메뉴 건너뛰기




Volumn 36, Issue 6, 2015, Pages 360-373

New therapeutic targets for cancer bone metastasis

Author keywords

Bone metastatic niche; Bone microenvironment; Macrometastasis; Osteoblast; Osteoclast; Tumor intrinsic factors

Indexed keywords

AFLIBERCEPT; ATRASENTAN; BEVACIZUMAB; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CABOZANTINIB; CEDIRANIB; DASATINIB; DENOSUMAB; DOVITINIB; FRESOLIMUMAB; GALUNISERTIB; MICRORNA 126; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; NINTEDANIB; PLERIXAFOR; SARACATINIB; SORAFENIB; SUNITINIB; ANTINEOPLASTIC AGENT;

EID: 84934923163     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2015.04.006     Document Type: Review
Times cited : (70)

References (166)
  • 1
    • 84911477110 scopus 로고    scopus 로고
    • A promise to our patients with metastatic bone disease
    • Randall, R.L. (2014) A promise to our patients with metastatic bone disease. Ann. Surg. Oncol. 21, 4049-4050
    • (2014) Ann. Surg. Oncol. , vol.21 , pp. 4049-4050
    • Randall, R.L.1
  • 2
    • 84919458734 scopus 로고    scopus 로고
    • Evaluation of osseous metastasis in bone scintigraphy
    • Davila, D. et al. (2015) Evaluation of osseous metastasis in bone scintigraphy. Semin. Nucl. Med. 45, 3-15
    • (2015) Semin. Nucl. Med. , vol.45 , pp. 3-15
    • Davila, D.1
  • 3
    • 84906955312 scopus 로고    scopus 로고
    • Contemporary management of metastatic bone disease: Tips and tools of the trade for general practitioners
    • Quinn, R.H. et al. (2014) Contemporary management of metastatic bone disease: tips and tools of the trade for general practitioners. Instr. Course Lect. 63, 431-441
    • (2014) Instr. Course Lect. , vol.63 , pp. 431-441
    • Quinn, R.H.1
  • 4
    • 84919664058 scopus 로고    scopus 로고
    • In vitro microenvironments to study breast cancer bone colonisation
    • Taubenberger, A.V. (2014) In vitro microenvironments to study breast cancer bone colonisation. Adv. Drug Deliv. Rev. 79-80C, 135-144
    • (2014) Adv. Drug Deliv. Rev. , vol.79-80 C , pp. 135-144
    • Taubenberger, A.V.1
  • 6
    • 67649421096 scopus 로고    scopus 로고
    • Molecular principles of cancer invasion and metastasis
    • Leber, M.F. and Efferth, T. (2009) Molecular principles of cancer invasion and metastasis. Int. J. Oncol. 34, 881-895
    • (2009) Int. J. Oncol. , vol.34 , pp. 881-895
    • Leber, M.F.1    Efferth, T.2
  • 7
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • Lamouille, S. et al. (2014) Molecular mechanisms of epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. 15, 178-196
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 178-196
    • Lamouille, S.1
  • 8
    • 57349114162 scopus 로고    scopus 로고
    • The cell-cell adhesion molecule E-cadherin
    • van Roy, F. and Berx, G. (2008) The cell-cell adhesion molecule E-cadherin. Cell. Mol. Life Sci. 65, 3756-3788
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 3756-3788
    • Van Roy, F.1    Berx, G.2
  • 9
    • 0026661360 scopus 로고
    • The vertebrate adhesive junction proteins betacatenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties
    • Peifer, M. et al. (1992) The vertebrate adhesive junction proteins betacatenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J. Cell Biol. 118, 681-691
    • (1992) J. Cell Biol. , vol.118 , pp. 681-691
    • Peifer, M.1
  • 10
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes, R.O. (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 11
    • 78650223132 scopus 로고    scopus 로고
    • Molecular signature of epithelial-mesenchymal transition (EMT) in human prostate cancer bone metastasis
    • Sethi, S. et al. (2010) Molecular signature of epithelial-mesenchymal transition (EMT) in human prostate cancer bone metastasis. Am. J. Transl. Res. 3, 90-99
    • (2010) Am. J. Transl. Res. , vol.3 , pp. 90-99
    • Sethi, S.1
  • 12
    • 85059207566 scopus 로고    scopus 로고
    • Abstract C60: Snail transcription factor contributes to bone metastasis in prostate and breast cancer cells
    • Smith, B.A. et al. (2014) Abstract C60: Snail transcription factor contributes to bone metastasis in prostate and breast cancer cells. Cancer Epidemiol. Biomark. Prev. 23, C60
    • (2014) Cancer Epidemiol. Biomark. Prev. , vol.23 , pp. C60
    • Smith, B.A.1
  • 13
    • 84904662973 scopus 로고    scopus 로고
    • TWIST1 expression in breast cancer cells facilitates bone metastasis formation
    • Croset, M. et al. (2014) TWIST1 expression in breast cancer cells facilitates bone metastasis formation. J. Bone Miner. Res. 29, 1886-1899
    • (2014) J. Bone Miner. Res. , vol.29 , pp. 1886-1899
    • Croset, M.1
  • 14
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza, G.L. (2010) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625-634
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 15
    • 61849136670 scopus 로고    scopus 로고
    • Prognostic potential of the pre-therapeutic tumor oxygenation status
    • Vaupel, P. (2009) Prognostic potential of the pre-therapeutic tumor oxygenation status. Adv. Exp. Med. Biol. 645, 241-246
    • (2009) Adv. Exp. Med. Biol. , vol.645 , pp. 241-246
    • Vaupel, P.1
  • 16
    • 79959908506 scopus 로고    scopus 로고
    • HIF induces human embryonic stem cell markers in cancer cells
    • Mathieu, J. et al. (2011) HIF induces human embryonic stem cell markers in cancer cells. Cancer Res. 71, 4640-4652
    • (2011) Cancer Res. , vol.71 , pp. 4640-4652
    • Mathieu, J.1
  • 17
    • 84872148970 scopus 로고    scopus 로고
    • Hypoxia suppresses E-cadherin and enhances matrix metalloproteinase-2 expression favoring esophageal carcinoma migration and invasion via hypoxia inducible factor-1 alpha activation
    • Jing, S-W. et al. (2013) Hypoxia suppresses E-cadherin and enhances matrix metalloproteinase-2 expression favoring esophageal carcinoma migration and invasion via hypoxia inducible factor-1 alpha activation. Dis. Esophagus 26, 75-83
    • (2013) Dis. Esophagus , vol.26 , pp. 75-83
