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Volumn 6, Issue 8, 2011, Pages

β-catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA CATENIN; CISPLATIN; DOXORUBICIN; DOXYCYCLINE; PKF 115 584; SHORT HAIRPIN RNA; TEMOZOLOMIDE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; PERYLENE; PKF115 584; PKF115-584; T CELL FACTOR PROTEIN;

EID: 80051738374     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023429     Document Type: Article
Times cited : (108)

References (58)
  • 1
    • 0037155691 scopus 로고    scopus 로고
    • Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu C, Li Y, Semenov M, Han C, Baeg GH, et al. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108: 837-847.
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.H.5
  • 2
    • 0344442773 scopus 로고    scopus 로고
    • Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex
    • Xing Y, Clements WK, Kimelman D, Xu W, (2003) Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Genes Dev 17: 2753-2764.
    • (2003) Genes Dev , vol.17 , pp. 2753-2764
    • Xing, Y.1    Clements, W.K.2    Kimelman, D.3    Xu, W.4
  • 3
    • 0030975671 scopus 로고    scopus 로고
    • Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
    • Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, et al. (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275: 1784-1787.
    • (1997) Science , vol.275 , pp. 1784-1787
    • Korinek, V.1    Barker, N.2    Morin, P.J.3    van Wichen, D.4    de Weger, R.5
  • 4
    • 0033486152 scopus 로고    scopus 로고
    • Beta-catenin signaling and cancer
    • Morin PJ, (1999) beta-catenin signaling and cancer. Bioessays 21: 1021-1030.
    • (1999) Bioessays , vol.21 , pp. 1021-1030
    • Morin, P.J.1
  • 5
    • 33745758173 scopus 로고    scopus 로고
    • Defining the conditions for the generation of melanocytes from human embryonic stem cells
    • Fang D, Leishear K, Nguyen TK, Finko R, Cai K, et al. (2006) Defining the conditions for the generation of melanocytes from human embryonic stem cells. Stem Cells 24: 1668-1677.
    • (2006) Stem Cells , vol.24 , pp. 1668-1677
    • Fang, D.1    Leishear, K.2    Nguyen, T.K.3    Finko, R.4    Cai, K.5
  • 6
    • 14544303647 scopus 로고    scopus 로고
    • Pax3 functions at a nodal point in melanocyte stem cell differentiation
    • Lang D, Lu MM, Huang L, Engleka KA, Zhang M, et al. (2005) Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature 433: 884-887.
    • (2005) Nature , vol.433 , pp. 884-887
    • Lang, D.1    Lu, M.M.2    Huang, L.3    Engleka, K.A.4    Zhang, M.5
  • 7
    • 36249026528 scopus 로고    scopus 로고
    • Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
    • Delmas V, Beermann F, Martinozzi S, Carreira S, Ackermann J, et al. (2007) Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development. Genes Dev 21: 2923-2935.
    • (2007) Genes Dev , vol.21 , pp. 2923-2935
    • Delmas, V.1    Beermann, F.2    Martinozzi, S.3    Carreira, S.4    Ackermann, J.5
  • 8
    • 41049095461 scopus 로고    scopus 로고
    • A new mechanism of release from senescence: suppression of p16INK4a by beta-catenin
    • Curley DP, Bosenberg MW, (2008) A new mechanism of release from senescence: suppression of p16INK4a by beta-catenin. Pigment Cell Melanoma Res 21: 5-6.
    • (2008) Pigment Cell Melanoma Res , vol.21 , pp. 5-6
    • Curley, D.P.1    Bosenberg, M.W.2
  • 9
    • 0032937232 scopus 로고    scopus 로고
    • Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma
    • Rimm DL, Caca K, Hu G, Harrison FB, Fearon ER, (1999) Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma. Am J Pathol 154: 325-329.
    • (1999) Am J Pathol , vol.154 , pp. 325-329
    • Rimm, D.L.1    Caca, K.2    Hu, G.3    Harrison, F.B.4    Fearon, E.R.5
  • 10
    • 0035877115 scopus 로고    scopus 로고
    • Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma
    • Omholt K, Platz A, Ringborg U, Hansson J, (2001) Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma. Int J Cancer 92: 839-842.
