Functional importance of angiotensin-converting enzyme-dependent in situ angiotensin II generation in the human forearm

Hypertension

Volumn 35, Issue 3, 2000, Pages 764-768

  Saris, Jasper J ^a   Van Dijk, Marjan A ^b   Kroon, Ingrid ^b   Schalekamp, Maarten A D H ^a   Danser, A H Jan ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Angiotensin; Angiotensin converting enzyme inhibitors; Blood flow; Receptors, angiotensin II

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRILAT; LOSARTAN; NITROPRUSSIDE SODIUM;

ADULT; AGED; ARM BLOOD FLOW; ARTICLE; CONTROLLED STUDY; ENZYME DEGRADATION; FOREARM; HUMAN; MALE; NORMAL HUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; VASOCONSTRICTION;

EID: 0034065988     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.35.3.764     Document Type: Article

References (29)

1. Ng KKF, Vane JR. Fate of angiotensin I in the circulation. Nature. 1968; 218:144-150.
2. Admiraal PJJ, Danser AHJ, Jong MS, Pieterman H, Derkx FHM, Schalekamp MADH. Regional angiotensin II production in essential hypertension and renal artery stenosis. Hypertension. 1993;21: 173-184.
3. Danser AHJ, Koning MM, Admiraal PJJ, Derkx FHM, Verdouw PD, Schalekamp MADH. Metabolism of angiotensin I by different tissues in the intact animal. Am J Physiol. 1992;263:H418-H428.
4. Danser AHJ, Admiraal PJJ, Derkx FHM, Schalekamp MADH. Angiotensin I-to-II conversion in the human renal vascular bed. J Hypertens. 1998;16:2051-2056.
5. Neri Serneri GG, Boddi M, Coppo M, Chechi T, Zarone N, Moira M, Poggessi L, Margheri M, Simonetti I. Evidence for the existence of a functional cardiac renin-angiotensin system in humans. Circulation. 1996;94:1886-1893.
6. Maassen Van Den Brink A, de Vries R, Saxena PR, Schalekamp MADH, Danser AHJ. Vasoconstriction by in-situ formed angiotensin II: role of ACE and chymase. Cardiovasc Res. 1999;44:407-415.
7. Voors AA, Pinto YM, Buikema Hurata H, Oosterga M, Rooks G, Grandjean JG, Ganten D, van Gilst WH. Dual pathways for angiotensin II formation in human internal mammary arteries. Br J Pharmacol. 1998;125:1028-1032.
8. Hilgers KF, Bingener E, Stumpf C, Müller DN, Schmieder RE, Veelken R. Angiotensinases restrict locally generated angiotensin II to the blood vessel wall. Hypertension. 1998;31:368-372.
9. Urata H, Strobel F, Ganten D. Widespread tissue distribution of human chymase. J Hypertens. 1994;12(suppl):S17-S22.
10. Ohishi M, Ueda M, Rakugi H, Naruko T, Kojima A, Okamura A, Higaki J, Ogihara T. Relative localization of angiotensin-converting enzyme, chymase and angiotensin II in human coronary atherosclerotic lesions. J Hypertens. 1999;17:547-553.
11. Urata H, Healy B, Stewart RW, Bumpus FM, Husain A. Angiotensin II-forming pathways in normal and failing human hearts. Circ Res. 1990;66:883-890.
12. Balcells E, Meng QC, Johnson WH Jr, Oparil S, Dell'Italia LJ. Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations. Am J Physiol. 1997;273:H1769-H1774.
13. Zisman LS, Abraham WT, Meixell GE, Vamvakias BN, Quaife RA, Lowes BD, Roden RL, Peacock SJ, Groves BM, Raynolds MV, Bristow MR, Perryman MB. Angiotensin II formation in the intact human heart: predominance of the angiotensin-converting enzyme pathway. J Clin Invest. 1995;96:1490-1498.
14. Chang PC, Verlinde R, Bruning TA, van Brummelen P. A microcomputer-based, R-wave triggered system for hemodynamic measurements in the forearm. Comput Biol Med. 1988;18:157-163.
15. Baan J Jr, Chang PC, Vermeij P, Pfaffendorf M, van Zwieten PA. Effects of losartan on vasoconstrictor responses to angiotensin II in the human forearm vascular bed of healthy volunteers. Cardiovasc Res. 1996;32:973-979.
16. van Veen S, Chang PC. Modulation of vasoconstriction by insulin. J Hypertens. 1998;16:1157-1164.
17. Bruning TA, Hendriks MGC, Chang PC, Kuypers EAP, van Zwieten PA. In vivo characterization of vasodilating muscarinic receptor subtypes in humans. Circ Res. 1994;74:912-919.
18. Esther CR, Marino EM, Howard TE, Machaud A, Corvol P, Capecchi MR, Bernstein KE. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest. 1997; 99:2375-2385.
19. Krege JH, John SWM, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, Smithies O. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 1995;375:146-148.
20. Regitz-Zagrosek V, Friedel N, Heymann A, Bauer P, Neuss M, Rolfs A, Steffen C, Hildebrandt A, Hetzer R, Fleck E. Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation. 1995;91:1461-1471.
21. Nozawa Y, Haruno A, Oda N, Yamasaki Y, Matsuura N, Yamada S, Inabe K, Kimura R, Suzuki H, Hoshino T. Angiotensin II receptor subtypes in bovine and human ventricular myocardium. J Pharmacol Exp Ther. 1994;270:566-571.
22. Borland JAA, Chester AH, Morrison KA, Yacoub MH. Alternative pathways of angiotensin II production in the human saphenous vein. Br J Pharmacol. 1998;125:423-428.
23. de Lannoy LM, Danser AHJ, van Kats JP, Schoemaker RG, Saxena PR, Schalekamp MADH. Renin-angiotensin system components in the interstitial fluid of the isolated perfused rat heart: local production of angiotensin I. Hypertension 1997;29:1240-1251.
24. de Lannoy LM, Danser AHJ. Bouhuizen AMB, Saxena PR, Schalekamp MADH. Localization and production of angiotensin II in the isolated perfused rat heart. Hypertension. 1998;31:1111-1117.
25. 12)-angiotensin I. Hypertension. 1994;23: 857-860.
26. Nishimura H, Buikema H, Baltatu O, Ganten D, Urata H. Functional evidence for alternative Ang II-forming pathways in hamster cardiovascular system. Am J Physiol. 1998;275:H1307-H1312.
27. Kokkonen JO, Saarinen J, Kovanen PT. Regulation of local angiotensin II formation in the human heart in the presence of interstitial fluid: inhibition of chymase by protease inhibitors of interstitial fluid and of angiotensin-converting enzyme by Ang-(1-9) formed by heart carboxypeptidase A-like activity. Circulation. 1997;95:1455-1463.
28. Takai S, Shiota N, Jin D, Miyazaki M. Functional role of chymase in angiotensin II formation in human vascular tissue. J Cardiovasc Pharmacol. 1998;32:826-833.
29. 1 receptors. Br J Pharmacol. 1999;126: 1057-1065.