메뉴 건너뛰기




Volumn 27, Issue 9, 2013, Pages 1902-1909

Oral lenalidomide with rituximab in relapsed or refractory diffuse large cell, follicular and transformed lymphoma: A phase II clinical trial

Author keywords

diffuse large B cell lymphoma; follicular lymphoma; lenalidomide; mantle cell lymphoma; rituximab; transformed lymphoma

Indexed keywords

ALKALINE PHOSPHATASE; BORTEZOMIB; CREATININE; LACTATE DEHYDROGENASE; LENALIDOMIDE; RITUXIMAB;

EID: 84883742025     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2013.95     Document Type: Article
Times cited : (199)

References (43)
  • 4
    • 34548410018 scopus 로고    scopus 로고
    • Natural history of follicular grade 3 non-Hodgkin's lymphoma
    • DOI 10.1097/CCO.0b013e3282c9ad78, PII 0000162220070900000003
    • Bierman PJ. Natural history of follicular grade 3 non-Hodgkin's lymphoma. Curr Opin Oncol 2007; 19: 433-437. (Pubitemid 47356597)
    • (2007) Current Opinion in Oncology , vol.19 , Issue.5 , pp. 433-437
    • Bierman, P.J.1
  • 5
    • 38549147027 scopus 로고    scopus 로고
    • Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20\+ B-cell lymphomas: A randomised controlled trial (RICOVER-60)
    • Pfreundschuh M, Schubert J, Ziepert M, Schmits R, Mohren M, Lengfelder E et al. Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20\+ B-cell lymphomas: a randomised controlled trial (RICOVER-60). Lancet Oncol 2008; 9: 105-116.
    • (2008) Lancet Oncol , vol.9 , pp. 105-116
    • Pfreundschuh, M.1    Schubert, J.2    Ziepert, M.3    Schmits, R.4    Mohren, M.5    Lengfelder, E.6
  • 6
    • 80053384016 scopus 로고    scopus 로고
    • CHOP-like chemotherapy with or without rituximab in young patients with goodprognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group
    • Pfreundschuh M, Kuhnt E, Trumper L, Osterborg A, Trneny M, Shepherd L et al. CHOP-like chemotherapy with or without rituximab in young patients with goodprognosis diffuse large-B-cell lymphoma: 6-year results of an open-label randomised study of the MabThera International Trial (MInT) Group. Lancet Oncol 2011; 12: 1013-1022.
    • (2011) Lancet Oncol , vol.12 , pp. 1013-1022
    • Pfreundschuh, M.1    Kuhnt, E.2    Trumper, L.3    Osterborg, A.4    Trneny, M.5    Shepherd, L.6
  • 7
    • 40949147480 scopus 로고    scopus 로고
    • Update of the M. D. Anderson Cancer Center experience with hyper-CVAD and rituximab for the treatment of mantle cell and Burkitt-type lymphomas
    • Fayad L, Thomas D, Romaguera J. Update of the M. D. Anderson Cancer Center experience with hyper-CVAD and rituximab for the treatment of mantle cell and Burkitt-type lymphomas. Clin Lymphoma Myeloma 2007; 8(Suppl 2): S57-S62.
    • (2007) Clin Lymphoma Myeloma , vol.8 , Issue.SUPPL. 2
    • Fayad, L.1    Thomas, D.2    Romaguera, J.3
  • 8
    • 54449095901 scopus 로고    scopus 로고
    • Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma
    • Wiernik PH, Lossos IS, Tuscano JM, Justice G, Vose JM, Cole CE et al. Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma. J Clin Oncol 2008; 26: 4952-4957.
    • (2008) J Clin Oncol , vol.26 , pp. 4952-4957
    • Wiernik, P.H.1    Lossos, I.S.2    Tuscano, J.M.3    Justice, G.4    Vose, J.M.5    Cole, C.E.6
  • 9
    • 73949145763 scopus 로고    scopus 로고
    • Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma
    • Witzig TE, Wiernik PH, Moore T, Reeder C, Cole C, Justice G et al. Lenalidomide oral monotherapy produces durable responses in relapsed or refractory indolent non-Hodgkin's Lymphoma. J Clin Oncol 2009; 27: 5404-5409.
