Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice

Gastroenterology

Volumn 146, Issue 4, 2014, Pages 1108-1118.e12

  Li, Ling ^a,b   Hao, Xinbao ^a,c   Qin, Jun ^d   Tang, Wenhua ^a,e   He, Fengtian ^a   Smith, Amber ^e   Zhang, Min ^a   Simeone, Diane M ^a   Qiao, Xiaotan T ^a   Chen, Zhi Nan ^b   Lawrence, Theodore S ^a   Xu, Liang ^a,e  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c HAINAN MEDICAL UNIVERSITY   (China)

^d FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF KANSAS   (United States)

Author keywords

Cancer Stem Cell; H4C4; Progression; Tumorigenesis

Indexed keywords

CD44S ANTIGEN; HERMES ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY H4C4; STAT3 PROTEIN; TRANSCRIPTION FACTOR NANOG; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RECURRENCE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OVERALL SURVIVAL; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL TIME; UPREGULATION;

CANCER STEM CELL; H4C4; PROGRESSION; TUMORIGENESIS;

ADENOCARCINOMA; ANIMALS; ANTIBODIES; ANTIGENS, CD44; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KAPLAN-MEIER ESTIMATE; MICE; MICE, NUDE; NEOPLASM RECURRENCE, LOCAL; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TIME FACTORS; TRANSCRIPTION FACTORS; TUMOR BURDEN; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84896489722     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.12.035     Document Type: Article

References (44)

