The role of the renin-angiotensin system in thoracic aortic aneurysms: Clinical implications

Pharmacology and Therapeutics

Volumn 131, Issue 1, 2011, Pages 50-60

  Moltzer, Els ^a   Essers, Jeroen ^a   Van Esch, Joep H M ^a   Roos Hesselink, Jolien W ^a   Danser, A H Jan ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Marfan's syndrome; Renin angiotensin system; Therapeutic treatment; Thoracic aortic aneurysm

Indexed keywords

AMLODIPINE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CELIPROLOL; COLLAGEN TYPE 3; ENALAPRIL; FIBRILLIN 1; FIBULIN; FIBULIN 4; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 10; IRBESARTAN; LOSARTAN; MYOSIN HEAVY CHAIN BETA; NEBIVOLOL; NOTCH1 RECEPTOR; PERINDOPRIL; PLACEBO; POLYCYSTIN 1; POLYCYSTIN 2; PROPRANOLOL; PROTEIN TYROSINE PHOSPHATASE SHP 2; RAS PROTEIN; SMOOTH MUSCLE ACTIN; TELMISARTAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG; VERAPAMIL;

ANEURYSM SURGERY; ARTICLE; CUTIS LAXA; DISEASE ASSOCIATION; DISEASE MODEL; DRUG EFFICACY; EHLERS DANLOS SYNDROME; ENDOVASCULAR ANEURYSM REPAIR; ENZYME INHIBITION; GENE MUTATION; HUMAN; LOEYS DIETZ SYNDROME; MARFAN SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; THORACIC AORTA ANEURYSM; THORACIC AORTA SURGERY; TURNER SYNDROME;

EID: 79956270308     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.04.002     Document Type: Review

References (143)

1. H.E. Achneck, J.A. Rizzo, M. Tranquilli, and J.A. Elefteriades Safety of thoracic aortic surgery in the present era Ann Thorac Surg 84 2007 1180 1185 (Pubitemid 47417896)
2. J.N. Adams, M. Brooks, T.W. Redpath, F.W. Smith, J. Dean, and J. Gray Aortic distensibility and stiffness index measured by magnetic resonance imaging in patients with Marfan's syndrome Br Heart J 73 1995 265 269
3. E. Agabiti-Rosei, E. Porteri, and D. Rizzoni Arterial stiffness, hypertension, and rational use of nebivolol Vasc Health Risk Manag 5 2009 353 360
4. A.A. Ahimastos, A. Aggarwal, K.M. D'Orsa, M.F. Formosa, A.J. White, and R. Savarirayan Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial JAMA 298 2007 1539 1547 (Pubitemid 47529388)
5. G. Albornoz, M.A. Coady, M. Roberts, R.R. Davies, M. Tranquilli, and J.A. Rizzo Familial thoracic aortic aneurysms and dissections-incidence, modes of inheritance, and phenotypic patterns Ann Thorac Surg 82 2006 1400 1405 (Pubitemid 44402354)
6. W.S. Argraves, L.M. Greene, M.A. Cooley, and W.M. Gallagher Fibulins: physiological and disease perspectives EMBO Rep 4 2003 1127 1131 (Pubitemid 38088406)
7. W.W. Batenburg, I.M. Garrelds, C.C. Bernasconi, L. Juillerat-Jeanneret, J.P. van Kats, and P.R. Saxena Angiotensin II type 2 receptor-mediated vasodilation in human coronary microarteries Circulation 109 2004 2296 2301 (Pubitemid 38656868)
8. H. Baumgartner, P. Bonhoeffer, N.M. De Groot, F. de Haan, J.E. Deanfield, and N. Galie ESC guidelines for the management of grown-up congenital heart disease (new version 2010): the Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC) Eur Heart J 31 2010 2915 2957
9. A. Biagini, S. Maffei, M. Baroni, M. Piacenti, M. Terrazzi, and F. Paoli Familiar clustering of aortic dissection in polycystic kidney disease Am J Cardiol 72 1993 741 742 (Pubitemid 23273569)
10. R.O. Bonow, B.A. Carabello, K. Chatterjee, A.C. de Leon Jr.; D.P. Faxon, and M.D. Freed 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): endorsed by the Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons Circulation 118 2008 e523 e661
11. W.A. Border, and N.A. Noble Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis Hypertension 31 1998 181 188
