Somatic Mutations and Altered Expression of the Candidate Tumor Suppressors CSNK1ε, DLG1, and EDD/hHYD in Mammary Ductal Carcinoma

Cancer Research

Volumn 64, Issue 3, 2004, Pages 942-951

  Fuja, Tannin J ^a   Lin, Fritz ^c   Osann, Kathryn E ^b   Bryant, Peter J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE I; DNA; GESTAGEN; KI 67 ANTIGEN; PROGESTERONE RECEPTOR; PROTEIN P53; SERINE; THREONINE; UBIQUITIN PROTEIN LIGASE;

ARTICLE; BREAST CARCINOMA; BREAST DUCT; CONTROLLED STUDY; CSNK1 EPSILON GENE; DLG1 GENE; DROSOPHILA; EDD GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; HETEROZYGOSITY LOSS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER MICRODISSECTION; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; POINT MUTATION; PRIORITY JOURNAL; SOMATIC MUTATION; STAINING; STATISTICAL SIGNIFICANCE; TISSUE GROWTH; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CASE-CONTROL STUDIES; CASEIN KINASES; DNA, NEOPLASM; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; LOSS OF HETEROZYGOSITY; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN KINASES; PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 0842347491     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2100     Document Type: Article

References (58)

1. Li, C. I., Anderson, B. O., Daling, J. R., and Moe, R. E. Trends in incidence rates of invasive lobular and ductal breast carcinoma. J. Am. Med. Assoc., 289: 1421-1424, 2003.
2. Weiss, N. S. Breast cancer mortality in relation to clinical breast examination and breast self-examination. Breast J., 9 (Suppl. 2): S86-S89, 2003.
3. Gruvberger, S. K., Ringner, M., Eden, P., Borg, A., Ferno, M., Peterson, C., and Meltzer, P. S. Expression profiling to predict outcome in breast cancer: the influence of sample selection. Breast Cancer Res., 5: 23-26, 2002.
4. Balmain, A., Gray, J., and Ponder, B. The genetics and genomics of cancer. Nat. Genet., 33 (Suppl.): 238-244, 2003.
5. Lou, Z., and Chen, J. Brca proteins and DNA damage checkpoints. Front Biosci., 8: S718-S721, 2003.
6. Vasen, H. F. Screening in breast cancer families: is it useful? Ann. Med., 26: 185-190, 1994.
7. Keen, J. C., and Davidson, N. E. The biology of breast carcinoma. Cancer (Phila.), 97: 825-833, 2003.
8. Porter, D., Lahti-Domenici, J., Keshaviah, A., Bae, Y. K., Argani, P., Marks, J., Richardson, A., Cooper, A., Strausberg, R., Riggins, G. J., Schnitt, S., Gabrielson, E., Gelman, R., and Polyak, K. Molecular markers in ductal carcinoma in situ of the breast. Mol. Cancer Res., 1: 362-375, 2003.
9. Balmain, A. Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models. Cell, 108: 145-152, 2002.
10. Rubin, G. M., and Lewis, E. B. A brief history of Drosophila's contributions to genome research. Science (Wash. DC), 287: 2216-2218, 2000.
11. Bryant, P. J., and Schmidt, O. The genetic control of cell proliferation in Drosophila imaginal discs. J. Cell Sci. Suppl., 13: 169-189, 1990.
12. Potter, C. J., Turenchalk, G. S., and Xu, T. Drosophila in cancer research. An expanding role. Trends. Genet., 16: 33-39, 2000.
13. Jursnich, V. A., Fraser, S. E., Held, L. I. J., Ryerse, J., and Bryant, P. J. Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila. Dev. Biol., 140: 413-429, 1990.
14. Zilian, O., Frei, E., Burke, R., Brentrup, D., Gutjahr, T., Bryant, P. J., and Noll, M. Double-time is identical to discs overgrown, which is required for cell survival, proliferation and growth arrest in Drosophila imaginal discs. Development (Camb.), 126: 5409-5420, 1999.
15. Amit, S., Hatzubai, A., Birman, Y., Andersen, J. S., Ben Shushan, E., Mann, M., Ben Neriah, Y., and Alkalay, I. Axin-mediated CK1 phosphorylation of β-catenin at Ser 45: a molecular switch for the Wnt pathway. Genes Dev., 16: 1066-1076, 2002.
16. Yanagawa, S., Matsuda, Y., Lee, J. S., Matsubayashi, H., Sese, S., Kadowaki, T., and Ishimoto, A. Casein kinase 1 phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J., 21: 1733-1742, 2002.
17. Caruana, G. Genetic studies define MAGUK proteins as regulators of epithelial cell polarity. Int. J. Dev. Biol., 46: 511-518, 2002.
