Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Schittek, Birgit ^a   Sinnberg, Tobias ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cancer; Casein kinase 1; Melanoma; p53; Tumor; catenin

Indexed keywords

APC PROTEIN; BETA CATENIN; CASEIN KINASE I; CASEIN KINASE I INHIBITOR; CASEIN KINASE IALPHA; CASEIN KINASE IDELTA; CASEIN KINASE IEPSILON; CKI 7; D 4476; DISHEVELLED PROTEIN; ENZYME INHIBITOR; FAS ASSOCIATED DEATH DOMAIN PROTEIN; IC 261; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BID; PROTEIN KINASE B; PROTEIN MDM2; PROTEIN P53; RNA; SR 1277; SR 2890; SR 3029; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR NFAT3; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; WNT PROTEIN;

ANTINEOPLASTIC ACTIVITY; CANCER CELL; CARCINOGENESIS; CELL ADHESION; CELL CYCLE; COLORECTAL CANCER; CYTOSKELETON; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; GENE DELETION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; LEUKEMIA; MELANOMA; MISSENSE MUTATION; NEUROBLASTOMA; NONHUMAN; NONSENSE MUTATION; OVERALL SURVIVAL; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; RNA TRANSLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; ENZYME SPECIFICITY; GENETICS; METABOLISM; PATHOLOGY; WNT SIGNALING PATHWAY;

ANIMALS; CARCINOGENESIS; CASEIN KINASE I; HUMANS; ISOENZYMES; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53; WNT SIGNALING PATHWAY;

EID: 84934940908     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-231     Document Type: Review

References (111)

1. Knippschild U, Gocht A, Wolff S, Huber N, Löhler J, Stöter M: The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal 1, 17:675-689. 10.1016/j.cellsig.2004.12.011
2. Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Wörl PU, Eismann T, Stöter M, Würl PU, Stöter M: The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie 1, 28:508-514. 10.1159/000087137
3. Gross SD, Anderson RA: Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell Signal 1, 10:699-711. 10.1016/S0898-6568(98)00042-4
4. Price MA: CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev 1, 20:399-410. 10.1101/gad.1394306
5. Cheong JK, Virshup DM: Casein kinase 1: Complexity in the family. Int J Biochem Cell Biol 1, 43:465-469. 10.1016/j.biocel.2010.12.004
6. Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM: Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family. J Biol Chem 1, 270:14875-14883. 10.1074/jbc.270.25.14875
7. Greer YE, Rubin JS: Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth. J Cell Biol 1, 192:993-1004. 10.1083/jcb.201011111
8. Carvalho G, Le Guelte A, Demian C, Vazquez A, Gavard J, Bidère N: Interplay between BCL10, MALT1 and IkappaBalpha during T-cell-receptor-mediated NFkappaB activation. J Cell Sci 2010,123(Pt 14):2375-2380.
9. Desagher S, Osen-Sand A, Montessuit S, Magnenat E, Vilbois F, Hochmann A, Journot L, Antonsson B, Martinou JC: Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8. Mol Cell 1, 8:601-611. 10.1016/S1097-2765(01)00335-5
10. Alappat EC, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann AE, Thorburn A, Kidd VJ, Slaughter CA, Osborn SL, Winoto A, Tang W-J, Peter ME: Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell 1, 19:321-332. 10.1016/j.molcel.2005.06.024
11. Huart A-S, MacLaine NJ, Meek DW, Hupp TR: CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability. J Biol Chem 1, 284:32384-32394. 10.1074/jbc.M109.052647
12. Bischof J, Randoll S-J, Süßner N, Henne-Bruns D, Pinna LA, Knippschild U: CK1δ kinase activity is modulated by Chk1-mediated phosphorylation. PLoS One 1, 8:e68803. 10.1371/journal.pone.0068803
13. Cruciat C-M, Dolde C, de Groot REA, Ohkawara B, Reinhard C, Korswagen HC, Niehrs C: RNA helicase DDX3 is a regulatory subunit of casein kinase 1 in Wnt-β-catenin signaling. Science 1, 339:1436-1441. doi:10.1038/onc.2013.564 10.1126/science.1231499
