The renin-angiotensin system and its involvement in vascular disease

European Journal of Pharmacology

Volumn 763, Issue , 2015, Pages 3-14

  Van Thiel, Bibi S ^a   Van Der Pluijm, Ingrid ^a   Te Riet, Luuk ^a   Essers, Jeroen ^a   Danser, A H Jan ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Ageing Therapeutic intervention; AngiotensinII; Atherosclerosis; Extracellular matrix; Reactiveoxygenspecies; Renin angiotensinsystem; Vascular disease

Indexed keywords

ACLERASTIDE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIOXIDANT; COLLAGEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRONECTIN; LOSARTAN; LOW DENSITY LIPOPROTEIN; MINERALOCORTICOID ANTAGONIST; MYOSIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEOGLYCAN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); RENIN INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ABDOMINAL AORTA ANEURYSM; AGING; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL INJURY; CALORIC RESTRICTION; CELL DAMAGE; CLINICAL TRIAL (TOPIC); CYTOKINE PRODUCTION; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; EXTRACELLULAR MATRIX DEFECT; HORMONE ACTION; HUMAN; MOLECULAR PATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SEX DIFFERENCE; THERAPY EFFECT; THORACIC AORTA ANEURYSM; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE CELL; VASOCONSTRICTION; ANIMAL; DRUG EFFECTS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; VASCULAR DISEASES;

ANIMALS; DISEASE PROGRESSION; HUMANS; MOLECULAR TARGETED THERAPY; RENIN-ANGIOTENSIN SYSTEM; VASCULAR DISEASES;

EID: 84934923739     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.03.090     Document Type: Article

References (167)

1. S. AbdAlla, H. Lother, A.M. Abdel-tawab, and U. Quitterer The angiotensin II AT(2) receptor is an AT(1) receptor antagonist J. Biol. Chem. 276 2001 39721 39726
2. R.M. Anderson, and R. Weindruch The caloric restriction paradigm: Implications for healthy human aging Am. J. Hum. Biol. 24 2012 101 106
3. J. Aono Deletion of the angiotensin II Type 1a receptor prevents atherosclerotic plaque rupture in apolipoprotein E-/- mice (vol. 32, pp. 1453, 2012) Arterioscler. Thromb. Vasc. Biol. 34 2014 E-18
4. N. Ayabe, V.R. Babaev, Y.W. Tang, T. Tanizawa, A.B. Fogo, M.F. Linton, and et al. Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice Atherosclerosis 184 2006 312 321
5. M.M. Bachschmid, S. Schildknecht, R. Matsui, R. Zee, D. Haeussler, R.A. Cohen, and et al. Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease Ann. Med. 45 2013 17 36
6. J. Balcarek, B. Seva Pessoa, C. Bryson, M. Azizi, J. Ménard, I.M. Garrelds, and et al. Multiple ascending dose study with the new renin inhibitor VTP-27999: nephrocentric consequences of too much renin inhibition Hypertension 63 2014 942 950
7. J.F. Bateman, R.P. Boot-Handford, and S.R. Lamande Genetic diseases of connective tissues: cellular and extracellular effects of ECM mutations Nat. Rev. Genet. 10 2009 173 183
8. W.W. Batenburg, I.M. Garrelds, C.C. Bernasconi, L. Juillerat-Jeanneret, J.P. van Kats, P.R. Saxena, and et al. Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries Circulation 109 2004 2296 2301
9. J.A. Baur, K.J. Pearson, N.L. Price, H.A. Jamieson, C. Lerin, A. Kalra, and et al. Resveratrol improves health and survival of mice on a high-calorie diet Nature 444 2006 337 342
10. A. Benigni, D. Corna, C. Zoja, A. Sonzogni, R. Latini, M. Salio, and et al. Disruption of the Ang II type 1 receptor promotes longevity in mice J. Clin. Investig. 119 2009 524 530
11. K.B. Brosnihan, P.S. Senanayake, P. Li, and C.M. Ferrario Bi-directional actions of estrogen on the renin-angiotensin system Braz. J. Med. Biol. Res. 32 1999 373 381
12. S. Busche, S. Gallinat, R.M. Bohle, A. Reinecke, J. Seebeck, F. Franke, and et al. Expression of angiotensin AT(1) and AT(2) receptors in adult rat cardiomyocytes after myocardial infarction-A single-cell reverse transcriptase-polymerase chain reaction study Am. J. Pathol. 157 2000 605 611
