
    • Ishimoto T, Nagano O, Yae T et al (2011) CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell 19(3):387–400. doi:10.1016/j.ccr.2011.01.038
    • (2011) Cancer Cell , vol.19 , Issue.3 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3
  • 45
    • 0028809263 scopus 로고
    • Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon
    • COI: 1:CAS:528:DyaK2MXjs1ehu78%3D, PID: 7532175
    • Jackson DG, Bell JI, Dickinson R, Timans J, Shields J, Whittle N (1995) Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J Cell Biol 128(4):673–685
    • (1995) J Cell Biol , vol.128 , Issue.4 , pp. 673-685
    • Jackson, D.G.1    Bell, J.I.2    Dickinson, R.3    Timans, J.4    Shields, J.5    Whittle, N.6
  • 46
    • 0023574615 scopus 로고
    • Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85–95 kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells
    • COI: 1:CAS:528:DyaL2sXlslersL4%3D, PID: 2442176
    • Jalkanen S, Bargatze RF, de los Toyos J, Butcher EC (1987) Lymphocyte recognition of high endothelium: antibodies to distinct epitopes of an 85–95 kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal, or synovial endothelial cells. J Cell Biol 105:983–990
    • (1987) J Cell Biol , vol.105 , pp. 983-990
    • Jalkanen, S.1    Bargatze, R.F.2    de los Toyos, J.3    Butcher, E.C.4
  • 47
    • 33749515476 scopus 로고    scopus 로고
    • Targeting of CD44 eradicates human acute myeloid leukemic stem cells
    • PID: 16998484
    • Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE (2006) Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med 12(10):1167–1174
    • (2006) Nat Med , vol.12 , Issue.10 , pp. 1167-1174
    • Jin, L.1    Hope, K.J.2    Zhai, Q.3    Smadja-Joffe, F.4    Dick, J.E.5
  • 48
    • 70149123439 scopus 로고    scopus 로고
    • CD44v6 dependence of premetastatic niche preparation by exosomes
    • COI: 1:CAS:528:DC%2BD1MXhtFKrsb7K, PID: 19794968
    • Jung T, Castellana D, Klingbeil P et al (2009) CD44v6 dependence of premetastatic niche preparation by exosomes. Neoplasia 11(10):1093–1105
    • (2009) Neoplasia , vol.11 , Issue.10 , pp. 1093-1105
    • Jung, T.1    Castellana, D.2    Klingbeil, P.3
  • 49
    • 79955541291 scopus 로고    scopus 로고
    • CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance
    • COI: 1:CAS:528:DC%2BC3MXlsVWjuro%3D, PID: 21372142
    • Jung T, Gross W, Zoller M (2011) CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance. J Biol Chem 286(18):15862–15874. doi:10.1074/jbc.M110.208421
    • (2011) J Biol Chem , vol.286 , Issue.18 , pp. 15862-15874
    • Jung, T.1    Gross, W.2    Zoller, M.3
  • 50
    • 0006585248 scopus 로고
    • Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis
    • COI: 1:CAS:528:DyaL2cXmt1Oqsbg%3D, PID: 6593727
    • Knudson W, Biswas C, Toole BP (1984) Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis. Proc Natl Acad Sci U S A 81(21):6767–6771
    • (1984) Proc Natl Acad Sci U S A , vol.81 , Issue.21 , pp. 6767-6771
    • Knudson, W.1    Biswas, C.2    Toole, B.P.3
  • 51
    • 14044263594 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, immunogenicity, and biodistribution of (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with early-stage breast cancer
    • COI: 1:CAS:528:DC%2BD2MXhs1Cjsr4%3D, PID: 15665619
    • Koppe M, Schaijk F, Roos J et al (2004) Safety, pharmacokinetics, immunogenicity, and biodistribution of (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with early-stage breast cancer. Cancer Biother Radiopharm 19(6):720–729. doi:10.1089/cbr.2004.19.720
    • (2004) Cancer Biother Radiopharm , vol.19 , Issue.6 , pp. 720-729
    • Koppe, M.1    Schaijk, F.2    Roos, J.3
  • 52
    • 0026623391 scopus 로고
    • Hyaluronan
    • COI: 1:CAS:528:DyaK38XltVKgu7o%3D, PID: 1563592
    • Laurent TC, Fraser JR (1992) Hyaluronan. Faseb J 6(7):2397–2404
    • (1992) Faseb J , vol.6 , Issue.7 , pp. 2397-2404
    • Laurent, T.C.1    Fraser, J.R.2
  • 53
    • 0026801075 scopus 로고
    • CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells
    • COI: 1:CAS:528:DyaK3sXitVGrsQ%3D%3D, PID: 1382996
    • Lesley J, Hyman R (1992) CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells. Eur J Immunol 22(10):2719–2723
    • (1992) Eur J Immunol , vol.22 , Issue.10 , pp. 2719-2723
    • Lesley, J.1    Hyman, R.2
  • 54
    • 81855194258 scopus 로고    scopus 로고
    • c-Met is a marker of pancreatic cancer stem cells and therapeutic target
    • COI: 1:CAS:528:DC%2BC3MXhsFSjt7rI, PID: 21864475