14. Yim DGR, Ghosh S, Guy GR, Virshup DM: Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene 2014.
15. Price MA, Kalderon D: Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell 1, 108:823-835. 10.1016/S0092-8674(02)00664-5
16. Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh-Hain JA, Ng S-K, Choi P-W, Fong W-P, Agar NYR, Welch WR, Berkowitz RS, Ng S-W: Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells. EMBO Mol Med 1, 4:952-963. 10.1002/emmm.201101094
17. Xu F, Wang Y-L, Chang J-J, Du S-C, Diao L, Jiang N, Wang H-J, Ma D, Zhang J: Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1. Biochem J 1, 458:159-169. 10.1042/BJ20130986
18. Bidère N, Ngo VN, Lee J, Collins C, Zheng L, Wan F, Davis RE, Lenz G, Anderson DE, Arnoult D, Vazquez A, Sakai K, Zhang J, Meng Z, Veenstra TD, Staudt LM, Lenardo MJ: Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature 1, 458:92-96. 10.1038/nature07613
19. Wang Y, Hu L, Tong X, Ye X: Casein kinase 1γ1 inhibits the RIG-I/TLR signaling pathway through phosphorylating p65 and promoting its degradation. J Immunol 1, 192:1855-1861. 10.4049/jimmunol.1302552
20. Wu S, Chen L, Becker A, Schonbrunn E, Chen J: Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding. Mol Cell Biol 1, 32:4821-4832. 10.1128/MCB.00851-12
21. Milne DM, Palmer RH, Campbell DG, Meek DW: Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme. Oncogene 1992, 7:1361-1369.
22. Rena G, Bain J, Elliott M, Cohen P: D1, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep 2004, 5:60-65. 10.1038/sj.embor.7400048
23. Magliozzi R, Low TY, Weijts BGMW, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJT, Bos JL, de Bruin A, Heck AJR, Guardavaccaro D: Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2. Dev Cell 1, 27:574-585. 10.1016/j.devcel.2013.10.023
24. Waddell DS, Liberati NT, Guo X, Frederick JP, Wang X-F: Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway. J Biol Chem 1, 279:29236-29246. 10.1074/jbc.M400880200
25. Rubinfeld B, Tice DA, Polakis P: Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. J Biol Chem 1, 276:39037-39045. 10.1074/jbc.M105148200
26. Shen T, Liu Y, Cseresnyés Z, Hawkins A, Randall WR, Schneider MF: Activity- and calcineurin-independent nuclear shuttling of NFATc1, but not NFATc3, in adult skeletal muscle fibers. Mol Biol Cell 2006, 17:1570-1582. 10.1091/mbc.E05-08-0780
27. Klein TJ, Jenny A, Djiane A, Mlodzik M: CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr Biol 1, 16:1337-1343. 10.1016/j.cub.2006.06.030
28. Venerando A, Girardi C, Ruzzene M, Pinna LA: Pyrvinium pamoate does not activate protein kinase CK1, but promotes Akt/PKB down-regulation and GSK3 activation. Biochem J 2013, 452:131-137.
29. Del Valle-Pérez B, Arqués O, Vinyoles M, de Herreros AG, Duñach M: Coordinated action of CK1 isoforms in canonical Wnt signaling. Mol Cell Biol 1, 31:2877-2888. 10.1128/MCB.01466-10
30. Flotow H, Graves PR, Wang AQ, Fiol CJ, Roeske RW, Roach PJ: Phosphate groups as substrate determinants for casein kinase I action. J Biol Chem 1990, 265:14264-14269.
31. McKenzie JAG, Riento K, Ridley AJ: Casein kinase I epsilon associates with and phosphorylates the tight junction protein occludin. FEBS Lett 1, 580:2388-2394. 10.1016/j.febslet.2006.03.048
32. Sillibourne JE, Milne DM, Takahashi M, Ono Y, Meek DW: Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450. J Mol Biol 1, 322:785-797. 10.1016/S0022-2836(02)00857-4
33. Wolff S, Stöter M, Giamas G, Piesche M, Henne-Bruns D, Banting G, Knippschild U: Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett 1, 580:6477-6484. 10.1016/j.febslet.2006.10.068
34. Wolff S, Xiao Z, Wittau M, Süssner N, Stöter M, Knippschild U: Interaction of casein kinase 1 delta (CK1 delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A). Biochim Biophys Acta 1, 1745:196-206. 10.1016/j.bbamcr.2005.05.004
35. Behrend L, Stöter M, Kurth M, Rutter G, Heukeshoven J, Deppert W, Knippschild U: Interaction of casein kinase 1 delta (CK1delta) with post-Golgi structures, microtubules and the spindle apparatus. Eur J Cell Biol 1, 79:240-251. 10.1078/S0171-9335(04)70027-8
36. Yin H, Laguna KA, Li G, Kuret J: Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1. Biochemistry 1, 45:5297-5308. 10.1021/bi052354e
37. Zemp I, Wandrey F, Rao S, Ashiono C, Wyler E, Montellese C, Kutay U: CK1δ and CK1 are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 2014,127(Pt 6):1242-1253.