13. M. Challah, S. Nadaud, M. Philippe, T. Battle, F. Soubrier, B. Corman, and et al. Circulating and cellular markers of endothelial dysfunction with aging in rats Am. J. Physiol. - Heart Circ. Physiol. 273 1997 H1941 H1948
14. P. Charpiot, P.H. Rolland, A. Friggi, P. Piquet, E. Scalbert, H. Bodard, and et al. Ace-inhibition with perindopril and atherogenesis-induced structural and functional-changes in minipig arteries Arterioscler. Thromb. 13 1993 1125 1138
15. C. Cheng, D. Tempel, R. van Haperen, L. van Damme, M. Algur, R. Krams, and et al. Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype Atherosclerosis 204 2009 26 33
16. R.J. Colman, R.M. Anderson, S.C. Johnson, E.K. Kastman, K.J. Kosmatka, T.M. Beasley, and et al. Caloric restriction delays disease onset and mortality in rhesus monkeys Science 325 2009 201 204
17. C. Costopoulos, T.V. Liew, and M. Bennett Ageing and atherosclerosis: mechanisms and therapeutic options Biochem. Pharmacol. 75 2008 1251 1261
18. A. Csiszar, N. Labinskyy, R. Jimenez, J.T. Pinto, P. Ballabh, G. Losonczy, and et al. Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1 Mech. Ageing Dev. 130 2009 518 527
19. V. da Cunha, B. Martin-McNulty, J. Vincelette, D.F. Choy, W.W. Li, M. Schroeder, and et al. Anglotensin II induces histomorphologic features of unstable plaque in a murine model of accelerated atherosclerosis J. Vasc. Surg. 44 2006 364 371
20. D.F. Dai, S.C. Johnson, J.J. Villarin, M.T. Chin, M. Nieves-Cintron, T. Chen, and et al. Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and g alpha q overexpression-induced heart failure Circ. Res. 108 2011 837 846
21. D.F. Dai, P.S. Rabinovitch, and Z. Ungvari Mitochondria and cardiovascular aging Circ. Res. 110 2012 1109 1124
22. A. Daugherty, L.A. Cassis, and H. Lu Complex pathologies of angiotensin II-induced abdominal aortic aneurysms J. Zhejiang Univ. - Sci. B 12 2011 624 628
23. A. Daugherty, M.W. Manning, and L.A. Cassis Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice J. Clin. Investig. 105 2000 1605 1612
24. A. Daugherty, D.L. Rateri, H. Lu, T. Inagami, and L.A. Cassis Hyperch olesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT(1A) receptor Circulation 110 2004 3849 3857
25. E.M. de Cavanagh, M. Ferder, F. Inserra, and L. Ferder Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint Am. J. Physiol. Heart Circ. Physiol. 296 2009 H550 H558
26. E.M.V. de Cavanagh, F. Inserra, and L. Ferder Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? Cardiovasc. Res. 89 2011 31 40
27. P. Delafontaine, and H. Lou Angiotensin II regulates insulin-like growth factor I gene expression in vascular smooth muscle cells J. Biol. Chem. 268 1993 16866 16870
28. H.C. Dietz, G.R. Cutting, R.E. Pyeritz, C.L. Maslen, L.Y. Sakai, G.M. Corson, and et al. Marfan-syndrome caused by a recurrent denovo missense mutation in the fibrillin gene Nature 352 1991 337 339
29. A.E. Dikalova, A.T. Bikineyeva, K. Budzyn, R.R. Nazarewicz, L. McCann, W. Lewis, and et al. Therapeutic targeting of mitochondrial superoxide in hypertension Circ. Res. 107 2010 106 U221
30. S. Dimmeler, V. Rippmann, U. Weiland, J. Haendeler, and A.M. Zeiher Angiotensin II induces apoptosis of human endothelial cells - protective effect of nitric oxide Circ. Res. 81 1997 970 976
31. Y. Dohi, M. Ohashi, M. Sugiyama, H. Takase, K. Sato, and R. Ueda Candesartan reduces oxidative stress and inflammation in patients with essential hypertension Hypertens. Res. 26 2003 691 697
32. A.J. Donato, I. Eskurza, A.E. Silver, A.S. Levy, G.L. Pierce, P.E. Gates, and et al. Direct evidence of endothelial oxidative stress with aging in humans - relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappa B Circ. Res. 100 2007 1659 1666
33. A.K. Doughan, D.G. Harrison, and S.I. Dikalov Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction - linking mitochondrial oxidative damage and vascular endothelial dysfunction Circ. Res. 102 2008 488 496