    • Jing, S.-W.1
  • 18
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1alpha promotes metastasis
    • Yang, M-H. et al. (2008) Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat. Cell Biol. 10, 295-305
    • (2008) Nat. Cell Biol. , vol.10 , pp. 295-305
    • Yang, M.-H.1
  • 19
    • 0042926509 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor- 1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
    • Stoeltzing, O. et al. (2003) Regulation of hypoxia-inducible factor- 1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am. J. Pathol. 163, 1001-1011
    • (2003) Am. J. Pathol. , vol.163 , pp. 1001-1011
    • Stoeltzing, O.1
  • 20
    • 78650373860 scopus 로고    scopus 로고
    • Hypoxia and hypoxia-inducible factors: Master regulators of metastasis
    • Lu, X. and Kang, Y. (2010) Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin. Cancer Res. 16, 5928-5935
    • (2010) Clin. Cancer Res. , vol.16 , pp. 5928-5935
    • Lu, X.1    Kang, Y.2
  • 21
    • 75549083984 scopus 로고    scopus 로고
    • Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
    • Chen, J. et al. (2010) Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br. J. Cancer 102, 351-360
    • (2010) Br. J. Cancer , vol.102 , pp. 351-360
    • Chen, J.1
  • 22
    • 70449527638 scopus 로고    scopus 로고
    • Hypoxia, snail and incomplete epithelialmesenchymal transition in breast cancer
    • Lundgren, K. et al. (2009) Hypoxia, Snail and incomplete epithelialmesenchymal transition in breast cancer. Br. J. Cancer 101, 1769-1781
    • (2009) Br. J. Cancer , vol.101 , pp. 1769-1781
    • Lundgren, K.1
  • 23
    • 85027941540 scopus 로고    scopus 로고
    • Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells
    • Xing, F. et al. (2011) Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells. Oncogene 30, 4075-4086
    • (2011) Oncogene , vol.30 , pp. 4075-4086
    • Xing, F.1
  • 24
    • 70249108848 scopus 로고    scopus 로고
    • Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment
    • Dunn, L.K. et al. (2009) Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS ONE 4, e6896
    • (2009) PLoS ONE , vol.4
    • Dunn, L.K.1
  • 25
    • 84862555781 scopus 로고    scopus 로고
    • Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer
    • Mishra, A. et al. (2012) Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer. Mol. Cancer Res. 10, 703-712
    • (2012) Mol. Cancer Res. , vol.10 , pp. 703-712
    • Mishra, A.1
  • 26
    • 84879885976 scopus 로고    scopus 로고
    • Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells
    • Harada, R. et al. (2013) Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells. Exp. Cell Res. 319, 1988-1997
    • (2013) Exp. Cell Res. , vol.319 , pp. 1988-1997
    • Harada, R.1
  • 27
    • 84901594345 scopus 로고    scopus 로고
    • Hypoxia and the extracellular matrix: Drivers of tumour metastasis
    • Gilkes, D.M. et al. (2014) Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat. Rev. Cancer 14, 430-439
    • (2014) Nat. Rev. Cancer , vol.14 , pp. 430-439
    • Gilkes, D.M.1
  • 28
    • 19944432209 scopus 로고    scopus 로고
    • Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix
    • Eckhardt, B.L. et al. (2005) Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Mol. Cancer Res. 3, 1-13
    • (2005) Mol. Cancer Res. , vol.3 , pp. 1-13
    • Eckhardt, B.L.1
  • 29
    • 84871244699 scopus 로고    scopus 로고
    • The biology of the extracellular matrix: Novel insights
    • Hubmacher, D. and Apte, S.S. (2013) The biology of the extracellular matrix: novel insights. Curr. Opin. Rheumatol. 25, 65-70
    • (2013) Curr. Opin. Rheumatol. , vol.25 , pp. 65-70
    • Hubmacher, D.1    Apte, S.S.2
  • 30
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens, L.M. et al. (2002) Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 295, 2387-2392
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1
  • 31
    • 84881176475 scopus 로고    scopus 로고
    • miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin b1 and matrix metalloproteinase2 (MMP2)
    • Wang, H. et al. (2013) miRNA-29c suppresses lung cancer cell adhesion to extracellular matrix and metastasis by targeting integrin b1 and matrix metalloproteinase2 (MMP2). PLoS ONE 8, e70192
    • (2013) PLoS ONE , vol.8 , pp. e70192
    • Wang, H.1
  • 32
    • 0036088478 scopus 로고    scopus 로고
    • Mechanisms of normal and tumor-derived angiogenesis
    • Papetti, M. and Herman, I.M. (2002) Mechanisms of normal and tumor-derived angiogenesis. Am. J. Physiol. Cell Physiol. 282, C947-C970
    • (2002) Am. J. Physiol. Cell Physiol. , vol.282 , pp. C947-C970
    • Papetti, M.1    Herman, I.M.2
  • 33
    • 84898903594 scopus 로고    scopus 로고
    • Angiogenesis in cancer - General pathways and their therapeutic implications
    • Dimova, I. et al. (2014) Angiogenesis in cancer - general pathways and their therapeutic implications. J. BUON 19, 15-21
    • (2014) J. BUON , vol.19 , pp. 15-21
    • Dimova, I.1
  • 34
    • 79960108792 scopus 로고    scopus 로고
    • FDA. Once on 'fast track'; avastin now derailed
    • Couzin-Frankel, J. and Ogale, Y. (2011) FDA. Once on 'fast track'; avastin now derailed. Science 333, 143-144
    • (2011) Science , vol.333 , pp. 143-144
    • Couzin-Frankel, J.1    Ogale, Y.2
  • 35
    • 84921478581 scopus 로고    scopus 로고
    • Current role of cabozantinib in metastatic castration-resistant prostate cancer
    • Fay, A.P. et al. (2015) Current role of cabozantinib in metastatic castration-resistant prostate cancer. Expert Rev. Anticancer Ther. 15, 151-156
    • (2015) Expert Rev. Anticancer Ther. , vol.15 , pp. 151-156
    • Fay, A.P.1
  • 36
    • 84873865047 scopus 로고    scopus 로고
    • From bevacizumab to tasquinimod: Angiogenesis as a therapeutic target in prostate cancer
    • Schweizer, M.T. and Carducci, M.A. (2013) From bevacizumab to tasquinimod: angiogenesis as a therapeutic target in prostate cancer. Cancer J. 19, 99-106