18. Marfatia, S. M., Byron, O., Campbell, G. Liu, S. C., and Chishti, A. H. Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site. J. Biol. Chem., 275: 13759-13770, 2000.
19. Purmonen, S., Ahola, T. M., Pennanen, P., Aksenov, N., Zhuang, Y. H., Tuohimaa, P., and Ylikomi, T. HDLG5/K1AA0583, encoding a MAGUK-family protein, is a primary progesterone target gene in breast cancer cells. Int. J. Cancer, 102: 1-6, 2002.
20. Müller, B. M., Kistner, U., Veh, R. W., Cases-Langhoff, C., Becker, B., Gundelfinger, E. D., and Garner, C. C. Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J. Neurosci., 15: 2354-2366, 1995.
21. Watson, R. A., Rollason, T. P., Reynolds, G. M., Murray, P. G., Banks, L., and Roberts, S. Changes in expression of the human homologue of the Drosophila discs large tumour suppressor protein in high-grade premalignant cervical neoplasias. Carcinogenesis (Lond.), 23: 1791-1796, 2002.
22. Liu, L. X., Liu, Z. H., Jiang, H. C., Qu, X., Zhang, W. H., Wu, L. F., Zhu, A. L., Wang, X. Q., and Wu, M. Profiling of differentially expressed genes in human gastric carcinoma by cDNA expression array. World J. Gastroenterol., 8: 580-585, 2002.
23. Caruana, G., and Bernstein, A. Craniofacial dysmorphogenesis including cleft palate in mice with an insertional mutation in the discs large gene. Mol. Cell. Biol., 21: 1475-1483, 2001.
24. Nix, S. L., Chishti, A. H., Anderson, J. M., and Walther, Z. hCASK and hDlg associate in epithelia, and their src homology 3 and guanylate kinase domains participate in both intramolecular and intermolecular interactions. J. Biol Chem., 275: 41192-41200, 2000.
25. 1 to S phase. Oncogene, 19: 365-372, 2000.
26. Adey, N. B., Huang, L., Ormonde, P. A., Baumgard, M. L., Pero, R., Byreddy, D. V., Tavtigian, S. V., and Bartel, P. L. Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding. Cancer Res., 60: 35-37, 2000.
27. Kiyono, T., Hiraiwa, A., Fujita, M., Hayashi, Y., Akiyama, T., and Ishibashi, M. Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc. Natl. Acad. Sci. USA, 94: 11612-11616, 1997.
28. Henderson, M. J., Russell, A. J., Hird, S., Munoz, M., Clancy, J. L., Lehrbach, G. M., Calanni, S. T., Jans, D. A., Sutherland, R. L., and Watts, C. K. EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. J. Biol. Chem., 277: 26468-26478, 2002.
29. Callaghan, M. J., Russell, A. J., Woollatt, E., Sutherland, G. R., Sutherland, R. L., and Watts, C. K. Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. Oncogene, 17: 3479-3491, 1998.
30. Lee, J. D., Amanai, K., Shearn, A., and Treisman, J. E. The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms. Development (Camb.), 129: 5697-5706, 2002.
31. Mansfield, E., Hersperger, E., Biggs, J., and Shearn, A. Genetic and molecular analysis of hyperplastic discs, a gene whose product is required for regulation of cell proliferation in Drosophila melanogaster imaginal discs and germ cells. Dev. Biol., 165: 507-526, 1994.
32. Honda, Y., Tojo, M., Matsuzaki, K., Anan, T., Matsumoto, M., Ando M., Saya H., and Nakao, M. Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. J. Biol. Chem., 277: 3599-3605, 2002.
33. Amat, S., Penault-Llorca, F., Cure, H., Le Bouedec, G., Achard, J. L., Van, P., I. Feillel, V., Mouret-Reynier, M. A., Dauplat, J., and Chollet, P. Scarff-Bloom-Richardson (SBR) grading: a pleiotropic marker of chemosensitivity in invasive ductal breast carcinomas treated by neoadjuvant chemotherapy. Int. J. Oncol. 20: 791-796, 2002.
34. Blumenstein, R., Dias, M., Russo, I. H., Tahin, Q., and Russo, J. DNA content and cell number determination in microdissected samples of breast carcinoma in situ. Int. J. Oncol., 21: 447-450, 2002.
35. Zhu, W., Zou, H., Beck, A., Chervinsky, D., Malik, D., Brooks, J., and Tan, D. Loss of heterozygosity in primary lung cancer using laser capture microdissection and WAVE DNA fragment analysis techniques. Med. Sci. Monit., 8: BR95-BR99, 2002.
36. Reifenberger, J., Knobbe, C. B., Wolter, M., Blaschke, B., Schulte, K. W., Pietsch, T., Ruzicka, T., and Reifenberger, G. Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT, and BTRC. Int. J. Cancer. 100: 549-556, 2002.