34. V.J. Dzau Tissue angiotensin and pathobiology of vascular disease - a unifying hypothesis Hypertension 37 2001 1047 1052
35. G. Fazeli, H. Stopper, R. Schinzel, C.W. Ni, H. Jo, and N. Schupp Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4 Mutagenesis 27 2012 673 681
36. E.P. Feener, J.M. Northrup, L.P. Aiello, and G.L. King Angiotensin II induces plasminogen activator inhibitor-1 and -2 expression in vascular endothelial and smooth muscle cells J. Clin. Investig. 95 1995 1353 1362
37. P. Finckenberg, O. Eriksson, M. Baumann, S. Merasto, M.M. Lalowski, J. Levijoki, and et al. Caloric restriction ameliorates angiotensin II-induced mitochondrial remodeling and cardiac hypertrophy Hypertension 59 2012 76 84
38. M. Fischer, A. Baessler, and H. Schunkert Renin angiotensin system and gender differences in the cardiovascular system Cardiovasc. Res. 53 2002 672 677
39. R.A. Fraga-Silva, F.P. Costa-Fraga, T.M. Murca, P.L. Moraes, A.M. Lima, R.Q. Lautner, and et al. Angiotensin-converting enzyme 2 activation improves endothelial function Hypertension 61 2013 1233 1238
40. Y. Funakoshi, T. Ichiki, K. Ito, and A. Takeshita Induction of interleukin-6 expression by angiotensin II in rat vascular smooth muscle cells Hypertension 34 1999 118 125
41. Z.S. Galis, and J.J. Khatri Matrix metalloproteinases in vascular remodeling and atherogenesis - the good, the bad, and the ugly Circ. Res. 90 2002 251 262
42. G.H. Gibbons The pathophysiology of hypertension-The importance of angiotensin II in cardiovascular remodeling Am. J. Hypertens. 11 1998 177s 181s
43. G.H. Gibbons, R.E. Pratt, and V.J. Dzau Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II J. Clin. Investig. 90 1992 456 461
44. R. Gredilla, A. Sanz, M. Lopez-Torres, and G. Barja Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart FASEB J. 15 2001 1589 1591
45. M. Groenink, A.W. den Hartog, R. Franken, T. Radonic, V. de Waard, J. Timmermans, and et al. Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial Eur. Heart J. 34 2013 3491 3500
46. Z. Guo, F. Mitchell-Raymundo, H. Yang, Y. Ikeno, J. Nelson, V. Diaz, and et al. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice Mech. Ageing Dev. 123 2002 1121 1131
47. J. Gutierrez, S.W. Ballinger, V.M. Darley-Usmar, and A. Landar Free radicals, mitochondria, and oxidized lipids - the emerging role in signal transduction in vascular cells Circ. Res. 99 2006 924 932
48. J.P. Habashi, J.J. Doyle, T.M. Holm, H. Aziz, F. Schoenhoff, D. Bedja, and et al. Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism Science 332 2011 361 365
49. J.P. Habashi, D.P. Judge, T.M. Holm, R.D. Cohn, B.L. Loeys, T.K. Cooper, and et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome Science 312 2006 117 121
50. A. Hamaguchi, S. Kim, Y. Izumi, Y. Zhan, S. Yamanaka, and H. Iwao Contribution of extracellular signal-regulated kinase to angiotensin II-induced transforming growth factor-beta1 expression in vascular smooth muscle cells Hypertension 34 1999 126 131
51. K. Hanada, M. Vermeij, G.A. Garinis, M.C. de Waard, M.G. Kunen, L. Myers, and et al. Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice Circ. Res. 100 2007 738 746
52. D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
53. T. Hayek, J. Attias, R. Coleman, S. Brodsky, J. Smith, J.L. Breslow, and et al. The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice Cardiovasc. Res. 44 1999 579 587
54. K.E. Herbert, Y. Mistry, R. Hastings, T. Poolman, L. Niklason, and B. Williams Angiotensin II-mediated oxidative DNA damage accelerates cellular senescence in cultured human vascular smooth muscle cells via telomere-dependent and independent pathways Circ. Res. 102 2008 201 208
55. L.M. Hilliard, A.K. Sampson, R.D. Brown, and K.M. Denton The "His and Hers" of the renin-angiotensin system Curr. Hypertens. Rep. 15 2013 71 79
56. J.H. Hoeijmakers DNA damage, aging, and cancer N. Engl. J. Med. 361 2009 1475 1485
57. L. Hunyady, and K.J. Catt Pleiotropic AT1 receptor signaling pathways mediating physiological and pathogenic actions of angiotensin II Mol. Endocrinol. 20 2006 953 970