38. Brockman JL, Gross SD, Sussman MR, Anderson RA: Cell cycle-dependent localization of casein kinase I to mitotic spindles. Proc Natl Acad Sci U S A 1, 89:9454-9458. 10.1073/pnas.89.20.9454
39. Gross SD, Simerly C, Schatten G, Anderson RA: A casein kinase I isoform is required for proper cell cycle progression in the fertilized mouse oocyte. J Cell Sci 1997,110(Pt 2):3083-3090.
40. Wang L, Lu A, Zhou H-X, Sun R, Zhao J, Zhou C-J, Shen J-P, Wu S-N, Liang C-G: Casein kinase 1 alpha regulates chromosome congression and separation during mouse oocyte meiotic maturation and early embryo development. PLoS One 1, 8:e63173. 10.1371/journal.pone.0063173
41. Duan S, Skaar JR, Kuchay S, Toschi A, Kanarek N, Ben-Neriah Y, Pagano M: mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR. Mol Cell 1, 44:317-324. 10.1016/j.molcel.2011.09.005
42. Izeradjene K, Douglas L, Delaney AB, Houghton JA: Casein kinase I attenuates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by regulating the recruitment of fas-associated death domain and procaspase-8 to the death-inducing signaling complex. Cancer Res 1, 64:8036-8044. 10.1158/0008-5472.CAN-04-0762
43. Zhao Y, Qin S, Atangan LI, Molina Y, Okawa Y, Arpawong HT, Ghosn C, Xiao J-H, Vuligonda V, Brown G, Chandraratna RAS: Casein kinase 1alpha interacts with retinoid X receptor and interferes with agonist-induced apoptosis. J Biol Chem 1, 279:30844-30849. 10.1074/jbc.M404651200
44. Sinnberg T, Menzel M, Kaesler S, Biedermann T, Sauer B, Nahnsen S, Schwarz M, Garbe C, Schittek B: Suppression of casein kinase 1alpha in melanoma cells induces a switch in beta-catenin signaling to promote metastasis. Cancer Res 1, 70:6999-7009. 10.1158/0008-5472.CAN-10-0645
45. Tobin AB: Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation. Trends Pharmacol Sci 1, 23:337-343. 10.1016/S0165-6147(02)02043-6
46. Waugh MG, Challiss RA, Berstein G, Nahorski SR, Tobin AB: Agonist-induced desensitization and phosphorylation of m1-muscarinic receptors. Biochem J 1999,338(Pt 1):175-183.
47. Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A: A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol 1, 24:4184-4195. 10.1128/MCB.24.10.4184-4195.2004
48. Dejmek J, Säfholm A, Kamp Nielsen C, Andersson T, Leandersson K: Wnt-5a/Ca2 + -induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol 1, 26:6024-6036. 10.1128/MCB.02354-05
49. Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM: Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol Cell Biol 1, 20:4888-4899. 10.1128/MCB.20.13.4888-4899.2000
50. Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray J-P, Traver D, Schultz PG, Kay SA: High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol 1, 8:e1000559. 10.1371/journal.pbio.1000559
51. Walton KM, Fisher K, Rubitski D, Marconi M, Meng Q-J, Sládek M, Adams J, Bass M, Chandrasekaran R, Butler T, Griffor M, Rajamohan F, Serpa M, Chen Y, Claffey M, Hastings M, Loudon A, Maywood E, Ohren J, Doran A, Wager TT: Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther 1, 330:430-439. 10.1124/jpet.109.151415
52. Harms E, Young MW, Saez L: CK1 and GSK3 in the Drosophila and mammalian circadian clock. Novartis Found Symp 2003,253(102-9):277-284. discussion
53. Meng Q-J, Maywood ES, Bechtold DA, Lu W-Q, Li J, Gibbs JE, Dupré SM, Chesham JE, Rajamohan F, Knafels J, Sneed B, Zawadzke LE, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon ASI: Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc Natl Acad Sci U S A 1, 107:15240-15245. 10.1073/pnas.1005101107
54. Behrend L, Milne DM, Stöter M, Deppert W, Campbell LE, Meek DW, Knippschild U: IC1, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 2000, 19:5303-5313. 10.1038/sj.onc.1203939
