Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: Controversies and clinical implications

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 17, Issue 1, 2014, Pages 51-58

  Willcox, Bradley J ^a,b   Willcox, Donald C ^a,b,c  

^a UNIVERSITY OF HAWAII   (United States)

^b KUAKINI MEDICAL CENTER   (United States)

^c OKINAWA INTERNATIONAL UNIVERSITY   (Japan)

Author keywords

Caloric restriction; Caloric restriction mimetic; Healthspan; Human longevity; Lifespan

Indexed keywords

CAROTENOID; TURMERIC;

BIOMIMETICS; BODY MASS; BODY WEIGHT; CALORIC RESTRICTION; CARDIOVASCULAR DISEASE; CAUSE SPECIFIC SURVIVAL; CLINICAL TRIAL (TOPIC); CURCUMA LONGA; DEMENTIA; FOOD INTAKE; HUMAN; LIFESPAN; MORTALITY; NEOPLASM; PHENOTYPIC VARIATION; REVIEW; SENESCENCE; SHORT STATURE; SWEET POTATO;

AGING; CALORIC RESTRICTION; CARDIOVASCULAR DISEASES; CHRONIC DISEASE; CURCUMA; DEMENTIA; DIET; FUNCTIONAL FOOD; HUMANS; IPOMOEA BATATAS; JAPAN; LONGEVITY; NEOPLASMS; SEAFOOD;

EID: 84890928478     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000019     Document Type: Review

References (48)