    • Li C, Wu JJ, Hynes M et al (2011) c-Met is a marker of pancreatic cancer stem cells and therapeutic target. Gastroenterology 141(6):2218–2227. doi:10.1053/j.gastro.2011.08.009
    • (2011) Gastroenterology , vol.141 , Issue.6 , pp. 2218-2227
    • Li, C.1    Wu, J.J.2    Hynes, M.3
  • 55
    • 84870576958 scopus 로고    scopus 로고
    • Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion
    • COI: 1:CAS:528:DC%2BC38XhsVehu73J, PID: 23032974
    • Li L, Xie X, Luo J et al (2012) Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. Mol Ther 20(12):2326–2334. doi:10.1038/mt.2012.201
    • (2012) Mol Ther , vol.20 , Issue.12 , pp. 2326-2334
    • Li, L.1    Xie, X.2    Luo, J.3
  • 56
    • 84896489722 scopus 로고    scopus 로고
    • Antibody against CD44 s inhibits pancreatic tumor initiation and postradiation recurrence in mice
    • COI: 1:CAS:528:DC%2BC2cXislCnsL0%3D, PID: 24397969
    • Li L, Hao X, Qin J et al (2014) Antibody against CD44 s inhibits pancreatic tumor initiation and postradiation recurrence in mice. Gastroenterology 146(4):1108–1118. doi:10.1053/j.gastro.2013.12.035
    • (2014) Gastroenterology , vol.146 , Issue.4 , pp. 1108-1118
    • Li, L.1    Hao, X.2    Qin, J.3
  • 57
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • COI: 1:CAS:528:DC%2BC3MXmsFCmsw%3D%3D, PID: 21240262
    • Liu C, Kelnar K, Liu B et al (2011) The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med 17(2):211–215. doi:10.1038/nm.2284
    • (2011) Nat Med , vol.17 , Issue.2 , pp. 211-215
    • Liu, C.1    Kelnar, K.2    Liu, B.3
  • 58
    • 0033200301 scopus 로고    scopus 로고
    • Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate
    • COI: 1:CAS:528:DyaK1MXksF2ltLs%3D, PID: 10502340
    • Luo Y, Prestwich GD (1999) Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate. Bioconjug Chem 10(5):755–763. doi:10.1021/bc9900338
    • (1999) Bioconjug Chem , vol.10 , Issue.5 , pp. 755-763
    • Luo, Y.1    Prestwich, G.D.2
  • 59
    • 0034601831 scopus 로고    scopus 로고
    • Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery
    • COI: 1:CAS:528:DC%2BD3cXmvFOrs7w%3D, PID: 11018555
    • Luo Y, Kirker KR, Prestwich GD (2000) Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J Control Release 69(1):169–184
    • (2000) J Control Release , vol.69 , Issue.1 , pp. 169-184
    • Luo, Y.1    Kirker, K.R.2    Prestwich, G.D.3
  • 60
    • 84880611660 scopus 로고    scopus 로고
    • MicroRNA-143 inhibits migration and invasion of human non-small-cell lung cancer and its relative mechanism
    • PID: 23904792
    • Ma Q, Jiang Q, Pu Q et al (2013) MicroRNA-143 inhibits migration and invasion of human non-small-cell lung cancer and its relative mechanism. Int J Biol Sci 9(7):680–692. doi:10.7150/ijbs.6623
    • (2013) Int J Biol Sci , vol.9 , Issue.7 , pp. 680-692
    • Ma, Q.1    Jiang, Q.2    Pu, Q.3
  • 61
    • 22244454747 scopus 로고    scopus 로고
    • A five-amino-acid peptide blocks Met- and Ron-dependent cell migration
    • COI: 1:CAS:528:DC%2BD2MXmt1ehur4%3D, PID: 16024611
    • Matzke A, Herrlich P, Ponta H, Orian-Rousseau V (2005) A five-amino-acid peptide blocks Met- and Ron-dependent cell migration. Cancer Res 65(14):6105–6110. doi:10.1158/0008-5472.CAN-05-0207
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6105-6110
    • Matzke, A.1    Herrlich, P.2    Ponta, H.3    Orian-Rousseau, V.4
  • 62
    • 0018344829 scopus 로고
    • Hyaluronidase-sensitive halos around adherent cells. Their role in blocking lymphocyte-mediated cytolysis
    • COI: 1:STN:280:DyaE1M7htV2qtQ%3D%3D, PID: 762499
    • McBride WH, Bard JB (1979) Hyaluronidase-sensitive halos around adherent cells. Their role in blocking lymphocyte-mediated cytolysis. J Exp Med 149(2):507–515
    • (1979) J Exp Med , vol.149 , Issue.2 , pp. 507-515
    • McBride, W.H.1    Bard, J.B.2
  • 63
    • 84969384394 scopus 로고    scopus 로고
    • A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms
    • Mielgo A, van Driel M, Bloem A, Landmann L, Gunthert U (2005) A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms. Cell Death Differ
    • (2005) Cell Death Differ
    • Mielgo, A.1    van Driel, M.2    Bloem, A.3    Landmann, L.4    Gunthert, U.5
  • 64
    • 66449110672 scopus 로고    scopus 로고
    • Delivery of CD44shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ mice
    • Misra S, Hascall VC, De Giovanni C, Markwald RR, Ghatak S (2009) Delivery of CD44shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ mice. J Biol Chem. doi:10.1074/jbc.M806772200
    • (2009) J Biol Chem