55. Stöter M, Bamberger AM, Aslan B, Kurth M, Speidel D, Löning T, Frank HG, Kaufmann P, Löhler J, HenneBruns D, Deppert W, Knippschild U: Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells . Oncogene 1, 24:7964-7975. 10.1038/sj.onc.1208941
56. Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS: Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis. Mol Biol Cell 1, 25:1629-1640. 10.1091/mbc.E13-10-0598
57. Hanger DP, Byers HL, Wray S, Leung K-Y, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH: Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis. J Biol Chem 1, 282:23645-23654. 10.1074/jbc.M703269200
58. León-Espinosa G, García E, García-Escudero V, Hernández F, Defelipe J, Avila J: Changes in tau phosphorylation in hibernating rodents. J Neurosci Res 1, 91:954-962. 10.1002/jnr.23220
59. Li G, Yin H, Kuret J: Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules. J Biol Chem 1, 279:15938-15945. 10.1074/jbc.M314116200
60. Johnson AE, Chen J-S, Gould KL: CK1 is required for a mitotic checkpoint that delays cytokinesis. Curr Biol 1, 23:1920-1926. 10.1016/j.cub.2013.07.077
61. Huart A-S, Saxty B, Merritt A, Nekulova M, Lewis S, Huang Y, Vojtesek B, Kettleborough C, Hupp TR: A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway. Bioorg Med Chem Lett 1, 23:5578-5585. 10.1016/j.bmcl.2013.08.046
62. Bernatik O, Ganji RS, Dijksterhuis JP, Konik P, Cervenka I, Polonio T, Krejci P, Schulte G, Bryja V: Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases. J Biol Chem 1, 286:10396-10410. 10.1074/jbc.M110.169870
63. Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X: Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 1, 108:837-847. 10.1016/S0092-8674(02)00685-2
64. Amit S, Hatzubai A, Birman Y, Andersen JS, Ben-Shushan E, Mann M, Ben-Neriah Y, Alkalay I: Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev 1, 16:1066-1076. 10.1101/gad.230302
65. Carreras Puigvert J, Von Stechow L, Siddappa R, Pines A, Bahjat M, Haazen LCJM, Olsen JV, Vrieling H, Meerman JHN, Mullenders LHF, Van De Water B, Danen EHJ: Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells. Sci Signal 2013, 6:ra5.
66. Ha N-C, Tonozuka T, Stamos JL, Choi H-J, Weis WI: Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell 1, 15:511-521. 10.1016/j.molcel.2004.08.010
67. Hämmerlein A, Weiske J, Huber O: A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/beta-catenin complex. Cell Mol Life Sci 1, 62:606-618. 10.1007/s00018-005-4507-7
68. Knippschild U, Milne DM, Campbell LE, DeMaggio AJ, Christenson E, Hoekstra MF, Meek DW: p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs. Oncogene 1, 15:1727-1736. 10.1038/sj.onc.1201541
69. Dumaz N, Milne DM, Meek DW: Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. FEBS Lett 1, 463:312-316. 10.1016/S0014-5793(99)01647-6
70. Winter M, Milne D, Dias S, Kulikov R, Knippschild U, Blattner C, Meek D: Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover. Biochemistry 1, 43:16356-16364. 10.1021/bi0489255
71. Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y: CKIα ablation highlights a critical role for p53 in invasiveness control. Nature 1, 470:409-413. 10.1038/nature09673
72. Sarasqueta AF, Forte G, Corver WE, de Miranda NF, Ruano D, van Eijk R, Oosting J, Tollenaar RAEM, van Wezel T, Morreau H: Integral analysis of p53 and its value as prognostic factor in sporadic colon cancer. BMC Cancer 1, 13:277. 10.1186/1471-2407-13-277
73. Järås M, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL: Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. J Exp Med 1, 211:605-612. 10.1084/jem.20131033
74. Chen L, Li C, Pan Y, Chen J: Regulation of p53-MDMX interaction by casein kinase 1 alpha. Mol Cell Biol 1, 25:6509-6520. 10.1128/MCB.25.15.6509-6520.2005
