A 17-residue sequence from the matrix metalloproteinase-9 (MMP-9) hemopexin domain binds α4β1 integrin and inhibits MMP-9-induced functions in chronic lymphocytic leukemia B cells

Journal of Biological Chemistry

Volumn 287, Issue 33, 2012, Pages 27601-27613

  Ugarte Berzal, Estefanía ^a   Bailón, Elvira ^a   Amigo Jiménez, Irene ^a   Vituri, Cidonia L ^b   Hernández Del Cerro, Mercedes ^a   José Terol, María ^c   Albar, Juan P ^d   Rivas, Germán ^a   García Marco, José A ^e   García Pardo, Angeles ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^c HOSPITAL CLÍNICO UNIVERSITARIO   (Spain)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^e HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE RESIDUE; B CELLS; CELL INCUBATION; CELL INTERACTION; CELL MIGRATION; CELL SURVIVAL; CHRONIC LYMPHOCYTIC LEUKEMIAS; FUNCTIONAL ASSAYS; HEMOPEXIN; IC50 VALUE; INTEGRINS; INTRACELLULAR SURVIVAL; MATRIX METALLOPROTEINASE-9; METALLOPROTEINASE-9; PRIMARY SAMPLES; SPECIFIC INHIBITORS; SYNTHETIC PEPTIDE; UP-REGULATION;

AMINO ACIDS; ANTIBODIES; CELL ADHESION; DISEASES; PEPTIDES; PHOSPHORYLATION;

CELLS;

ALANINE; AMINO ACID; ASPARTIC ACID; GELATINASE B; GLUTATHIONE TRANSFERASE; HEMOPEXIN; MUTANT PROTEIN; PEPTIDE; PHENYLALANYLPROLYLGLYCYLVALYLPROLYLLEUCYLASPARTYLTHREONYLHISTIDYLASPARTYLVALYLPHENYLALANYLGLUTAMYLTYROSYLARGYNYLGLUTAMYLLYSYLALANYLTYROSYLPHENYLALANYLCYSTEINE; PROTEIN KINASE LYN; PROTEIN MCL 1; UNCLASSIFIED DRUG; VALYLPROLYLLEUCYLASPARTYLTHREONYLHISTIDYLASPARTYLVALYLPHENYLALANYLGLUTAMINE; VERY LATE ACTIVATION ANTIGEN 4;

AMINO ACID SEQUENCE; ARTICLE; B CELL LEUKEMIA; BINDING SITE; CANCER STAGING; CELL ADHESION; CELL INTERACTION; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; ENZYME BINDING; ENZYME IMMOBILIZATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PULMONARY VEIN ISOLATION; SIGNAL TRANSDUCTION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UPREGULATION;

AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODIES, NEOPLASM; CELL ADHESION; CELL MOVEMENT; CELL SURVIVAL; ENZYME PRECURSORS; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; INTEGRIN ALPHA4BETA1; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; MUTAGENESIS; MUTATION, MISSENSE; PEPTIDE MAPPING; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; SRC-FAMILY KINASES; UP-REGULATION;

EID: 84864967480     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.354670     Document Type: Article

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