Phosphorylation by Casein Kinase I promotes the turnover of the Mdm2 oncoprotein via the SCFβ-TRCP ubiquitin ligase

Cancer Cell

Volumn 18, Issue 2, 2010, Pages 147-159

  Inuzuka, Hiroyuki ^a   Tseng, Alan ^a   Gao, Daming ^a   Zhai, Bo ^a   Zhang, Qing ^b   Shaik, Shavali ^a   Wan, Lixin ^a   Ang, Xiaolu L ^a   Mock, Caroline ^a   Yin, Haoqiang ^b,c   Stommel, Jayne M ^b   Gygi, Steven ^a   Lahav, Galit ^a   Asara, John ^a   Xiao, Zhi Xiong Jim ^c   Kaelin, William G ^b   Harper, J Wade ^a   Wei, Wenyi ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Cellcycle

Indexed keywords

BETA CATENIN; CASEIN KINASE I; CELL CYCLE PROTEIN 20; CYCLIN A; CYCLIN B; CYCLIN E; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MYC PROTEIN; POLO LIKE KINASE 1; PROTEIN BAX; PROTEIN MDM2; PROTEIN P27; PROTEIN P53; SCF BETA TRCP UBIQUITIN LIGASE; TUBULIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; VINCULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER GROWTH; CONTROLLED STUDY; DNA DAMAGE; ENZYME INACTIVATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION;

EID: 77955535107     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2010.06.015     Document Type: Article

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