    • (2001) Int J Cancer , vol.92 , pp. 839-842
    • Omholt, K.1    Platz, A.2    Ringborg, U.3    Hansson, J.4
  • 12
    • 32944460267 scopus 로고    scopus 로고
    • The WNT/Beta-catenin pathway in melanoma
    • Larue L, Delmas V, (2006) The WNT/Beta-catenin pathway in melanoma. Front Biosci 11: 733-742.
    • (2006) Front Biosci , vol.11 , pp. 733-742
    • Larue, L.1    Delmas, V.2
  • 13
    • 0037455843 scopus 로고    scopus 로고
    • Tissue microarray-based analysis shows phospho-beta-catenin expression in malignant melanoma is associated with poor outcome
    • Kielhorn E, Provost E, Olsen D, D'Aquila TG, Smith BL, et al. (2003) Tissue microarray-based analysis shows phospho-beta-catenin expression in malignant melanoma is associated with poor outcome. Int J Cancer 103: 652-656.
    • (2003) Int J Cancer , vol.103 , pp. 652-656
    • Kielhorn, E.1    Provost, E.2    Olsen, D.3    D'Aquila, T.G.4    Smith, B.L.5
  • 15
    • 0037119948 scopus 로고    scopus 로고
    • Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor
    • Widlund HR, Horstmann MA, Price ER, Cui J, Lessnick SL, et al. (2002) Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol 158: 1079-1087.
    • (2002) J Cell Biol , vol.158 , pp. 1079-1087
    • Widlund, H.R.1    Horstmann, M.A.2    Price, E.R.3    Cui, J.4    Lessnick, S.L.5
  • 16
    • 59049101982 scopus 로고    scopus 로고
    • Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model
    • Chien AJ, Moore EC, Lonsdorf AS, Kulikauskas RM, Rothberg BG, et al. (2009) Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model. Proc Natl Acad Sci U S A 106: 1193-1198.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 1193-1198
    • Chien, A.J.1    Moore, E.C.2    Lonsdorf, A.S.3    Kulikauskas, R.M.4    Rothberg, B.G.5
  • 17
    • 53449090205 scopus 로고    scopus 로고
    • Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice
    • Takahashi Y, Nishikawa M, Suehara T, Takiguchi N, Takakura Y, (2008) Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice. Int J Cancer 123: 2315-2320.
    • (2008) Int J Cancer , vol.123 , pp. 2315-2320
    • Takahashi, Y.1    Nishikawa, M.2    Suehara, T.3    Takiguchi, N.4    Takakura, Y.5
  • 18
    • 70350100352 scopus 로고    scopus 로고
    • Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt
    • O'Connell MP, Weeraratna AT, (2009) Hear the Wnt Ror: how melanoma cells adjust to changes in Wnt. Pigment Cell Melanoma Res 22: 724-739.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 724-739
    • O'Connell, M.P.1    Weeraratna, A.T.2
  • 19
    • 49549120607 scopus 로고    scopus 로고
    • GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes
    • Bellei B, Flori E, Izzo E, Maresca V, Picardo M, (2008) GSK3beta inhibition promotes melanogenesis in mouse B16 melanoma cells and normal human melanocytes. Cell Signal 20: 1750-1761.
    • (2008) Cell Signal , vol.20 , pp. 1750-1761
    • Bellei, B.1    Flori, E.2    Izzo, E.3    Maresca, V.4    Picardo, M.5
  • 20
    • 77956266718 scopus 로고    scopus 로고
    • A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers
    • Lucero OM, Dawson DW, Moon RT, Chien AJ, (2010) A re-evaluation of the "oncogenic" nature of Wnt/beta-catenin signaling in melanoma and other cancers. Curr Oncol Rep 12: 314-318.