    • (2013) Cancer J. , vol.19 , pp. 99-106
    • Schweizer, M.T.1    Carducci, M.A.2
  • 37
    • 84858256127 scopus 로고    scopus 로고
    • Novel targets for VEGF-independent antiangiogenic drugs
    • Petrillo, M. et al. (2012) Novel targets for VEGF-independent antiangiogenic drugs. Expert Opin. Investig. Drugs 21, 451-472
    • (2012) Expert Opin. Investig. Drugs , vol.21 , pp. 451-472
    • Petrillo, M.1
  • 38
    • 65349186800 scopus 로고    scopus 로고
    • Aflibercept (AVE0005): An alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors
    • Chu, Q.S-C. (2009) Aflibercept (AVE0005): an alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors. Expert Opin. Biol. Ther. 9, 263-271
    • (2009) Expert Opin. Biol. Ther. , vol.9 , pp. 263-271
    • Chu, Q.S.-C.1
  • 40
    • 84895071039 scopus 로고    scopus 로고
    • Changes in the peripheral blood and bone marrow from untreated advanced breast cancer patients that are associated with the establishment of bone metastases
    • Martinez, L.M. et al. (2014) Changes in the peripheral blood and bone marrow from untreated advanced breast cancer patients that are associated with the establishment of bone metastases. Clin. Exp. Metastasis 31, 213-232
    • (2014) Clin. Exp. Metastasis , vol.31 , pp. 213-232
    • Martinez, L.M.1
  • 41
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang, Y. et al. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3, 537-549
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1
  • 42
    • 84894931059 scopus 로고    scopus 로고
    • Mapping protein signal pathway interaction in sarcoma bone metastasis: Linkage between rank, metalloproteinases turnover and growth factor signaling pathways
    • Conti, A. et al. (2014) Mapping protein signal pathway interaction in sarcoma bone metastasis: linkage between rank, metalloproteinases turnover and growth factor signaling pathways. Clin. Exp. Metastasis 31, 15-24
    • (2014) Clin. Exp. Metastasis , vol.31 , pp. 15-24
    • Conti, A.1
  • 43
    • 84897037502 scopus 로고    scopus 로고
    • Paracrine interactions between LNCaP prostate cancer cells and bioengineered bone in 3D in vitro culture reflect molecular changes during bone metastasis
    • Sieh, S. et al. (2014) Paracrine interactions between LNCaP prostate cancer cells and bioengineered bone in 3D in vitro culture reflect molecular changes during bone metastasis. Bone 63, 121-131
    • (2014) Bone , vol.63 , pp. 121-131
    • Sieh, S.1
  • 44
    • 84969387200 scopus 로고    scopus 로고
    • Gene expression markers in circulating tumor cells may predict bone metastasis and response to hormonal treatment in breast cancer
    • Wang, H. et al. (2013) Gene expression markers in circulating tumor cells may predict bone metastasis and response to hormonal treatment in breast cancer. Mol. Clin. Oncol. 1, 1031-1038
    • (2013) Mol. Clin. Oncol. , vol.1 , pp. 1031-1038
    • Wang, H.1
  • 45
    • 1542316051 scopus 로고    scopus 로고
    • Microarrays bring new insights into understanding of breast cancer metastasis to bone
    • Welch, D.R. (2004) Microarrays bring new insights into understanding of breast cancer metastasis to bone. Breast Cancer Res. 6, 61-64
    • (2004) Breast Cancer Res. , vol.6 , pp. 61-64
    • Welch, D.R.1
  • 46
    • 34347385401 scopus 로고    scopus 로고
    • Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms
    • Palumbo, J.S. et al. (2007) Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood 110, 133-141
    • (2007) Blood , vol.110 , pp. 133-141
    • Palumbo, J.S.1
  • 47
    • 84866385928 scopus 로고    scopus 로고
    • Platelets and P-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells
    • Coupland, L.A. et al. (2012) Platelets and P-selectin control tumor cell metastasis in an organ-specific manner and independently of NK cells. Cancer Res. 72, 4662-4671
    • (2012) Cancer Res. , vol.72 , pp. 4662-4671
    • Coupland, L.A.1
  • 48
    • 84880008122 scopus 로고    scopus 로고
    • Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor
    • Schumacher, D. et al. (2013) Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor. Cancer Cell 24, 130-137
    • (2013) Cancer Cell , vol.24 , pp. 130-137
    • Schumacher, D.1
  • 49
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • Labelle, M. et al. (2011) Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20, 576-590
    • (2011) Cancer Cell , vol.20 , pp. 576-590
    • Labelle, M.1
  • 50
    • 84873845603 scopus 로고    scopus 로고
    • Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity
    • Okamoto, T. et al. (2013) Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunity. Mol. Med. Rep. 7, 359-364
    • (2013) Mol. Med. Rep. , vol.7 , pp. 359-364
    • Okamoto, T.1
  • 51
    • 84909629677 scopus 로고    scopus 로고
    • Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination
    • Giuliano, M. et al. (2014) Circulating tumor cells as early predictors of metastatic spread in breast cancer patients with limited metastatic dissemination. Breast Cancer Res. 16, 440
    • (2014) Breast Cancer Res. , vol.16 , pp. 440
    • Giuliano, M.1
  • 52
    • 84924276104 scopus 로고    scopus 로고
    • Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis
    • Giuliano, M. et al. (2015) Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Res. 17, 3
    • (2015) Breast Cancer Res. , vol.17 , pp. 3
    • Giuliano, M.1
  • 53
    • 84897389572 scopus 로고    scopus 로고
    • Circulating melanoma cells in the diagnosis and monitoring of melanoma: An appraisal of clinical potential
    • Mumford, B.S. and Robertson, G.P. (2014) Circulating melanoma cells in the diagnosis and monitoring of melanoma: an appraisal of clinical potential. Mol. Diagn. Ther. 18, 175-183
    • (2014) Mol. Diagn. Ther. , vol.18 , pp. 175-183
    • Mumford, B.S.1    Robertson, G.P.2
  • 54
    • 77950882020 scopus 로고    scopus 로고
    • The CXCR4/SDF-1 chemokine axis: A potential therapeutic target for bone metastases?