    • (2009) J Clin Oncol , vol.27 , pp. 5404-5409
    • Witzig, T.E.1    Wiernik, P.H.2    Moore, T.3    Reeder, C.4    Cole, C.5    Justice, G.6
  • 10
    • 79959722615 scopus 로고    scopus 로고
    • An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma
    • Witzig TE, Vose JM, Zinzani PL, Reeder CB, Buckstein R, Polikoff JA et al. An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin's lymphoma. Ann Oncol 2011; 22: 1622-1627.
    • (2011) Ann Oncol , vol.22 , pp. 1622-1627
    • Witzig, T.E.1    Vose, J.M.2    Zinzani, P.L.3    Reeder, C.B.4    Buckstein, R.5    Polikoff, J.A.6
  • 11
    • 73949116990 scopus 로고    scopus 로고
    • Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: Implications for the tumor microenvironment and immunotherapy
    • Ramsay AG, Clear AJ, Kelly G, Fatah R, Matthews J, Macdougall F et al. Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy. Blood 2009; 114: 4713-4720.
    • (2009) Blood , vol.114 , pp. 4713-4720
    • Ramsay, A.G.1    Clear, A.J.2    Kelly, G.3    Fatah, R.4    Matthews, J.5    MacDougall, F.6
  • 12
    • 23844435619 scopus 로고    scopus 로고
    • Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model
    • DOI 10.1158/1078-0432.CCR-05-0577
    • Hernandez-Ilizaliturri FJ, Reddy N, Holkova B, Ottman E, Czuczman MS. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res 2005; 11: 5984-5992. (Pubitemid 41170330)
    • (2005) Clinical Cancer Research , vol.11 , Issue.16 , pp. 5984-5992
    • Hernandez-Ilizaliturri, F.J.1    Reddy, N.2    Holkova, B.3    Ottman, E.4    Czuczman, M.S.5
  • 13
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20\+ tumor cells
    • Wu L, Adams M, Carter T, Chen R, Muller G, Stirling D et al. Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-treated CD20\+ tumor cells. Clin Cancer Res 2008; 14: 4650-4657.
    • (2008) Clin Cancer Res , vol.14 , pp. 4650-4657
    • Wu, L.1    Adams, M.2    Carter, T.3    Chen, R.4    Muller, G.5    Stirling, D.6
  • 14
    • 36849024949 scopus 로고    scopus 로고
    • Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the anti-tumour activity of rituximab in vivo
    • DOI 10.1111/j.1365-2141.2007.06841.x
    • Reddy N, Hernandez-Ilizaliturri FJ, Deeb G, Roth M, Vaughn M, Knight J et al. Immunomodulatory drugs stimulate natural killer-cell function, alter cytokine production by dendritic cells, and inhibit angiogenesis enhancing the antitumour activity of rituximab in vivo. Br J Haematol 2008; 140: 36-45. (Pubitemid 350233246)
    • (2008) British Journal of Haematology , vol.140 , Issue.1 , pp. 36-45
    • Reddy, N.1    Hernandez-Ilizaliturri, F.J.2    Deeb, G.3    Roth, M.4    Vaughn, M.5    Knight, J.6    Wallace, P.7    Czuczman, M.S.8
  • 15
    • 69549116054 scopus 로고    scopus 로고
    • Synergistic antitumor effects of lenalidomide and rituximab on mantle cell lymphoma in vitro and in vivo
    • Zhang L, Qian Z, Cai Z, Sun L, Wang H, Bartlett JB et al. Synergistic antitumor effects of lenalidomide and rituximab on mantle cell lymphoma in vitro and in vivo. Am J Hematol 2009; 84: 553-559.
    • (2009) Am J Hematol , vol.84 , pp. 553-559
    • Zhang, L.1    Qian, Z.2    Cai, Z.3    Sun, L.4    Wang, H.5    Bartlett, J.B.6
  • 16
    • 84863107308 scopus 로고    scopus 로고
    • Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: A phase 1/2 clinical trial
    • Wang M, Fayad L, Wagner-Bartak N, Zhang L, Hagemeister F, Neelapu SS et al. Lenalidomide in combination with rituximab for patients with relapsed or refractory mantle-cell lymphoma: a phase 1/2 clinical trial. Lancet Oncol 2012; 13: 716-723.
