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Volumn 6, Issue JUN, 2015, Pages

Impaired T-cell function in B-cell lymphoma: A direct consequence of events at the immunological synapse?

Author keywords

Immunological synapse; Lymphoma; T cell function; T cell tolerance

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; T LYMPHOCYTE RECEPTOR;

EID: 84935086452     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00258     Document Type: Short Survey
Times cited : (18)

References (142)
  • 1
    • 16844381831 scopus 로고    scopus 로고
    • Mechanisms of B-cell lymphoma pathogenesis
    • Kuppers R. Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer (2005) 5:251-62. doi: 10.1038/nrc1589
    • (2005) Nat Rev Cancer , vol.5 , pp. 251-262
    • Kuppers, R.1
  • 2
    • 84935144496 scopus 로고    scopus 로고
    • (accessed October 27 )
    • National Cancer Institute Non-Hodgkin Lymphoma. Available from: http://www.cancer.gov/cancertopics/types/non-hodgkin (accessed October 27 2014)
    • (2014)
  • 4
    • 0028003441 scopus 로고
    • Depressed immunity and the development of cancer
    • Penn I. Depressed immunity and the development of cancer. Cancer Detect Prev (1994) 18:241-52.
    • (1994) Cancer Detect Prev , vol.18 , pp. 241-252
    • Penn, I.1
  • 6
    • 0038307784 scopus 로고    scopus 로고
    • Immunodeficiency and cancer: prospects for correction
    • Hadden JW. Immunodeficiency and cancer: prospects for correction. Int Immunopharmacol (2003) 3:1061-71. doi:10.1016/s1567-5769(03)00060-2
    • (2003) Int Immunopharmacol , vol.3 , pp. 1061-1071
    • Hadden, J.W.1
  • 7
    • 84865688046 scopus 로고    scopus 로고
    • T-cell therapy in the treatment of post-transplant lymphoproliferative disease
    • Bollard CM, Rooney CM, Heslop HE. T-cell therapy in the treatment of post-transplant lymphoproliferative disease. Nat Rev Clin Oncol (2012) 9:510-9. doi:10.1038/nrclinonc.2012.111
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 510-519
    • Bollard, C.M.1    Rooney, C.M.2    Heslop, H.E.3
  • 8
    • 85047700205 scopus 로고
    • Expression of MHC class II antigens in human B-cell leukaemia and non-Hodgkin's lymphoma
    • Guy K, Krajewski AS, Dewar AE. Expression of MHC class II antigens in human B-cell leukaemia and non-Hodgkin's lymphoma. Br J Cancer (1986) 53:161-73. doi:10.1038/bjc.1986.31
    • (1986) Br J Cancer , vol.53 , pp. 161-173
    • Guy, K.1    Krajewski, A.S.2    Dewar, A.E.3
  • 9
    • 0022485216 scopus 로고
    • The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression
    • Moller P, Lammler B, Herrmann B, Otto HF, Moldenhauer G, Momburg F. The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression. Immunology (1986) 59:411-7.
    • (1986) Immunology , vol.59 , pp. 411-417
    • Moller, P.1    Lammler, B.2    Herrmann, B.3    Otto, H.F.4    Moldenhauer, G.5    Momburg, F.6
  • 10
    • 53149139859 scopus 로고    scopus 로고
    • Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways
    • Booman M, Szuhai K, Rosenwald A, Hartmann E, Kluin-Nelemans H, de Jong D, et al. Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways. J Pathol (2008) 216:209-17. doi:10.1002/path.2399
    • (2008) J Pathol , vol.216 , pp. 209-217
    • Booman, M.1    Szuhai, K.2    Rosenwald, A.3    Hartmann, E.4    Kluin-Nelemans, H.5    de Jong, D.6
  • 11
    • 2542429298 scopus 로고    scopus 로고
    • Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular Profiling Project
    • Rimsza LM, Roberts RA, Miller TP, Unger JM, LeBlanc M, Braziel RM, et al. Loss of MHC class II gene and protein expression in diffuse large B-cell lymphoma is related to decreased tumor immunosurveillance and poor patient survival regardless of other prognostic factors: a follow-up study from the Leukemia and Lymphoma Molecular Profiling Project. Blood (2004) 103:4251-8. doi:10.1182/blood-2003-07-2365
    • (2004) Blood , vol.103 , pp. 4251-4258
    • Rimsza, L.M.1    Roberts, R.A.2    Miller, T.P.3    Unger, J.M.4    LeBlanc, M.5    Braziel, R.M.6
  • 12
    • 84861861104 scopus 로고    scopus 로고
    • Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes
    • Calcinotto A, Filipazzi P, Grioni M, Iero M, De Milito A, Ricupito A, et al. Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. Cancer Res (2012) 72:2746-56. doi:10.1158/0008-5472.can-11-1272
    • (2012) Cancer Res , vol.72 , pp. 2746-2756
    • Calcinotto, A.1    Filipazzi, P.2    Grioni, M.3    Iero, M.4    De Milito, A.5    Ricupito, A.6
  • 13
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer (2004) 4:891-9. doi:10.1038/nrc1478
    • (2004) Nat Rev Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 15
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove C, Pilotte L, Theate I, Stroobant V, Colau D, Parmentier N, et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med (2003) 9:1269-74. doi:10.1038/nm934
    • (2003) Nat Med , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3    Stroobant, V.4    Colau, D.5    Parmentier, N.6
  • 16
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol (2006) 6:295-307. doi:10.1038/nri1806
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 17
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 9:162-74. doi:10.1038/nri2506
    • (2009) Nat Rev Immunol , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 18
    • 61449260054 scopus 로고    scopus 로고
    • Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-gamma T cell responses
    • Moormann AM, Heller KN, Chelimo K, Embury P, Ploutz-Snyder R, Otieno JA, et al. Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-gamma T cell responses. Int J Cancer (2009) 124:1721-6. doi:10.1002/ijc.24014
    • (2009) Int J Cancer , vol.124 , pp. 1721-1726
    • Moormann, A.M.1    Heller, K.N.2    Chelimo, K.3    Embury, P.4    Ploutz-Snyder, R.5    Otieno, J.A.6
  • 19
    • 33749127585 scopus 로고    scopus 로고
    • Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients
    • Gandhi MK, Lambley E, Duraiswamy J, Dua U, Smith C, Elliott S, et al. Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. Blood (2006) 108:2280-9. doi:10.1182/blood-2006-04-015164
    • (2006) Blood , vol.108 , pp. 2280-2289
    • Gandhi, M.K.1    Lambley, E.2    Duraiswamy, J.3    Dua, U.4    Smith, C.5    Elliott, S.6
  • 20
    • 42549093544 scopus 로고    scopus 로고
    • Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy
    • Li J, Zeng XH, Mo HY, Rolén U, Gao YF, Zhang XS, et al. Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy. PLoS One (2007) 2:e1122. doi:10.1371/journal.pone.0001122
    • (2007) PLoS One , vol.2
    • Li, J.1    Zeng, X.H.2    Mo, H.Y.3    Rolén, U.4    Gao, Y.F.5    Zhang, X.S.6
  • 21
    • 62549087067 scopus 로고    scopus 로고
    • Decreased EBNA-1-specific CD8+ T cells in patients with Epstein-Barr virus-associated nasopharyngeal carcinoma
    • Fogg MH, Wirth LJ, Posner M, Wang F. Decreased EBNA-1-specific CD8+ T cells in patients with Epstein-Barr virus-associated nasopharyngeal carcinoma. Proc Natl Acad Sci U S A (2009) 106:3318-23. doi:10.1073/pnas.0813320106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3318-3323
    • Fogg, M.H.1    Wirth, L.J.2    Posner, M.3    Wang, F.4
  • 22
    • 0029087498 scopus 로고
    • Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBVpositive Hodgkin's disease
    • Frisan T, Sjoberg J, Dolcetti R, Boiocchi M, De Re V, Carbone A, et al. Local suppression of Epstein-Barr virus (EBV)-specific cytotoxicity in biopsies of EBVpositive Hodgkin's disease. Blood (1995) 86:1493-501.