58. Y. Iida, B.H. Xu, G.M. Schultz, V. Chow, J.J. White, S. Sulaimon, and et al. Efficacy and mechanism of angiotensin II receptor blocker treatment in experimental abdominal aortic aneurysms Plos One 2012 7
59. H.D. Intengan, and E.L. Schiffrin Vascular remodeling in hypertension - rRoles of apoptosis, inflammation, and fibrosis Hypertension 38 2001 581 587
60. E.M. Isselbacher Thoracic and abdominal aortic aneurysms Circulation 111 2005 816 828
61. J. Iwanami, M. Mogi, M. Iwai, and M. Horiuchi Inhibition of the renin-angiotensin system and target organ protection Hypertens. Res. 32 2009 229 237
62. R.W. Jeremy, H. Huang, J. Hwa, H. McCarron, C.F. Hughes, and J.G. Richards Relation between age, arterial distensibility, and aortic dilatation in the Marfan syndrome Am. J. Cardiol. 74 1994 369 373
63. M. Jiang, H. Bujo, K. Ohwaki, H. Unoki, H. Yarnazaki, T. Kanaki, and et al. Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice J. Clin. Investig. 118 2008 2733 2746
64. H. Kanaide, T. Ichiki, J. Nishimura, and K. Hirano Cellular mechanism of vasoconstriction induced by angiotensin II - it remains to be determined Circ. Res. 93 2003 1015 1017
65. H. Kato, H. Suzuki, S. Tajima, Y. Ogata, T. Tominaga, A. Sato, and et al. Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells J. Hypertens. 9 1991 17 22
66. S. Kim, K. Ohta, A. Hamaguchi, T. Omura, K. Tominaga, T. Yukimura, and et al. AT1 receptor-mediated stimulation by angiotensin II of rat aortic fibronectin gene expression in vivo Br. J. Pharmacol. 113 1994 662 663
67. S. Kimura, G.X. Zhang, A. Nishiyama, T. Shokoji, L. Yao, Y.Y. Fan, and et al. Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide Hypertension 45 2005 438 444
68. M.C. Kowala, R.I. Grove, and G. Aberg Inhibitors of angiotensin-converting enzyme decrease early atherosclerosis in hyperlipidemic Hamsters-fosinopril reduces plasma-cholesterol and captopril inhibits macrophage foam cell accumulation independently of blood-pressure and plasma-lipids Atherosclerosis 108 1994 61 72
69. A. Kuenzli, H.C. Bucher, I. Anand, G. Arutiunov, L.C. Kum, R. McKelvie, and et al. Meta-analysis of combined therapy with angiotensin receptor antagonists versus ACE inhibitors alone in patients with heart failure Plos One 5 2010
70. T. Kunieda, T. Minamino, J.I. Nishi, K. Tateno, T. Oyama, T. Katsuno, and et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway Circulation 114 2006 953 960
71. P. Lacolley, V. Regnault, A. Nicoletti, Z.L. Li, and J.B. Michel The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles Cardiovasc. Res. 95 2012 194 204
72. E.G. Lakatta Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises - Part III: cellular and molecular clues to heart and arterial aging Circulation 107 2003 490 497
73. E.G. Lakatta, and D. Levy Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises Part I: aging arteries: A "set up" for vascular disease Circulation 107 2003 139 146
74. D.Y. Li, Y.C. Zhang, M.I. Philips, T. Sawamura, and J.L. Mehta Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation Circ. Res. 84 1999 1043 1049
75. S.X. Liao, M. Miralles, B.J. Kelley, J.A. Curci, M. Borhani, and R.W. Thompson Suppression of experimental abdominal aortic aneurysms in the rat by treatment with angiotensin-converting enzyme inhibitors J. Vasc. Surg. 33 2001 1057 1064
76. P. Libby, P.M. Ridker, and G.K. Hansson Progress and challenges in translating the biology of atherosclerosis Nature 473 2011 317 325
77. P. Libby, and P. Theroux Pathophysiology of coronary artery disease Circulation 111 2005 3481 3488
78. S.I. Liochev Reactive oxygen species and the free radical theory of aging Free Radic. Biol. Med. 60 2013 1 4
79. C. Lopez-Otin, M.A. Blasco, L. Partridge, M. Serrano, and G. Kroemer The hallmarks of aging Cell 153 2013 1194 1217
80. F. Lovren, Y. Pan, A. Quan, H. Teoh, G.L. Wang, P.C. Shukla, and et al. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis Am. J. Physiol. - Heart Circ. Physiol. 295 2008 H1377 H1384