    • (2012) Lancet Oncol , vol.13 , pp. 716-723
    • Wang, M.1    Fayad, L.2    Wagner-Bartak, N.3    Zhang, L.4    Hagemeister, F.5    Neelapu, S.S.6
  • 17
    • 84857654592 scopus 로고    scopus 로고
    • Combination of lenalidomide and rituximab in elderly patients with relapsed or refractory diffuse large B-cell lymphoma: A phase 2 trial
    • Zinzani PL, Pellegrini C, Gandolfi L, Stefoni V, Quirini F, Derenzini E et al. Combination of lenalidomide and rituximab in elderly patients with relapsed or refractory diffuse large B-cell lymphoma: a phase 2 trial. Clin Lymphoma Myeloma Leuk 2011; 11: 462-466.
    • (2011) Clin Lymphoma Myeloma Leuk , vol.11 , pp. 462-466
    • Zinzani, P.L.1    Pellegrini, C.2    Gandolfi, L.3    Stefoni, V.4    Quirini, F.5    Derenzini, E.6
  • 18
    • 84858322709 scopus 로고    scopus 로고
    • High response rates with lenalidomide plus rituximab for untreated indolent B-cell non-Hodgkin lymphoma, including those meeting GELF criteria
    • Samaniego F, Hagemeister F, Mclaughlin P, Kwak LW, Romaguera J, Fanale MA et al. High response rates with lenalidomide plus rituximab for untreated indolent B-cell non-Hodgkin lymphoma, including those meeting GELF criteria. J Clin Oncol 2011; 29: 8030.
    • (2011) J Clin Oncol , vol.29 , pp. 8030
    • Samaniego, F.1    Hagemeister, F.2    McLaughlin, P.3    Kwak, L.W.4    Romaguera, J.5    Fanale, M.A.6
  • 19
    • 84868193664 scopus 로고    scopus 로고
    • CALGB 50401: A randomized trial of lenalidomide alone versus lenalidomide plus rituximab in patients with recurrent follicular lymphoma
    • Leonard J, Jung S-H, Johnson JL, Bartlett N, Blum KA, Cheson BD et al. CALGB 50401: A randomized trial of lenalidomide alone versus lenalidomide plus rituximab in patients with recurrent follicular lymphoma. ASCO Meeting Abstr 2012; 30: 8000.
    • (2012) ASCO Meeting Abstr , vol.30 , pp. 8000
    • Leonard, J.1    Jung, S.-H.2    Johnson, J.L.3    Bartlett, N.4    Blum, K.A.5    Cheson, B.D.6
  • 20
    • 0042449063 scopus 로고    scopus 로고
    • Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas
    • NCI Sponsored International Working Group
    • Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM et al. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J Clin Oncol 1999; 17: 1244.
    • (1999) J Clin Oncol , vol.17 , pp. 1244
    • Cheson, B.D.1    Horning, S.J.2    Coiffier, B.3    Shipp, M.A.4    Fisher, R.I.5    Connors, J.M.6
  • 22
    • 84865865930 scopus 로고    scopus 로고
    • Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: A report from the International DLBCL Rituximab-CHOP Consortium Program Study
    • Visco C, Li Y, Xu-Monette ZY, Miranda RN, Green TM, Tzankov A et al. Comprehensive gene expression profiling and immunohistochemical studies support application of immunophenotypic algorithm for molecular subtype classification in diffuse large B-cell lymphoma: a report from the International DLBCL Rituximab-CHOP Consortium Program Study. Leukemia 2012; 26: 2103-2113.
    • (2012) Leukemia , vol.26 , pp. 2103-2113
    • Visco, C.1    Li, Y.2    Xu-Monette, Z.Y.3    Miranda, R.N.4    Green, T.M.5    Tzankov, A.6
  • 23
    • 0024536437 scopus 로고
    • Optimal two-stage designs for phase II clinical trials
    • DOI 10.1016/0197-2456(89)90015-9
    • Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials 1989; 10: 1-10. (Pubitemid 19099520)
    • (1989) Controlled Clinical Trials , vol.10 , Issue.1 , pp. 1-10
    • Simon, R.1
  • 24
    • 77957965500 scopus 로고    scopus 로고
    • Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era
    • Gisselbrecht C, Glass B, Mounier N, Singh Gill D, Linch DC, Trneny M et al. Salvage regimens with autologous transplantation for relapsed large B-cell lymphoma in the rituximab era. J Clin Oncol 2010; 28: 4184-4190.
    • (2010) J Clin Oncol , vol.28 , pp. 4184-4190
    • Gisselbrecht, C.1    Glass, B.2    Mounier, N.3    Singh Gill, D.4    Linch, D.C.5    Trneny, M.6
  • 31
    • 80755143466 scopus 로고    scopus 로고
    • The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: A bio-CORAL study
    • Thieblemont C, Briere J, Mounier N, Voelker HU, Cuccuini W, Hirchaud E et al. The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: a bio-CORAL study. J Clin Oncol 2011; 29: 4079-4087.