    • (1995) Blood , vol.86 , pp. 1493-1501
    • Frisan, T.1    Sjoberg, J.2    Dolcetti, R.3    Boiocchi, M.4    De Re, V.5    Carbone, A.6
  • 23
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer (2012) 12:252-64. doi:10.1038/nrc3239
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 24
    • 84877059916 scopus 로고    scopus 로고
    • T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
    • Crespo J, Sun H, Welling TH, Tian Z, Zou W. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment. Curr Opin Immunol (2013) 25:214-21. doi:10.1016/j.coi.2012.12.003
    • (2013) Curr Opin Immunol , vol.25 , pp. 214-221
    • Crespo, J.1    Sun, H.2    Welling, T.H.3    Tian, Z.4    Zou, W.5
  • 25
    • 4344671644 scopus 로고    scopus 로고
    • Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance
    • Zippelius A, Batard P, Rubio-Godoy V, Bioley G, Lienard D, Lejeune F, et al. Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res (2004) 64:2865-73. doi:10.1158/0008-5472.CAN-03-3066
    • (2004) Cancer Res , vol.64 , pp. 2865-2873
    • Zippelius, A.1    Batard, P.2    Rubio-Godoy, V.3    Bioley, G.4    Lienard, D.5    Lejeune, F.6
  • 26
    • 27144500671 scopus 로고    scopus 로고
    • Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma
    • Rosenberg SA, Sherry RM, Morton KE, Scharfman WJ, Yang JC, Topalian SL, et al. Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanoma. J Immunol (2005) 175:6169-76. doi:10.4049/jimmunol.175.9.6169
    • (2005) J Immunol , vol.175 , pp. 6169-6176
    • Rosenberg, S.A.1    Sherry, R.M.2    Morton, K.E.3    Scharfman, W.J.4    Yang, J.C.5    Topalian, S.L.6
  • 27
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood (2009) 114:1537-44. doi:10.1182/blood-2008-12-195792
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3    Wunderlich, J.R.4    Dudley, M.E.5    White, D.E.6
  • 28
    • 84863393290 scopus 로고    scopus 로고
    • CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
    • Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, et al. CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res (2012) 72:887-96. doi:10.1158/0008-5472.can-11-2637
    • (2012) Cancer Res , vol.72 , pp. 887-896
    • Fourcade, J.1    Sun, Z.2    Pagliano, O.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6
  • 29
    • 79957925314 scopus 로고    scopus 로고
    • Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients
    • Baitsch L, Baumgaertner P, Devevre E, Raghav SK, Legat A, Barba L, et al. Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients. J Clin Invest (2011) 121:2350-60. doi:10.1172/jci46102
    • (2011) J Clin Invest , vol.121 , pp. 2350-2360
    • Baitsch, L.1    Baumgaertner, P.2    Devevre, E.3    Raghav, S.K.4    Legat, A.5    Barba, L.6
  • 30
    • 33846938773 scopus 로고    scopus 로고
    • Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells
    • Steptoe RJ, Ritchie JM, Wilson NS, Villadangos JA, Lew AM, Harrison LC. Cognate CD4+ help elicited by resting dendritic cells does not impair the induction of peripheral tolerance in CD8+ T cells. J Immunol (2007) 178:2094-103. doi:10.4049/jimmunol.178.4.2094
    • (2007) J Immunol , vol.178 , pp. 2094-2103
    • Steptoe, R.J.1    Ritchie, J.M.2    Wilson, N.S.3    Villadangos, J.A.4    Lew, A.M.5    Harrison, L.C.6
  • 31
    • 0037122011 scopus 로고    scopus 로고
    • Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance
    • Bonifaz L, Bonnyay D, Mahnke K, Rivera M, Nussenzweig MC, Steinman RM. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J Exp Med (2002) 196:1627-38. doi:10.1084/jem.20021598
    • (2002) J Exp Med , vol.196 , pp. 1627-1638
    • Bonifaz, L.1    Bonnyay, D.2    Mahnke, K.3    Rivera, M.4    Nussenzweig, M.C.5    Steinman, R.M.6
  • 33
    • 0032543208 scopus 로고    scopus 로고
    • Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo
    • Townsend SE, Goodnow CC. Abortive proliferation of rare T cells induced by direct or indirect antigen presentation by rare B cells in vivo. J Exp Med (1998) 187:1611-21. doi:10.1084/jem.187.10.1611
    • (1998) J Exp Med , vol.187 , pp. 1611-1621
    • Townsend, S.E.1    Goodnow, C.C.2
  • 34
    • 0027270850 scopus 로고
    • Parameters of tolerance induction by antigen targeted to B lymphocytes
    • Eynon EE, Parker DC. Parameters of tolerance induction by antigen targeted to B lymphocytes. J Immunol (1993) 151:2958-64.
    • (1993) J Immunol , vol.151 , pp. 2958-2964
    • Eynon, E.E.1    Parker, D.C.2
  • 36
    • 34250221038 scopus 로고    scopus 로고
    • Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance
    • Werner-Klein M, Dresch C, Marcon IP, Brocker T. Transcriptional targeting of B cells for induction of peripheral CD8 T cell tolerance. J Immunol (2007) 178:7738-46. doi:10.4049/jimmunol.178.12.7738
    • (2007) J Immunol , vol.178 , pp. 7738-7746
    • Werner-Klein, M.1    Dresch, C.2    Marcon, I.P.3    Brocker, T.4
  • 38
    • 76249092898 scopus 로고    scopus 로고
    • Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function
    • Kenna TJ, Waldie T, McNally A, Thomson M, Yagita H, Thomas R, et al. Targeting antigen to diverse APCs inactivates memory CD8+ T cells without eliciting tissue-destructive effector function. J Immunol (2010) 184:598-606. doi:10.4049/jimmunol.0900032
    • (2010) J Immunol , vol.184 , pp. 598-606
    • Kenna, T.J.1    Waldie, T.2    McNally, A.3    Thomson, M.4    Yagita, H.5    Thomas, R.6
  • 39
    • 79961017479 scopus 로고    scopus 로고
    • Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletion
    • Morlacchi S, Soldani C, Viola A, Sarukhan A. Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletion. Blood (2011) 118:984-91. doi:10.1182/blood-2011-02-336115
    • (2011) Blood , vol.118 , pp. 984-991
    • Morlacchi, S.1    Soldani, C.2    Viola, A.3    Sarukhan, A.4
  • 40
    • 84901823579 scopus 로고    scopus 로고
    • TGF-beta-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance
    • Lee KM, Stott RT, Zhao G, SooHoo J, Xiong W, Lian MM, et al. TGF-beta-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance. Eur J Immunol (2014) 44:1728-36. doi:10.1002/eji.201344062
    • (2014) Eur J Immunol , vol.44 , pp. 1728-1736
    • Lee, K.M.1    Stott, R.T.2    Zhao, G.3    SooHoo, J.4    Xiong, W.5    Lian, M.M.6
  • 41
    • 84928589983 scopus 로고    scopus 로고
    • B-Cells induce regulatory T cells through TGF-beta/IDO production in A CTLA-4 dependent manner
    • Nouel A, Pochard P, Simon Q, Segalen I, Le Meur Y, Pers JO, et al. B-Cells induce regulatory T cells through TGF-beta/IDO production in A CTLA-4 dependent manner. J Autoimmun (2015) 59:53-60. doi:10.1016/j.jaut.2015.02.004
    • (2015) J Autoimmun , vol.59 , pp. 53-60
    • Nouel, A.1    Pochard, P.2    Simon, Q.3    Segalen, I.4    Le Meur, Y.5    Pers, J.O.6
  • 42
    • 84897942212 scopus 로고    scopus 로고
    • B10 cell regulation of health and disease
    • Candando KM, Lykken JM, Tedder TF. B10 cell regulation of health and disease. Immunol Rev (2014) 259:259-72. doi:10.1111/imr.12176
    • (2014) Immunol Rev , vol.259 , pp. 259-272
    • Candando, K.M.1    Lykken, J.M.2    Tedder, T.F.3
  • 43
    • 84858311213 scopus 로고    scopus 로고
    • Murine models of B-Cell lymphomas: promising tools for designing cancer therapies
    • Donnou S, Galand C, Touitou V, Saut'es-Fridman C, Fabry Z, Fisson S. Murine models of B-Cell lymphomas: promising tools for designing cancer therapies. Adv Hematol (2012) 2012:701704. doi:10.1155/2012/701704
    • (2012) Adv Hematol , vol.2012
    • Donnou, S.1    Galand, C.2    Touitou, V.3    Saut'es-Fridman, C.4    Fabry, Z.5    Fisson, S.6
  • 45
    • 33645500590 scopus 로고    scopus 로고
    • In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity
    • Horna P, Cuenca A, Cheng F, Brayer J, Wang HW, Borrello I, et al. In vivo disruption of tolerogenic cross-presentation mechanisms uncovers an effective T-cell activation by B-cell lymphomas leading to antitumor immunity. Blood (2006) 107:2871-8. doi:10.1182/blood-2005-07-3014
    • (2006) Blood , vol.107 , pp. 2871-2878
    • Horna, P.1    Cuenca, A.2    Cheng, F.3    Brayer, J.4    Wang, H.W.5    Borrello, I.6
  • 46
    • 0035883073 scopus 로고    scopus 로고
    • Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression
    • Sotomayor EM, Borrello I, Rattis FM, Cuenca AG, Abrams J, Staveley-O'Carroll K, et al. Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression. Blood (2001) 98:1070-7. doi:10.1182/blood.V98.4.1070
    • (2001) Blood , vol.98 , pp. 1070-1077
    • Sotomayor, E.M.1    Borrello, I.2    Rattis, F.M.3    Cuenca, A.G.4    Abrams, J.5    Staveley-O'Carroll, K.6
  • 47
    • 79959933130 scopus 로고    scopus 로고
    • Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma
    • Prato S, Mintern JD, Lahoud MH, Huang DC, Villadangos JA. Induction of antigen-specific effector-phase tolerance following vaccination against a previously ignored B-cell lymphoma. Immunol Cell Biol (2011) 89:595-603. doi:10.1038/icb.2010.131
    • (2011) Immunol Cell Biol , vol.89 , pp. 595-603
    • Prato, S.1    Mintern, J.D.2    Lahoud, M.H.3    Huang, D.C.4    Villadangos, J.A.5
  • 48
    • 84859128189 scopus 로고    scopus 로고
    • Stromal interferon-? signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice
    • Gerbitz A, Sukumar M, Helm F, Wilke A, Friese C, Fahrenwald C, et al. Stromal interferon-? signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice. PLoS One (2012) 7:e34552. doi:10.1371/journal.pone.0034552
    • (2012) PLoS One , vol.7
    • Gerbitz, A.1    Sukumar, M.2    Helm, F.3    Wilke, A.4    Friese, C.5    Fahrenwald, C.6
  • 49
    • 84885121180 scopus 로고    scopus 로고
    • Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold
    • Prato S, Zhan Y, Mintern JD, Villadangos JA. Rapid deletion and inactivation of CTLs upon recognition of a number of target cells over a critical threshold. J Immunol (2013) 191:3534-44. doi:10.4049/jimmunol.1300803
    • (2013) J Immunol , vol.191 , pp. 3534-3544
    • Prato, S.1    Zhan, Y.2    Mintern, J.D.3    Villadangos, J.A.4
  • 50
    • 27844473354 scopus 로고    scopus 로고
    • A dynamic view of the immunological synapse
    • Dustin ML. A dynamic view of the immunological synapse. Semin Immunol (2005) 17:400-10. doi:10.1016/j.smim.2005.09.002
    • (2005) Semin Immunol , vol.17 , pp. 400-410
    • Dustin, M.L.1
  • 51
    • 77950881648 scopus 로고    scopus 로고
    • The immunological synapse, TCR microclusters, and T cell activation
    • Yokosuka T, Saito T. The immunological synapse, TCR microclusters, and T cell activation. Curr Top Microbiol Immunol (2010) 340:81-107. doi:10.1007/978-3-642-03858-7_5
    • (2010) Curr Top Microbiol Immunol , vol.340 , pp. 81-107
    • Yokosuka, T.1    Saito, T.2
  • 52
    • 79952201000 scopus 로고    scopus 로고
    • Understanding the structure and function of the immunological synapse
    • Dustin ML, Chakraborty AK, Shaw AS. Understanding the structure and function of the immunological synapse. Cold Spring Harb Perspect Biol (2010) 2:a002311. doi:10.1101/cshperspect.a002311
    • (2010) Cold Spring Harb Perspect Biol , vol.2
    • Dustin, M.L.1    Chakraborty, A.K.2    Shaw, A.S.3
  • 53
    • 78149367110 scopus 로고    scopus 로고
    • Diversity in immunological synapse structure
    • Thauland TJ, Parker DC. Diversity in immunological synapse structure. Immunology (2010) 131:466-72. doi:10.1111/j.1365-2567.2010.03366.x
    • (2010) Immunology , vol.131 , pp. 466-472
    • Thauland, T.J.1    Parker, D.C.2
  • 54
    • 33746011209 scopus 로고    scopus 로고
    • T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster
    • Varma R, Campi G, Yokosuka T, Saito T, Dustin ML. T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity (2006) 25:117-27. doi:10.1016/j.immuni.2006.04.010
    • (2006) Immunity , vol.25 , pp. 117-127
    • Varma, R.1    Campi, G.2    Yokosuka, T.3    Saito, T.4    Dustin, M.L.5
  • 55
    • 0032480279 scopus 로고    scopus 로고
    • Three-dimensional segregation of supramolecular activation clusters in T cells
    • Monks CR, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature (1998) 395:82-6. doi:10.1038/25764
    • (1998) Nature , vol.395 , pp. 82-86
    • Monks, C.R.1    Freiberg, B.A.2    Kupfer, H.3    Sciaky, N.4    Kupfer, A.5
  • 56
    • 33746210261 scopus 로고    scopus 로고
    • Filamin A is required for T cell activation mediated by protein kinase C-theta
    • Hayashi K, Altman A. Filamin A is required for T cell activation mediated by protein kinase C-theta. J Immunol (2006) 177:1721-8. doi:10.4049/jimmunol.177.3.1721
    • (2006) J Immunol , vol.177 , pp. 1721-1728
    • Hayashi, K.1    Altman, A.2
  • 57
    • 54949103906 scopus 로고    scopus 로고
    • Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation
    • Yokosuka T, Kobayashi W, Sakata-Sogawa K, Takamatsu M, Hashimoto-Tane A, Dustin ML, et al. Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity (2008) 29:589-601. doi:10.1016/j.immuni.2008.08.011
    • (2008) Immunity , vol.29 , pp. 589-601
    • Yokosuka, T.1    Kobayashi, W.2    Sakata-Sogawa, K.3    Takamatsu, M.4    Hashimoto-Tane, A.5    Dustin, M.L.6
  • 59
    • 58149402404 scopus 로고    scopus 로고
    • Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering
    • Fisher PJ, Bulur PA, Vuk-Pavlovic S, Prendergast FG, Dietz AB. Dendritic cell microvilli: a novel membrane structure associated with the multifocal synapse and T-cell clustering. Blood (2008) 112:5037-45. doi:10.1182/blood-2008-04-149526
    • (2008) Blood , vol.112 , pp. 5037-5045
    • Fisher, P.J.1    Bulur, P.A.2    Vuk-Pavlovic, S.3    Prendergast, F.G.4    Dietz, A.B.5
  • 60
    • 58149280838 scopus 로고    scopus 로고
    • T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta
    • Tseng SY, Waite JC, Liu M, Vardhana S, Dustin ML. T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J Immunol (2008) 181:4852-63. doi:10.4049/jimmunol.181.7.4852
    • (2008) J Immunol , vol.181 , pp. 4852-4863
    • Tseng, S.Y.1    Waite, J.C.2    Liu, M.3    Vardhana, S.4    Dustin, M.L.5
  • 61
    • 0033538574 scopus 로고    scopus 로고
    • The immunological synapse: a molecular machine controlling T cell activation
    • Grakoui A, Bromley SK, Sumen C, Davis MM, Shaw AS, Allen PM, et al. The immunological synapse: a molecular machine controlling T cell activation. Science (1999) 285:221-7. doi:10.1126/science.285.5425.221
    • (1999) Science , vol.285 , pp. 221-227
    • Grakoui, A.1    Bromley, S.K.2    Sumen, C.3    Davis, M.M.4    Shaw, A.S.5    Allen, P.M.6
  • 62
    • 0036696174 scopus 로고    scopus 로고
    • The immunological synapse: integrins take the stage
    • Sims TN, Dustin ML. The immunological synapse: integrins take the stage. Immunol Rev (2002) 186:100-17. doi:10.1034/j.1600-065X.2002.18610.x
    • (2002) Immunol Rev , vol.186 , pp. 100-117
    • Sims, T.N.1    Dustin, M.L.2
  • 63
    • 0024443411 scopus 로고
    • T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
    • Dustin ML, Springer TA. T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1. Nature (1989) 341:619-24. doi:10.1038/341619a0
    • (1989) Nature , vol.341 , pp. 619-624
    • Dustin, M.L.1    Springer, T.A.2
  • 64
    • 84857688656 scopus 로고    scopus 로고
    • Integrin inside-out signaling and the immunological synapse
    • Springer TA, Dustin ML. Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol (2012) 24:107-15. doi:10.1016/j.ceb.2011.10.004
    • (2012) Curr Opin Cell Biol , vol.24 , pp. 107-115
    • Springer, T.A.1    Dustin, M.L.2
  • 65
    • 0042490495 scopus 로고    scopus 로고
    • RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1
    • Katagiri K, Maeda A, Shimonaka M, Kinashi T. RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol (2003) 4:741-8. doi:10.1038/ni950
    • (2003) Nat Immunol , vol.4 , pp. 741-748
    • Katagiri, K.1    Maeda, A.2    Shimonaka, M.3    Kinashi, T.4
  • 66
    • 34447302007 scopus 로고    scopus 로고
    • The role of the integrin LFA-1 in T-lymphocyte migration
    • Smith A, Stanley P, Jones K, Svensson L, McDowall A, Hogg N. The role of the integrin LFA-1 in T-lymphocyte migration. Immunol Rev (2007) 218:135-46. doi:10.1111/j.1600-065X.2007.00537.x
    • (2007) Immunol Rev , vol.218 , pp. 135-146
    • Smith, A.1    Stanley, P.2    Jones, K.3    Svensson, L.4    McDowall, A.5    Hogg, N.6
  • 67
    • 34548650329 scopus 로고    scopus 로고
    • LFA-1-mediated T cell costimulation through increased localization of TCR/class II complexes to the central supramolecular activation cluster and exclusion of CD45 from the immunological synapse
    • Graf B, Bushnell T, Miller J. LFA-1-mediated T cell costimulation through increased localization of TCR/class II complexes to the central supramolecular activation cluster and exclusion of CD45 from the immunological synapse. J Immunol (2007) 179:1616-24. doi:10.4049/jimmunol.179.3.1616
    • (2007) J Immunol , vol.179 , pp. 1616-1624
    • Graf, B.1    Bushnell, T.2    Miller, J.3
  • 68
    • 0034624809 scopus 로고    scopus 로고
    • Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes
    • Leupin O, Zaru R, Laroche T, Muller S, Valitutti S. Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes. Curr Biol (2000) 10:277-80. doi:10.1016/S0960-9822(00)00362-6
    • (2000) Curr Biol , vol.10 , pp. 277-280
    • Leupin, O.1    Zaru, R.2    Laroche, T.3    Muller, S.4    Valitutti, S.5
  • 69
    • 69149100929 scopus 로고    scopus 로고
    • Cluster size regulates protein sorting in the immunological synapse
    • Hartman NC, Nye JA, Groves JT. Cluster size regulates protein sorting in the immunological synapse. Proc Natl Acad Sci U S A (2009) 106:12729-34. doi:10.1073/pnas.0902621106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12729-12734
    • Hartman, N.C.1    Nye, J.A.2    Groves, J.T.3
  • 70
    • 30044441433 scopus 로고    scopus 로고
    • Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
    • Yokosuka T, Sakata-Sogawa K, Kobayashi W, Hiroshima M, Hashimoto-Tane A, Tokunaga M, et al. Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol (2005) 6:1253-62. doi:10.1038/ni1272
    • (2005) Nat Immunol , vol.6 , pp. 1253-1262
    • Yokosuka, T.1    Sakata-Sogawa, K.2    Kobayashi, W.3    Hiroshima, M.4    Hashimoto-Tane, A.5    Tokunaga, M.6
  • 71
    • 77951688912 scopus 로고    scopus 로고
    • Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster
    • Vardhana S, Choudhuri K, Varma R, Dustin ML. Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity (2010) 32:531-40. doi:10.1016/j.immuni.2010.04.005
    • (2010) Immunity , vol.32 , pp. 531-540
    • Vardhana, S.1    Choudhuri, K.2    Varma, R.3    Dustin, M.L.4
  • 72
    • 1842331510 scopus 로고    scopus 로고
    • Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation
    • Valitutti S, Muller S, Salio M, Lanzavecchia A. Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation. J Exp Med (1997) 185:1859-64. doi:10.1084/jem.185.10.1859
    • (1997) J Exp Med , vol.185 , pp. 1859-1864
    • Valitutti, S.1    Muller, S.2    Salio, M.3    Lanzavecchia, A.4
  • 73
    • 79959906941 scopus 로고    scopus 로고
    • The immunological synapse: a cause or consequence of T-cell receptor triggering?
    • Alarcon B, Mestre D, Martinez-Martin N. The immunological synapse: a cause or consequence of T-cell receptor triggering? Immunology (2011) 133:420-5. doi:10.1111/j.1365-2567.2011.03458.x
    • (2011) Immunology , vol.133 , pp. 420-425
    • Alarcon, B.1    Mestre, D.2    Martinez-Martin, N.3
  • 75
    • 0034014179 scopus 로고    scopus 로고
    • Genomic-scale analysis of gene expression in resting and activated T cells
    • Marrack P, Mitchell T, Hildeman D, Kedl R, Teague TK, Bender J, et al. Genomic-scale analysis of gene expression in resting and activated T cells. Curr Opin Immunol (2000) 12:206-9. doi:10.1016/S0952-7915(99)00075-8
    • (2000) Curr Opin Immunol , vol.12 , pp. 206-209
    • Marrack, P.1    Mitchell, T.2    Hildeman, D.3    Kedl, R.4    Teague, T.K.5    Bender, J.6
  • 76
    • 3142744689 scopus 로고    scopus 로고
    • Modeling T-cell activation using gene expression profiling and state-space models
    • Rangel C, Angus J, Ghahramani Z, Lioumi M, Sotheran E, Gaiba A, et al. Modeling T-cell activation using gene expression profiling and state-space models. Bioinformatics (2004) 20:1361-72. doi:10.1093/bioinformatics/bth093
    • (2004) Bioinformatics , vol.20 , pp. 1361-1372
    • Rangel, C.1    Angus, J.2    Ghahramani, Z.3    Lioumi, M.4    Sotheran, E.5    Gaiba, A.6
  • 77
    • 34447339202 scopus 로고    scopus 로고
    • Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse
    • Reichardt P, Dornbach B, Rong S, Beissert S, Gueler F, Loser K, et al. Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse. Blood (2007) 110:1519-29. doi:10.1182/blood-2006-10-053793
    • (2007) Blood , vol.110 , pp. 1519-1529
    • Reichardt, P.1    Dornbach, B.2    Rong, S.3    Beissert, S.4    Gueler, F.5    Loser, K.6
  • 78
    • 0034769286 scopus 로고    scopus 로고
    • Functional antigen-independent synapses formed between T cells and dendritic cells
    • Revy P, Sospedra M, Barbour B, Trautmann A. Functional antigen-independent synapses formed between T cells and dendritic cells. Nat Immunol (2001) 2:925-31. doi:10.1038/ni713
    • (2001) Nat Immunol , vol.2 , pp. 925-931
    • Revy, P.1    Sospedra, M.2    Barbour, B.3    Trautmann, A.4
  • 79
    • 0032547759 scopus 로고    scopus 로고
    • Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cells
    • Delon J, Bercovici N, Raposo G, Liblau R, Trautmann A. Antigen-dependent and -independent Ca2+ responses triggered in T cells by dendritic cells compared with B cells. J Exp Med (1998) 188:1473-84. doi:10.1084/jem.188.8.1473
    • (1998) J Exp Med , vol.188 , pp. 1473-1484
    • Delon, J.1    Bercovici, N.2    Raposo, G.3    Liblau, R.4    Trautmann, A.5
  • 80
    • 0142242134 scopus 로고    scopus 로고
    • Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent
    • Al-Alwan MM, Liwski RS, Haeryfar SM, Baldridge WH, Hoskin DW, Rowden G, et al. Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. J Immunol (2003) 171:4479-83. doi:10.4049/jimmunol.171.9.4479
    • (2003) J Immunol , vol.171 , pp. 4479-4483
    • Al-Alwan, M.M.1    Liwski, R.S.2    Haeryfar, S.M.3    Baldridge, W.H.4    Hoskin, D.W.5    Rowden, G.6
  • 81
    • 73949116990 scopus 로고    scopus 로고
    • Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy
    • Ramsay AG, Clear AJ, Kelly G, Fatah R, Matthews J, Macdougall F, et al. Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy. Blood (2009) 114:4713-20. doi:10.1182/blood-2009-04-217687
    • (2009) Blood , vol.114 , pp. 4713-4720
    • Ramsay, A.G.1    Clear, A.J.2    Kelly, G.3    Fatah, R.4    Matthews, J.5    Macdougall, F.6
  • 82
    • 46749132717 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
    • Ramsay AG, Johnson AJ, Lee AM, Gorgun G, Le Dieu R, Blum W, et al. Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest (2008) 118:2427-37. doi:10.1172/jci35017
    • (2008) J Clin Invest , vol.118 , pp. 2427-2437
    • Ramsay, A.G.1    Johnson, A.J.2    Lee, A.M.3    Gorgun, G.4    Le Dieu, R.5    Blum, W.6
  • 83
    • 22144489127 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells
    • Gorgun G, Holderried TA, Zahrieh D, Neuberg D, Gribben JG. Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells. J Clin Invest (2005) 115:1797-805. doi:10.1172/jci24176
    • (2005) J Clin Invest , vol.115 , pp. 1797-1805
    • Gorgun, G.1    Holderried, T.A.2    Zahrieh, D.3    Neuberg, D.4    Gribben, J.G.5
  • 84
    • 65549151712 scopus 로고    scopus 로고
    • E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction
    • Gorgun G, Ramsay AG, Holderried TA, Zahrieh D, Le Dieu R, Liu F, et al. E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction. Proc Natl Acad Sci U S A (2009) 106:6250-5. doi:10.1073/pnas.0901166106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 6250-6255
    • Gorgun, G.1    Ramsay, A.G.2    Holderried, T.A.3    Zahrieh, D.4    Le Dieu, R.5    Liu, F.6
  • 85
    • 0036798653 scopus 로고    scopus 로고
    • In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern
    • Blanchard N, Di Bartolo V, Hivroz C. In the immune synapse, ZAP-70 controls T cell polarization and recruitment of signaling proteins but not formation of the synaptic pattern. Immunity (2002) 17:389-99. doi:10.1016/S1074-7613(02)00421-1
    • (2002) Immunity , vol.17 , pp. 389-399
    • Blanchard, N.1    Di Bartolo, V.2    Hivroz, C.3
  • 86
    • 0035889958 scopus 로고    scopus 로고
    • Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70
    • Morgan MM, Labno CM, Van Seventer GA, Denny MF, Straus DB, Burkhardt JK. Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70. J Immunol (2001) 167:5708-18. doi:10.4049/jimmunol.167.10.5708
    • (2001) J Immunol , vol.167 , pp. 5708-5718
    • Morgan, M.M.1    Labno, C.M.2    Van Seventer, G.A.3    Denny, M.F.4    Straus, D.B.5    Burkhardt, J.K.6
  • 87
    • 70449711157 scopus 로고    scopus 로고
    • Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts
    • Le Dieu R, Taussig DC, Ramsay AG, Mitter R, Miraki-Moud F, Fatah R, et al. Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts. Blood (2009) 114:3909-16. doi:10.1182/blood-2009-02-206946
    • (2009) Blood , vol.114 , pp. 3909-3916
    • Le Dieu, R.1    Taussig, D.C.2    Ramsay, A.G.3    Mitter, R.4    Miraki-Moud, F.5    Fatah, R.6
  • 88
    • 84890531605 scopus 로고    scopus 로고
    • Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation
    • Kiaii S, Clear AJ, Ramsay AG, Davies D, Sangaralingam A, Lee A, et al. Follicular lymphoma cells induce changes in T-cell gene expression and function: potential impact on survival and risk of transformation. J Clin Oncol (2013) 31:2654-61. doi:10.1200/jco.2012.44.2137
    • (2013) J Clin Oncol , vol.31 , pp. 2654-2661
    • Kiaii, S.1    Clear, A.J.2    Ramsay, A.G.3    Davies, D.4    Sangaralingam, A.5    Lee, A.6
  • 89
    • 54449095901 scopus 로고    scopus 로고
    • Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma
    • Wiernik PH, Lossos IS, Tuscano JM, Justice G, Vose JM, Cole CE, et al. Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma. J Clin Oncol (2008) 26:4952-7. doi:10.1200/jco.2007.15.3429
    • (2008) J Clin Oncol , vol.26 , pp. 4952-4957
    • Wiernik, P.H.1    Lossos, I.S.2    Tuscano, J.M.3    Justice, G.4    Vose, J.M.5    Cole, C.E.6
  • 90
    • 73949145763 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma
    • Witzig TE, Wiernik PH, Moore T, Reeder C, Cole C, Justice G, et al. Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma. J Clin Oncol (2009) 27:5404-9. doi:10.1200/jco.2008.21.1169
    • (2009) J Clin Oncol , vol.27 , pp. 5404-5409
    • Witzig, T.E.1    Wiernik, P.H.2    Moore, T.3    Reeder, C.4    Cole, C.5    Justice, G.6
  • 91
    • 84887030194 scopus 로고    scopus 로고
    • Long-term follow-up of lenalidomide in relapsed/refractory mantle cell lymphoma: subset analysis of the NHL-003 study
    • Zinzani PL, Vose JM, Czuczman MS, Reeder CB, Haioun C, Polikoff J, et al. Long-term follow-up of lenalidomide in relapsed/refractory mantle cell lymphoma: subset analysis of the NHL-003 study. Ann Oncol (2013) 24:2892-7. doi:10.1093/annonc/mdt366
    • (2013) Ann Oncol , vol.24 , pp. 2892-2897
    • Zinzani, P.L.1    Vose, J.M.2    Czuczman, M.S.3    Reeder, C.B.4    Haioun, C.5    Polikoff, J.6
  • 92
    • 84883742025 scopus 로고    scopus 로고
    • Oral lenalidomide with rituximab in relapsed or refractory diffuse large cell, follicular and transformed lymphoma: a phase II clinical trial
    • Wang M, Fowler N, Wagner-Bartak N, Feng L, Romaguera J, Neelapu SS, et al. Oral lenalidomide with rituximab in relapsed or refractory diffuse large cell, follicular and transformed lymphoma: a phase II clinical trial. Leukemia (2013) 27:1902-9. doi:10.1038/leu.2013.95
    • (2013) Leukemia , vol.27 , pp. 1902-1909
    • Wang, M.1    Fowler, N.2    Wagner-Bartak, N.3    Feng, L.4    Romaguera, J.5    Neelapu, S.S.6
  • 93
    • 84891868901 scopus 로고    scopus 로고
    • Combined lenalidomide, low-dose dexamethasone, and rituximab achieves durable responses in rituximab-resistant indolent and mantle cell lymphomas
    • Ahmadi T, Chong EA, Gordon A, Aqui NA, Nasta SD, Svoboda J, et al. Combined lenalidomide, low-dose dexamethasone, and rituximab achieves durable responses in rituximab-resistant indolent and mantle cell lymphomas. Cancer (2014) 120:222-8. doi:10.1002/cncr.28405
    • (2014) Cancer , vol.120 , pp. 222-228
    • Ahmadi, T.1    Chong, E.A.2    Gordon, A.3    Aqui, N.A.4    Nasta, S.D.5    Svoboda, J.6
  • 94
    • 84863107308 scopus 로고    scopus 로고
    • Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: a phase 1/2 clinical trial
    • Wang M, Fayad L, Wagner-Bartak N, Zhang L, Hagemeister F, Neelapu SS, et al. Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: a phase 1/2 clinical trial. Lancet Oncol (2012) 13:716-23. doi:10.1016/s1470-2045(12)70200-0
    • (2012) Lancet Oncol , vol.13 , pp. 716-723
    • Wang, M.1    Fayad, L.2    Wagner-Bartak, N.3    Zhang, L.4    Hagemeister, F.5    Neelapu, S.S.6
  • 95
    • 84924090823 scopus 로고    scopus 로고
    • Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment
    • Blake SJ, Ching ALH, Kenna TJ, Galea R, Large J, Yagita H, et al. Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment. PLoS One (2015) 10:e0119483. doi:10.1371/journal.pone.0119483
    • (2015) PLoS One , vol.10
    • Blake, S.J.1    Ching, A.L.H.2    Kenna, T.J.3    Galea, R.4    Large, J.5    Yagita, H.6
  • 96
    • 34347389213 scopus 로고    scopus 로고
    • Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells
    • Goldberg MV, Maris CH, Hipkiss EL, Flies AS, Zhen L, Tuder RM, et al. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood (2007) 110:186-92. doi:10.1182/blood-2006-12-062422
    • (2007) Blood , vol.110 , pp. 186-192
    • Goldberg, M.V.1    Maris, C.H.2    Hipkiss, E.L.3    Flies, A.S.4    Zhen, L.5    Tuder, R.M.6
  • 98
    • 32544459770 scopus 로고    scopus 로고
    • Restoring function in exhausted CD8+ T cells during chronic viral infection
    • Barber DL, Wherry EJ, Masupost D, Zhu B, Allison JP, Sharpe AH, et al. Restoring function in exhausted CD8+ T cells during chronic viral infection. Nature (2006) 439:682-7. doi:10.1038/nature04444
    • (2006) Nature , vol.439 , pp. 682-687
    • Barber, D.L.1    Wherry, E.J.2    Masupost, D.3    Zhu, B.4    Allison, J.P.5    Sharpe, A.H.6
  • 99
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
    • Egen JG, Allison JP. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity (2002) 16:23-35. doi:10.1016/S1074-7613(01)00259-X
    • (2002) Immunity , vol.16 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 100
    • 77957099358 scopus 로고    scopus 로고
    • Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation
    • Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, et al. Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation. Immunity (2010) 33:326-39. doi:10.1016/j.immuni.2010.09.006
    • (2010) Immunity , vol.33 , pp. 326-339
    • Yokosuka, T.1    Kobayashi, W.2    Takamatsu, M.3    Sakata-Sogawa, K.4    Zeng, H.5    Hashimoto-Tane, A.6
  • 102
    • 67650547454 scopus 로고    scopus 로고
    • The T-cell-receptor signaling network
    • Huse M. The T-cell-receptor signaling network. J Cell Sci (2009) 122:1269-73. doi:10.1242/jcs.042762
    • (2009) J Cell Sci , vol.122 , pp. 1269-1273
    • Huse, M.1
  • 103
    • 0030874921 scopus 로고    scopus 로고
    • In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from human lymphomas
    • Xerri L, Devilard E, Hassoun J, Olive D, Birg F. In vivo expression of the CTLA4 inhibitory receptor in malignant and reactive cells from human lymphomas. J Pathol (1997) 183:182-7. doi:10.1002/(sici)1096-9896(199710)183:2<182:aid-path918>3.0.co;2-i
    • (1997) J Pathol , vol.183 , pp. 182-187
    • Xerri, L.1    Devilard, E.2    Hassoun, J.3    Olive, D.4    Birg, F.5
  • 104
    • 70350244852 scopus 로고    scopus 로고
    • Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma
    • Ansell SM, Hurvitz SA, Koenig PA, LaPlant BR, Kabat BF, Fernando D, et al. Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma. Clin Cancer Res (2009) 15:6446-53. doi:10.1158/1078-0432.ccr-09-1339
    • (2009) Clin Cancer Res , vol.15 , pp. 6446-6453
    • Ansell, S.M.1    Hurvitz, S.A.2    Koenig, P.A.3    LaPlant, B.R.4    Kabat, B.F.5    Fernando, D.6
  • 105
    • 61849165013 scopus 로고    scopus 로고
    • CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation
    • Bashey A, Medina B, Corringham S, Pasek M, Carrier E, Vrooman L, et al. CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation. Blood (2009) 113:1581-8. doi:10.1182/blood-2008-07-168468
    • (2009) Blood , vol.113 , pp. 1581-1588
    • Bashey, A.1    Medina, B.2    Corringham, S.3    Pasek, M.4    Carrier, E.5    Vrooman, L.6
  • 106
    • 84899723363 scopus 로고    scopus 로고
    • Association of cytotoxic T-lymphocyte antigen 4 genetic polymorphism, hepatitis C viral infection and B-cell non-Hodgkin lymphoma: an Egyptian study
    • Khorshied MM, Gouda HM, Khorshid OM. Association of cytotoxic T-lymphocyte antigen 4 genetic polymorphism, hepatitis C viral infection and B-cell non-Hodgkin lymphoma: an Egyptian study. Leuk Lymphoma (2014) 55:1061-6. doi:10.3109/10428194.2013.820294
    • (2014) Leuk Lymphoma , vol.55 , pp. 1061-1066
    • Khorshied, M.M.1    Gouda, H.M.2    Khorshid, O.M.3
  • 107
    • 33749324118 scopus 로고    scopus 로고
    • Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade
    • Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med (2006) 203:2223-7. doi:10.1084/jem.20061800
    • (2006) J Exp Med , vol.203 , pp. 2223-2227
    • Freeman, G.J.1    Wherry, E.J.2    Ahmed, R.3    Sharpe, A.H.4
  • 108
    • 84878585947 scopus 로고    scopus 로고
    • PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
    • West EE, Jin HT, Rasheed AU, Penaloza-Macmaster P, Ha SJ, Tan WG, et al. PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells. J Clin Invest (2013) 123:2604-15. doi:10.1172/jci67008
    • (2013) J Clin Invest , vol.123 , pp. 2604-2615
    • West, E.E.1    Jin, H.T.2    Rasheed, A.U.3    Penaloza-Macmaster, P.4    Ha, S.J.5    Tan, W.G.6
  • 109
    • 62249172189 scopus 로고    scopus 로고
    • Enhancing SIV-specific immunity in vivo by PD-1 blockade
    • Velu V, Titanji K, Zhu B, Husain S, Pladevega A, Lai L, et al. Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature (2009) 458:206-10. doi:10.1038/nature07662
    • (2009) Nature , vol.458 , pp. 206-210
    • Velu, V.1    Titanji, K.2    Zhu, B.3    Husain, S.4    Pladevega, A.5    Lai, L.6
  • 110
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med (2002) 8:793-800. doi:10.1038/nm730
    • (2002) Nat Med , vol.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 111
    • 33645736792 scopus 로고    scopus 로고
    • Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up
    • Thompson RH, Kuntz SM, Leibovich BC, Dong H, Lohse CM, Webster WS, et al. Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res (2006) 66:3381-5. doi:10.1158/0008-5472.can-05-4303
    • (2006) Cancer Res , vol.66 , pp. 3381-3385
    • Thompson, R.H.1    Kuntz, S.M.2    Leibovich, B.C.3    Dong, H.4    Lohse, C.M.5    Webster, W.S.6
  • 112
    • 20244384862 scopus 로고    scopus 로고
    • Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
    • Ohigashi Y, Sho M, Yamada Y, Tsurui Y, Hamada K, Ikeda N, et al. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res (2005) 11:2947-53. doi:10.1158/1078-0432.ccr-04-1469
    • (2005) Clin Cancer Res , vol.11 , pp. 2947-2953
    • Ohigashi, Y.1    Sho, M.2    Yamada, Y.3    Tsurui, Y.4    Hamada, K.5    Ikeda, N.6
  • 113
    • 77950283280 scopus 로고    scopus 로고
    • Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma
    • Hino R, Kabashima K, Kato Y, Yagi H, Nakamura M, Honjo T, et al. Tumor cell expression of programmed cell death-1 ligand 1 is a prognostic factor for malignant melanoma. Cancer (2010) 116:1757-66. doi:10.1002/cncr.24899
    • (2010) Cancer , vol.116 , pp. 1757-1766
    • Hino, R.1    Kabashima, K.2    Kato, Y.3    Yagi, H.4    Nakamura, M.5    Honjo, T.6
  • 114
    • 78049370405 scopus 로고    scopus 로고
    • Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
    • Green MR, Monti S, Rodig SJ, Juszczynski P, Currie T, O'Donnell E, et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood (2010) 116:3268-77. doi:10.1182/blood-2010-05-282780
    • (2010) Blood , vol.116 , pp. 3268-3277
    • Green, M.R.1    Monti, S.2    Rodig, S.J.3    Juszczynski, P.4    Currie, T.5    O'Donnell, E.6
  • 115
    • 84907497893 scopus 로고    scopus 로고
    • High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial
    • Rossille D, Gressier M, Damotte D, Maucort-Boulch D, Pangault C, Semana G, et al. High level of soluble programmed cell death ligand 1 in blood impacts overall survival in aggressive diffuse large B-Cell lymphoma: results from a French multicenter clinical trial. Leukemia (2014) 28:2367-75. doi:10.1038/leu.2014.137
    • (2014) Leukemia , vol.28 , pp. 2367-2375
    • Rossille, D.1    Gressier, M.2    Damotte, D.3    Maucort-Boulch, D.4    Pangault, C.5    Semana, G.6
  • 116
    • 84880747587 scopus 로고    scopus 로고
    • Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells
    • Wang L, Qian J, Lu Y, Li H, Bao H, He D, et al. Immune evasion of mantle cell lymphoma: expression of B7-H1 leads to inhibited T-cell response to and killing of tumor cells. Haematologica (2013) 98:1458-66. doi:10.3324/haematol.2012.071340
    • (2013) Haematologica , vol.98 , pp. 1458-1466
    • Wang, L.1    Qian, J.2    Lu, Y.3    Li, H.4    Bao, H.5    He, D.6
  • 117
    • 70349561448 scopus 로고    scopus 로고
    • PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model
    • Zhang L, Gajewski TF, Kline J. PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. Blood (2009) 114:1545-52. doi:10.1182/blood-2009-03-206672
    • (2009) Blood , vol.114 , pp. 1545-1552
    • Zhang, L.1    Gajewski, T.F.2    Kline, J.3
  • 118
    • 4444317516 scopus 로고    scopus 로고
    • PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta
    • Sheppard KA, Fitz LJ, Lee JM, Benander C, George JA, Wooters J, et al. PD-1 inhibits T-cell receptor induced phosphorylation of the ZAP70/CD3zeta signalosome and downstream signaling to PKCtheta. FEBS Lett (2004) 574:37-41. doi:10.1016/j.febslet.2004.07.083
    • (2004) FEBS Lett , vol.574 , pp. 37-41
    • Sheppard, K.A.1    Fitz, L.J.2    Lee, J.M.3    Benander, C.4    George, J.A.5    Wooters, J.6
  • 119
    • 84864324543 scopus 로고    scopus 로고
    • Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
    • Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tane A, Azuma M, Saito T. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2. J Exp Med (2012) 209:1201-17. doi:10.1084/jem.20112741
    • (2012) J Exp Med , vol.209 , pp. 1201-1217
    • Yokosuka, T.1    Takamatsu, M.2    Kobayashi-Imanishi, W.3    Hashimoto-Tane, A.4    Azuma, M.5    Saito, T.6
  • 120
    • 36749010774 scopus 로고    scopus 로고
    • Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
    • Pentcheva-Hoang T, Chen L, Pardoll DM, Allison JP. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability. Proc Natl Acad Sci U S A (2007) 104:17765-70. doi:10.1073/pnas.0708767104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 17765-17770
    • Pentcheva-Hoang, T.1    Chen, L.2    Pardoll, D.M.3    Allison, J.P.4
  • 121
    • 70350433514 scopus 로고    scopus 로고
    • Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal
    • Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, et al. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nat Immunol (2009) 10:1185-92. doi:10.1038/ni.1790
    • (2009) Nat Immunol , vol.10 , pp. 1185-1192
    • Fife, B.T.1    Pauken, K.E.2    Eagar, T.N.3    Obu, T.4    Wu, J.5    Tang, Q.6
  • 122
    • 84865165316 scopus 로고    scopus 로고
    • Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer
    • Ramsay AG, Clear AJ, Fatah R, Gribben JG. Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Blood (2012) 120:1412-21. doi:10.1182/blood-2012-02-411678
    • (2012) Blood , vol.120 , pp. 1412-1421
    • Ramsay, A.G.1    Clear, A.J.2    Fatah, R.3    Gribben, J.G.4
  • 123
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol (2014) 32:1020-30. doi:10.1200/jco.2013.53.0105
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3    Kluger, H.M.4    Carvajal, R.D.5    Sharfman, W.H.6
  • 125
    • 49649114804 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • Berger R, Rotem-Yehudar R, Slama G, Landes S, Kneller A, Leiba M, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res (2008) 14:3044-51. doi:10.1158/1078-0432.ccr-07-4079
    • (2008) Clin Cancer Res , vol.14 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3    Landes, S.4    Kneller, A.5    Leiba, M.6
  • 126
    • 84890096527 scopus 로고    scopus 로고
    • Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial
    • Armand P, Nagler A, Weller EA, Devine SM, Avigan DE, Chen YB, et al. Disabling immune tolerance by programmed death-1 blockade with pidilizumab after autologous hematopoietic stem-cell transplantation for diffuse large B-cell lymphoma: results of an international phase II trial. J Clin Oncol (2013) 31:4199-206. doi:10.1200/jco.2012.48.3685