81. H. Lu, A. Daugherty, and L.A. Cassis Atherosclerosis and arterial blood pressure in mice Curr. Drug Targets 8 2007 1181 1189
82. H. Lu, D.L. Rateri, D. Bruemmer, L.A. Cassis, and A. Daugherty Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms Clin. Sci. 123 2012 531 543
83. H. Lu, D.L. Rateri, D.L. Feldman, R.J. Charnigo, A. Fukamizu, J.J. Ishida, and et al. Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice J. Clin. Investig. 118 2008 984 993
84. N.R. Madamanchi, and M.S. Runge Mitochondrial dysfunction in atherosclerosis Circ. Res. 100 2007 460 473
85. N.R. Madamanchi, A. Vendrov, and M.S. Runge Oxidative stress and vascular disease Arterioscler. Thromb. Vasc. Biol. 25 2005 29 38
86. M. Mahmoudi, J. Mercer, and M. Bennett DNA damage and repair in atherosclerosis Cardiovasc. Res. 71 2006 259 268
87. S.G. Mallat Dual renin-angiotensin system inhibition for prevention of renal and cardiovascular events: do the latest trials challenge existing evidence? Cardiovasc. Diabetol. 2013 12
88. C. Mammucari, and R. Rizzuto Signaling pathways in mitochondrial dysfunction and aging Mech. Ageing Dev. 131 2010 536 543
89. J.A. Marteijn, H. Lans, W. Vermeulen, and J.H. Hoeijmakers Understanding nucleotide excision repair and its roles in cancer and ageing Nat. Rev. Mol. Cell Biol. 15 2014 465 481
90. L. Mazzolai, M.A. Duchosal, M. Korber, K. Bouzourene, J.F. Aubert, H. Hao, and et al. Endogenous angiotensin II induces atherosclerotic plaque vulnerability and elicits a Th1 response in ApoE(-/-) mice Hypertension 44 2004 277 282
91. L. Mazzolai, and D. Hayoz The renin-angiotensin system and atherosclerosis Curr. Hypertens. Rep. 8 2006 47 53
92. F.A. McAlister, J.G. Zhang, M. Tonelli, S. Klarenbach, B.J. Manns, B.R. Hemmelgarn, and et al. The safety of combining angiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers in elderly patients: a population-based longitudinal analysis Can. Med. Assoc. J. 183 2011 655 662
93. J. McLachlan, E. Beattie, M.P. Murphy, C.H.H. Koh-Tan, E. Olson, W. Beattie, and et al. Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ(10), and angiotensin receptor blocker, losartan, on cardiovascular function J. Hypertens. 32 2014 555 564
94. J. Mercer, M. Mahmoudi, and M. Bennett DNA damage, p53, apoptosis and vascular disease Mutat. Res. - Fundam. Mol. Mech. Mutagen. 621 2007 75 86
95. L.J. Min, M. Mogi, M. Iwai, and M. Horiuchi Signaling mechanisms of angiotensin II in regulating vascular senescence Ageing Res. Rev. 8 2009 113 121
96. E. Moltzer, J. Essers, J.H.M. van Esch, J.W. Roos-Hesselink, and A.H.J. Danser The role of the renin-angiotensin system in thoracic aortic aneurysms: clinical implications Pharmacol. Ther. 131 2011 50 60
97. E. Moltzer, L. te Riet, S.M.A. Swagemakers, P.M. van Heijningen, M. Vermeij, R. van Veghel, and et al. Impaired vascular contractility and aortic wall degeneration in fibulin-4 deficient mice: effect of angiotensin II type 1 (AT(1)) receptor blockade Plos One 2011 6
98. E. Moltzer, A.V.A. Verkuil, R. van Veghel, A.H.J. Danser, and J.H.M. van Esch Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat loss of angiotensin II type 2 receptor-mediated vasodilation Hypertension 55 2010 516 522
99. A.C. Montezano, and R.M. Touyz Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research Antioxid. Redox Signal. 20 2014 164 182
100. A.J. Naftilan, R.E. Pratt, C.S. Eldridge, H.L. Lin, and V.J. Dzau Angiotensin II induces c-fos expression in smooth muscle via transcriptional control Hypertension 13 1989 706 711
101. A.C. Newby Do metalloproteinases destabilize vulnerable atherosclerotic plaques? Curr. Opin. Lipidol. 17 2006 556 561
102. T. Niccoli, and L. Partridge Ageing as a risk factor for disease Curr. Biol. 22 2012 R741 R752
103. G. Nickenig, and D.G. Harrison The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis - Part II: AT(1) receptor regulation Circulation 105 2002 530 536