37. Schildkraut, J. M., Collins, N. K., Dent, G. A., Tucker, J. A., Barrett, J. C., Berchuck, A., and Boyd, J. Loss of heterozygosity on chromosome 17q11-21 in cancers of women who have both breast and ovarian cancer. Am. J. Obstet. Gynecol., 172: 908-913, 1995.
38. Callen, D. F., Crawford, J., Derwas, C., Cleton-Jansen, A. M., Cornelisse, C. J., and Baker, E. Defining regions of loss of heterozygosity of 16q in breast cancer cell lines. Cancer Genet. Cytogenet., 133: 76-82, 2002.
39. Kleymenova, E., and Walker, C. L. Determination of loss of heterozygosity in frozen and paraffin embedded tumors by denaturing high-performance liquid chromatography (DHPLC). J. Biochem. Biophys. Methods, 47: 83-90, 2001.
40. Liu, W., Smith, D. I., Rechtzigel, K. J., Thibodeau, S. N., and James, C. D. Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations. Nucleic Acids Res., 26: 1396-1400, 1998.
41. Cobb, C. J., Scott, G., Swingler, R. J., Wilson, S., Ellis, J., MacEwen, C. J., and McLean, W. H. Rapid mutation detection by the transgenomic wave analyser DHPLC identifies MYOC mutations in patients with ocular hypertension and/or open angle glaucoma. Br. J. Ophthalmol., 86: 191-195, 2002.
42. Rossetti, S., Chauveau, D., Walker, D., Saggar-Malik, A., Winearls, C. G., Torres, V. E., and Harris, P. C. A complete mutation screen of the ADPKD genes by DHPLC. Kidney Int., 61: 1588-1599, 2002.
43. Frost, A. R., Sparks, D., and Grizzle, W. E. Methods of antigen recovery vary in their usefulness in unmasking specific antigens in immunohistochemistry. Appl. Immunohistochem. Mol. Morphol., 8: 236-243, 2000.
44. Winer, B. J. Statistical Principles in Experimental Design, Ed. 2. New York City: McGraw-Hill, 1971.
45. Nusse, R. The int genes in mouse mammary tumorigenesis and in normal development. CIBA Found. Symp., 150: 212-222; discussion 222-226, 1990.
46. Brown, A. M. Wnt signaling in breast cancer: have we come full circle? Breast Cancer Res., 3: 351-355, 2001.
47. Lin, S. Y., Xia, W., Wang, J. C., Kwong, K. Y., Spohn, B., Wen, Y., Pestell, R. G., and Hung, M. C. β-Catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc. Natl. Acad. Sci. USA, 97: 4262-4266, 2000.
48. Wong, S. C., Lo, S. F., Lee, K. C., Yam, J. W., Chan, J. K., and Wendy Hsiao, W. L. Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours. J. Pathol., 196: 145-153, 2002.
49. Sakanaka, C., Leong, P., Xu, L., Harrison, S. D., and Williams, L. T. Casein kinase 1 epsilon in the wnt pathway: regulation of β-catenin function. Proc. Natl. Acad. Sci. USA, 96: 12548-12552, 1999.
50. Peters, J. M., McKay, R. M., McKay, J. P., and Graff, J. M. Casein kinase 1 transduces Wnt signals. Nature (Lond.), 401: 345-350, 1999.
51. Lee, E., Salic, A., and Kirschner, M. W. Physiological regulation of β-catenin stability by Tcf3 and CK1ε. J. Cell Biol., 154: 983-993, 2001.
52. Rubinfeld, B., Tice, D. A., and Polakis, P. Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase lepsilon. J. Biol. Chem., 276: 39037-39045, 2001.
53. Matsumine, A., Ogai, A., Senda, T., Okumura, N., Satoh, K., Baeg, G. H., Kawahara, T., Kobayashi, S., Okada, M., Toyoshima, K., and Akiyama, T. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science (Wash. DC). 272: 1020-1023, 1996.
54. Hering, H., and Sheng, M. Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. FEBS Lett., 521: 185-189, 2002.
55. Bardelli, A., Parsons, D. W., Silliman, N., Ptak, J., Szabo, S., Saha, S., Markowitz, S., Willson, J. K., Parmigiani, G., Kinzler, K. W., Vogelstein, B., and Velculescu, V. E. Mutational analysis of the tyrosin kinome in colorectal cancers. Science (Wash. DC), 300: 949, 2003.
56. Watson, K. L., Justice, R. W., and Bryant, P. J. Drosophila in cancer research: the first fifty tumor suppressor genes. J. Cell Sci. Suppl., 18: 19-33, 1994.
57. Hay, B. A., and Guo, M. Coupling cell growth, proliferation, and death. Hippo weighs in. Dev. Cell. 5: 361-363, 2003.
58. Pearson, W. R., Wood, T., Zhang, Z., and Miller, W. Comparison of DNA sequences with protein sequences. Genomics. 46: 24-36, 1997.