    • Misra, S.1    Hascall, V.C.2    De Giovanni, C.3    Markwald, R.R.4    Ghatak, S.5
  • 65
    • 79955063673 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interactions as potential targets for cancer therapy
    • COI: 1:CAS:528:DC%2BC3MXls1Oit7w%3D, PID: 21362138
    • Misra S, Heldin P, Hascall VC et al (2011) Hyaluronan-CD44 interactions as potential targets for cancer therapy. FEBS J 278(9):1429–1443. doi:10.1111/j.1742-4658.2011.08071.x
    • (2011) FEBS J , vol.278 , Issue.9 , pp. 1429-1443
    • Misra, S.1    Heldin, P.2    Hascall, V.C.3
  • 66
    • 84896344539 scopus 로고    scopus 로고
    • Tumor targeting profiling of hyaluronan-coated lipid based-nanoparticles
    • COI: 1:CAS:528:DC%2BC2cXkt1ymtbo%3D, PID: 24569711
    • Mizrahy S, Goldsmith M, Leviatan-Ben-Arye S et al (2014) Tumor targeting profiling of hyaluronan-coated lipid based-nanoparticles. Nanoscale 6(7):3742–3752. doi:10.1039/c3nr06102g
    • (2014) Nanoscale , vol.6 , Issue.7 , pp. 3742-3752
    • Mizrahy, S.1    Goldsmith, M.2    Leviatan-Ben-Arye, S.3
  • 67
    • 0030966842 scopus 로고    scopus 로고
    • CD44: structure, function and association with the malignant process
    • Elsevier, San-Diego
    • Naor D, Sionov RV, Ish-Shalom D (1997) CD44: structure, function and association with the malignant process. In: VandeWoude GF, Klein G (eds) Advances in cancer research, vol 71. Elsevier, San-Diego, pp 243–318
    • (1997) Advances in cancer research , vol.71 , pp. 243-318
    • Naor, D.1    Sionov, R.V.2    Ish-Shalom, D.3    VandeWoude, G.F.4    Klein, G.5
  • 69
    • 63049085576 scopus 로고    scopus 로고
    • MicroRNAs—the micro steering wheel of tumour metastases
    • COI: 1:CAS:528:DC%2BD1MXis1ChtLs%3D, PID: 19262572
    • Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA (2009) MicroRNAs—the micro steering wheel of tumour metastases. Nat Rev Cancer 9(4):293–302. doi:10.1038/nrc2619
    • (2009) Nat Rev Cancer , vol.9 , Issue.4 , pp. 293-302
    • Nicoloso, M.S.1    Spizzo, R.2    Shimizu, M.3    Rossi, S.4    Calin, G.A.5
  • 70
    • 0024404442 scopus 로고
    • Antibody which defines a subset of bone marrow cells that can migrate to thymus
    • PID: 2680909
    • O’Neill HC (1989) Antibody which defines a subset of bone marrow cells that can migrate to thymus. Immunology 68(1):59–65
    • (1989) Immunology , vol.68 , Issue.1 , pp. 59-65
    • O’Neill, H.C.1
  • 71
    • 0025288450 scopus 로고
    • Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell
    • COI: 1:CAS:528:DyaK3cXlsFSmu7g%3D, PID: 1972715
    • Oppenheimer-Marks N, Davis LS, Lipsky PE (1990) Human T lymphocyte adhesion to endothelial cells and transendothelial migration. Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell. J Immunol 145(1):140–148
    • (1990) J Immunol , vol.145 , Issue.1 , pp. 140-148
    • Oppenheimer-Marks, N.1    Davis, L.S.2    Lipsky, P.E.3
  • 72
    • 77950561915 scopus 로고    scopus 로고
    • CD44, a therapeutic target for metastasising tumours
    • COI: 1:CAS:528:DC%2BC3cXkvFKqt74%3D, PID: 20303742
    • Orian-Rousseau V (2010) CD44, a therapeutic target for metastasising tumours. Eur J Cancer 46(7):1271–1277. doi:10.1016/j.ejca.2010.02.024
    • (2010) Eur J Cancer , vol.46 , Issue.7 , pp. 1271-1277
    • Orian-Rousseau, V.1
  • 73
    • 84904903610 scopus 로고    scopus 로고
    • CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals
    • PID: 25081532
    • Orian-Rousseau V, Sleeman J (2014) CD44 is a multidomain signaling platform that integrates extracellular matrix cues with growth factor and cytokine signals. Adv Cancer Res 123:231–254. doi:10.1016/B978-0-12-800092-2.00009-5
    • (2014) Adv Cancer Res , vol.123 , pp. 231-254
    • Orian-Rousseau, V.1    Sleeman, J.2
  • 74
    • 0036896923 scopus 로고    scopus 로고
    • CD44 is required for two consecutive steps in HGF/c-met signaling
    • COI: 1:CAS:528:DC%2BD38XpsVamtbw%3D, PID: 12464636
    • Orian-Rousseau V, Chen L, Sleeman JP, Herrlich P, Ponta H (2002) CD44 is required for two consecutive steps in HGF/c-met signaling. Genes Dev 16(23):3074–3086
    • (2002) Genes Dev , vol.16 , Issue.23 , pp. 3074-3086
    • Orian-Rousseau, V.1    Chen, L.2    Sleeman, J.P.3    Herrlich, P.4    Ponta, H.5
  • 75
    • 33846077485 scopus 로고    scopus 로고
    • Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin
    • COI: 1:CAS:528:DC%2BD2sXmsFynsg%3D%3D, PID: 17065554
    • Orian-Rousseau V, Morrison H, Matzke A et al (2007) Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin. Mol Biol Cell 18(1):76–83