    • Hirbe, A.C. et al. (2010) The CXCR4/SDF-1 chemokine axis: a potential therapeutic target for bone metastases? Curr. Pharm. Des. 16, 1284-1290
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 1284-1290
    • Hirbe, A.C.1
  • 55
    • 64849102577 scopus 로고    scopus 로고
    • Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone
    • Richert, M.M. et al. (2009) Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone. Oncol. Rep. 21, 761-767
    • (2009) Oncol. Rep. , vol.21 , pp. 761-767
    • Richert, M.M.1
  • 56
    • 9244234390 scopus 로고    scopus 로고
    • CXCR4 regulates growth of both primary and metastatic breast cancer
    • Smith, M.C.P. et al. (2004) CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res. 64, 8604-8612
    • (2004) Cancer Res. , vol.64 , pp. 8604-8612
    • Smith, M.C.P.1
  • 57
    • 35348884254 scopus 로고    scopus 로고
    • Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone
    • Hirbe, A.C. et al. (2007) Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone. Proc. Natl. Acad. Sci. U.S.A. 104, 14062-14067
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 14062-14067
    • Hirbe, A.C.1
  • 58
    • 0036800296 scopus 로고    scopus 로고
    • The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice
    • Lapidot, T. and Kollet, O. (2002) The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice. Leukemia 16, 1992-2003
    • (2002) Leukemia , vol.16 , pp. 1992-2003
    • Lapidot, T.1    Kollet, O.2
  • 59
    • 33748474838 scopus 로고    scopus 로고
    • A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    • Burns, J.M. et al. (2006) A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J. Exp. Med. 203, 2201-2213
    • (2006) J. Exp. Med. , vol.203 , pp. 2201-2213
    • Burns, J.M.1
  • 60
    • 84907223851 scopus 로고    scopus 로고
    • CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma
    • Azab, A.K. et al. (2014) CXCR7-dependent angiogenic mononuclear cell trafficking regulates tumor progression in multiple myeloma. Blood 124, 1905-1914
    • (2014) Blood , vol.124 , pp. 1905-1914
    • Azab, A.K.1
  • 61
    • 84863569576 scopus 로고    scopus 로고
    • CXCL10 promotes osteolytic bone metastasis by enhancing cancer outgrowth and osteoclastogenesis
    • Lee, J-H. et al. (2012) CXCL10 promotes osteolytic bone metastasis by enhancing cancer outgrowth and osteoclastogenesis. Cancer Res. 72, 3175-3186
    • (2012) Cancer Res. , vol.72 , pp. 3175-3186
    • Lee, J.-H.1
  • 62
    • 0032918414 scopus 로고    scopus 로고
    • TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
    • Yin, J.J. et al. (1999) TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J. Clin. Invest. 103, 197-206
    • (1999) J. Clin. Invest. , vol.103 , pp. 197-206
    • Yin, J.J.1
  • 63
    • 25444479744 scopus 로고    scopus 로고
    • Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    • Kang, Y. et al. (2005) Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl. Acad. Sci. U.S.A. 102, 13909-13914
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 13909-13914
    • Kang, Y.1
  • 64
    • 0036792257 scopus 로고    scopus 로고
    • Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo
    • Bendre, M.S. et al. (2002) Expression of interleukin 8 and not parathyroid hormone-related protein by human breast cancer cells correlates with bone metastasis in vivo. Cancer Res. 62, 5571-5579
    • (2002) Cancer Res. , vol.62 , pp. 5571-5579
    • Bendre, M.S.1
  • 65
    • 84924259250 scopus 로고    scopus 로고
    • Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis
    • Siclari, V.A. et al. (2014) Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis. Breast Cancer Res. 16, 1693
    • (2014) Breast Cancer Res. , vol.16 , pp. 1693
    • Siclari, V.A.1
  • 66
    • 84855813448 scopus 로고    scopus 로고
    • A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
    • Png, K.J. et al. (2012) A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature 481, 190-194
    • (2012) Nature , vol.481 , pp. 190-194
    • Png, K.J.1
  • 67
    • 38049115129 scopus 로고    scopus 로고
    • Endogenous human microRNAs that suppress breast cancer metastasis
    • Tavazoie, S.F. et al. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451, 147-152
    • (2008) Nature , vol.451 , pp. 147-152
    • Tavazoie, S.F.1
  • 68
    • 84878551352 scopus 로고    scopus 로고
    • Interleukin-1b promotes skeletal colonization and progression of metastatic prostate cancer cells with neuroendocrine features
    • Liu, Q. et al. (2013) Interleukin-1b promotes skeletal colonization and progression of metastatic prostate cancer cells with neuroendocrine features. Cancer Res. 73, 3297-3305
    • (2013) Cancer Res. , vol.73 , pp. 3297-3305
    • Liu, Q.1
  • 69
    • 84924328207 scopus 로고    scopus 로고
    • Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment
    • Lee, Y-C. et al. (2015) Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment. Mol. Cell Proteomics 14, 471-483
    • (2015) Mol. Cell Proteomics , vol.14 , pp. 471-483
    • Lee, Y.-C.1
  • 70
    • 84857093651 scopus 로고    scopus 로고
    • Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis
    • Valencia, K. et al. (2012) Inhibition of collagen receptor discoidin domain receptor-1 (DDR1) reduces cell survival, homing, and colonization in lung cancer bone metastasis. Clin. Cancer Res. 18, 969-980
    • (2012) Clin. Cancer Res. , vol.18 , pp. 969-980
    • Valencia, K.1
  • 71
    • 84863469949 scopus 로고    scopus 로고
    • Receptor of activated protein C promotes metastasis and correlates with clinical outcome in lung adenocarcinoma
    • Antón, I. et al. (2012) Receptor of activated protein C promotes metastasis and correlates with clinical outcome in lung adenocarcinoma. Am. J. Respir. Crit. Care Med. 186, 96-105
    • (2012) Am. J. Respir. Crit. Care Med. , vol.186 , pp. 96-105
    • Antón, I.1
  • 72
    • 84886107854 scopus 로고    scopus 로고
    • A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer
    • Luis-Ravelo, D. et al. (2014) A gene signature of bone metastatic colonization sensitizes for tumor-induced osteolysis and predicts survival in lung cancer. Oncogene 33, 5090-5099
    • (2014) Oncogene , vol.33 , pp. 5090-5099
    • Luis-Ravelo, D.1
  • 73
    • 67649662201 scopus 로고    scopus 로고
    • WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis
    • Nguyen, D.X. et al. (2009) WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell 138, 51-62
    • (2009) Cell , vol.138 , pp. 51-62
    • Nguyen, D.X.1
  • 74
    • 84893082993 scopus 로고    scopus 로고
    • miR-335 inhibits small cell lung cancer bone metastases via IGF-IR and RANKL pathways
    • Gong, M. et al. (2014) miR-335 inhibits small cell lung cancer bone metastases via IGF-IR and RANKL pathways. Mol. Cancer Res. 12, 101-110
    • (2014) Mol. Cancer Res. , vol.12 , pp. 101-110
    • Gong, M.1
  • 75
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado, H. et al. (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 18, 883-891
    • (2012) Nat. Med. , vol.18 , pp. 883-891
    • Peinado, H.1
  • 76
    • 0018102359 scopus 로고
    • The relationship between the spleen colonyforming cell and the haemopoietic stem cell
    • Schofield, R. (1978) The relationship between the spleen colonyforming cell and the haemopoietic stem cell. Blood Cells 4, 7-25
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 77
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel, M.J. et al. (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109-1121
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1
  • 78
    • 58149250287 scopus 로고    scopus 로고
    • Detection of functional haematopoietic stem cell niche using real-time imaging
    • Xie, Y. et al. (2009) Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 457, 97-101
    • (2009) Nature , vol.457 , pp. 97-101
    • Xie, Y.1
  • 79
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Müller, A. et al. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56
    • (2001) Nature , vol.410 , pp. 50-56
    • Müller, A.1
  • 80
    • 0037085938 scopus 로고    scopus 로고
    • Use of the stromal cell-derived factor-1/ CXCR4 pathway in prostate cancer metastasis to bone
    • Taichman, R.S. et al. (2002) Use of the stromal cell-derived factor-1/ CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 62, 1832-1837
    • (2002) Cancer Res. , vol.62 , pp. 1832-1837
    • Taichman, R.S.1
  • 81
    • 79953331206 scopus 로고    scopus 로고
    • Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
    • Shiozawa, Y. et al. (2011) Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J. Clin. Invest. 121, 1298-1312
    • (2011) J. Clin. Invest. , vol.121 , pp. 1298-1312
    • Shiozawa, Y.1
  • 82
    • 0242268524 scopus 로고    scopus 로고
    • Osteoblastic cells regulate the haematopoietic stem cell niche
    • Calvi, L.M. et al. (2003) Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 425, 841-846
    • (2003) Nature , vol.425 , pp. 841-846
    • Calvi, L.M.1
  • 83
    • 84897123138 scopus 로고    scopus 로고
    • TBK1 regulates prostate cancer dormancy through mTOR inhibition
    • Kim, J.K. et al. (2013) TBK1 regulates prostate cancer dormancy through mTOR inhibition. NEO 15, 1064-1074
    • (2013) NEO , vol.15 , pp. 1064-1074
    • Kim, J.K.1
  • 84
    • 76749109371 scopus 로고    scopus 로고
    • GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche
    • Shiozawa, Y. et al. (2010) GAS6/AXL axis regulates prostate cancer invasion, proliferation, and survival in the bone marrow niche. NEO 12, 116-127
    • (2010) NEO , vol.12 , pp. 116-127
    • Shiozawa, Y.1
  • 85
    • 73949130412 scopus 로고    scopus 로고
    • GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche
    • Shiozawa, Y. et al. (2010) GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp. Hematol. 38, 132-140
    • (2010) Exp. Hematol. , vol.38 , pp. 132-140
    • Shiozawa, Y.1
  • 86
    • 53349105777 scopus 로고    scopus 로고
    • Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche
    • Jung, Y. et al. (2008) Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche. Stem Cells 26, 2042-2051
    • (2008) Stem Cells , vol.26 , pp. 2042-2051
    • Jung, Y.1
  • 87
    • 84863338444 scopus 로고    scopus 로고
    • Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype
    • Joseph, J. et al. (2012) Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol. Cancer Res. 10, 282-292
    • (2012) Mol. Cancer Res. , vol.10 , pp. 282-292
    • Joseph, J.1
  • 88
    • 36749049256 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines
    • Grassinger, J. et al. (2007) Bone morphogenetic protein (BMP)-7 but not BMP-2 and BMP-4 improves maintenance of primitive peripheral blood-derived hematopoietic progenitor cells (HPC) cultured in serum-free medium supplemented with early acting cytokines. Cytokine 40, 165-171
    • (2007) Cytokine , vol.40 , pp. 165-171
    • Grassinger, J.1
  • 89
    • 84862917865 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
    • Kobayashi, A. et al. (2011) Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J. Exp. Med. 208, 2641-2655
    • (2011) J. Exp. Med. , vol.208 , pp. 2641-2655
    • Kobayashi, A.1
  • 90
    • 79551514021 scopus 로고    scopus 로고
    • TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling
    • Johnson, R.W. et al. (2011) TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res. 71, 822-831
    • (2011) Cancer Res. , vol.71 , pp. 822-831
    • Johnson, R.W.1
  • 91
    • 33746145265 scopus 로고    scopus 로고
    • Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor
    • Bandyopadhyay, A. et al. (2006) Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor. Cancer Res. 66, 6714-6721
    • (2006) Cancer Res. , vol.66 , pp. 6714-6721
    • Bandyopadhyay, A.1
  • 92
    • 78651399324 scopus 로고    scopus 로고
    • TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases
    • Mohammad, K.S. et al. (2011) TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases. Cancer Res. 71, 175-184
    • (2011) Cancer Res. , vol.71 , pp. 175-184
    • Mohammad, K.S.1
  • 93
    • 84859827014 scopus 로고    scopus 로고
    • Loss of TGF-b responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions
    • Li, X. et al. (2012) Loss of TGF-b responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol. Cancer Res. 10, 494-503
    • (2012) Mol. Cancer Res. , vol.10 , pp. 494-503
    • Li, X.1
  • 94
    • 78649544062 scopus 로고    scopus 로고
    • IGF-1 and bone: New discoveries from mouse models