104. G. Nickenig, K. Strehlow, A.T. Baumer, S. Baudler, S. Wassmann, H. Sauer, and et al. Negative feedback regulation of reactive oxygen species on AT1 receptor gene expression Br. J. Pharmacol. 131 2000 795 803
105. B.J. North, and D.A. Sinclair The intersection between aging and cardiovascular disease Circ. Res. 110 2012 1097 1108
106. R.H. Noth, M.N. Lassman, S.Y. Tan, A. Fernandez-Cruz Jr., and P.J. Murlow Age and the renin-aldosterone system Arch. Intern. Med. 137 1977 1414 1417
107. S. Novella, M. Heras, C. Hermenegildo, and A.P. Dantas Effects of estrogen on vascular inflammation a matter of timing Arterioscler. Thromb. Vasc. Biol. 32 2012 2035 2042
108. L. Novensa, S. Novella, P. Medina, G. Segarra, N. Castillo, M. Heras, and et al. Aging negatively affects estrogens-mediated effects on nitric oxide bioavailability by shifting ER alpha/ER beta balance in female mice Plos One 2011 6
109. J. Nussberger, J.F. Aubert, K. Bouzourene, M. Pellegrin, D. Hayoz, and L. Mazzolai Renin inhibition by aliskiren prevents atherosclerosis progression - comparison with irbesartan, atenolol, and amlodipine Hypertension 51 2008 1306 1311
110. A. Oudot, C. Martin, D. Busseuil, C. Vergely, L. Demaison, and L. Rochette NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging Free Radic. Biol. Med. 40 2006 2214 2222
111. R. Pamplona, M. Portero-Otin, J. Requena, R. Gredilla, and G. Barja Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls Mech. Ageing Dev. 123 2002 1437 1446
112. C.O. Phillips, A. Kashani, D.K. Ko, G. Francis, and H.M. Krumholz Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction-A quantitative review of data from randomized clinical trials Arch. Intern. Med. 167 2007 1930 1936
113. B. Poljsak, and I. Milisav The neglected significance of "antioxidative stress" Oxid. Med. Cell. Longev. 2012
114. M.E. Pueyo, W. Gonzalez, A. Nicoletti, F. Savoie, J.F. Arnal, and J.B. Michel Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappa B activation induced by intracellular oxidative stress Arterioscler. Thromb. Vasc. Biol. 20 2000 645 651
115. S. Rajagopalan, S. Kurz, T. Munzel, M. Tarpey, B.A. Freeman, K.K. Griendling, and et al. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation - contribution to alterations of vasomotor tone. J. Clin. Investig. 97 1996 1916 1923
116. C. Rammos, U.B. Hendgen-Cotta, R. Deenen, J. Pohl, P. Stock, C. Hinzmann, and et al. Age-related vascular gene expression profiling in mice Mech. Ageing Dev. 135 2014 15 23
117. J.F. Reckelhoff Gender differences in the regulation of blood pressure Hypertension 37 2001 1199 1208
118. A.D. Rickman, D.A. Williamson, C.K. Martin, C.H. Gilhooly, R.I. Stein, C.W. Bales, and et al. The CALERIE study: design and methods of an innovative 25% caloric restriction intervention Contemp. Clin. Trials 32 2011 874 881
119. P.M. Ridker, C.L. Gaboury, P.R. Conlin, E.W. Seely, G.H. Williams, and D.E. Vaughan Stimulation of plasminogen-activator inhibitor in vivo by infusion of angiotensin-II - evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function Circulation 87 1993 1969 1973
120. C. Rippe, L. Lesniewski, M. Connell, T. LaRocca, A. Donato, and D. Seals Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress Aging Cell 9 2010 304 312
121. E.G. Rosenbaugh, K.K. Savalia, D.S. Manickam, and M.C. Zimmerman Antioxidant-based therapies for angiotensin II-associated cardiovascular diseases Am. J. Physiol. - Regul. Integr. Comp. Physiol. 304 2013 R917 R928
122. J.J. Saris, M.A. van Dijk, I. Kroon, M.A. Schalekamp, and A.H. Danser Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm Hypertension 35 2000 764 768
123. M. Sata, and D. Fukuda Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis J. Med. Investig. 57 2010 12 25
124. B. Schieffer, E. Schieffer, D. Hilfiker-Kleiner, A. Hilfiker, P.T. Kovanen, M. Kaartinen, and et al. Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques - potential implications for inflammation and plaque instability Circulation 101 2000 1372 1378