    • (2007) Mol Biol Cell , vol.18 , Issue.1 , pp. 76-83
    • Orian-Rousseau, V.1    Morrison, H.2    Matzke, A.3
  • 76
    • 0024349707 scopus 로고
    • Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor
    • COI: 1:CAS:528:DyaL1MXltlajt7c%3D, PID: 2663988
    • Pals ST, Hogervorst F, Keizer GD, Thepen T, Horst E, Figdor CC (1989) Identification of a widely distributed 90-kDa glycoprotein that is homologous to the Hermes-1 human lymphocyte homing receptor. J Immunol 143(3):851–857
    • (1989) J Immunol , vol.143 , Issue.3 , pp. 851-857
    • Pals, S.T.1    Hogervorst, F.2    Keizer, G.D.3    Thepen, T.4    Horst, E.5    Figdor, C.C.6
  • 77
    • 0027269982 scopus 로고
    • Identification of hyaluronic acid binding sites in the extracellular domain of CD44
    • COI: 1:CAS:528:DyaK3sXltFGjs7g%3D, PID: 8314845
    • Peach RJ, Hollenbaugh D, Stamenkovic I, Aruffo A (1993) Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol 122(1):257–264
    • (1993) J Cell Biol , vol.122 , Issue.1 , pp. 257-264
    • Peach, R.J.1    Hollenbaugh, D.2    Stamenkovic, I.3    Aruffo, A.4
  • 78
    • 0347285397 scopus 로고    scopus 로고
    • Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models
    • COI: 1:CAS:528:DC%2BD2cXmvFWltA%3D%3D, PID: 14696107
    • Peer D, Margalit R (2004) Loading mitomycin C inside long circulating hyaluronan targeted nano-liposomes increases its antitumor activity in three mice tumor models. Int J Cancer 108(5):780–789. doi:10.1002/ijc.11615
    • (2004) Int J Cancer , vol.108 , Issue.5 , pp. 780-789
    • Peer, D.1    Margalit, R.2
  • 79
    • 0033895822 scopus 로고    scopus 로고
    • Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites
    • COI: 1:CAS:528:DC%2BD3cXksFSqsrs%3D, PID: 10854236
    • Peterson RM, Yu Q, Stamenkovic I, Toole BP (2000) Perturbation of hyaluronan interactions by soluble CD44 inhibits growth of murine mammary carcinoma cells in ascites. Am J Pathol 156(6):2159–2167
    • (2000) Am J Pathol , vol.156 , Issue.6 , pp. 2159-2167
    • Peterson, R.M.1    Yu, Q.2    Stamenkovic, I.3    Toole, B.P.4
  • 80
    • 81055127027 scopus 로고    scopus 로고
    • A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells
    • COI: 1:CAS:528:DC%2BC3MXhsVeltLbF, PID: 21885863
    • Piotrowicz RS, Damaj BB, Hachicha M, Incardona F, Howell SB, Finlayson M (2011) A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther 10(11):2072–2082. doi:10.1158/1535-7163.MCT-11-0351
    • (2011) Mol Cancer Ther , vol.10 , Issue.11 , pp. 2072-2082
    • Piotrowicz, R.S.1    Damaj, B.B.2    Hachicha, M.3    Incardona, F.4    Howell, S.B.5    Finlayson, M.6
  • 81
    • 0037227965 scopus 로고    scopus 로고
    • CD44: from adhesion molecules to signalling regulators
    • COI: 1:CAS:528:DC%2BD3sXptV0%3D, PID: 12511867
    • Ponta H, Sherman L, Herrlich PA (2003) CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 4(1):33–45
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.1 , pp. 33-45
    • Ponta, H.1    Sherman, L.2    Herrlich, P.A.3
  • 82
    • 0642341592 scopus 로고    scopus 로고
    • Dosimetric analysis of radioimmunotherapy with 186Re-labeled bivatuzumab in patients with head and neck cancer
    • COI: 1:CAS:528:DC%2BD3sXovVCkt7w%3D, PID: 14530488
    • Postema EJ, Borjesson PK, Buijs WC et al (2003) Dosimetric analysis of radioimmunotherapy with 186Re-labeled bivatuzumab in patients with head and neck cancer. J Nucl Med 44(10):1690–1699
    • (2003) J Nucl Med , vol.44 , Issue.10 , pp. 1690-1699
    • Postema, E.J.1    Borjesson, P.K.2    Buijs, W.C.3
  • 83
    • 0028472794 scopus 로고
    • Functionalized derivatives of hyaluronic acid oligosaccharides: drug carriers and novel biomaterials
    • COI: 1:CAS:528:DyaK2cXkvVeku74%3D, PID: 7948100
    • Pouyani T, Prestwich GD (1994) Functionalized derivatives of hyaluronic acid oligosaccharides: drug carriers and novel biomaterials. Bioconjug Chem 5(4):339–347
    • (1994) Bioconjug Chem , vol.5 , Issue.4 , pp. 339-347
    • Pouyani, T.1    Prestwich, G.D.2
  • 84
    • 84898056682 scopus 로고    scopus 로고
    • Self-assembled pH-responsive hyaluronic acid-g-poly[(l)-histidine] copolymer micelles for targeted intracellular delivery of doxorubicin
    • COI: 1:CAS:528:DC%2BC2cXjs1KrtL8%3D, PID: 24365705
    • Qiu L, Li Z, Qiao M et al (2014) Self-assembled pH-responsive hyaluronic acid-g-poly[(l)-histidine] copolymer micelles for targeted intracellular delivery of doxorubicin. Acta Biomater 10(5):2024–2035. doi:10.1016/j.actbio.2013.12.025