    • Yakar, S. et al. (2010) IGF-1 and bone: New discoveries from mouse models. J. Bone Miner. Res. 25, 2543-2552
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 2543-2552
    • Yakar, S.1
  • 95
    • 84865116604 scopus 로고    scopus 로고
    • Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases
    • Hiraga, T. et al. (2012) Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases. Cancer Res. 72, 4238-4249
    • (2012) Cancer Res. , vol.72 , pp. 4238-4249
    • Hiraga, T.1
  • 96
    • 84887047233 scopus 로고    scopus 로고
    • Targeting fibroblast growth factor pathways in prostate cancer
    • Corn, P.G. et al. (2013) Targeting fibroblast growth factor pathways in prostate cancer. Clin. Cancer Res. 19, 5856-5866
    • (2013) Clin. Cancer Res. , vol.19 , pp. 5856-5866
    • Corn, P.G.1
  • 97
    • 84896713052 scopus 로고    scopus 로고
    • Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: An open-label, randomised phase 3 trial
    • Motzer, R.J. et al. (2014) Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial. Lancet Oncol. 15, 286-296
    • (2014) Lancet Oncol. , vol.15 , pp. 286-296
    • Motzer, R.J.1
  • 98
    • 84907289340 scopus 로고    scopus 로고
    • Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases
    • Wan, X. et al. (2014) Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases. Sci. Transl. Med. 6, 252ra122
    • (2014) Sci. Transl. Med. , vol.6 , pp. 252ra122
    • Wan, X.1
  • 99
    • 78651405675 scopus 로고    scopus 로고
    • PDGFR signaling blockade in marrow stroma impairs lung cancer bone metastasis
    • Catena, R. et al. (2011) PDGFR signaling blockade in marrow stroma impairs lung cancer bone metastasis. Cancer Res. 71, 164-174
    • (2011) Cancer Res. , vol.71 , pp. 164-174
    • Catena, R.1
  • 100
    • 84902588701 scopus 로고    scopus 로고
    • CCL5 secreted from bone marrow stromal cells stimulates the migration and invasion of Huh7 hepatocellular carcinoma cells via the PI3K-Akt pathway
    • Bai, H. et al. (2014) CCL5 secreted from bone marrow stromal cells stimulates the migration and invasion of Huh7 hepatocellular carcinoma cells via the PI3K-Akt pathway. Int. J. Oncol. 45, 333-343
    • (2014) Int. J. Oncol. , vol.45 , pp. 333-343
    • Bai, H.1
  • 101
    • 0035852648 scopus 로고    scopus 로고
    • Integrin activation controls metastasis in human breast cancer
    • Felding-Habermann, B. et al. (2001) Integrin activation controls metastasis in human breast cancer. Proc. Natl. Acad. Sci. U.S.A. 98, 1853-1858
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 1853-1858
    • Felding-Habermann, B.1
  • 102
    • 33746513396 scopus 로고    scopus 로고
    • Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone
    • Sloan, E.K. et al. (2006) Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone. Breast Cancer Res. 8, R20
    • (2006) Breast Cancer Res. , vol.8 , pp. R20
    • Sloan, E.K.1
  • 103
    • 34250865694 scopus 로고    scopus 로고
    • Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases
    • Zhao, Y. et al. (2007) Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases. Cancer Res. 67, 5821-5830
    • (2007) Cancer Res. , vol.67 , pp. 5821-5830
    • Zhao, Y.1
  • 104
    • 33745240059 scopus 로고    scopus 로고
    • 2), a beta integrin antagonist, in patients with solid tumours
    • 2), a beta integrin antagonist, in patients with solid tumours. Br. J. Cancer 94, 1621-1626
    • (2006) Br. J. Cancer , vol.94 , pp. 1621-1626
    • Cianfrocca, M.E.1
  • 105
    • 33749577839 scopus 로고    scopus 로고
    • A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo
    • Khalili, P. et al. (2006) A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo. Mol. Cancer Ther. 5, 2271-2280
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2271-2280
    • Khalili, P.1
  • 106
    • 0034974989 scopus 로고    scopus 로고
    • Targeted disruption of cadherin-11 leads to a reduction in bone density in calvaria and long bone metaphyses
    • Kawaguchi, J. et al. (2001) Targeted disruption of cadherin-11 leads to a reduction in bone density in calvaria and long bone metaphyses. J. Bone Miner. Res. 16, 1265-1271
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 1265-1271
    • Kawaguchi, J.1
  • 107
    • 77953153372 scopus 로고    scopus 로고
    • Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts
    • Huang, C-F. et al. (2010) Cadherin-11 increases migration and invasion of prostate cancer cells and enhances their interaction with osteoblasts. Cancer Res. 70, 4580-4589
    • (2010) Cancer Res. , vol.70 , pp. 4580-4589
    • Huang, C.-F.1
  • 108
    • 52449124146 scopus 로고    scopus 로고
    • Cadherin-11 promotes the metastasis of prostate cancer cells to bone
    • Chu, K. et al. (2008) Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol. Cancer Res. 6, 1259-1267
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1259-1267
    • Chu, K.1
  • 109
    • 51049112515 scopus 로고    scopus 로고
    • Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone
    • Tamura, D. et al. (2008) Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. Int. J. Oncol. 33, 17-24
    • (2008) Int. J. Oncol. , vol.33 , pp. 17-24
    • Tamura, D.1
  • 110
    • 84922804572 scopus 로고    scopus 로고
    • The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells
    • Wang, H. et al. (2015) The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells. Cancer Cell 27, 193-210
    • (2015) Cancer Cell , vol.27 , pp. 193-210
    • Wang, H.1
  • 111
    • 85003394010 scopus 로고    scopus 로고
    • Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity
    • Ferrari-Amorotti, G. et al. (2014) Suppression of invasion and metastasis of triple-negative breast cancer lines by pharmacological or genetic inhibition of slug activity. NEO 16, 1047-1058
    • (2014) NEO , vol.16 , pp. 1047-1058
    • Ferrari-Amorotti, G.1
  • 112
    • 84908609087 scopus 로고    scopus 로고
    • The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma
    • Glavey, S.V. et al. (2014) The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma. Blood 124, 1765-1776
    • (2014) Blood , vol.124 , pp. 1765-1776
    • Glavey, S.V.1
  • 113
    • 84906835207 scopus 로고    scopus 로고
    • Modulation of selectin-mediated adhesion of flowing lymphoma and bone marrow cells by immobilized SDF-1