125. J.E. Schilders, H. Wu, F. Boomsma, A.H. van den Meiracker, and A.H. Danser Renin-angiotensin system phenotyping as a guidance toward personalized medicine for ACE inhibitors: can the response to ACE inhibition be predicted on the basis of plasma renin or ACE? Cardiovasc. Drugs Ther. 28 2014 335 345
126. U. Schmid, H. Stopper, F. Schweda, N. Queisser, and N. Schupp Angiotensin II induces DNA damage in the kidney Cancer Res. 68 2008 9239 9246
127. K.M. Schmidt-Ott, S. Kagiyama, and M.I. Phillips The multiple actions of angiotensin II in atherosclerosis Regul. Pept. 93 2000 65 77
128. S.W. Seto, S.M. Krishna, H.Y. Yu, D. Liu, S. Khosla, and J. Golledge Impaired acetylcholine-induced endothelium-dependent aortic relaxation by caveolin-1 in angiotensin II-infused apolipoprotein-E (ApoE(-/-)) knockout mice Plos One 2013 8
129. B.G. Sharifi, D.W. LaFleur, C.J. Pirola, J.S. Forrester, and J.A. Fagin Angiotensin II regulates tenascin gene expression in vascular smooth muscle cells J. Biol. Chem. 267 1992 23910 23915
130. A. Shatanawi, M.J. Romero, J.A. Iddings, S. Chandra, N.S. Umapathy, A.D. Verin, and et al. Angiotensin II-induced vascular endothelial dysfunction through RhoA/Rho kinase/p38 mitogen-activated protein kinase/arginase pathway Am. J. Physiol. - Cell Physiol. 300 2011 C1181 C1192
131. M.M. Silva-Antonialli, Z.B. Fortes, M.H.C. Carvalho, R. Scivoletto, and D. Nigro Sexual dimorphism in the response of thoracic aorta from SHRs to losartan Gen. Pharmacol. - Vasc. Syst. 34 2000 329 335
132. D. Sorescu, D. Weiss, B. Lassegue, R.E. Clempus, K. Szocs, G.P. Sorescu, and et al. Superoxide production and expression of Nox family proteins in human atherosclerosis Circulation 105 2002 1429 1435
133. J.P. Stice, J.P. Eiserich, and A.A. Knowlton Role of aging versus the loss of estrogens in the reduction in vascular function in female rats Endocrinology 150 2009 212 219
134. K. Sugamura, and J.F. Keaney Reactive oxygen species in cardiovascular disease Free Radic. Biol. Med. 51 2011 978 992
135. M.J. Sweeting, S.G. Thompson, L.C. Brown, R.M. Greenhalgh, and J.T. Powell Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms J. Vasc. Surg. 52 2010 1 4
136. K. Tamura, N. Nyui, N. Tamura, T. Fujita, M. Kihara, Y. Toya, and et al. Mechanism of angiotensin II-mediated regulation of fibronectin gene in rat vascular smooth muscle cells J. Biol. Chem. 273 1998 26487 26496
137. D.M. Tham, B. Martin-McNulty, Y.X. Wang, D.W. Wilson, R. Vergona, M.E. Sullivan, and et al. Angiotensin II is associated with activation of NF-kappa B-mediated genes and downregulation of PPARs Physiol. Genomics 11 2002 21 30
138. A. Thompson, J.A. Cooper, M. Fabricius, S.E. Humphries, H.A. Ashton, and H. Hafez An analysis of drug modulation of abdominal aortic aneurysm growth through 25 years of surveillance J. Vasc. Surg. 52 2010 55 61
139. B. Tom, I.M. Garrelds, E. Scalbert, A.P. Stegmann, F. Boomsma, P.R. Saxena, and et al. ACE-versus chymase-dependent angiotensin II generation in human coronary arteries: a matter of efficiency? Arterioscler. Thromb. Vasc. Biol. 23 2003 251 256
140. R.M. Touyz Reactive oxygen species and angiotensin II signaling in vascular cells - implications in cardiovascular disease Braz. J. Med. Biol. Res. 37 2004 1263 1273
141. R.M. Touyz, and E.L. Schiffrin Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells Pharmacol. Rev. 52 2000 639 672
142. A. Trifunovic, and N.G. Larsson Mitochondrial dysfunction as a cause of ageing J. Intern. Med. 263 2008 167 178
143. P.E. Tummala, X.L. Chen, C.L. Sundell, J.B. Laursen, C.P. Hammes, R.W. Alexander, and et al. Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature - a potential link between the renin-angiotensin system and atherosclerosis Circulation 100 1999 1223 1229
144. T. Unger The role of the renin-angiotensin system in the development of cardiovascular disease Am. J. Cardiol. 89 2002 3A 9A