75. Venerando A, Marin O, Cozza G, Bustos VH, Sarno S, Pinna LA: Isoform specific phosphorylation of p53 by protein kinase CK1. Cell Mol Life Sci 1, 67:1105-1118. 10.1007/s00018-009-0236-7
76. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao Z-XJ, Kaelin WG, Harper JW, Wei W: Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell 1, 18:147-159. 10.1016/j.ccr.2010.06.015
77. Zhang P, Bill K, Liu J, Young E, Peng T, Bolshakov S, Hoffman A, Song Y, Demicco EG, Terrada DL, Creighton CJ, Anderson ML, Lazar AJ, Calin GG, Pollock RE, Lev D: MiR-155 is a liposarcoma oncogene that targets casein kinase-1α and enhances β-catenin signaling. Cancer Res 1, 72:1751-1762. 10.1158/0008-5472.CAN-11-3027
78. Lee C, Etchegaray JP, Cagampang FR, Loudon AS, Reppert SM: Posttranslational mechanisms regulate the mammalian circadian clock. Cell 1, 107:855-867. 10.1016/S0092-8674(01)00610-9
79. Yong TJ, Gan YY, Toh BH, Sentry JW: Human CKIalpha(L) and CKIalpha(S) are encoded by both 2.4- and 4. 2-kb transcripts, the longer containing multiple RNA-destablising elements. Biochim Biophys Acta 1, 1492:425-433. 10.1016/S0167-4781(00)00146-9
80. Green CL, Bennett GS: Identification of four alternatively spliced isoforms of chicken casein kinase I alpha that are all expressed in diverse cell types. Gene 1, 216:189-195. 10.1016/S0378-1119(98)00291-1
81. Fu Z, Green CL, Bennett GS: Relationship between casein kinase I isoforms and a neurofilament-associated kinase. J Neurochem 1999, 73:830-838.
82. Budini M, Jacob G, Jedlicki A, Pérez C, Allende CC, Allende JE: Autophosphorylation of carboxy-terminal residues inhibits the activity of protein kinase CK1alpha. J Cell Biochem 1, 106:399-408. 10.1002/jcb.22019
83. Cegielska A, Gietzen KF, Rivers A, Virshup DM: Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis. J Biol Chem 1, 273:1357-1364. 10.1074/jbc.273.3.1357
84. Graves PR, Roach PJ: Role of COOH-terminal phosphorylation in the regulation of casein kinase I delta. J Biol Chem 1, 270:21689-21694. 10.1074/jbc.270.37.21689
85. Longenecker KL, Roach PJ, Hurley TD: Crystallographic studies of casein kinase I delta toward a structural understanding of auto-inhibition. Acta Crystallogr D Biol Crystallogr 1998,54(Pt 3):473-475.
86. Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM 3rd, Lee E, Miller DM: Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nat Chem Biol 1, 6:829-836. 10.1038/nchembio.453
87. Maritzen T, Lohler J, Deppert W, Knippschild U: Casein kinase I delta (CKIdelta) is involved in lymphocyte physiology. Eur J Cell Biol 1, 82:369-378. 10.1078/0171-9335-00323
88. Masuda K, Ono M, Okamoto M, Morikawa W, Otsubo M, Migita T, Tsuneyoshi M, Okuda H, Shuin T, Naito S, Kuwano M: Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells. Int J Cancer 1, 105:803-810. 10.1002/ijc.11152
89. Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, Radunsky B, Ammerpohl O, Bohm B, Henne-Bruns D, Kalthoff H, Leithäuser F, Trauzold A, Knippschild U, Leithäuser F: Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo. Gut 1, 57:799-806. 10.1136/gut.2007.123695
90. Knippschild U, Krüger M, Richter J, Xu P, García-Reyes B, Peifer C, Halekotte J, Bakulev V, Bischof J: The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis. Front Oncol 2014, 4:96.
91. Sun D, Zhou M, Kowolik CM, Trisal V, Huang Q, Kernstine KH, Lian F, Shen B: Differential expression patterns of capping protein, protein phosphatase 1, and casein kinase 1 may serve as diagnostic markers for malignant melanoma. Melanoma Res 2011, 21:335-343. 10.1097/CMR.0b013e328346b715
92. Fuja TJ, Lin F, Osann KE, Bryant PJ: Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Cancer Res 2004, 64:942-951. 10.1158/0008-5472.CAN-03-2100
93. Tsai I-C, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM: Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer 2007, 120:1005-1012.
94. Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N: ntegrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013, 6:pl1.
95. Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, Antipin Y, Reva B, Goldberg AP, Sander C, Schultz N: The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 1, 2:401-404. 10.1158/2159-8290.CD-12-0095
96. Antonov AV, Krestyaninova M, Knight RA, Rodchenkov I, Melino G, Barlev NA: PPISURV: a novel bioinformatics tool for uncovering the hidden role of specific genes in cancer survival outcome. Oncogene 1, 33:1621-1628. 10.1038/onc.2013.119
97. Kim SY, Dunn IF, Firestein R, Gupta P, Wardwell L, Repich K, Schinzel AC, Wittner B, Silver SJ, Root DE, Boehm JS, Ramaswamy S, Lander ES, Hahn WC: CK1epsilon is required for breast cancers dependent on beta-catenin activity. PLoS One 1, 5:e8979. 10.1371/journal.pone.0008979
98. Lin S-H, Lin Y-M, Yeh C-M, Chen C-J, Chen M-W, Hung H-F, Yeh K-T, Yang S-F: Casein kinase 1 epsilon expression predicts poorer prognosis in low T-stage oral cancer patients. Int J Mol Sci 1, 15:2876-2891. 10.3390/ijms15022876
99. Cheong JK, Nguyen TH, Wang H, Tan P, Voorhoeve PM, Lee SH, Virshup DM: IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ε and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene 1, 30:2558-2569. 10.1038/onc.2010.627
100. Hirner H, Günes C, Bischof J, Wolff S, Grothey A, Kühl M, Oswald F, Wegwitz F, Bösl MR, Trauzold A, Henne-Bruns D, Peifer C, Leithäuser F, Deppert W, Knippschild U: Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS One 1, 7:e29709. 10.1371/journal.pone.0029709
101. Sinnberg T, Menzel M, Ewerth D, Sauer B, Schwarz M, Schaller M, Garbe C, Schittek B: β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One 1, 6:e23429. 10.1371/journal.pone.0023429
102. Vaid M, Prasad R, Sun Q, Katiyar SK: Silymarin Targets ?-Catenin Signaling in Blocking Migration/Invasion of Human Melanoma Cells. PLoS One 1, 6:e23000. 10.1371/journal.pone.0023000
103. Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, Berger AJ, Major MB, Hwang ST, Rimm DL, Moon RT: Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A 1, 106:1193-1198. 10.1073/pnas.0811902106
104. Lucero OM, Dawson DW, Moon RT, Chien AJ: A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep 1, 12:314-318. 10.1007/s11912-010-0114-3
105. Chien AJ, Haydu LE, Biechele TL, Kulikauskas RM, Rizos H, Kefford RF, Scolyer RA, Moon RT, Long GV: Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling. PLoS One 1, 9:e94748. 10.1371/journal.pone.0094748
106. Yu DH, Macdonald J, Liu G, Lee AS, Ly M, Davis T, Ke N, Zhou D, Wong Staal F, Li QX: Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. PLoS One 1, 3:e3951. 10.1371/journal.pone.0003951
107. Deng L, Lei Y, Liu R, Li J, Yuan K, Li Y, Chen Y, Liu Y, Lu Y, Edwards CK, Huang C, Wei Y: Pyrvinium targets autophagy addiction to promote cancer cell death. Cell Death Dis 1, 4:e614. 10.1038/cddis.2013.142
108. Zou F-Y, Xie H-L, Chen Z-C, He C-M, Guan Y-J, Li YJ: [Effect of HLCDG1 gene transfection on growth of lung carcinoma cells]. Ai Zheng 2003, 22:1121-1126.
109. Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y: A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell 1, 24:242-256. 10.1016/j.ccr.2013.06.005
110. Toyoshima M, Howie HL, Imakura M, Walsh RM, Annis JE, Chang AN, Frazier J, Chau BN, Loboda A, Linsley PS, Cleary MA, Park JR, Grandori C: Functional genomics identifies therapeutic targets for MYC-driven cancer. Proc Natl Acad Sci U S A 1, 109:9545-9550. 10.1073/pnas.1121119109
111. Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR: Development of highly selective casein kinase 1δ/1 (CK1δ/) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett 1, 23:4374-4380. 10.1016/j.bmcl.2013.05.075