12. S. Bosnyak, I.K. Welungoda, A. Hallberg, M. Alterman, R.E. Widdop, and E.S. Jones Stimulation of angiotensin AT2 receptors by the non-peptide agonist, Compound 21, evokes vasodepressor effects in conscious spontaneously hypertensive rats Br J Pharmacol 159 2010 709 716
13. L. Botta, V. Russo, C. La Palombara, M. Rosati, R. Di Bartolomeo, and R. Fattori Stent graft repair of descending aortic dissection in patients with Marfan syndrome: an effective alternative to open reoperation? J Thorac Cardiovasc Surg 138 2009 1108 1114
14. B.S. Brooke, J.P. Habashi, D.P. Judge, N. Patel, B. Loeys, and H.C. Dietz III Angiotensin II blockade and aortic-root dilation in Marfan's syndrome N Engl J Med 358 2008 2787 2795 (Pubitemid 351930853)
15. W. Chai, I.M. Garrelds, R. de Vries, W.W. Batenburg, J.P. van Kats, and A.H. Danser Nongenomic effects of aldosterone in the human heart: interaction with angiotensin II Hypertension 46 2005 701 706 (Pubitemid 43186741)
16. Y.C. Chan, C.W. Ting, P. Ho, J.T. Poon, G.C. Cheung, and S.W. Cheng Ten-year epidemiological review of in-hospital patients with Marfan syndrome Ann Vasc Surg 22 2008 608 612
17. Q. Chen, T. Zhang, J.F. Roshetsky, Z. Ouyang, J. Essers, and C. Fan Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts Biochem J 423 2009 79 89
18. W.D. Clouse, J.W. Hallett Jr.; H.V. Schaff, P.C. Spittell, C.M. Rowland, and D.M. Ilstrup Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture Mayo Clin Proc 79 2004 176 180 (Pubitemid 38140801)
19. R.D. Cohn, C. van Erp, J.P. Habashi, A.A. Soleimani, E.C. Klein, and M.T. Lisi Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states Nat Med 13 2007 204 210
20. G. Collod, M.C. Babron, G. Jondeau, M. Coulon, J. Weissenbach, and O. Dubourg A second locus for Marfan syndrome maps to chromosome 3p24.2-p25 Nat Genet 8 1994 264 268 (Pubitemid 24338738)
21. P.J. Coucke, A. Willaert, M.W. Wessels, B. Callewaert, N. Zoppi, and J. De Backer Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome Nat Genet 38 2006 452 457
22. A.H.J. Danser Local renin-angiotensin systems: the unanswered questions Int J Biochem Cell Biol 35 2003 759 768 (Pubitemid 36379316)
23. A.H.J. Danser Novel drugs targeting hypertension: renin inhibitors J Cardiovasc Pharmacol 50 2007 105 111 (Pubitemid 47267735)
24. A.H.J. Danser, J.P. van Kats, P.J.J. Admiraal, F.H. Derkx, J.M.J. Lamers, and P.D. Verdouw Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis Hypertension 24 1994 37 48 (Pubitemid 24195402)
25. A.H.J. Danser, W.W. Batenburg, A.H. van den Meiracker, and S.M. Danilov ACE phenotyping as a first step toward personalized medicine for ACE inhibitors. Why does ACE genotyping not predict the therapeutic efficacy of ACE inhibition? Pharmacol Ther 113 2007 607 618 (Pubitemid 46365959)
26. A.M. Dart, and B.A. Kingwell Pulse pressure-a review of mechanisms and clinical relevance J Am Coll Cardiol 37 2001 975 984 (Pubitemid 32217593)
27. M. Dasouki, D. Markova, R. Garola, T. Sasaki, N.L. Charbonneau, and L.Y. Sakai Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa Am J Med Genet A 143 2007 2635 2641 (Pubitemid 350076765)
28. A. Daugherty, and L. Cassis Angiotensin II-mediated development of vascular diseases Trends Cardiovasc Med 14 2004 117 120 (Pubitemid 38569679)
29. A. Daugherty, and L. Cassis Angiotensin II and abdominal aortic aneurysms Curr Hypertens Rep 6 2004 442 446 (Pubitemid 39600100)
30. A. Daugherty, M.W. Manning, and L.A. Cassis Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis Br J Pharmacol 134 2001 865 870 (Pubitemid 33016158)
31. L.M. de Lannoy, A.H.J. Danser, J.P. van Kats, R.G. Schoemaker, P.R. Saxena, and M.A.D.H. Schalekamp Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart. Local production of angiotensin I Hypertension 29 1997 1240 1251 (Pubitemid 27233172)