145. Z. Ungvari, N. Labinskyy, P. Mukhopadhyay, J.T. Pinto, Z. Bagi, P. Ballabh, and et al. Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells Am. J. Physiol. - Heart Circ. Physiol. 297 2009 H1876 H1881
146. D.E. Vaughan, S.A. Lazos, and K. Tong Angiotensin-II regulates the expression of plasminogen-activator inhibitor-1 in cultured endothelial-cells-a potential link between the renin-angiotensin system and thrombosis J. Clin. Investig. 95 1995 995 1001
147. K. Verdonk, Danser AHJ, and J.H.M. van Esch Angiotensin II type 2 receptor agonists: where should they be applied? Expert Opin. Investig. Drugs 21 2012 501 513
148. F. Verrecchia, and A. Mauviel Transforming growth factor-beta and fibrosis World J. Gastroenterol. 13 2007 3056 3062
149. A. Virdis, M.F. Neves, F. Amiri, R.M. Touyz, and E.L. Schiffrin Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice J. Hypertens. 22 2004 535 542
150. R. Virmani, A.P. Burke, A. Farb, and F.D. Kolodgie Pathology of the unstable plaque Prog. Cardiovasc. Dis. 44 2002 349 356
151. J.E. Wagenseil, and R.P. Mecham Vascular extracellular matrix and arterial mechanics Physiol. Rev. 89 2009 957 989
152. M. Wang, J. Zhang, L.Q. Jiang, G. Spinetti, G. Pintus, R. Monticone, and et al. Proinflammatory profile within the grossly normal aged human aortic wall Hypertension 50 2007 219 227
153. M.Y. Wang, G. Takagi, K. Asai, R.G. Resuello, F.F. Natividad, D.E. Vatner, and et al. Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates Hypertension 41 2003 1308 1316
154. M.Y. Wang, J. Zhang, G. Spinetti, L.Q. Jiang, R. Monticone, D. Zhao, and et al. Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats Am. J. Pathol. 167 2005 1429 1442
155. A. Warnholtz, G. Nickenig, E. Schulz, R. Macharzina, J.H. Brasen, M. Skatchkov, and et al. Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis - evidence for involvement of the renin-angiotensin system Circulation 99 1999; 2027 2033
156. S. Wassmann, and G. Nickenig Pathophysiological regulation of the AT(1)-receptor and implications for vascular disease J. Hypertens. 24 2006 S15 S21
157. P. Weidmann, S. De Myttenaere-Bursztein, M.H. Maxwell, and J. de Lima Effect on aging on plasma renin and aldosterone in normal man Kidney Int. 8 1975 325 333
158. D. Weiss, D. Sorescu, and W.R. Taylor Angiotensin II and atherosclerosis Am. J. Cardiol. 87 2001 25c 32c
159. E.P. Weiss, and L. Fontana Caloric restriction: powerful protection for the aging heart and vasculature Am. J. Physiol. Heart Circ. Physiol. 301 2011 H1205 H1219
160. J.D. Widder, D. Fraccarollo, P. Galuppo, J.M. Hansen, D.P. Jones, G. Ertl, and et al. Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of thioredoxin 2 Hypertension 54 2009 338 344
161. B.J. Willcox, and D.C. Willcox Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications Curr. Opin. Clin. Nutr. Metab. Care 17 2014 51 58
162. B. Williams, A.Q. Baker, B. Gallacher, and D. Lodwick Angiotensin II increases vascular permeability factor gene expression by human vascular smooth muscle cells Hypertension 25 1995 913 917
163. Z. Wu, C. Maric, D.M. Roesch, W. Zheng, J.G. Verbalis, and K. Sandberg Estrogen regulates adrenal angiotensin AT(1) receptors by modulating AT(1) receptor translation Endocrinology 144 2003 3251 3261
164. J. Xu, Y. Sun, O.A. Carretero, L.P. Zhu, P. Harding, E.G. Shesely, and et al. Effects of cardiac overexpression of the angiotensin II type 2 receptor on remodeling and dysfunction in mice post-myocardial infarction Hypertension 63 2014 1251 1259
165. B.B. Yavuz, B. Yavuz, D.D. Sener, M. Cankurtaran, M. Halil, Z. Ulger, and et al. Advanced age is associated with endothelial dysfunction in healthy elderly subjects Gerontology 54 2008 153 156
166. D. You, L. Loufrani, C. Baron, B.I. Levy, R.E. Widdop, and D. Henrion High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats Circulation 111 2005 1006 1011
167. F. Zhang, Y.H. Hu, Q.B. Xu, and S. Ye Different effects of angiotensin II and angiotensin-(1-7) on vascular smooth muscle cell proliferation and migration Plos One 2010 5