    • (2014) Acta Biomater , vol.10 , Issue.5 , pp. 2024-2035
    • Qiu, L.1    Li, Z.2    Qiao, M.3
  • 85
    • 50049134725 scopus 로고    scopus 로고
    • Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma
    • COI: 1:CAS:528:DC%2BD1cXhtVKju7rM, PID: 18203652
    • Riechelmann H, Sauter A, Golze W et al (2008) Phase I trial with the CD44v6-targeting immunoconjugate bivatuzumab mertansine in head and neck squamous cell carcinoma. Oral Oncol 44(9):823–829. doi:10.1016/j.oraloncology.2007.10.009
    • (2008) Oral Oncol , vol.44 , Issue.9 , pp. 823-829
    • Riechelmann, H.1    Sauter, A.2    Golze, W.3
  • 86
    • 0027410839 scopus 로고
    • The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior
    • COI: 1:CAS:528:DyaK3sXitFSnt74%3D, PID: 8443806
    • Rudy W, Hofmann M, Schwartz-Albiez R et al (1993) The two major CD44 proteins expressed on a metastatic rat tumor cell line are derived from different splice variants: each one individually suffices to confer metastatic behavior. Cancer Res 53(6):1262–1268
    • (1993) Cancer Res , vol.53 , Issue.6 , pp. 1262-1268
    • Rudy, W.1    Hofmann, M.2    Schwartz-Albiez, R.3
  • 88
    • 84860299128 scopus 로고    scopus 로고
    • A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio
    • COI: 1:STN:280:DC%2BC38zgtVGhtw%3D%3D, PID: 22307465
    • Sandstrom K, Haylock AK, Spiegelberg D, Qvarnstrom F, Wester K, Nestor M (2012) A novel CD44v6 targeting antibody fragment with improved tumor-to-blood ratio. Int J Oncol 40(5):1525–1532. doi:10.3892/ijo.2012.1352
    • (2012) Int J Oncol , vol.40 , Issue.5 , pp. 1525-1532
    • Sandstrom, K.1    Haylock, A.K.2    Spiegelberg, D.3    Qvarnstrom, F.4    Wester, K.5    Nestor, M.6
  • 89
    • 34247890107 scopus 로고    scopus 로고
    • Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck
    • COI: 1:CAS:528:DC%2BD2sXkt1WhtLg%3D, PID: 17332932
    • Sauter A, Kloft C, Gronau S et al (2007) Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck. Int J Oncol 30(4):927–935
    • (2007) Int J Oncol , vol.30 , Issue.4 , pp. 927-935
    • Sauter, A.1    Kloft, C.2    Gronau, S.3
  • 91
    • 0027816263 scopus 로고
    • MAb U36, a novel monoclonal antibody successful in immunotargeting of squamous cell carcinoma of the head and neck
    • COI: 1:CAS:528:DyaK3sXms1Gms7s%3D, PID: 8364934
    • Schrijvers AH, Quak JJ, Uyterlinde AM et al (1993) MAb U36, a novel monoclonal antibody successful in immunotargeting of squamous cell carcinoma of the head and neck. Cancer Res 53(18):4383–4390
    • (1993) Cancer Res , vol.53 , Issue.18 , pp. 4383-4390
    • Schrijvers, A.H.1    Quak, J.J.2    Uyterlinde, A.M.3
  • 92
    • 84888089856 scopus 로고    scopus 로고
    • Targeted nanomedicine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: an optimal delivery of siRNA and anticancer drug
    • COI: 1:CAS:528:DC%2BC3sXhslyku7vO, PID: 24036854
    • Shah V, Taratula O, Garbuzenko OB, Taratula OR, Rodriguez-Rodriguez L, Minko T (2013) Targeted nanomedicine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: an optimal delivery of siRNA and anticancer drug. Clin Cancer Res 19(22):6193–6204. doi:10.1158/1078-0432.CCR-13-1536
    • (2013) Clin Cancer Res , vol.19 , Issue.22 , pp. 6193-6204
    • Shah, V.1    Taratula, O.2    Garbuzenko, O.B.3    Taratula, O.R.4    Rodriguez-Rodriguez, L.5    Minko, T.6
  • 93
    • 84897094416 scopus 로고    scopus 로고
    • Multifunctional tumor-targeting nanocarriers based on hyaluronic acid-mediated and pH-sensitive properties for efficient delivery of docetaxel
    • COI: 1:CAS:528:DC%2BC3sXhs1Kis7zN, PID: 24154802
    • Song S, Chen F, Qi H et al (2014a) Multifunctional tumor-targeting nanocarriers based on hyaluronic acid-mediated and pH-sensitive properties for efficient delivery of docetaxel. Pharm Res 31(4):1032–1045. doi:10.1007/s11095-013-1225-y
    • (2014) Pharm Res , vol.31 , Issue.4 , pp. 1032-1045
    • Song, S.1    Chen, F.2    Qi, H.3
  • 94
    • 84932121396 scopus 로고    scopus 로고
    • Hyaluronan-based nanocarriers with CD44-overexpressed cancer cell targeting
    • Song S, Qi H, Xu J et al (2014b) Hyaluronan-based nanocarriers with CD44-overexpressed cancer cell targeting. Pharm Res. doi:10.1007/s11095-014-1393-4
    • (2014) Pharm Res
    • Song, S.1    Qi, H.2    Xu, J.3
  • 95
    • 67651002343 scopus 로고    scopus 로고
    • Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell
    • COI: 1:CAS:528:DC%2BD1MXpsFOlurs%3D, PID: 19561119