1. World Health Organization. Joint WHO/FAO expert consultation on diet, nutrition and the prevention of the chronic diseases. Geneva: World Health Organization; 2003.
2. World Health Organization. Preventing chronic diseases: a vital investment: WHO global report. Geneva: Who Press; 2005.
3. Centers for Disease Control and Prevention. The power of prevention. Chronic disease the public health challenge of the 21st century. National Center for Chronic Disease Prevention and Health Promotion. Department of Health and Human Services; 2009.
4. US Burden of Disease Collaborators. The state of US health, 1990-2010: burden of diseases, injuries, and risk factors. JAMA 2013; 310: 591-608. Excellent manuscript that measured the burden of diseases, injuries, and leading risk factors in the USA from 1990 to 2010 and compared these data to 34 other Organization for Economic Cooperation and Development (OECD) countries. Two hundred ninety one diseases/injuries, 1160 sequelae of these diseases/injuries, and 67 risk factors (or risk factor clusters) were measured. The leading risk factors for disease were dietary risks, tobacco smoking, high BMI, high blood pressure, high fasting plasma glucose, physical inactivity, and alcohol use. There was improvement in both life expectancy and healthy life years of life over the past 2 decades, but the rate of improvement lagged in the United States versus other OECD countries.
5. Willcox BJ, Willcox DC, Todoriki H, et al. Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. Ann NY Acad Sci 2007; 1114: 454-455.
6. Willcox DC, Willcox BJ, Todoriki H, Suzuki M. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr 2009; 28 (Suppl):500S-516S.
7. Willcox DC, Willcox BJ, Yasura S, et al. Gender gap in healthspan and life expectancy in Okinawa: health behaviours. Asian J Gerontol Geriatr 2012; 7: 49-58.
8. Gavrilova NS, Gavrilov LA. Comments on dietary restriction, Okinawa diet and longevity. Gerontology 2012; 58: 221-223.
9. WillcoxDC,Willcox BJ,Todoriki H, et al. Caloric restriction andhuman longevity: what can we learn from the Okinawans? Biogerontology 2006; 7: 173-177. (Pubitemid 44151629)
10. Anderson RM, Weindruch R. The caloric restriction paradigm: implications for healthy human aging. Am J Hum Biol 2012; 24: 101-106. Fascinating review of rodent and human studies of the caloric restriction paradigm by leading experts in the field that addresses: molecular mechanisms related to caloric restriction-induced slower aging in model organisms; caloric restriction mimetics; and whether caloric restriction slows human aging.
11. Lee IM, Blair SN, Allison DB, et al. Epidemiological data on the relationships of energy intake, energy balance, and weight gain over the life span with longevity and morbidity. J Gerontol Biol Sci 2001; 56A:B7-B19.
12. Willcox DC, Willcox BJ, He Q, et al. They really are that old: a validation study of centenarian prevalence in Okinawa. J Gerontol A Biol Sci Med Sci 2008; 63: 338-349. (Pubitemid 351738415)
13. Le Bourg E. Dietary restriction studies in humans: focusing on obesity, forgetting longevity. Gerontology 2012; 58: 126-128.
14. Willcox BJ, Suzuki M, Donlon TA, et al. Optimizing human health span and life span: insights from Okinawa and Hawaii. Ann Rev Gerontol Geriatr 2013; 33: 133-170. Comprehensive review of past and current research on healthspan and lifespan from the Honolulu Heart Program studies and the Okinawa Centenarian Study that highlights nutrition and other modifiable risk factors.
15. Robine JM, Herrmann FR, Arai Y, et al. Accuracy of the centenarian numbers in Okinawa and the role of the Okinawan diet on longevity: responses to Le Bourg about the article 'Exploring the impact of climate on human longevity'. Exp Gerontol 2013; 48: 840-842.
16. Mattison JA, Roth GS, Beasley TM, et al. Impact of caloric restriction on heath and survival in rhesus monkeys from the NIA study. Nature 2012; 489: 318-321. One of the landmark studies of the health and lifespan effects of several years of caloric restriction on nonhuman primates.
17. Messaoudi I, Ingram DK. Overview of aging research using nonhuman primate models. Age (Dordr) 2012; 34: 1047-1049. Well written summary of important nonhuman primate research by experts in the field with a focus on caloric restriction.
18. Gems D, Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol 2013; 75: 621-644. Comprehensive, thought-provoking review of the biological basis of aging that reexamines central concepts of aging including the free radical theory and new theories, such as the hyperfunction theory. This theory hypothesizes that much of age associated disease is hypertrophic and hyperplastic due to processes that contribute to growth and reproduction at younger ages running unchecked into later life. Incorporates the latest data on a signaling network that includes insulin- IGF-1 and target of rapamycin (mTOR) signaling. This network has FOXO3 as a major regulatory gene, is sensitive to nutritional status (nutrient-sensing pathway), and in response modulates growth, stress resistance, and aging.