    • (2010) Curr Oncol Rep , vol.12 , pp. 314-318
    • Lucero, O.M.1    Dawson, D.W.2    Moon, R.T.3    Chien, A.J.4
  • 21
    • 77956297018 scopus 로고    scopus 로고
    • Suppression of Casein Kinase 1a in Melanoma Cells Induces a Switch in β-Catenin Signaling to Promote Metastasis
    • Sinnberg T, Menzel M, Kaesler S, Biedermann T, Sauer B, et al. (2010) Suppression of Casein Kinase 1a in Melanoma Cells Induces a Switch in β-Catenin Signaling to Promote Metastasis. Cancer Res 70: 6999-7009.
    • (2010) Cancer Res , vol.70 , pp. 6999-7009
    • Sinnberg, T.1    Menzel, M.2    Kaesler, S.3    Biedermann, T.4    Sauer, B.5
  • 22
    • 0001278782 scopus 로고    scopus 로고
    • Melanoma: The Wistar Melanoma (WM) Cell Lines
    • In: Masters JaPB, editors, Kluwer Academic Publishers
    • Hsu M-YEDHM, (1999) Melanoma: The Wistar Melanoma (WM) Cell Lines. In: Masters JaPB, editors. Human Cell Culture, Vol I Kluwer Academic Publishers pp. 259-274.
    • (1999) Human Cell Culture , vol.I , pp. 259-274
    • Hsu, M.-Y.E.D.H.M.1
  • 23
    • 34147097875 scopus 로고    scopus 로고
    • The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance
    • Schittek B, Psenner K, Sauer B, Meier F, Iftner T, et al. (2007) The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance. Int J Cancer 120: 2110-2118.
    • (2007) Int J Cancer , vol.120 , pp. 2110-2118
    • Schittek, B.1    Psenner, K.2    Sauer, B.3    Meier, F.4    Iftner, T.5
  • 24
    • 33745075558 scopus 로고    scopus 로고
    • Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
    • Smalley KS, Haass NK, Brafford PA, Lioni M, Flaherty KT, et al. (2006) Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases. Mol Cancer Ther 5: 1136-1144.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1136-1144
    • Smalley, K.S.1    Haass, N.K.2    Brafford, P.A.3    Lioni, M.4    Flaherty, K.T.5
  • 25
    • 1642512639 scopus 로고    scopus 로고
    • Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
    • Lepourcelet M, Chen YN, France DS, Wang H, Crews P, et al. (2004) Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 5: 91-102.
    • (2004) Cancer Cell , vol.5 , pp. 91-102
    • Lepourcelet, M.1    Chen, Y.N.2    France, D.S.3    Wang, H.4    Crews, P.5
  • 26
    • 0034889197 scopus 로고    scopus 로고
    • Drug synergism: its detection and applications
    • Tallarida RJ, (2001) Drug synergism: its detection and applications. J Pharmacol Exp Ther 298: 865-872.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 865-872
    • Tallarida, R.J.1
  • 27
    • 41649089525 scopus 로고    scopus 로고
    • Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
    • Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, et al. (2008) Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature 452: 650-653.
    • (2008) Nature , vol.452 , pp. 650-653
    • Malanchi, I.1    Peinado, H.2    Kassen, D.3    Hussenet, T.4    Metzger, D.5
  • 28
    • 0037444482 scopus 로고    scopus 로고
    • A beta-catenin survival signal is required for normal lobular development in the mammary gland
    • Tepera SB, McCrea PD, Rosen JM, (2003) A beta-catenin survival signal is required for normal lobular development in the mammary gland. J Cell Sci 116: 1137-1149.
    • (2003) J Cell Sci , vol.116 , pp. 1137-1149
    • Tepera, S.B.1    McCrea, P.D.2    Rosen, J.M.3
  • 29
    • 34250678970 scopus 로고    scopus 로고
    • Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma
    • Sukhdeo K, Mani M, Zhang Y, Dutta J, Yasui H, et al. (2007) Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. Proc Natl Acad Sci U S A 104: 7516-7521.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 7516-7521
    • Sukhdeo, K.1    Mani, M.2    Zhang, Y.3    Dutta, J.4    Yasui, H.5
  • 30
    • 0035893568 scopus 로고    scopus 로고
    • Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer
    • Zhang T, Otevrel T, Gao Z, Gao Z, Ehrlich SM, et al. (2001) Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer. Cancer Res 61: 8664-8667.