    • Sotiropoulou G, Pampalakis G, Lianidou E, Mourelatos Z (2009) Emerging roles of microRNAs as molecular switches in the integrated circuit of the cancer cell. RNA 15(8):1443–1461. doi:10.1261/rna.1534709
    • (2009) RNA , vol.15 , Issue.8 , pp. 1443-1461
    • Sotiropoulou, G.1    Pampalakis, G.2    Lianidou, E.3    Mourelatos, Z.4
  • 96
    • 19344365874 scopus 로고    scopus 로고
    • An inducible caspase 9 safety switch for T-cell therapy
    • COI: 1:CAS:528:DC%2BD2MXks12isr8%3D, PID: 15728125
    • Straathof KC, Pule MA, Yotnda P et al (2005) An inducible caspase 9 safety switch for T-cell therapy. Blood 105(11):4247–4254. doi:10.1182/blood-2004-11-4564
    • (2005) Blood , vol.105 , Issue.11 , pp. 4247-4254
    • Straathof, K.C.1    Pule, M.A.2    Yotnda, P.3
  • 97
    • 0033624181 scopus 로고    scopus 로고
    • Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients
    • COI: 1:CAS:528:DC%2BD3cXmsVOmsb0%3D, PID: 10955783
    • Stroomer JW, Roos JC, Sproll M et al (2000) Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients. Clin Cancer Res 6(8):3046–3055
    • (2000) Clin Cancer Res , vol.6 , Issue.8 , pp. 3046-3055
    • Stroomer, J.W.1    Roos, J.C.2    Sproll, M.3
  • 98
    • 80052971224 scopus 로고    scopus 로고
    • Head neck squamous cell carcinoma c-Met(+) cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis
    • COI: 1:CAS:528:DC%2BC3MXhtF2jtrfM, PID: 21225626
    • Sun S, Wang Z (2011) Head neck squamous cell carcinoma c-Met(+) cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis. Int J Cancer 129(10):2337–2348. doi:10.1002/ijc.25927
    • (2011) Int J Cancer , vol.129 , Issue.10 , pp. 2337-2348
    • Sun, S.1    Wang, Z.2
  • 99
    • 33750685640 scopus 로고    scopus 로고
    • A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus
    • COI: 1:CAS:528:DC%2BD28XhtFWhsbnN, PID: 17062682
    • Tijink BM, Buter J, de Bree R et al (2006) A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus. Clin Cancer Res 12(20 Pt 1):6064–6072
    • (2006) Clin Cancer Res , vol.12 , pp. 6064-6072
    • Tijink, B.M.1    Buter, J.2    de Bree, R.3
  • 100
    • 84896115102 scopus 로고    scopus 로고
    • CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis
    • COI: 1:CAS:528:DC%2BC2cXjvFSlur0%3D, PID: 24607406
    • Todaro M, Gaggianesi M, Catalano V et al (2014) CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. Cell Stem Cell 14(3):342–356. doi:10.1016/j.stem.2014.01.009
    • (2014) Cell Stem Cell , vol.14 , Issue.3 , pp. 342-356
    • Todaro, M.1    Gaggianesi, M.2    Catalano, V.3
  • 101
    • 84872223569 scopus 로고    scopus 로고
    • Role of CD44 as a marker of cancer stem cells in head and neck cancer
    • COI: 1:CAS:528:DC%2BC38XhslajtbzK, PID: 23152667
    • Trapasso S, Allegra E (2012) Role of CD44 as a marker of cancer stem cells in head and neck cancer. Biologics 6:379–383. doi:10.2147/BTT.S37906
    • (2012) Biologics , vol.6 , pp. 379-383
    • Trapasso, S.1    Allegra, E.2
  • 102
    • 73949097022 scopus 로고    scopus 로고
    • A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis
    • COI: 1:CAS:528:DC%2BC3cXls1aqsQ%3D%3D, PID: 19773544
    • Tremmel M, Matzke A, Albrecht I et al (2009) A CD44v6 peptide reveals a role of CD44 in VEGFR-2 signaling and angiogenesis. Blood 114(25):5236–5244. doi:10.1182/blood-2009-04-219204
    • (2009) Blood , vol.114 , Issue.25 , pp. 5236-5244
    • Tremmel, M.1    Matzke, A.2    Albrecht, I.3
  • 103
    • 0022409599 scopus 로고
    • Glycosaminoglycan production by murine melanoma variants in vivo and in vitro
    • COI: 1:CAS:528:DyaL2MXlslKgu74%3D, PID: 4027988
    • Turley EA, Tretiak M (1985) Glycosaminoglycan production by murine melanoma variants in vivo and in vitro. Cancer Res 45(10):5098–5105
    • (1985) Cancer Res , vol.45 , Issue.10 , pp. 5098-5105
    • Turley, E.A.1    Tretiak, M.2
  • 104
    • 84864967480 scopus 로고    scopus 로고
    • A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds alpha4beta1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells
    • COI: 1:CAS:528:DC%2BC38XhtFOksLfN, PID: 22730324
    • Ugarte-Berzal E, Bailon E, Amigo-Jimenez I et al (2012) A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds alpha4beta1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells. J Biol Chem 287(33):27601–27613. doi:10.1074/jbc.M112.354670
    • (2012) J Biol Chem , vol.287 , Issue.33 , pp. 27601-27613
    • Ugarte-Berzal, E.1    Bailon, E.2    Amigo-Jimenez, I.3
  • 105
    • 84901705753 scopus 로고    scopus 로고
    • A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells
    • COI: 1:CAS:528:DC%2BC2cXovVehu70%3D, PID: 24739387
    • Ugarte-Berzal E, Bailon E, Amigo-Jimenez I, Albar JP, Garcia-Marco JA, Garcia-Pardo A (2014) A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells. J Biol Chem 289(22):15340–15349. doi:10.1074/jbc.M114.559187
    • (2014) J Biol Chem , vol.289 , Issue.22 , pp. 15340-15349
    • Ugarte-Berzal, E.1    Bailon, E.2    Amigo-Jimenez, I.3    Albar, J.P.4    Garcia-Marco, J.A.5    Garcia-Pardo, A.6
  • 106
    • 79952258417 scopus 로고    scopus 로고
    • FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism
    • COI: 1:CAS:528:DC%2BC3MXis1eisbs%3D, PID: 21364036
    • Valentine A, O’Rourke M, Yakkundi A et al (2011) FKBPL and peptide derivatives: novel biological agents that inhibit angiogenesis by a CD44-dependent mechanism. Clin Cancer Res 17(5):1044–1056. doi:10.1158/1078-0432.CCR-10-2241
    • (2011) Clin Cancer Res , vol.17 , Issue.5 , pp. 1044-1056
    • Valentine, A.1    O’Rourke, M.2    Yakkundi, A.3
  • 107
    • 0029803888 scopus 로고    scopus 로고
    • Monoclonal antibody U36, a suitable candidate for clinical immunotherapy of squamous-cell carcinoma, recognizes a CD44 isoform
    • PID: 8945625
    • Van Hal NL, Van Dongen GA, Rood-Knippels EM, Van Der Valk P, Snow GB, Brakenhoff RH (1996) Monoclonal antibody U36, a suitable candidate for clinical immunotherapy of squamous-cell carcinoma, recognizes a CD44 isoform. Int J Cancer 68(4):520–527
    • (1996) Int J Cancer , vol.68 , Issue.4 , pp. 520-527
    • Van Hal, N.L.1    Van Dongen, G.A.2    Rood-Knippels, E.M.3    Van Der Valk, P.4    Snow, G.B.5    Brakenhoff, R.H.6
  • 109
    • 60149084560 scopus 로고    scopus 로고
    • MicroRNAs and cancer: short RNAs go a long way
    • COI: 1:CAS:528:DC%2BD1MXkvFGksLg%3D, PID: 19239879
    • Ventura A, Jacks T (2009) MicroRNAs and cancer: short RNAs go a long way. Cell 136(4):586–591. doi:10.1016/j.cell.2009.02.005
    • (2009) Cell , vol.136 , Issue.4 , pp. 586-591
    • Ventura, A.1    Jacks, T.2
  • 110
    • 0037140958 scopus 로고    scopus 로고
    • Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts
    • COI: 1:CAS:528:DC%2BD38XjsFagtbw%3D, PID: 11992408
    • Verel I, Heider KH, Siegmund M et al (2002) Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts. Int J Cancer 99(3):396–402
    • (2002) Int J Cancer , vol.99 , Issue.3 , pp. 396-402
    • Verel, I.1    Heider, K.H.2    Siegmund, M.3
  • 111
    • 84877784814 scopus 로고    scopus 로고
    • Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: a preclinical study
    • PID: 23184608
    • Vermeulen JF, van Brussel AS, Adams A et al (2013) Near-infrared fluorescence molecular imaging of ductal carcinoma in situ with CD44v6-specific antibodies in mice: a preclinical study. Mol Imaging Biol 15(3):290–298. doi:10.1007/s11307-012-0605-8
    • (2013) Mol Imaging Biol , vol.15 , Issue.3 , pp. 290-298
    • Vermeulen, J.F.1    van Brussel, A.S.2    Adams, A.3
  • 112
    • 84896533782 scopus 로고    scopus 로고
    • Preclinical evaluation of 89Zr-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys: prelude to Phase 1 clinical studies
    • PID: 24492295
    • Vugts DJ, Heuveling DA, Stigter-van Walsum M et al (2014) Preclinical evaluation of 89Zr-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys: prelude to Phase 1 clinical studies. MAbs 6(2):567–575. doi:10.4161/mabs.27415
    • (2014) MAbs , vol.6 , Issue.2 , pp. 567-575
    • Vugts, D.J.1    Heuveling, D.A.2    Stigter-van Walsum, M.3
  • 113
    • 84865713442 scopus 로고    scopus 로고
    • Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist
    • COI: 1:CAS:528:DC%2BC38Xht1ygur%2FP, PID: 22777824
    • Weigand S, Herting F, Maisel D et al (2012) Global quantitative phosphoproteome analysis of human tumor xenografts treated with a CD44 antagonist. Cancer Res 72(17):4329–4339. doi:10.1158/0008-5472.CAN-12-0136
    • (2012) Cancer Res , vol.72 , Issue.17 , pp. 4329-4339
    • Weigand, S.1    Herting, F.2    Maisel, D.3
  • 114
    • 84877666481 scopus 로고    scopus 로고
    • CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches
    • COI: 1:CAS:528:DC%2BC3sXntVCku78%3D
    • Williams K, Motiani K, Giridhar PV, Kasper S (2013) CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches. Exp Biol Med 238(3):324–338. doi:10.1177/1535370213480714
    • (2013) Exp Biol Med , vol.238 , Issue.3 , pp. 324-338
    • Williams, K.1    Motiani, K.2    Giridhar, P.V.3    Kasper, S.4
  • 115
    • 47949086256 scopus 로고    scopus 로고
    • Cancer stem cells: markers or biomarkers?