    • (2011) J Clin Oncol , vol.29 , pp. 4079-4087
    • Thieblemont, C.1    Briere, J.2    Mounier, N.3    Voelker, H.U.4    Cuccuini, W.5    Hirchaud, E.6
  • 32
    • 80053502780 scopus 로고    scopus 로고
    • Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype
    • Hernandez-Ilizaliturri FJ, Deeb G, Zinzani PL, Pileri SA, Malik F, Macon WR et al. Higher response to lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in nongerminal center B-cell-like than in germinal center B-cell-like phenotype. Cancer 2011; 117: 5058-5066.
    • (2011) Cancer , vol.117 , pp. 5058-5066
    • Hernandez-Ilizaliturri, F.J.1    Deeb, G.2    Zinzani, P.L.3    Pileri, S.A.4    Malik, F.5    MacOn, W.R.6
  • 33
    • 77949449775 scopus 로고    scopus 로고
    • The incidence, natural history, biology, and treatment of transformed lymphomas
    • Bernstein SH, Burack WR. The incidence, natural history, biology, and treatment of transformed lymphomas. Hematology Am Soc Hematol Educ Program 2009 532-541.
    • (2009) Hematology Am Soc Hematol Educ Program , pp. 532-541
    • Bernstein, S.H.1    Burack, W.R.2
  • 34
    • 84881476331 scopus 로고    scopus 로고
    • The use of the immunomodulatory drug, lenalidomide (Revlimid(R)) as a novel strategy to overcome acquired antibody resistance in rituximab-resistant non-Hodgkin's lymphoma (NHL) cell lines
    • Reddy NM, Hernandez-Ilizaliturri FJ, Czuczman MS. The use of the immunomodulatory drug, lenalidomide (Revlimid(R)) as a novel strategy to overcome acquired antibody resistance in rituximab-resistant non-Hodgkin's lymphoma (NHL) cell lines. AACR Meet Abstr 2006; 2006: 154a.
    • (2006) AACR Meet Abstr , vol.2006
    • Reddy, N.M.1    Hernandez-Ilizaliturri, F.J.2    Czuczman, M.S.3
  • 35
    • 78650823247 scopus 로고    scopus 로고
    • Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): A phase 3, randomised controlled trial
    • Salles G, Seymour JF, Offner F, Lopez-Guillermo A, Belada D, Xerri L et al. Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial. Lancet 2011; 377: 42-51.
    • (2011) Lancet , vol.377 , pp. 42-51
    • Salles, G.1    Seymour, J.F.2    Offner, F.3    Lopez-Guillermo, A.4    Belada, D.5    Xerri, L.6
  • 36
    • 33845515497 scopus 로고    scopus 로고
    • Maintenance therapy with rituximab leads to a significant prolongation of response duration after salvage therapy with a combination of rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) in patients with recurring and refractory follicular and mantle cell lymphomas: Results of a prospective randomized study of the German Low Grade Lymphoma Study Group (GLSG)
    • DOI 10.1182/blood-2006-04-016725
    • Forstpointner R, Unterhalt M, Dreyling M, Bock HP, Repp R, Wandt H et al. Maintenance therapy with rituximab leads to a significant prolongation of response duration after salvage therapy with a combination of rituximab, fludarabine, cyclophosphamide, and mitoxantrone (R-FCM) in patients with recurring and refractory follicular and mantle cell lymphomas: Results of a prospective randomized study of the German Low Grade Lymphoma Study Group (GLSG). Blood 2006; 108: 4003-4008. (Pubitemid 44920177)
    • (2006) Blood , vol.108 , Issue.13 , pp. 4003-4008
    • Forstpointner, R.1    Unterhalt, M.2    Dreyling, M.3    Bock, H.-P.4    Repp, R.5    Wandt, H.6    Pott, C.7    Seymour, J.F.8    Metzner, B.9    Hanel, A.10    Lehmann, T.11    Hartmann, F.12    Einsele, H.13    Hiddemann, W.14
  • 37
    • 83255176958 scopus 로고    scopus 로고
    • Rituximab maintenance for the treatment of patients with follicular lymphoma: An updated systematic review and meta-analysis of randomized trials
    • Vidal L, Gafter-Gvili A, Salles G, Dreyling MH, Ghielmini M, Hsu Schmitz SF et al. Rituximab maintenance for the treatment of patients with follicular lymphoma: an updated systematic review and meta-analysis of randomized trials. J Natl Cancer Inst 2011; 103: 1799-1806.
