TCR/CD3 down-modulation and ζ degradation are regulated by ZAP-70

Journal of Immunology

Volumn 169, Issue 4, 2002, Pages 1705-1712

  Dumont, Céline ^a   Blanchard, Nicolas ^a   Di Bartolo, Vincenzo ^a   Lezot, Nathalie ^a   Dufour, Evelyne ^a   Jauliac, Sébastien ^a   Hivroz, Claire ^a  

^a INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; PROTEIN KINASE ZAP 70; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DESENSITIZATION; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN BINDING; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; T LYMPHOCYTE ACTIVATION;

EID: 0037103374     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.4.1705     Document Type: Article

References (49)

1. The T cell receptor/CD3 complex: A dynamic protein ensemble
2. The T cell antigen receptor: Insights into organelle biology
3. Internalization and cycling of the T cell antigen receptor: Role of protein kinase C
4. Endocytosis and recycling of the T3-T cell receptor complex: The role of T3 phosphorylation
5. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation
6. Tolerance of T-cell clones is associated with membrane antigen changes
7. Clonotypic surface structure on human T lymphocytes: Functional and biochemical analysis of the antigen receptor complex
8. Internalization and intracellular fate of TCR-CD3 complexes
9. Signal extinction and T cell repolarization in T helper cell-antigen-presenting cell conjugates
10. Serial triggering of many T-cell receptors by a few peptide-MHC complexes
11. Immunodeficiency diseases: Multiple roles for ZAP-70
12. The Syk family of protein tyrosine kinases in T-cell activation and development
13. Receptor signalling and the regulation of endocytic membrane transport
14. Opposing effects of protein tyrosine kinase inhibitors on the monoclonal antibody induced internalization of CD3 and CD4 antigens
15. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation
16. Agonist-induced T cell receptor down-regulation: Molecular requirements and dissociation from T cell activation
17. Two distinct pathways exist for down-regulation of the TCR
18. Peptide-induced T cell receptor down-regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation
19. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells
20. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation
21. Serial TCR engagement and down-modulation by peptide: MHC molecule ligands: Relationship to the quality of individual TCR signaling events
22. T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: Evidence for a protein kinase C-independent staurosporin-sensitive step
23. Differential cytosolic tail dependence and intracellular fate of T-cell receptors internalized upon activation with superantigen or phorbol ester
24. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigenic stimulation
25. syk protein tyrosine kinase regulates Fc receptor γ-chain-mediated transport to lysosomes
26. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: Reconstitution studies in a ZAP-70-deficient Jurkat T-cell line
27. Differential requirement of ZAP-70 for CD2-mediated activation pathways of mature human T cells
28. Herpesvirus saimiri replaces ZAP-70 for CD3 and CD2-mediated T cell activation
29. + T cell populations
30. Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways
31. Peptide antigen or superantigen-induced down-regulation of TCRs involves both stimulated and unstimulated receptors
32. Rapid turnover of the CD3 ζ chain independent of the TCR-CD3 complex in normal T cells
33. Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism
34. Signal transduction by lymphocyte antigen receptors
35. Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck
36. Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes
37. c-cbl in T lymphocytes
38. A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells
39. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
40. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α
41. The tyrosine kinase negative regulator c-Cbl as a RING-type-E2-dependent ubiquitin-protein ligase
42. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1
43. Ubiquitin and the control of protein fate in the secretory and endocytic pathways
44. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
45. The product of the proto-oncogene c-cbl: A negative regulator of the Syk tyrosine kinase
46. Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice
47. Altered thymic positive selection and intracellular signals in Cbl-deficient mice
48. Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes
49. Cbl promotes ubiquitination of the T cell receptor ζ through an adaptor function of Zap-70