    • COI: 1:CAS:528:DC%2BD1cXovFyitLw%3D, PID: 18437295
    • Woodward WA, Sulman EP (2008) Cancer stem cells: markers or biomarkers? Cancer Metastasis Rev 27(3):459–470. doi:10.1007/s10555-008-9130-2
    • (2008) Cancer Metastasis Rev , vol.27 , Issue.3 , pp. 459-470
    • Woodward, W.A.1    Sulman, E.P.2
  • 116
    • 0141483365 scopus 로고    scopus 로고
    • A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis
    • COI: 1:CAS:528:DC%2BD3sXnvVSjt70%3D, PID: 14522884
    • Xu XM, Chen Y, Chen J et al (2003) A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis. Cancer Res 63(18):5685–5690
    • (2003) Cancer Res , vol.63 , Issue.18 , pp. 5685-5690
    • Xu, X.M.1    Chen, Y.2    Chen, J.3
  • 117
    • 47649103158 scopus 로고    scopus 로고
    • Preparation and characterization of HA–PEG–PCL intelligent core-corona nanoparticles for delivery of doxorubicin
    • COI: 1:CAS:528:DC%2BD1cXotFejtLY%3D, PID: 18604659
    • Yadav AK, Mishra P, Jain S, Mishra AK, Agrawal GP (2008) Preparation and characterization of HA–PEG–PCL intelligent core-corona nanoparticles for delivery of doxorubicin. J Drug Target 16(6):464–478. doi:10.1080/10611860802095494
    • (2008) J Drug Target , vol.16 , Issue.6 , pp. 464-478
    • Yadav, A.K.1    Mishra, P.2    Jain, S.3    Mishra, A.K.4    Agrawal, G.P.5
  • 118
    • 0028097742 scopus 로고
    • Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein
    • PID: 7508860
    • Yang B, Yang BL, Savani RC, Turley EA (1994) Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J 13(2):286–296
    • (1994) EMBO J , vol.13 , Issue.2 , pp. 286-296
    • Yang, B.1    Yang, B.L.2    Savani, R.C.3    Turley, E.A.4
  • 119
    • 0032926177 scopus 로고    scopus 로고
    • Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion
    • COI: 1:CAS:528:DyaK1MXnvF2gtg%3D%3D, PID: 9887098
    • Yu Q, Stamenkovic I (1999) Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev 13(1):35–48
    • (1999) Genes Dev , vol.13 , Issue.1 , pp. 35-48
    • Yu, Q.1    Stamenkovic, I.2
  • 120
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • PID: 10652271
    • Yu Q, Stamenkovic I (2000) Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev 14(2):163–176
    • (2000) Genes Dev , vol.14 , Issue.2 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 121
    • 4344654754 scopus 로고    scopus 로고
    • Transforming growth factor-beta facilitates breast carcinoma metastasis by promoting tumor cell survival
    • COI: 1:CAS:528:DC%2BD2cXmsFSks7g%3D, PID: 15387373
    • Yu Q, Stamenkovic I (2004) Transforming growth factor-beta facilitates breast carcinoma metastasis by promoting tumor cell survival. Clin Exp Metastasis 21(3):235–242
    • (2004) Clin Exp Metastasis , vol.21 , Issue.3 , pp. 235-242
    • Yu, Q.1    Stamenkovic, I.2
  • 122
    • 0031453690 scopus 로고    scopus 로고
    • Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function
    • COI: 1:CAS:528:DyaK2sXotVGhs7Y%3D, PID: 9396767
    • Yu Q, Toole BP, Stamenkovic I (1997) Induction of apoptosis of metastatic mammary carcinoma cells in vivo by disruption of tumor cell surface CD44 function. J Exp Med 186(12):1985–1996
    • (1997) J Exp Med , vol.186 , Issue.12 , pp. 1985-1996
    • Yu, Q.1    Toole, B.P.2    Stamenkovic, I.3
  • 123
    • 0036468005 scopus 로고    scopus 로고
    • CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling
    • COI: 1:CAS:528:DC%2BD38XhtFWmu7g%3D, PID: 11825873
    • Yu WH, Woessner JF Jr, McNeish JD, Stamenkovic I (2002) CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev 16(3):307–323
    • (2002) Genes Dev , vol.16 , Issue.3 , pp. 307-323
    • Yu, W.H.1    Woessner, J.F.2    McNeish, J.D.3    Stamenkovic, I.4
  • 124
    • 45549109525 scopus 로고    scopus 로고
    • Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis
    • COI: 1:CAS:528:DC%2BD1cXlvVOitL0%3D, PID: 18483247
    • Zeilstra J, Joosten SP, Dokter M, Verwiel E, Spaargaren M, Pals ST (2008) Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res 68(10):3655–3661
    • (2008) Cancer Res , vol.68 , Issue.10 , pp. 3655-3661
    • Zeilstra, J.1    Joosten, S.P.2    Dokter, M.3    Verwiel, E.4    Spaargaren, M.5    Pals, S.T.6
  • 125
    • 84893328640 scopus 로고    scopus 로고
    • Stem cell CD44v isoforms promote intestinal cancer formation in apc(min) mice downstream of wnt signaling
    • COI: 1:CAS:528:DC%2BC3sXntFyitg%3D%3D, PID: 23318432
    • Zeilstra J, Joosten SP, van Andel H et al (2014) Stem cell CD44v isoforms promote intestinal cancer formation in apc(min) mice downstream of wnt signaling. Oncogene 33(5):665–670. doi:10.1038/onc.2012.611
    • (2014) Oncogene , vol.33 , Issue.5 , pp. 665-670
    • Zeilstra, J.1    Joosten, S.P.2    van Andel, H.3
  • 126
    • 0028796676 scopus 로고
    • Hyaluronan on the surface of tumor cells is correlated with metastatic behavior
    • COI: 1:CAS:528:DyaK2MXjtFyjtro%3D, PID: 7529138
    • Zhang L, Underhill CB, Chen L (1995) Hyaluronan on the surface of tumor cells is correlated with metastatic behavior. Cancer Res 55(2):428–433
    • (1995) Cancer Res , vol.55 , Issue.2 , pp. 428-433
    • Zhang, L.1    Underhill, C.B.2    Chen, L.3
  • 127
    • 84876037294 scopus 로고    scopus 로고
    • Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44
    • COI: 1:CAS:528:DC%2BC3sXnsFKkt7g%3D
    • Zhang S, Wu CC, Fecteau JF et al (2013) Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44. Proc Natl Acad 110(15):6127–6132. doi:10.1073/pnas.1221841110
    • (2013) Proc Natl Acad , vol.110 , Issue.15 , pp. 6127-6132
    • Zhang, S.1    Wu, C.C.2    Fecteau, J.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.