    • (2013) J Clin Oncol , vol.31 , pp. 4199-4206
    • Armand, P.1    Nagler, A.2    Weller, E.A.3    Devine, S.M.4    Avigan, D.E.5    Chen, Y.B.6
  • 127
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial
    • Westin JR, Chu F, Zhang M, Fayad LE, Kwak LW, Fowler N, et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol (2014) 15:69-77. doi:10.1016/s1470-2045(13)70551-5
    • (2014) Lancet Oncol , vol.15 , pp. 69-77
    • Westin, J.R.1    Chu, F.2    Zhang, M.3    Fayad, L.E.4    Kwak, L.W.5    Fowler, N.6
  • 128
    • 84891371901 scopus 로고    scopus 로고
    • Anti-PD1 antibody: a new approach to treatment of lymphomas
    • Bachy E, Coiffier B. Anti-PD1 antibody: a new approach to treatment of lymphomas. Lancet Oncol (2014) 15:7-8. doi:10.1016/s1470-2045(13)70587-4
    • (2014) Lancet Oncol , vol.15 , pp. 7-8
    • Bachy, E.1    Coiffier, B.2
  • 129
    • 84878263355 scopus 로고    scopus 로고
    • Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide
    • Ramsay AG, Evans R, Kiaii S, Svensson L, Hogg N, Gribben JG. Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide. Blood (2013) 121:2704-14. doi:10.1182/blood-2012-08-448332
    • (2013) Blood , vol.121 , pp. 2704-2714
    • Ramsay, A.G.1    Evans, R.2    Kiaii, S.3    Svensson, L.4    Hogg, N.5    Gribben, J.G.6
  • 130
    • 38949174996 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory
    • Scholer A, Hugues S, Boissonnas A, Fetler L, Amigorena S. Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory. Immunity (2008) 28:258-70. doi:10.1016/j.immuni.2007.12.016
    • (2008) Immunity , vol.28 , pp. 258-270
    • Scholer, A.1    Hugues, S.2    Boissonnas, A.3    Fetler, L.4    Amigorena, S.5
  • 131
    • 65549085367 scopus 로고    scopus 로고
    • Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab
    • Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, et al. Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab. Blood (2009) 113:3809-12. doi:10.1182/blood-2008-10-185280
    • (2009) Blood , vol.113 , pp. 3809-3812
    • Hilchey, S.P.1    Hyrien, O.2    Mosmann, T.R.3    Livingstone, A.M.4    Friedberg, J.W.5    Young, F.6
  • 132
    • 43049179817 scopus 로고    scopus 로고
    • Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor
    • Teague RM, Greenberg PD, Fowler C, Huang MZ, Tan X, Morimoto J, et al. Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor. Immunity (2008) 28:662-74. doi:10.1016/j.immuni.2008.03.012
    • (2008) Immunity , vol.28 , pp. 662-674
    • Teague, R.M.1    Greenberg, P.D.2    Fowler, C.3    Huang, M.Z.4    Tan, X.5    Morimoto, J.6
  • 133
    • 79960513666 scopus 로고    scopus 로고
    • Impairment of immunological synapse formation in adaptively tolerant T cells
    • Choi S, Schwartz RH. Impairment of immunological synapse formation in adaptively tolerant T cells. J Immunol (2011) 187:805-16. doi:10.4049/jimmunol.1003314
    • (2011) J Immunol , vol.187 , pp. 805-816
    • Choi, S.1    Schwartz, R.H.2
  • 134
    • 28444455974 scopus 로고    scopus 로고
    • Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse
    • Carlin LM, Yanagi K, Verhoef A, Nolte-'t Hoen EN, Yates J, Gardner L, et al. Secretion of IFN-gamma and not IL-2 by anergic human T cells correlates with assembly of an immature immune synapse. Blood (2005) 106:3874-9. doi:10.1182/blood-2005-03-0996
    • (2005) Blood , vol.106 , pp. 3874-3879
    • Carlin, L.M.1    Yanagi, K.2    Verhoef, A.3    Nolte-'t Hoen, E.N.4    Yates, J.5    Gardner, L.6
  • 135
    • 23244442070 scopus 로고    scopus 로고
    • Orally tolerized T cells can form conjugates with APCs but are defective in immunological synapse formation
    • Ise W, Nakamura K, Shimizu N, Goto H, Fujimoto K, Kaminogawa S, et al. Orally tolerized T cells can form conjugates with APCs but are defective in immunological synapse formation. J Immunol (2005) 175:829-38. doi:10.4049/jimmunol.175.2.829
    • (2005) J Immunol , vol.175 , pp. 829-838
    • Ise, W.1    Nakamura, K.2    Shimizu, N.3    Goto, H.4    Fujimoto, K.5    Kaminogawa, S.6
  • 136
    • 33750017072 scopus 로고    scopus 로고
    • In vivo anergized T cells form altered immunological synapses in vitro
    • Zambricki E, Zal T, Yachi P, Shigeoka A, Sprent J, Gascoigne N, et al. In vivo anergized T cells form altered immunological synapses in vitro. Am J Transplant (2006) 6:2572-9. doi:10.1111/j.1600-6143.2006.01517.x
    • (2006) Am J Transplant , vol.6 , pp. 2572-2579
    • Zambricki, E.1    Zal, T.2    Yachi, P.3    Shigeoka, A.4    Sprent, J.5    Gascoigne, N.6
  • 137
    • 77951642054 scopus 로고    scopus 로고
    • Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b
    • Doherty M, Osborne DG, Browning DL, Parker DC, Wetzel SA. Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b. J Immunol (2010) 184:3598-608. doi:10.4049/jimmunol.0902285
    • (2010) J Immunol , vol.184 , pp. 3598-3608
    • Doherty, M.1    Osborne, D.G.2    Browning, D.L.3    Parker, D.C.4    Wetzel, S.A.5
  • 138
    • 0037103374 scopus 로고    scopus 로고
    • TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70
    • Dumont C, Blanchard N, Di Bartolo V, Lezot N, Dufour E, Jauliac S, et al. TCR/CD3 down-modulation and zeta degradation are regulated by ZAP-70. J Immunol (2002) 169:1705-12. doi:10.4049/jimmunol.169.4.1705
    • (2002) J Immunol , vol.169 , pp. 1705-1712
    • Dumont, C.1    Blanchard, N.2    Di Bartolo, V.3    Lezot, N.4    Dufour, E.5    Jauliac, S.6
  • 139
    • 70349751653 scopus 로고    scopus 로고
    • The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse
    • Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM. The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse. Immunity (2009) 31:621-31. doi:10.1016/j.immuni.2009.08.024
    • (2009) Immunity , vol.31 , pp. 621-631
    • Jenkins, M.R.1    Tsun, A.2    Stinchcombe, J.C.3    Griffiths, G.M.4
  • 140
    • 1842713125 scopus 로고    scopus 로고
    • Rafting MHC-II domains in the APC (presynaptic) plasma membrane and the thresholds for T-cell activation and immunological synapse formation
    • Gombos I, Detre C, Vamosi G, Matko J. Rafting MHC-II domains in the APC (presynaptic) plasma membrane and the thresholds for T-cell activation and immunological synapse formation. Immunol Lett (2004) 92:117-24. doi:10.1016/j.imlet.2003.11.022
    • (2004) Immunol Lett , vol.92 , pp. 117-124
    • Gombos, I.1    Detre, C.2    Vamosi, G.3    Matko, J.4
  • 141
    • 0034252971 scopus 로고    scopus 로고
    • Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation
    • Anderson HA, Hiltbold EM, Roche PA. Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat Immunol (2000) 1:156-62. doi:10.1038/77842
    • (2000) Nat Immunol , vol.1 , pp. 156-162
    • Anderson, H.A.1    Hiltbold, E.M.2    Roche, P.A.3
  • 142
    • 0037310832 scopus 로고    scopus 로고
    • MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse
    • Hiltbold EM, Poloso NJ, Roche PA. MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse. J Immunol (2003) 170:1329-38. doi:10.4049/jimmunol.170.3.1329
    • (2003) J Immunol , vol.170 , pp. 1329-1338
    • Hiltbold, E.M.1    Poloso, N.J.2    Roche, P.A.3


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