    • (2001) Cancer Res , vol.61 , pp. 8664-8667
    • Zhang, T.1    Otevrel, T.2    Gao, Z.3    Gao, Z.4    Ehrlich, S.M.5
  • 31
    • 58649124942 scopus 로고    scopus 로고
    • The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cells
    • Lapham A, Adams JE, Paterson A, Lee M, Brimmell M, et al. (2009) The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cells. Gene 432: 112-117.
    • (2009) Gene , vol.432 , pp. 112-117
    • Lapham, A.1    Adams, J.E.2    Paterson, A.3    Lee, M.4    Brimmell, M.5
  • 33
    • 34347364625 scopus 로고    scopus 로고
    • A novel role of phospho-beta-catenin in microtubule regrowth at centrosome
    • Huang P, Senga T, Hamaguchi M, (2007) A novel role of phospho-beta-catenin in microtubule regrowth at centrosome. Oncogene 26: 4357-4371.
    • (2007) Oncogene , vol.26 , pp. 4357-4371
    • Huang, P.1    Senga, T.2    Hamaguchi, M.3
  • 34
    • 1642442739 scopus 로고    scopus 로고
    • Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle
    • Kaplan DD, Meigs TE, Kelly P, Casey PJ, (2004) Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem 279: 10829-10832.
    • (2004) J Biol Chem , vol.279 , pp. 10829-10832
    • Kaplan, D.D.1    Meigs, T.E.2    Kelly, P.3    Casey, P.J.4
  • 35
    • 35348943278 scopus 로고    scopus 로고
    • Phospho-regulation of Beta-catenin adhesion and signaling functions
    • Daugherty RL, Gottardi CJ, (2007) Phospho-regulation of Beta-catenin adhesion and signaling functions. Physiology (Bethesda) 22: 303-309.
    • (2007) Physiology (Bethesda) , vol.22 , pp. 303-309
    • Daugherty, R.L.1    Gottardi, C.J.2
  • 37
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson WJ, Nusse R, (2004) Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303: 1483-1487.
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 38
    • 2942612844 scopus 로고    scopus 로고
    • Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling
    • Li G, Fukunaga M, Herlyn M, (2004) Reversal of melanocytic malignancy by keratinocytes is an E-cadherin-mediated process overriding beta-catenin signaling. Exp Cell Res 297: 142-151.
    • (2004) Exp Cell Res , vol.297 , pp. 142-151
    • Li, G.1    Fukunaga, M.2    Herlyn, M.3
  • 39
    • 67449106155 scopus 로고    scopus 로고
    • Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells
    • Medrek C, Landberg G, Andersson T, Leandersson K, (2009) Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells. J Biol Chem 284: 10968-10979.
    • (2009) J Biol Chem , vol.284 , pp. 10968-10979
    • Medrek, C.1    Landberg, G.2    Andersson, T.3    Leandersson, K.4
  • 40
    • 0035913994 scopus 로고    scopus 로고
    • Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential
    • Murakami T, Toda S, Fujimoto M, Ohtsuki M, Byers HR, et al. (2001) Constitutive activation of Wnt/beta-catenin signaling pathway in migration-active melanoma cells: role of LEF-1 in melanoma with increased metastatic potential. Biochem Biophys Res Commun 288: 8-15.
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 8-15
    • Murakami, T.1    Toda, S.2    Fujimoto, M.3    Ohtsuki, M.4    Byers, H.R.5
  • 41
    • 24344467835 scopus 로고    scopus 로고
    • Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway
    • Qi J, Chen N, Wang J, Siu CH, (2005) Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway. Mol Biol Cell 16: 4386-4397.