    • (2011) J Natl Cancer Inst , vol.103 , pp. 1799-1806
    • Vidal, L.1    Gafter-Gvili, A.2    Salles, G.3    Dreyling, M.H.4    Ghielmini, M.5    Hsu Schmitz, S.F.6
  • 39
    • 84858316300 scopus 로고    scopus 로고
    • Maintenance with rituximab after autologous stem cell transplantation in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL): CORAL final analysis
    • Gisselbrecht C, Glass B, Laurent G, Gill DS, Linch MD, Trneny M et al. Maintenance with rituximab after autologous stem cell transplantation in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL): CORAL final analysis. ASCO Meet Abstr 2011; 29: 8004.
    • (2011) ASCO Meet Abstr , vol.29 , pp. 8004
    • Gisselbrecht, C.1    Glass, B.2    Laurent, G.3    Gill, D.S.4    Linch, M.D.5    Trneny, M.6
  • 40
    • 84886946107 scopus 로고    scopus 로고
    • Maintenance rituximab versus observation after R-CHOP or R-EPOCH in patients with untreated poor-prognosis diffuse large B-cell lymphoma and grade III follicular lymphoma
    • Li YJ, Xia ZJ, Li S, Chen XQ, Xia Y, Xu F et al. Maintenance rituximab versus observation after R-CHOP or R-EPOCH in patients with untreated poor-prognosis diffuse large B-cell lymphoma and grade III follicular lymphoma. ASCO Meet Abstr 2010; 28: 8084.
    • (2010) ASCO Meet Abstr , vol.28 , pp. 8084
    • Li, Y.J.1    Xia, Z.J.2    Li, S.3    Chen, X.Q.4    Xia, Y.5    Xu, F.6
  • 41
    • 67650025949 scopus 로고    scopus 로고
    • Brief duration rituximab(R)/chemotherapy (CNOP or CVP) followed by maintenance rituximab in elderly/poor performance status patients (pts) with diffuse large B-cell lymphoma (DLBCL): A phase II trial of the Minnie Pearl Cancer Research Network
    • Raefsky EL, Greco FA, Spigel DR, Doss HH, Farley C, Saez R et al. Brief duration rituximab(R)/chemotherapy (CNOP or CVP) followed by maintenance rituximab in elderly/poor performance status patients (pts) with diffuse large B-cell lymphoma (DLBCL): A phase II trial of the Minnie Pearl Cancer Research Network. ASCO Meet Abstr 2006; 24: 7577.
    • (2006) ASCO Meet Abstr , vol.24 , pp. 7577
    • Raefsky, E.L.1    Greco, F.A.2    Spigel, D.R.3    Doss, H.H.4    Farley, C.5    Saez, R.6
  • 42
    • 80054757580 scopus 로고    scopus 로고
    • Lenalidomide plus rituximab is a highly effective and well-tolerated biologic therapy in untreated indolent B cell non-Hodgkin's lymphoma
    • Fowler N, Hagemeister F, McLaughlin P, Kwak L, Romaguera J, Fanale M et al. Lenalidomide plus rituximab is a highly effective and well-tolerated biologic therapy in untreated indolent B cell non-Hodgkin's lymphoma. Ann Oncol 2011; 22: 128-129.
    • (2011) Ann Oncol , vol.22 , pp. 128-129
    • Fowler, N.1    Hagemeister, F.2    McLaughlin, P.3    Kwak, L.4    Romaguera, J.5    Fanale, M.6
  • 43
    • 84881377241 scopus 로고    scopus 로고
    • Lenalidomide plus rituximab leads to a high rate of durable responses in patients with relapsed/refractory indolent non-Hodgkin's lymphoma
    • Dutia M, Deroock I, Reed-Pease C, Tuscano J. Lenalidomide plus rituximab leads to a high rate of durable responses in patients with relapsed/refractory indolent non-Hodgkin's lymphoma. Ann Oncol 2011; 22: 186-186.
    • (2011) Ann Oncol , vol.22 , pp. 186-186
    • Dutia, M.1    Deroock, I.2    Reed-Pease, C.3    Tuscano, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.