    • Hedges, E.A. et al. (2014) Modulation of selectin-mediated adhesion of flowing lymphoma and bone marrow cells by immobilized SDF-1. Int. J. Mol. Sci. 15, 15061-15072
    • (2014) Int. J. Mol. Sci. , vol.15 , pp. 15061-15072
    • Hedges, E.A.1
  • 114
    • 84880059674 scopus 로고    scopus 로고
    • Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production
    • Hiraga, T. et al. (2013) Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res. 73, 4112-4122
    • (2013) Cancer Res. , vol.73 , pp. 4112-4122
    • Hiraga, T.1
  • 116
    • 85011669516 scopus 로고    scopus 로고
    • Treatment and prevention of bone metastases from breast cancer: A comprehensive review of evidence for clinical practice
    • Li, B. et al. (2014) Treatment and prevention of bone metastases from breast cancer: a comprehensive review of evidence for clinical practice. J. Clin. Med. 3, 1-24
    • (2014) J. Clin. Med. , vol.3 , pp. 1-24
    • Li, B.1
  • 117
    • 84870679586 scopus 로고    scopus 로고
    • Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid
    • Misso, G. et al. (2012) Evaluation of the in vitro and in vivo antiangiogenic effects of denosumab and zoledronic acid. Cancer Biol. Ther. 13, 1491-1500
    • (2012) Cancer Biol. Ther. , vol.13 , pp. 1491-1500
    • Misso, G.1
  • 118
    • 0036093899 scopus 로고    scopus 로고
    • Pamidronate induces modifications of circulating angiogenetic factors in cancer patients
    • Santini, D. et al. (2002) Pamidronate induces modifications of circulating angiogenetic factors in cancer patients. Clin. Cancer Res. 8, 1080-1084
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1080-1084
    • Santini, D.1
  • 119
    • 10744227993 scopus 로고    scopus 로고
    • Zoledronic acid induces significant and longlasting modifications of circulating angiogenic factors in cancer patients
    • Santini, D. et al. (2003) Zoledronic acid induces significant and longlasting modifications of circulating angiogenic factors in cancer patients. Clin. Cancer Res. 9, 2893-2897
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2893-2897
    • Santini, D.1
  • 120
    • 34547653957 scopus 로고    scopus 로고
    • Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients
    • Santini, D. et al. (2007) Repeated intermittent low-dose therapy with zoledronic acid induces an early, sustained, and long-lasting decrease of peripheral vascular endothelial growth factor levels in cancer patients. Clin. Cancer Res. 13, 4482-4486
    • (2007) Clin. Cancer Res. , vol.13 , pp. 4482-4486
    • Santini, D.1
  • 121
    • 0037767146 scopus 로고    scopus 로고
    • Bisphosphonates: New antiangiogenic molecules in cancer treatment?
    • Vincenzi, B. et al. (2003) Bisphosphonates: new antiangiogenic molecules in cancer treatment? Ann. Oncol. 14, 806-807
    • (2003) Ann. Oncol. , vol.14 , pp. 806-807
    • Vincenzi, B.1
  • 122
    • 34250333326 scopus 로고    scopus 로고
    • The use of bisphosphonates in cancer patients
    • Wu, S. et al. (2007) The use of bisphosphonates in cancer patients. Acta Oncol. 46, 581-591
    • (2007) Acta Oncol. , vol.46 , pp. 581-591
    • Wu, S.1
  • 123
    • 84885955833 scopus 로고    scopus 로고
    • Denosumab in breast cancer treatment
    • Drooger, J.C. et al. (2013) Denosumab in breast cancer treatment. Eur. J. Pharmacol. 717, 12-19
    • (2013) Eur. J. Pharmacol. , vol.717 , pp. 12-19
    • Drooger, J.C.1
  • 124
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massagué, J. (2008) TGFbeta in Cancer. Cell 134, 215-230
    • (2008) Cell , vol.134 , pp. 215-230
    • Massagué, J.1
  • 125
    • 84856454999 scopus 로고    scopus 로고
    • TGF-b in the bone microenvironment: Role in breast cancer metastases
    • Buijs, J.T. et al. (2011) TGF-b in the bone microenvironment: role in breast cancer metastases. Cancer Microenviron. 4, 261-281
    • (2011) Cancer Microenviron. , vol.4 , pp. 261-281
    • Buijs, J.T.1
  • 126
    • 84866029510 scopus 로고    scopus 로고
    • Complexities of TGF-b targeted cancer therapy
    • Connolly, E.C. et al. (2012) Complexities of TGF-b targeted cancer therapy. Int. J. Biol. Sci. 8, 964-978
    • (2012) Int. J. Biol. Sci. , vol.8 , pp. 964-978
    • Connolly, E.C.1
  • 127
    • 67650601930 scopus 로고    scopus 로고
    • Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis
    • Koreckij, T. et al. (2009) Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis. Br. J. Cancer 101, 263-268
    • (2009) Br. J. Cancer , vol.101 , pp. 263-268
    • Koreckij, T.1
  • 128
    • 77950616066 scopus 로고    scopus 로고
    • SRC kinase inhibition: Targeting bone metastases and tumor growth in prostate and breast cancer
    • Saad, F. and Lipton, A. (2010) SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancer. Cancer Treat. Rev. 36, 177-184
    • (2010) Cancer Treat. Rev. , vol.36 , pp. 177-184
    • Saad, F.1    Lipton, A.2
  • 129
    • 0034676060 scopus 로고    scopus 로고
    • Decreased c-Src expression enhances osteoblast differentiation and bone formation
    • Marzia, M. et al. (2000) Decreased c-Src expression enhances osteoblast differentiation and bone formation. J. Cell Biol. 151, 311-320
    • (2000) J. Cell Biol. , vol.151 , pp. 311-320
    • Marzia, M.1
  • 130
    • 84855748821 scopus 로고    scopus 로고
    • Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptornegative metastatic breast cancer
    • Gucalp, A. et al. (2011) Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptornegative metastatic breast cancer. Clin. Breast Cancer 11, 306-311
    • (2011) Clin. Breast Cancer , vol.11 , pp. 306-311
    • Gucalp, A.1
  • 131
    • 77953433829 scopus 로고    scopus 로고
    • Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: A randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial
    • Hannon, R.A. et al. (2010) Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: a randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial. J. Bone Miner. Res. 25, 463-471
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 463-471
    • Hannon, R.A.1
  • 132
    • 84862809842 scopus 로고    scopus 로고
    • Denosumab in patients with cancer-a surgical strike against the osteoclast
    • Brown, J.E. and Coleman, R.E. (2012) Denosumab in patients with cancer-a surgical strike against the osteoclast. Nat. Rev. Clin. Oncol. 9, 110-118