    • (2005) Mol Biol Cell , vol.16 , pp. 4386-4397
    • Qi, J.1    Chen, N.2    Wang, J.3    Siu, C.H.4
  • 42
    • 58849147900 scopus 로고    scopus 로고
    • Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells
    • Minke KS, Staib P, Puetter A, Gehrke I, Gandhirajan RK, et al. (2009) Small molecule inhibitors of WNT signaling effectively induce apoptosis in acute myeloid leukemia cells. Eur J Haematol 82: 165-175.
    • (2009) Eur J Haematol , vol.82 , pp. 165-175
    • Minke, K.S.1    Staib, P.2    Puetter, A.3    Gehrke, I.4    Gandhirajan, R.K.5
  • 44
    • 77951877496 scopus 로고    scopus 로고
    • NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation
    • Bosco EE, Nakai Y, Hennigan RF, Ratner N, Zheng Y, (2010) NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene 29: 2540-2549.
    • (2010) Oncogene , vol.29 , pp. 2540-2549
    • Bosco, E.E.1    Nakai, Y.2    Hennigan, R.F.3    Ratner, N.4    Zheng, Y.5
  • 45
    • 38849203228 scopus 로고    scopus 로고
    • In vivo switching of human melanoma cells between proliferative and invasive states
    • Hoek KS, Eichhoff OM, Schlegel NC, Dobbeling U, Kobert N, et al. (2008) In vivo switching of human melanoma cells between proliferative and invasive states. Cancer Res 68: 650-656.
    • (2008) Cancer Res , vol.68 , pp. 650-656
    • Hoek, K.S.1    Eichhoff, O.M.2    Schlegel, N.C.3    Dobbeling, U.4    Kobert, N.5
  • 46
    • 0036901896 scopus 로고    scopus 로고
    • Beta-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes
    • Posthaus H, Williamson L, Baumann D, Kemler R, Caldelari R, et al. (2002) beta-Catenin is not required for proliferation and differentiation of epidermal mouse keratinocytes. J Cell Sci 115: 4587-4595.
    • (2002) J Cell Sci , vol.115 , pp. 4587-4595
    • Posthaus, H.1    Williamson, L.2    Baumann, D.3    Kemler, R.4    Caldelari, R.5
  • 47
    • 29144470151 scopus 로고    scopus 로고
    • Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion: isolation of beta-catenin/plakoglobin-deficient F9 cells
    • Fukunaga Y, Liu H, Shimizu M, Komiya S, Kawasuji M, Nagafuchi A, (2005) Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion: isolation of beta-catenin/plakoglobin-deficient F9 cells. Cell Struct Funct 30: 25-34.
    • (2005) Cell Struct Funct , vol.30 , pp. 25-34
    • Fukunaga, Y.1    Liu, H.2    Shimizu, M.3    Komiya, S.4    Kawasuji, M.5    Nagafuchi, A.6
  • 48
    • 77951675861 scopus 로고    scopus 로고
    • Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo
    • Gandhirajan RK, Staib PA, Minke K, Gehrke I, Plickert G, et al. (2010) Small molecule inhibitors of Wnt/beta-catenin/lef-1 signaling induces apoptosis in chronic lymphocytic leukemia cells in vitro and in vivo. Neoplasia 12: 326-335.
    • (2010) Neoplasia , vol.12 , pp. 326-335
    • Gandhirajan, R.K.1    Staib, P.A.2    Minke, K.3    Gehrke, I.4    Plickert, G.5
  • 49
    • 77951230705 scopus 로고    scopus 로고
    • Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo
    • Wei W, Chua MS, Grepper S, So S, (2010) Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer 126: 2426-2436.
    • (2010) Int J Cancer , vol.126 , pp. 2426-2436
    • Wei, W.1    Chua, M.S.2    Grepper, S.3    So, S.4
  • 50
    • 34250678970 scopus 로고    scopus 로고
    • Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma
    • Sukhdeo K, Mani M, Zhang Y, Dutta J, Yasui H, et al. (2007) Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. PNAS 104: 7516-7521.
    • (2007) PNAS , vol.104 , pp. 7516-7521
    • Sukhdeo, K.1    Mani, M.2    Zhang, Y.3    Dutta, J.4    Yasui, H.5
  • 51
    • 0030853288 scopus 로고    scopus 로고
    • Melanoma cell lines from different stages of progression and their biological and molecular analyses
    • Satyamoorthy K, DeJesus E, Linnenbach AJ, Kraj B, Kornreich DL, et al. (1997) Melanoma cell lines from different stages of progression and their biological and molecular analyses. Melanoma Res 7 (Suppl 2): S35-S42.
    • (1997) Melanoma Res , vol.7 , Issue.SUPPL. 2 , pp. 35-42
    • Satyamoorthy, K.1    DeJesus, E.2    Linnenbach, A.J.3    Kraj, B.4    Kornreich, D.L.5
  • 52
    • 0025209833 scopus 로고
    • In vitro properties of human melanoma cells metastatic in nude mice
    • Herlyn D, Iliopoulos D, Jensen PJ, Parmiter A, Baird J, et al. (1990) In vitro properties of human melanoma cells metastatic in nude mice. Cancer Res 50: 2296-2302.
    • (1990) Cancer Res , vol.50 , pp. 2296-2302
    • Herlyn, D.1    Iliopoulos, D.2    Jensen, P.J.3    Parmiter, A.4    Baird, J.5
  • 53
    • 10744228941 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma
    • Meier F, Caroli U, Satyamoorthy K, Schittek B, Bauer J, et al. (2003) Fibroblast growth factor-2 but not Mel-CAM and/or beta3 integrin promotes progression of melanocytes to melanoma. Exp Dermatol 12: 296-306.
    • (2003) Exp Dermatol , vol.12 , pp. 296-306
    • Meier, F.1    Caroli, U.2    Satyamoorthy, K.3    Schittek, B.4    Bauer, J.5
  • 54
    • 0033883797 scopus 로고    scopus 로고
    • Human melanoma progression in skin reconstructs: biological significance of bFGF
    • Meier F, Nesbit M, Hsu MY, Martin B, Van Belle P, et al. (2000) Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol 156: 193-200.
    • (2000) Am J Pathol , vol.156 , pp. 193-200
    • Meier, F.1    Nesbit, M.2    Hsu, M.Y.3    Martin, B.4    Van Belle, P.5
  • 55
    • 2042436199 scopus 로고
    • Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells
    • Carey TE, Takahashi T, Resnick LA, Oettgen HF, Old LJ, (1976) Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells. Proc Natl Acad Sci U S A 73: 3278-3282.
    • (1976) Proc Natl Acad Sci U S A , vol.73 , pp. 3278-3282
    • Carey, T.E.1    Takahashi, T.2    Resnick, L.A.3    Oettgen, H.F.4    Old, L.J.5
  • 56
    • 67349103358 scopus 로고    scopus 로고
    • Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide
    • Sinnberg T, Lasithiotakis K, Niessner H, Schittek B, Flaherty KT, et al. (2009) Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide. J Invest Dermatol 129: 1500-1515.
    • (2009) J Invest Dermatol , vol.129 , pp. 1500-1515
    • Sinnberg, T.1    Lasithiotakis, K.2    Niessner, H.3    Schittek, B.4    Flaherty, K.T.5
  • 57
    • 47349099502 scopus 로고    scopus 로고
    • Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells
    • Lasithiotakis KG, Sinnberg TW, Schittek B, Flaherty KT, Kulms D, et al. (2008) Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. J Invest Dermatol 128: 2013-2023.
    • (2008) J Invest Dermatol , vol.128 , pp. 2013-2023
    • Lasithiotakis, K.G.1    Sinnberg, T.W.2    Schittek, B.3    Flaherty, K.T.4    Kulms, D.5
  • 58
    • 33749510883 scopus 로고    scopus 로고
    • LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
    • Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, et al. (2006) LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia. Nat Med 12: 1191-1197.
    • (2006) Nat Med , vol.12 , pp. 1191-1197
    • Skokowa, J.1    Cario, G.2    Uenalan, M.3    Schambach, A.4    Germeshausen, M.5


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