32. D. Detaint, P. Aegerter, F. Tubach, I. Hoffman, H. Plauchu, and Y. Dulac Rationale and design of a randomized clinical trial (Marfan Sartan) of angiotensin II receptor blocker therapy versus placebo in individuals with Marfan syndrome Arch Cardiovasc Dis 103 2010 317 325
33. H.C. Dietz, G.R. Cutting, R.E. Pyeritz, C.L. Maslen, L.Y. Sakai, and G.M. Corson Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene Nature 352 1991 337 339 (Pubitemid 21912353)
34. S. Dogan, A. Memis, A. Kale, and S. Buket Endovascular stent graft placement in the treatment of ruptured tuberculous pseudoaneurysm of the descending thoracic aorta: case report and review of the literature Cardiovasc Intervent Radiol 32 2009 572 576
35. J.J. Doyle, J.P. Habashi, M. Lindsay, D. Bedja, and H.C. Dietz Calcium channel blockers exacerbate aortic disease and cause premature lethality in Marfan syndrome Circulation 122 2010 A14647 Abstract
36. L.M. Duke, R.E. Widdop, M.M. Kett, and R.G. Evans AT(2) receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension Br J Pharmacol 144 2005 486 492 (Pubitemid 40352559)
37. I. El-Hamamsy, and M.H. Yacoub Cellular and molecular mechanisms of thoracic aortic aneurysms Nat Rev Cardiol 6 2009 771 786
38. M. Elsheikh, B. Casadei, G.S. Conway, and J.A. Wass Hypertension is a major risk factor for aortic root dilatation in women with Turner's syndrome Clin Endocrinol 54 2001 69 73 (Pubitemid 32158707)
39. A.D. Frutkin, G. Otsuka, A. Stempien-Otero, C. Sesti, L. Du, and M. Jaffe TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice Arterioscler Thromb Vasc Biol 29 2009 1251 1257
40. F.I. Gambarin, V. Favalli, A. Serio, M. Regazzi, M. Pasotti, and C. Klersy Rationale and design of a trial evaluating the effects of losartan vs. nebivolol vs. the association of both on the progression of aortic root dilation in Marfan syndrome with FBN1 gene mutations J Cardiovasc Med 10 2009 354 362
41. V. Garg, A.N. Muth, J.F. Ransom, M.K. Schluterman, R. Barnes, and I.N. King Mutations in NOTCH1 cause aortic valve disease Nature 437 2005 270 274 (Pubitemid 41294491)
42. P. Gelosa, A. Pignieri, L. Fandriks, M. de Gasparo, A. Hallberg, and C. Banfi Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage J Hypertens 27 2009 2444 2451
43. D.P. Germain Ehlers-Danlos syndrome type IV Orphanet J Rare Dis 2 2007 32
44. D.R. Gersony, M.A. McClaughlin, Z. Jin, and W.M. Gersony The effect of beta-blocker therapy on clinical outcome in patients with Marfan's syndrome: a meta-analysis Int J Cardiol 114 2007 303 308 (Pubitemid 44855907)
45. G.H. Gibbons, R.E. Pratt, and V.J. Dzau Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II J Clin Invest 90 1992 456 461
46. R.R. Gopaldas, J. Huh, T.K. Dao, S.A. LeMaire, D. Chu, and F.G. Bakaeen Superior nationwide outcomes of endovascular versus open repair for isolated descending thoracic aortic aneurysm in 11,669 patients J Thorac Cardiovasc Surg 140 2010 1001 1010
47. D. Guo, S. Hasham, S.Q. Kuang, C.J. Vaughan, E. Boerwinkle, and H. Chen Familial thoracic aortic aneurysms and dissections: genetic heterogeneity with a major locus mapping to 5q13-14 Circulation 103 2001 2461 2468 (Pubitemid 32493372)
48. D.C. Guo, H. Pannu, V. Tran-Fadulu, C.L. Papke, R.K. Yu, and N. Avidan Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections Nat Genet 39 2007 1488 1493 (Pubitemid 350191352)
49. J.P. Habashi, D.P. Judge, T.M. Holm, R.D. Cohn, B.L. Loeys, and T.K. Cooper Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome Science 312 2006 117 121
50. J.P. Habashi, T.M. Holm, J.J. Doyle, H. Aziz, D. Bedja, and H.C. Dietz AT2 Signaling is a positive prognostic and therapeutic modifier of Marfan syndrome: lessons on the inequality of ACEi and ARBs Circulation 120 2009 S963 Abstract