19. Willcox BJ, Yano K, Chen R, et al. How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese- American men. J Gerontol A Biol Sci Med Sci 2004; 59: 789-795. (Pubitemid 39167420)
20. Gallinetti J, Harputlugil E, Mitchell Jr. Amino acid sensing in dietary-restriction- mediated longevity: roles of signal-transducing kinases GCN2 and TOR. Biochem J 2013; 449: 1-10.
21. Donlon TA, Curb JD, He Q, et al. FOXO3 gene variants and human aging: coding variants may not be key players. J Gerontol A Biol Sci Med Sci 2012; 67: 1132-1139.
22. Weiss EP, Fontana L. Caloric restriction: powerful protection for the aging heart and vasculature. Am J Physiol Heart Circ Physiol 2011; 301:H1205- H1219.
23. Davinelli S, Willcox DC, Scapagnini G. Extending healthy ageing: nutrient sensitive pathway and centenarian population. Immun Ageing 2012; 9:9.
24. Mercken EM, Carboneau BA, Krzysik-Walker SM, de Cabo R. Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev 2012; 11: 390-398.
25. Rattan SI. Rationale and methods of discovering hormetins as drugs for healthy ageing. Expert Opin Drug Disc 2012; 7: 439-448.
26. Martin-Montalvo A, Mercken EM, Mitchell SJ, et al. Metformin improves healthspan and lifespan in mice. Nat Commun 2013; 4:2192.
27. Robine JM, Herrmann FR, Arai Y, et al. Exploring the impact of climate on human longevity. Exp Gerontol 2012; 47: 660-671.
28. Murakami A, Ishida H, Kubo K, et al. Suppressive effects of Okinawan food items on free radical generation from stimulated leukocytes and identification of some active constituents: implications for the prevention of inflammationassociated carcinogenesis. Asian Pacific J Cancer Prev 2005; 6: 437-448.
29. de Magalhaes JP, Wuttke D, Wood SH, et al. Genome-environment interactions that modulate aging: powerful targets for drug discovery. Pharmacol Rev 2012; 64: 88-101.
30. Senthilkumar R, Yeh KW. Multiple biological functions of sporamin related to stress tolerance in sweet potato (Ipomoea batatas Lam). Biotechnol Adv 2012; 30: 1309-1317.
31. Payyavula RS, Navarre DA, Kuhl J, Pantoja A. Developmental effects on phenolic, flavonol, anthocyanin, and carotenoid metabolites and gene expression in potatoes. J Agric Food Chem 2013; 61: 7357-7365.
32. Teas J, Irhimeh MR, Druker S, et al. Serum IGF-1 concentrations change with soy and seaweed supplements in healthy postmenopausal American women. Nutr Cancer 2011; 63: 743-748.
33. Kim SK, Pangestuti R. Biological activities and potential health benefits of fucoxanthin derived from marine brown algae. Adv Food Nutr Res 2011; 64: 111-128.
34. Miyashita K, Nishikawa S, Beppu F, et al. The carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds. J Sci Food Agric 2011; 91: 1166-1174.
35. D'Orazio N, Gemello E, Gammone MA. Fucoxanthin: a treasure from the sea. Mar Drugs 2012; 10: 604-616.
36. Senni K, Pereira J, Gueniche F, et al. Marine polysaccharides: a source of bioactive molecules for cell therapy and tissue engineering. Mar Drugs 2011; 9: 1664-1681.
37. Senthilkumar K, Manivasagan P, Venkatesan J, Kim SK. Brown seaweed fucoidan: biological activity and apoptosis, growth signaling mechanism in cancer. Int J Biol Macromol 2013; 60: 366-374.
38. Wang J, Jin W, Zhang W, et al. Hypoglycemic property of acidic polysaccharide extracted from Saccharina japonica and its potential mechanism. Carbohydr Polym 2013; 95: 143-147.
39. Kim MJ, Jeon J, Lee JS. Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation. Phytother Res 2013. [Epub ahead of print]. doi:10.1002/ptr.4965.
40. Guedes AC, Amaro HM, Malcata FX. Microalgae as sources of Carotenoids. Drugs 2011; 9: 625-644.
41. Yazaki K, Yoshikoshi C, Oshiro S, Yanase S. Supplemental cellular protection by a carotenoid extends lifespan via Ins/IGF-1 signaling in Caenorhabditis elegans. Oxid Med Cell Longev 2011; 2011:596240.
42. Kidd P. Astaxanthin, cell membrane nutrient with diverse clinical benefits and antiaging potential. Altern Med Rev 2011; 16: 355-364.
43. Asher GN, Spelman K. Clinical utility of curcumin extract. Altern Ther Health Med 2013; 19: 20-22.
44. Liao V, Yu CW, Chu YJ, et al. Curcumin-mediated lifespan extension in Caenorhabditis elegans. Mech Ageing Dev 2011; 132: 480-487.
45. Xiang L, Nakamura Y, Lim YM, et al. Tetrahydrocurcumin extends life span and inhibits the oxidative stress response by regulating the FOXO forkhead transcription factor. Aging 2011; 3: 1098-1109.
46. Shen LR, Parnell LD, Ordovas JM, Lai CQ. Curcumin and aging. Biofactors 2013; 39: 133-140.
47. Chin D, Huebbe P, Pallauf K, Rimbach G. Neuroprotective properties of curcumin in Alzheimer's disease: merits and limitations. Curr Med Chem 2013; 20: 3955-3985.
48. Dodge HH, Buracchio TJ, Fisher GG, et al. Trends in the prevalence of dementia in Japan. Int J Alzheimers Dis 2012; 2012:956354.