Self-assembled pH-responsive hyaluronic acid-g-poly(l-histidine) copolymer micelles for targeted intracellular delivery of doxorubicin

Acta Biomaterialia

Volumn 10, Issue 5, 2014, Pages 2024-2035

  Qiu, Lipeng ^a   Li, Zhen ^b   Qiao, Mingxi ^a   Long, Miaomiao ^a   Wang, Mingyue ^a   Zhang, Xiaojun ^a   Tian, Chenmin ^c   Chen, Dawei ^a,c  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b DALIAN MEDICAL UNIVERSITY   (China)

^c MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Doxorubicin; Hyaluronic acid g poly(l histidine); pH responsive; Self assembled micelles; Targeted intracellular delivery

Indexed keywords

AMINO ACIDS; ASSAYS; BINDING SITES; BIOCOMPATIBILITY; CELLS; CONTROLLED DRUG DELIVERY; CYTOTOXICITY; DISEASES; HYALURONIC ACID; MOLECULAR BIOLOGY; NANOSYSTEMS; TARGETED DRUG DELIVERY;

COPOLYMER MICELLES; DEGREE OF SUBSTITUTION; DOXORUBICIN; HYALURONIC ACID-G-POLY(L-HISTIDINE); INTRACELLULAR DELIVERY; PH-RESPONSIVE; POLIES (LHISTIDINE); POLY-L-HISTIDINE; SELF-ASSEMBLED MICELLE; TARGETED INTRACELLULAR DELIVERY;

MICELLES;

CLATHRIN; COPOLYMER; DOXORUBICIN; HYALURONIC ACID; HISTIDINE; MICELLE; POLYHISTIDINE;

ARTICLE; BINDING SITE; CYTOTOXICITY ASSAY; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENDOCYTOSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MICELLE; PH; PRIORITY JOURNAL; TARGETED INTRACELLULAR DELIVERY; ANIMAL; CELL DEATH; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; HEMOLYSIS; INTRACELLULAR SPACE; MCF 7 CELL LINE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; RABBIT; SYNTHESIS; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CELL DEATH; CELL SURVIVAL; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; HEMOLYSIS; HISTIDINE; HUMANS; HYALURONIC ACID; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; MAGNETIC RESONANCE SPECTROSCOPY; MCF-7 CELLS; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; RABBITS;

EID: 84898056682     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.12.025     Document Type: Article

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