51. K. Hanada, M. Vermeij, G.A. Garinis, M.C. de Waard, M.G. Kunen, and L. Myers Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice Circ Res 100 2007 738 746 (Pubitemid 46594889)
52. S.N. Hasham, M.C. Willing, D.C. Guo, A. Muilenburg, R. He, and V.T. Tran Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24-25 Circulation 107 2003 3184 3190 (Pubitemid 36793089)
53. W. Hayashida, M. Horiuchi, and V.J. Dzau Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function J Biol Chem 271 1996 21985 21992 (Pubitemid 26303824)
54. L.F. Hiratzka, G.L. Bakris, J.A. Beckman, R.M. Bersin, V.F. Carr, and D.E. Casey Jr. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the diagnosis and management of patients with thoracic aortic disease. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology,American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons,and Society for Vascular Medicine. J Am Coll Cardiol 55 2010 e27 e129
55. D. Horbelt, G. Guo, P.N. Robinson, and P. Knaus Quantitative analysis of TGFBR2 mutations in Marfan-syndrome-related disorders suggests a correlation between phenotypic severity and Smad signaling activity J Cell Sci 123 2010 4340 4350
56. M. Horiguchi, T. Inoue, T. Ohbayashi, M. Hirai, K. Noda, and L.Y. Marmorstein Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase Proc Natl Acad Sci USA 106 2009 19029 19034
57. J. Hoyer, C. Kraus, G. Hammersen, J.P. Geppert, and A. Rauch Lethal cutis laxa with contractural arachnodactyly, overgrowth and soft tissue bleeding due to a novel homozygous fibulin-4 gene mutation Clin Genet 76 2009 276 281
58. J. Huang, E.C. Davis, S.L. Chapman, M. Budatha, L.Y. Marmorstein, and R.A. Word Fibulin-4 deficiency results in ascending aortic aneurysms. A potential link between abnormal smooth muscle cell phenotype and aneurysm progression Circ Res 106 2009 583 592
59. V. Hucthagowder, N. Sausgruber, K.H. Kim, B. Angle, L.Y. Marmorstein, and Z. Urban Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome Am J Hum Genet 78 2006 1075 1080 (Pubitemid 43787699)
60. H. Ince, T.C. Rehders, M. Petzsch, S. Kische, and C.A. Nienaber Stent-grafts in patients with marfan syndrome J Endovasc Ther 12 2005 82 88 (Pubitemid 40229393)
61. E.M. Isselbacher Thoracic and abdominal aortic aneurysms Circulation 111 2005 816 828 (Pubitemid 40250643)
62. K.W. Johnston, R.B. Rutherford, M.D. Tilson, D.M. Shah, L. Hollier, and J.C. Stanley Suggested standards for reporting on arterial aneurysms. Subcommittee on Reporting Standards for Arterial Aneurysms, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery J Vasc Surg 13 1991 452 458
63. G.T. Jones, A.R. Thompson, F.M. van Bockxmeer, H. Hafez, J.A. Cooper, and J. Golledge Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts Arterioscler Thromb Vasc Biol 28 2008 764 770 (Pubitemid 351651328)
64. D.P. Judge, N.J. Biery, D.R. Keene, J. Geubtner, L. Myers, and D.L. Huso Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome J Clin Invest 114 2004 172 181 (Pubitemid 39071622)
65. S. Kagami, W.A. Border, D.E. Miller, and N.A. Noble Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells J Clin Invest 93 1994 2431 2437 (Pubitemid 24177156)
66. E. Kaschina, A. Grzesiak, J. Li, A. Foryst-Ludwig, M. Timm, and F. Rompe Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation 118 2008 2523 2532
67. E. Kaschina, H. Scholz, U.M. Steckelings, M. Sommerfeld, U.R. Kemnitz, and M. Artuc Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components Atherosclerosis 205 2009 396 403
68. P. Khau Van Kien, F. Mathieu, L. Zhu, A. Lalande, C. Betard, and M. Lathrop Mapping of familial thoracic aortic aneurysm/dissection with patent ductus arteriosus to 16p12.2-p13.13 Circulation 112 2005 200 206 (Pubitemid 40982302)
69. V. Koka, X.R. Huang, A.C. Chung, W. Wang, L.D. Truong, and H.Y. Lan Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway Am J Pathol 172 2008 1174 1183 (Pubitemid 351671532)
70. M. Krop, R. van Veghel, I.M. Garrelds, R.J. de Bruin, J.M. van Gool, and A.H. van den Meiracker Cardiac renin levels are not influenced by the amount of resident mast cells Hypertension 54 2009 315 321
71. M. Krop, Z.G. Ozunal, W. Chai, R. de Vries, D. Fekkes, and A.M. Bouhuizen Mast cell degranulation mediates bronchoconstriction via serotonin and not via renin release Eur J Pharmacol 640 2010 185 189
72. S. Kurisu, R. Ozono, T. Oshima, M. Kambe, T. Ishida, and H. Sugino Cardiac angiotensin II type 2 receptor activates the kinin/NO system and inhibits fibrosis Hypertension 41 2003 99 107 (Pubitemid 36056799)
73. R.V. Lacro, H.C. Dietz, L.M. Wruck, T.J. Bradley, S.D. Colan, and R.B. Devereux Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome Am Heart J 154 2007 624 631 (Pubitemid 47429596)
74. M. Ladouceur, C. Fermanian, J.M. Lupoglazoff, T. Edouard, Y. Dulac, and P. Acar Effect of beta-blockade on ascending aortic dilatation in children with the Marfan syndrome Am J Cardiol 99 2007 406 409 (Pubitemid 46149560)
75. S. Laurent, P. Boutouyrie, R. Asmar, I. Gautier, B. Laloux, and L. Guize Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients Hypertension 37 2001 1236 1241 (Pubitemid 34163575)
76. P. Lavoie, G. Robitaille, M. Agharazii, S. Ledbetter, M. Lebel, and R. Lariviere Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats J Hypertens 23 2005 1895 1903 (Pubitemid 41830430)
77. F. Lin, and X. Yang TGF-beta signaling in aortic aneurysm: another round of controversy J Genet Genomics 37 2010 583 591
78. B.L. Loeys, J. Chen, E.R. Neptune, D.P. Judge, M. Podowski, and T. Holm A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2 Nat Genet 37 2005 275 281 (Pubitemid 41716254)
79. B.L. Loeys, U. Schwarze, T. Holm, B.L. Callewaert, G.H. Thomas, and H. Pannu Aneurysm syndromes caused by mutations in the TGF-beta receptor N Engl J Med 355 2006 788 798 (Pubitemid 44285584)
80. H. Lu, D.L. Rateri, L.A. Cassis, and A. Daugherty The role of the renin-angiotensin system in aortic aneurysmal diseases Curr Hypertens Rep 10 2008 99 106
81. C.J. Mackins, S. Kano, N. Seyedi, U. Schafer, A.C. Reid, and T. Machida Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion J Clin Invest 116 2006 1063 1070
82. A. Mahmud, and J. Feely Antihypertensive drugs and arterial stiffness Exp Rev Cardiovasc Ther 1 2003 65 78
83. P. Matt, F. Schoenhoff, J. Habashi, T. Holm, C. Van Erp, and D. Loch Circulating transforming growth factor-beta in Marfan syndrome Circulation 120 2009 526 532
84. L.A. Matura, V.B. Ho, D.R. Rosing, and C.A. Bondy Aortic dilatation and dissection in Turner syndrome Circulation 116 2007 1663 1670 (Pubitemid 47542238)
85. S.H. McKellar, D.J. Tester, M. Yagubyan, R. Majumdar, M.J. Ackerman, and T.M. Sundt III Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms J Thorac Cardiovasc Surg 134 2007 290 296 (Pubitemid 47088578)
86. P.J. McLaughlin, Q. Chen, M. Horiguchi, B.C. Starcher, J.B. Stanton, and T.J. Broekelmann Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice Mol Cell Biol 26 2006 1700 1709
87. D.M. Milewicz, H.C. Dietz, and D.C. Miller Treatment of aortic disease in patients with Marfan syndrome Circulation 111 2005 e150 e157
88. D.M. Milewicz, D.C. Guo, V. Tran-Fadulu, A.L. Lafont, C.L. Papke, and S. Inamoto Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction Annu Rev Genomics Hum Genet 9 2008 283 302
89. E. Moltzer, A.V. Verkuil, R. van Veghel, A.H.J. Danser, and J.H.M. van Esch Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation Hypertension 55 2010 516 522
90. J.M. Morgan, M.O. Coupe, M. Honey, and G.A. Miller Aneurysms of the sinuses of Valsalva in Noonan's syndrome Eur Heart J 10 1989 190 193 (Pubitemid 19081867)
91. H. Nagashima, Y. Sakomura, Y. Aoka, K. Uto, K. Kameyama, and M. Ogawa Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis in cystic medial degeneration associated with Marfan's syndrome Circulation 104 2001 I282 I287
92. National Center for Injury Prevention and Control WISQARS Leading Causes of Death Reports 2007 from http://webappa.cdc.gov/sasweb/ncipc/leadcaus10.html
93. E.R. Neptune, P.A. Frischmeyer, D.E. Arking, L. Myers, T.E. Bunton, and B. Gayraud Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome Nat Genet 33 2003 407 411 (Pubitemid 36278859)
94. C.M. Ng, A. Cheng, L.A. Myers, F. Martinez-Murillo, C. Jie, and D. Bedja TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome J Clin Invest 114 2004 1586 1592 (Pubitemid 40385549)
95. S. Nistri, M.D. Sorbo, M. Marin, M. Palisi, R. Scognamiglio, and G. Thiene Aortic root dilatation in young men with normally functioning bicuspid aortic valves Heart 82 1999 19 22 (Pubitemid 29309229)
96. V.T. Nkomo, M. Enriquez-Sarano, N.M. Ammash, L.J. Melton III, K.R. Bailey, and V. Desjardins Bicuspid aortic valve associated with aortic dilatation: a community-based study Arterioscler Thromb Vasc Biol 23 2003 351 356 (Pubitemid 36231952)
97. G.J. Nollen, M. Groenink, J.G. Tijssen, E.E. Van Der Wall, and B.J. Mulder Aortic stiffness and diameter predict progressive aortic dilatation in patients with Marfan syndrome Eur Heart J 25 2004 1146 1152 (Pubitemid 38834072)
98. K.T. Ong, J. Perdu, J. De Backer, E. Bozec, P. Collignon, and J. Emmerich Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a prospective randomised, open, blinded-endpoints trial Lancet 376 2010 1476 1484
99. S. Otsuka, M. Sugano, N. Makino, S. Sawada, T. Hata, and Y. Niho Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats Hypertension 32 1998 467 472 (Pubitemid 28429135)
100. S.H. Padia, N.L. Howell, H.M. Siragy, and R.M. Carey Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat Hypertension 47 2006 537 544 (Pubitemid 43843872)
101. H. Pannu, V.T. Fadulu, J. Chang, A. Lafont, S.N. Hasham, and E. Sparks Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections Circulation 112 2005 513 520 (Pubitemid 41060791)
102. H. Pannu, V. Tran-Fadulu, C.L. Papke, S. Scherer, Y. Liu, and C. Presley MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II Hum Mol Genet 16 2007 2453 2462 (Pubitemid 47500631)
103. M. Pepin, U. Schwarze, A. Superti-Furga, and P.H. Byers Clinical and genetic features of Ehlers-Danlos syndrome type IV, the vascular type N Engl J Med 342 2000 673 680 (Pubitemid 30131419)
104. L. Pereira, K. Andrikopoulos, J. Tian, S.Y. Lee, D.R. Keene, and R. Ono Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome Nat Genet 17 1997 218 222
105. L. Pereira, S.Y. Lee, B. Gayraud, K. Andrikopoulos, S.D. Shapiro, and T. Bunton Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1 Proc Natl Acad Sci USA 96 1999 3819 3823 (Pubitemid 29168994)
106. H. Peters, W.A. Border, and N.A. Noble Angiotensin II blockade and low-protein diet produce additive therapeutic effects in experimental glomerulonephritis Kidney Int 57 2000 1493 1501 (Pubitemid 30207908)
107. F. Pinaud, A. Bocquet, O. Dumont, K. Retailleau, C. Baufreton, and R. Andriantsitohaina Paradoxical role of angiotensin II type 2 receptors in resistance arteries of old rats Hypertension 50 2007 96 102 (Pubitemid 46986016)
108. T. Radonic, P. de Witte, M.J. Baars, A.H. Zwinderman, B.J. Mulder, and M. Groenink Losartan therapy in adults with Marfan syndrome: study protocol of the multi-center randomized controlled COMPARE trial Trials 11 2010 3
109. D. Reed, C. Reed, G. Stemmermann, and T. Hayashi Are aortic aneurysms caused by atherosclerosis? Circulation 85 1992 205 211
110. M. Renard, T. Holm, R. Veith, B.L. Callewaert, L.C. Ades, and O. Baspinar Altered TGFbeta signaling and cardiovascular manifestations in patients with autosomal recessive cutis laxa type I caused by fibulin-4 deficiency Eur J Hum Genet 18 2010 895 901
111. P.N. Robinson, P. Booms, S. Katzke, M. Ladewig, L. Neumann, and M. Palz Mutations of FBN1 and genotype-phenotype correlations in Marfan syndrome and related fibrillinopathies Hum Mutat 20 2002 153 161 (Pubitemid 34966843)
112. J. Rodriguez-Vita, E. Sanchez-Lopez, V. Esteban, M. Ruperez, J. Egido, and M. Ruiz-Ortega Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism Circulation 111 2005 2509 2517 (Pubitemid 40696140)
113. F. Rompe, T. Unger, and U.M. Steckelings The angiotensin AT2 receptor in inflammation Drug News Perspect 23 2010 104 111
114. R. Rossi-Foulkes, M.J. Roman, S.E. Rosen, R. Kramer-Fox, K.H. Ehlers, and J.E. O'Loughlin Phenotypic features and impact of beta blocker or calcium antagonist therapy on aortic lumen size in the Marfan syndrome Am J Cardiol 83 1999 1364 1368 (Pubitemid 29205747)
115. M. Ruiz-Ortega, J. Rodriguez-Vita, E. Sanchez-Lopez, G. Carvajal, and J. Egido TGF-beta signaling in vascular fibrosis Cardiovasc Res 74 2007 196 206
116. Y. Sakomura, S. Yoshioka, N. Ishizuka, T. Horie, S. Aomi, and F. Yamaki Apoptosis of medial smooth muscle cells in dilated ascending aortas of patients with Marfan's syndrome and annulo-aortic ectasia Circulation 96 suppl I 1997 I-126 Abstract
117. M.A. Salim, B.S. Alpert, J.C. Ward, and R.E. Pyeritz Effect of beta-adrenergic blockade on aortic root rate of dilation in the Marfan syndrome Am J Cardiol 74 1994 629 633 (Pubitemid 24279954)
118. M.P. Schuijt, and A.H.J. Danser Cardiac angiotensin II: an intracrine hormone? Am J Hypertens 15 2002 1109 1116 (Pubitemid 35397547)
119. M.P. Schuijt, M. Basdew, R. van Veghel, R. de Vries, P.R. Saxena, and R.G. Schoemaker AT(2) receptor-mediated vasodilation in the heart: effect of myocardial infarction Am J Physiol Heart Circ Physiol 281 2001 H2590 H2596
120. E.S. Selamet Tierney, B. Feingold, B.F. Printz, S.C. Park, D. Graham, and C.S. Kleinman Beta-blocker therapy does not alter the rate of aortic root dilation in pediatric patients with Marfan syndrome J Pediatr 150 2007 77 82 (Pubitemid 44940887)
121. J. Shores, K.R. Berger, E.A. Murphy, and R.E. Pyeritz Progression of aortic dilatation and the benefit of long-term beta-adrenergic blockade in Marfan's syndrome N Engl J Med 330 1994 1335 1341
122. U.M. Steckelings, R.E. Widdop, L. Paulis, and T. Unger The angiotensin AT2 receptor in left ventricular hypertrophy J Hypertens 28 Suppl 1 2010 S50 S55
123. S. Subramanian, and E.E. Roselli Thoracic aortic dissection: long-term results of endovascular and open repair Semin Vasc Surg 22 2009 61 68
124. Y. Sun, J.Q. Zhang, J. Zhang, and F.J. Ramires Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart J Mol Cell Cardiol 30 1998 1559 1569 (Pubitemid 28418646)
125. F. Tavora, and A. Burke Review of isolated ascending aortitis: differential diagnosis, including syphilitic, Takayasu's and giant cell aortitis Pathology 38 2006 302 308 (Pubitemid 44266626)
126. A.R. Thompson, F. Drenos, H. Hafez, and S.E. Humphries Candidate gene association studies in abdominal aortic aneurysm disease: a review and meta-analysis Eur J Vasc Endovasc Surg 35 2008 19 30 (Pubitemid 350235228)
127. J.H.M. van Esch, M.P. Schuijt, J. Sayed, Y. Choudhry, T. Walther, and A.H.J. Danser AT(2) receptor-mediated vasodilation in the mouse heart depends on AT(1A) receptor activation Br J Pharmacol 148 2006 452 458 (Pubitemid 43882081)
128. J.H.M. van Esch, F. Gembardt, A. Sterner-Kock, S. Heringer-Walther, T.H. Le, and D. Lassner Cardiac phenotype and angiotensin II levels in AT1a, AT1b and AT2 receptor single, double and triple knockouts Cardiovasc Res 86 2010 401 409
129. P.P. van Geel, Y.M. Pinto, A.A. Voors, H. Buikema, M. Oosterga, and H.J. Crijns Angiotensin II type 1 receptor A1166C gene polymorphism is associated with an increased response to angiotensin II in human arteries Hypertension 35 2000 717 721 (Pubitemid 30165315)
130. J.P. van Kats, D.J. Duncker, D.B. Haitsma, M.P. Schuijt, R. Niebuur, and R. Stubenitsky Angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade prevent cardiac remodeling in pigs after myocardial infarction: role of tissue angiotensin II Circulation 102 2000 1556 1563
131. J.P. van Kats, M.A.D.H. Schalekamp, P.D. Verdouw, D.J. Duncker, and A.H.J. Danser Intrarenal angiotensin II: interstitial and cellular levels and site of production Kidney Int 60 2001 2311 2317 (Pubitemid 33070473)
132. J.P. van Kats, J.R. van Meegen, P.D. Verdouw, D.J. Duncker, M.A.D.H. Schalekamp, and A.H.J. Danser Subcellular localization of angiotensin II in kidney and adrenal J Hypertens 19 2001 583 589 (Pubitemid 32280950)
133. J.P. van Kats, W. Chai, D.J. Duncker, M.A.D.H. Schalekamp, and A.H.J. Danser Adrenal angiotensin: origin and site of generation Am J Hypertens 18 2005 1104 1110 (Pubitemid 41139910)
134. C.A.M. van Kesteren, H.A.A. van Heugten, J.M.J. Lamers, P.R. Saxena, M.A.D.H. Schalekamp, and A.H.J. Danser Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts J Mol Cell Cardiol 29 1997 2147 2157 (Pubitemid 27348525)
135. C.J. Vaughan, M. Casey, J. He, M. Veugelers, K. Henderson, and D. Guo Identification of a chromosome 11q23.2-q24 locus for familial aortic aneurysm
136. A. Veerappan, A.C. Reid, R. Estephan, N. O'Connor, M. Thadani-Mulero, and M. Salazar-Rodriguez Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction Proc Natl Acad Sci USA 105 2008 1315 1320 (Pubitemid 351397050)
137. Y. Wan, C. Wallinder, B. Johansson, M. Holm, A.K. Mahalingam, and X. Wu First reported nonpeptide AT1 receptor agonist (L-162,313) acts as an AT2 receptor agonist in vivo J Med Chem 47 2004 1536 1546 (Pubitemid 38327477)
138. T. Willum-Hansen, J.A. Staessen, C. Torp-Pedersen, S. Rasmussen, L. Thijs, and H. Ibsen Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population Circulation 113 2006 664 670
139. G. Wolf, and U.O. Wenzel Angiotensin II and cell cycle regulation Hypertension 43 2004 693 698 (Pubitemid 38405570)
140. A.T. Yetman, R.A. Bornemeier, and B.W. McCrindle Usefulness of enalapril versus propranolol or atenolol for prevention of aortic dilation in patients with the Marfan syndrome Am J Cardiol 95 2005 1125 1127 (Pubitemid 40544327)
141. D. You, L. Loufrani, C. Baron, B.I. Levy, R.E. Widdop, and D. Henrion High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats Circulation 111 2005 1006 1011 (Pubitemid 40354518)
142. K.J. Zehr, T.A. Orszulak, C.J. Mullany, A. Matloobi, R.C. Daly, and J.A. Dearani Surgery for aneurysms of the aortic root: a 30-year experience Circulation 110 2004 1364 1371 (Pubitemid 39242689)
143. L. Zhu, R. Vranckx, P. Khau Van Kien, A. Lalande, N. Boisset, and F. Mathieu Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus Nat Genet 38 2006 343 349