1. A. Vincent, J. Herman, and R. Schulick et al. Pancreatic cancer Lancet 378 2011 607 620
2. C.A. Iacobuzio-Donahue, B. Fu, and S. Yachida et al. DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer J Clin Oncol 27 2009 1806 1813
3. R. Gutt, S.L. Liauw, and R.R. Weichselbaum The role of radiotherapy in locally advanced pancreatic carcinoma Nat Rev Gastroenterol Hepatol 7 2010 437 447
4. N. Trakul, A.C. Koong, and P.G. Maxim et al. Modern radiation therapy techniques for pancreatic cancer Gastroenterol Clin North Am 41 2012 223 235
5. M. Zöller CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? Nat Rev Cancer 11 2011 254 267
6. Y. Hu, and L. Fu Targeting cancer stem cells: a new therapy to cure cancer patients Am J Cancer Res 2 2012 340 356
7. J.A. McCubrey, L.S. Steelman, and S.L. Abrams et al. Targeting the cancer initiating cell: the ultimate target for cancer therapy Curr Pharm Des 18 2012 1784 1795
8. C. Li, D.G. Heidt, and P. Dalerba et al. Identification of pancreatic cancer stem cells Cancer Res 67 2007 1030 1037
9. M.C. de Jong, J. Pramana, and J.E. van der Wal et al. CD44 expression predicts local recurrence after radiotherapy in larynx cancer Clin Cancer Res 16 2010 5329 5338
10. W. Xiao, P.H. Graham, and C.A. Power et al. CD44 is a biomarker associated with human prostate cancer radiation sensitivity Clin Exp Metastasis 29 2012 1 9
11. Q. Ji, X. Hao, and M. Zhang et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells PLoS One 4 2009 e6816
12. S. Takaishi, T. Okumura, and S. Tu et al. Identification of gastric cancer stem cells using the cell surface marker CD44 Stem Cells 27 2009 1006 1020
13. S.P. Hong, J. Wen, and S. Bang et al. CD44-positive cells are responsible for gemcitabine resistance in pancreatic cancer cells Int J Cancer 125 2009 2323 2331
14. K. Mima, H. Okabe, and T. Ishimoto et al. CD44s regulates the TGF-beta-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma Cancer Res 72 2012 3414 3423
15. J.L. Hao, P.J. Cozzi, and A. Khatri et al. CD147/EMMPRIN and CD44 are potential therapeutic targets for metastatic prostate cancer Curr Cancer Drug Targets 10 2010 287 306
16. V. Orian-Rousseau CD44, a therapeutic target for metastasising tumours Eur J Cancer 46 2010 1271 1277
17. R.L. Brown, L.M. Reinke, and M.S. Damerow et al. CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression J Clin Invest 121 2011 1064 1074
18. S.A. Mani, W. Guo, and M.J. Liao et al. The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715
19. H. Immervoll, D. Hoem, and O.J. Steffensen et al. Visualization of CD44 and CD133 in normal pancreas and pancreatic ductal adenocarcinomas: non-overlapping membrane expression in cell populations positive for both markers J Histochem Cytochem 59 2011 441 455
20. R. Tomaszewska, K. Nowak, and J. Stachura CD44 isoforms expression in intraductal and invasive pancreatic cancer and its correlation to p53 gene mutations Pol J Pathol 50 1999 145 153
21. L.Y. Bourguignon, C. Earle, and G. Wong et al. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells Oncogene 31 2012 149 160
22. L.Y. Bourguignon, K. Peyrollier, and W. Xia et al. Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells J Biol Chem 283 2008 17635 17651
23. L.L. Marotta, V. Almendro, and A. Marusyk et al. The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors J Clin Invest 121 2011 2723 2735
24. M.B. Penno, J.T. August, and S.B. Baylin et al. Expression of CD44 in human lung tumors Cancer Res 54 1994 1381 1387
25. Y. Dai, J.T. DeSano, and Y. Meng et al. Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer Int J Radiat Oncol Biol Phys 74 2009 1217 1225
26. L. Li, W. Tang, and X. Wu et al. HAb18G/CD147 Promotes pSTAT3-Mediated Pancreatic Cancer Development via CD44s Clin Cancer Res 19 2013 6703 6715
27. Y. Dai, M. Liu, and W. Tang et al. Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis Clin Cancer Res 14 2008 7701 7710
28. L. Lin, B. Hutzen, and M. Zuo et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells Cancer Res 70 2010 2445 2454
29. Y. Xu, I. Stamenkovic, and Q. Yu CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma Cancer Res 70 2010 2455 2464
30. J.T. Lin, T.H. Chang, and C.S. Chang et al. Prognostic value of pretreatment CD44 mRNA in peripheral blood of patients with locally advanced head and neck cancer Oral Oncol 46 2010 e29 e33
31. Y.J. Su, H.M. Lai, and Y.W. Chang et al. Direct reprogramming of stem cell properties in colon cancer cells by CD44 EMBO J 30 2011 3186 3199
32. M.P. Deonarain, C.A. Kousparou, and A.A. Epenetos Antibodies targeting cancer stem cells: a new paradigm in immunotherapy? MAbs 1 2009 12 25
33. A.M. Scott, J.D. Wolchok, and L.J. Old Antibody therapy of cancer Nat Rev Cancer 12 2012 278 287
34. X. Pan, R. Thompson, and X. Meng et al. Tumor-targeted RNA-interference: functional non-viral nanovectors Am J Cancer Res 1 2010 32 49
35. L. Jin, K.J. Hope, and Q. Zhai et al. Targeting of CD44 eradicates human acute myeloid leukemic stem cells Nat Med 12 2006 1167 1174
36. Y. Dai, M. Liu, and W. Tang et al. Molecularly targeted radiosensitization of human prostate cancer by modulating inhibitor of apoptosis Clin Cancer Res 14 2008 7701 7710
37. L. Lin, B. Hutzen, and M. Zuo et al. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells Cancer Res 70 2010 2445 2454
38. L. Li, W. Tang, and X. Wu et al. HAb18G/CD147 Promotes pSTAT3-mediated pancreatic cancer development via CD44s Clin Cancer Res 19 2013 6703 6715
39. C. Chang, A. Takayanagi, and T. Yoshida et al. Screening of scFv-displaying phages recognizing distinct extracellular domains of EGF receptor by target-guided proximity labeling method J Immunol Methods 372 2011 127 136
40. J. Lian, X. Wu, and F. He et al. A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum Cell Death Differ 18 2011 60 71
41. Q. Ji, X. Hao, and M. Zhang et al. MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells PLoS One 4 2009 e6816
42. C. Li, D.G. Heidt, and P. Dalerba et al. Identification of pancreatic cancer stem cells Cancer Res 67 2007 1030 1037
43. Y. Dai, J.T. DeSano, and Y. Meng et al. Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer Int J Radiat Oncol Biol Phys 74 2009 1217 1225
44. L. Jia, J. Yang, and X. Hao et al. Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target Clin Cancer Res 16 2010 814 824