Liposome-encapsulated doxorubicin targeted to CD44: A strategy to kill CD44-overexpressing tumor cells

Cancer Research

Volumn 61, Issue 6, 2001, Pages 2592-2601

  Eliaz, R E ^a   Szoka F C , Jr ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE MARKER; DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; DOXORUBICIN; HERMES ANTIGEN; HYALURONIC ACID; LIGAND; LIPOSOME; PHOSPHATIDYLETHANOLAMINE;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; ENCAPSULATION; IC 50; KIDNEY CELL; LIPID BILAYER; MELANOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR BINDING; TEMPERATURE DEPENDENCE; TUMOR CELL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, CD44; CARBOHYDRATE SEQUENCE; DOXORUBICIN; FLOW CYTOMETRY; HAPLORHINI; HUMANS; HYALURONIC ACID; LIPOSOMES; MELANOMA, EXPERIMENTAL; MICE; MOLECULAR SEQUENCE DATA;

EID: 0035866799     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. CD44: Physiological expression of distinct isoforms as evidence for organ-specific metastasis formation
2. CD44 and hyaluronan binding by human myeloid cells
3. CD44 and the adhesion of neoplastic cells
4. The normal structure and function of CD44 and its role in neoplasia
5. CD-44 structure and function
6. Forms and functions of CD44
7. Adhesion proteins in the biology of breast cancer: Contribution of CD44
8. Expression of CD44 standard form and variant isoforms in non-small cell lung carcinomas
9. CD44 and its v6 spliced variant in lung tumors: A role in histogenesis?
10. Lymphocyte homing receptors
11. Homing receptors and the control of lymphocyte migration
12. The cell surface hyaluronate binding sites of invasive human bladder carcinoma cells
13. Homing receptors and metastasis
14. Hyaluronate and invasiveness of the rabbit V2 carcinoma
15. Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development
16. Isolation and characterization of human melanoma cell variants expressing high and low levels of CD44
17. Expression of CD44 in human lung tumors
18. Inhibition of tumor growth in vivo by hyaluronan oligomers
19. Blockade of metastasis formation by CD44-receptor globulin
20. Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein
21. Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
22. Synthesis and selective cytotoxicity of a hyaluronic acid-antitumor bioconjugate
23. Evaluation of antitumor activities of hyaluronate binding antitumor drugs: Synthesis, characterization and antitumor activity
24. Lateral interactions among membrane proteins. Implications for the organization of gap junctions
25. Synthetic glycolipids: Interaction with galactose-binding lectin and hepatic cells
26. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes
27. The use of a new radioactive-iodine labeled lipid marker to follow in vivo disposition of liposomes: Comparison with an encapsulated aqueous space marker
28. Optimization and upscaling of doxorubicin-containing liposomes for clinical use
29. Ammonium sulfate gradients for efficient and stable remote loading of amphipathic weak bases into liposomes and ligandoliposomes
30. Phosphorous assay in column chromatography
31. New colorimetric cytotoxicity assay for anticancer-drug screening
32. Binding of hyaluronate and chondroitin sulphate to liver endothelial cells
33. Sterically stabilized liposomes: Improvements in pharmacokinetics and antitumor therapeutic efficacy
34. Polyethylene glycol-coated (pegylated) liposomal doxorubicin. Rationale for use in solid tumours
35. Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes
36. Inhibition of experimental metastasis and cell adhesion of murine melanoma cells by chondroitin sulfate-derivatized lipid, a neoproteoglycan with anti-cell adhesion activity
37. Synthesis of novel polyampholyte comb-type copolymers consisting of a poly(L-lysine) backbone and hyaluronic acid side chains for a DNA carrier
38. Targeted gene transfer to sinusoidal endothelial cells and expression in vivo
39. The endocytic hyaluronan receptor in rat liver sinusoidal endothelial cells is Ca(+2)-independent and distinct from a Ca(+2)-dependent hyaluronan binding activity
40. Degradation and intracellular accumulation of a residualizing hyaluronan derivative by liver endothelial cells
41. Molecular and cellular studies of hyaluronic acid-modified liposomes as bioadhesive carriers for topical drug delivery in wound healing
42. Hyaluronic acid-modified bioadhesive liposomes as local drug depots: Effects of cellular and fluid dynamics on liposome retention at target sites
43. Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats
44. Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing Adriamycin. Immunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro
45. Immunoliposome-mediated targeting of doxorubicin to human ovarian carcinoma in vitro and in vivo
46. Development of anti-p185HER2 immunoliposomes for cancer therapy
47. Antibody-mediated specific binding and cytotoxicity of liposome-entrapped doxorubicin to lung cancer cells in vitro
48. A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells
49. In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma
50. Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro