MicroRNA-328 inhibits renal tubular cell epithelial-to-mesenchymal transition by targeting the CD44 in pressure-induced renal fibrosis

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Chen, Cheng Hsien ^a,b   Cheng, Chung Yi ^a   Chen, Yen Cheng ^a   Sue, Yuh Mou ^a   Liu, Chung Te ^a   Cheng, Tzu Hurng ^c   Hsu, Yung Ho ^b   Chen, Tso Hsiao ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; HERMES ANTIGEN; HYALURONIC ACID BINDING PROTEIN; MICRORNA; MICRORNA 129 5P; MICRORNA 193 5P; MICRORNA 204 5P; MICRORNA 207; MICRORNA 211 5P; MICRORNA 223 3P; MICRORNA 301B 3P; MICRORNA 322 3P; MICRORNA 328; MICRORNA 346; MICRORNA 349; MICRORNA 378A 5P; MICRORNA 743A; MICRORNA 878; OSTEOPONTIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UVOMORULIN; ACTIN; CADHERIN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE IDENTIFICATION; GENE SEQUENCE; GENE TARGETING; GENETIC TRANSFECTION; KIDNEY FIBROSIS; KIDNEY TUBULE CELL; MALE; MICROARRAY ANALYSIS; NONHUMAN; PRESSURE INDUCED KIDNEY FIBROSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; URETER OBSTRUCTION; ANIMAL; EPITHELIUM CELL; FIBROSIS; GENETICS; KIDNEY DISEASE; KIDNEY TUBULE; METABOLISM; PATHOLOGY; PRESSURE;

ACTINS; ANIMALS; ANTIGENS, CD44; CADHERINS; CONNECTIVE TISSUE GROWTH FACTOR; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; FIBRONECTINS; FIBROSIS; KIDNEY DISEASES; KIDNEY TUBULES; MICRORNAS; OSTEOPONTIN; PRESSURE; RATS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; URETERAL OBSTRUCTION;

EID: 84903388427     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099802     Document Type: Article

References (49)

1. Kaneto H, Ohtani H, Fukuzaki A, Ishidoya S, Takeda A, et al. (1999) Increased expression of TGF-beta1 but not of its receptors contributes to human obstructive nephropathy. Kidney Int 56: 2137-2146. (Pubitemid 30004742)
2. Felsen D, Schulsinger D, Gross SS, Kim FY, Marion D, et al. (2003) Renal hemodynamic and ureteral pressure changes in response to ureteral obstruction: the role of nitric oxide. J Urol 169: 373-376. (Pubitemid 35461649)
3. Vaughan ED Jr, Marion D, Poppas DP, Felsen D (2004) Pathophysiology of unilateral ureteral obstruction: studies from Charlottesville to New York. J Urol 172: 2563-2569. (Pubitemid 39507471)
4. Chen CH, Cheng CY, Chen YC, Sue YM, Hsu YH, et al. (2013) Rosuvastatin inhibits pressure-induced fibrotic responses via the expression regulation of prostacyclin and prostaglandin E2 in rat renal tubular cells. Eur J Pharmacol 700: 65-73.
5. Broadbelt NV, Stahl PJ, Chen J, Mizrahi M, Lal A, et al. (2007) Early upregulation of iNOS mRNA expression and increase in NO metabolites in pressurized renal epithelial cells. Am J Physiol Renal Physiol 293: F1877-1888. (Pubitemid 350179612)
6. Cicha I, Goppelt-Struebe M (2009) Connective tissue growth factor: context-dependent functions and mechanisms of regulation. Biofactors 35: 200-208.
7. Xu C, Wang W, Xu M, Zhang J (2013) Asiatic acid ameliorates tubulointerstitial fibrosis in mice with ureteral obstruction. Exp Ther Med 6: 731-736.
8. Loeffler I, Wolf G (2014) Transforming growth factor-beta and the progression of renal disease. Nephrol Dial Transplant 29 Suppl 1: i37-i45.
9. Kriz W, Kaissling B, Le Hir M (2011) Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy? J Clin Invest 121: 468-474.
10. Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 119: 1429-1437.
11. Carew RM, Wang B, Kantharidis P (2012) The role of EMT in renal fibrosis. Cell Tissue Res 347: 103-116.
12. Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428.
13. Winter J, Jung S, Keller S, Gregory RI, Diederichs S (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol 11: 228-234.
14. Ambros V (2003) MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. Cell 113: 673-676.
15. Vandewalle C, Comijn J, De Craene B, Vermassen P, Bruyneel E, et al. (2005) SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res 33: 6566-6578. (Pubitemid 41806421)
16. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601. (Pubitemid 351627379)
17. Wang B, Koh P, Winbanks C, Coughlan MT, McClelland A, et al. (2011) miR-200a Prevents renal fibrogenesis through repression of TGF-beta2 expression. Diabetes 60: 280-287.
18. Kato M, Zhang J, Wang M, Lanting L, Yuan H, et al. (2007) MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A 104: 3432-3437. (Pubitemid 46364176)
19. Wang Q, Wang Y, Minto AW, Wang J, Shi Q, et al. (2008) MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J 22: 4126-4135.
20. Wang CH, Lee DY, Deng Z, Jeyapalan Z, Lee SC, et al. (2008) MicroRNA miR-328 regulates zonation morphogenesis by targeting CD44 expression. PLoS One 3: e2420.
21. Marhaba R, Zoller M (2004) CD44 in cancer progression: adhesion, migration and growth regulation. J Mol Histol 35: 211-231. (Pubitemid 40585308)
22. Naor D, Nedvetzki S, Walmsley M, Yayon A, Turley EA, et al. (2007) CD44 involvement in autoimmune inflammations: the lesson to be learned from CD44-targeting by antibody or from knockout mice. Ann N Y Acad Sci 1110: 233-247. (Pubitemid 350043012)
23. Mummert ME (2005) Immunologic roles of hyaluronan. Immunol Res 31: 189-206.
24. Mummert ME, Mohamadzadeh M, Mummert DI, Mizumoto N, Takashima A (2000) Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking. J Exp Med 192: 769-779.
25. Chen CF, Yeh SU, Chien CT, Wu MS (2001) Renal response during acute unilateral ureteral obstruction in rats. Neurourol Urodyn 20: 125-137. (Pubitemid 32096334)
26. Wang S, Mitu GM, Hirschberg R (2008) Osmotic polyuria: an overlooked mechanism in diabetic nephropathy. Nephrol Dial Transplant 23: 2167-2172. (Pubitemid 351957618)
27. Li Y, Sun Y, Liu F, Sun L, Li J, et al. (2013) Norcantharidin inhibits renal interstitial fibrosis by blocking the tubular epithelial-mesenchymal transition. PLoS One 8: e66356.
28. Misseri R, Meldrum KK (2005) Mediators of fibrosis and apoptosis in obstructive uropathies. Curr Urol Rep 6: 140-145.
29. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, et al. (2006) Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 103: 13180-13185. (Pubitemid 44338936)
30. Zeisberg EM, Tarnavski O, Zeisberg M, Dorfman AL, McMullen JR, et al. (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13: 952-961. (Pubitemid 47222040)
31. Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, et al. (2007) Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 282: 22089-22101. (Pubitemid 47195788)
32. Vongwiwatana A, Tasanarong A, Rayner DC, Melk A, Halloran PF (2005) Epithelial to mesenchymal transition during late deterioration of human kidney transplants: the role of tubular cells in fibrogenesis. Am J Transplant 5: 1367-1374. (Pubitemid 40839427)
33. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, et al. (2010) Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 176: 85-97.
34. Li L, Zepeda-Orozco D, Black R, Lin F (2010) Autophagy is a component of epithelial cell fate in obstructive uropathy. Am J Pathol 176: 1767-1778.
35. Kim MK, Maeng YI, Sung WJ, Oh HK, Park JB, et al. (2013) The differential expression of TGF-beta1, ILK and wnt signaling inducing epithelial to mesenchymal transition in human renal fibrogenesis: an immunohistochemical study. Int J Clin Exp Pathol 6: 1747-1758.
36. Wu Z, Sun L, Wang H, Yao J, Jiang C, et al. (2012) MiR-328 expression is decreased in high-grade gliomas and is associated with worse survival in primary glioblastoma. PLoS One 7: e47270.
37. Xu XT, Xu Q, Tong JL, Zhu MM, Nie F, et al. (2012) MicroRNA expression profiling identifies miR-328 regulates cancer stem cell-like SP cells in colorectal cancer. Br J Cancer 106: 1320-1330.
38. Pan YZ, Morris ME, Yu AM (2009) MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells. Mol Pharmacol 75: 1374-1379.
39. Garg M (2013) Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancer. World J Stem Cells 5: 188-195.
40. Lin CH, Hung PH, Chen YJ (2013) CD44 Is Associated with the Aggressive Phenotype of Nasopharyngeal Carcinoma through Redox Regulation. Int J Mol Sci 14: 13266-13281.
41. Wu B, Brooks JD (2012) Gene expression changes induced by unilateral ureteral obstruction in mice. J Urol 188: 1033-1041.
42. Naor D, Nedvetzki S, Golan I, Melnik L, Faitelson Y (2002) CD44 in cancer. Crit Rev Clin Lab Sci 39: 527-579. (Pubitemid 35425379)
43. Li Y, Jiang D, Liang J, Meltzer EB, Gray A, et al. (2011) Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44. J Exp Med 208: 1459-1471.
44. Phillips A (2007) The role of proximal tubular cells in interstitial fibrosis: understanding TGF-beta1. Chang Gung Med J 30: 2-6.
45. Graf K, Stawowy P (2004) Osteopontin: a protective mediator of cardiac fibrosis? Hypertension 44: 809-810. (Pubitemid 39577403)
46. Zahradka P (2008) Novel role for osteopontin in cardiac fibrosis. Circ Res 102: 270-272.
47. Nicholas SB, Liu J, Kim J, Ren Y, Collins AR, et al. (2010) Critical role for osteopontin in diabetic nephropathy. Kidney Int 77: 588-600.
48. Xu D, Zhang T, Chen X, Zhou Q, Liu C, et al. (2013) Reduction of osteopontin in vivo inhibits tubular epithelial to mesenchymal transition in rats with chronic allograft nephropathy. Transplant Proc 45: 659-665.
49. Eddy AA (2005) Can renal fibrosis be reversed? Pediatr Nephrol 20: 1369-1375.