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 110-118
    • Brown, J.E.1    Coleman, R.E.2
  • 133
    • 84856611805 scopus 로고    scopus 로고
    • Bone cancer in 2011: Prevention and treatment of bone metastases
    • Coleman, R.E. (2012) Bone cancer in 2011: prevention and treatment of bone metastases. Nat. Rev. Clin. Oncol. 9, 76-78
    • (2012) Nat. Rev. Clin. Oncol. , vol.9 , pp. 76-78
    • Coleman, R.E.1
  • 134
    • 34848841461 scopus 로고    scopus 로고
    • Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research
    • Khosla, S. et al. (2007) Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J. Bone Miner. Res. 22, 1479-1491
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 1479-1491
    • Khosla, S.1
  • 135
    • 84885368280 scopus 로고    scopus 로고
    • Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis
    • Ell, B. et al. (2013) Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. Cancer Cell 24, 542-556
    • (2013) Cancer Cell , vol.24 , pp. 542-556
    • Ell, B.1
  • 136
    • 84907406375 scopus 로고    scopus 로고
    • miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2
    • Krzeszinski, J.Y. et al. (2014) miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature 512, 431-435
    • (2014) Nature , vol.512 , pp. 431-435
    • Krzeszinski, J.Y.1
  • 137
    • 35748961986 scopus 로고    scopus 로고
    • p53 enters the microRNA world
    • Hermeking, H. (2007) p53 enters the microRNA world. Cancer Cell 12, 414-418
    • (2007) Cancer Cell , vol.12 , pp. 414-418
    • Hermeking, H.1
  • 138
    • 79751473114 scopus 로고    scopus 로고
    • The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
    • Liu, C. et al. (2011) The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat. Med. 17, 211-215
    • (2011) Nat. Med. , vol.17 , pp. 211-215
    • Liu, C.1
  • 139
    • 84899474348 scopus 로고    scopus 로고
    • miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization
    • Valencia, K. et al. (2014) miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization. Mol. Oncol. 8, 689-703
    • (2014) Mol. Oncol. , vol.8 , pp. 689-703
    • Valencia, K.1
  • 140
    • 70349108389 scopus 로고    scopus 로고
    • Breaking down bone: New insight into site-specific mechanisms of breast cancer osteolysis mediated by metalloproteinases
    • Guise, T.A. (2009) Breaking down bone: new insight into site-specific mechanisms of breast cancer osteolysis mediated by metalloproteinases. Genes Dev. 23, 2117-2123
    • (2009) Genes Dev. , vol.23 , pp. 2117-2123
    • Guise, T.A.1
  • 141
    • 77958056316 scopus 로고    scopus 로고
    • A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes
    • Jones, M.D. et al. (2010) A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin. Cancer Res. 16, 4978-4989
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4978-4989
    • Jones, M.D.1
  • 142
    • 20444433230 scopus 로고    scopus 로고
    • Bortezomib or high-dose dexamethasone for relapsed multiple myeloma
    • Richardson, P.G. et al. (2005) Bortezomib or high-dose dexamethasone for relapsed multiple myeloma. N. Engl. J. Med. 352, 2487-2498
    • (2005) N. Engl. J. Med. , vol.352 , pp. 2487-2498
    • Richardson, P.G.1
  • 143
    • 33846624243 scopus 로고    scopus 로고
    • Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation
    • Clines, G.A. et al. (2007) Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation. Mol. Endocrinol. 21, 486-498
    • (2007) Mol. Endocrinol. , vol.21 , pp. 486-498
    • Clines, G.A.1
  • 144
    • 33750728404 scopus 로고    scopus 로고
    • Targeting bone metastasis in prostate cancer with endothelin receptor antagonists
    • Carducci, M.A. and Jimeno, A. (2006) Targeting bone metastasis in prostate cancer with endothelin receptor antagonists. Clin. Cancer Res. 12, 6296s-6300s
    • (2006) Clin. Cancer Res. , vol.12 , pp. 6296s-6300s
    • Carducci, M.A.1    Jimeno, A.2
  • 145
    • 0033919232 scopus 로고    scopus 로고
    • Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption
    • Chiao, J.W. et al. (2000) Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption. Br. J. Cancer 83, 360-365
    • (2000) Br. J. Cancer , vol.83 , pp. 360-365
    • Chiao, J.W.1
  • 146
    • 84860278133 scopus 로고    scopus 로고
    • Targeting the endothelin axis in prostate carcinoma
    • Pinto, A. et al. (2012) Targeting the endothelin axis in prostate carcinoma. Tumour Biol. 33, 421-426
    • (2012) Tumour Biol. , vol.33 , pp. 421-426
    • Pinto, A.1
  • 147
    • 84905093564 scopus 로고    scopus 로고
    • Bone marrow fat: Linking adipocyteinduced inflammation with skeletal metastases
    • Hardaway, A.L. et al. (2014) Bone marrow fat: linking adipocyteinduced inflammation with skeletal metastases. Cancer Metastasis Rev. 33, 527-543
    • (2014) Cancer Metastasis Rev. , vol.33 , pp. 527-543
    • Hardaway, A.L.1
  • 148
    • 34548178349 scopus 로고    scopus 로고
    • Direct evidence of lipid translocation between adipocytes and prostate cancer cells with imaging FTIR microspectroscopy
    • Gazi, E. et al. (2007) Direct evidence of lipid translocation between adipocytes and prostate cancer cells with imaging FTIR microspectroscopy. J. Lipid Res. 48, 1846-1856
    • (2007) J. Lipid Res. , vol.48 , pp. 1846-1856
    • Gazi, E.1
  • 149
    • 0037568482 scopus 로고    scopus 로고
    • Prostate cancer cell growth is modulated by adipocyte-cancer cell interaction
    • Tokuda, Y. et al. (2003) Prostate cancer cell growth is modulated by adipocyte-cancer cell interaction. BJU Int. 91, 716-720
    • (2003) BJU Int. , vol.91 , pp. 716-720
    • Tokuda, Y.1
  • 150
    • 44449118921 scopus 로고    scopus 로고
    • Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets
    • Furuhashi, M. and Hotamisligil, G.S. (2008) Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat. Rev. Drug Discov. 7, 489-503
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 489-503
    • Furuhashi, M.1    Hotamisligil, G.S.2
  • 151
    • 84890221321 scopus 로고    scopus 로고
    • Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms
    • Herroon, M.K. et al. (2013) Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms. Oncotarget 4, 2108-2123
    • (2013) Oncotarget , vol.4 , pp. 2108-2123
    • Herroon, M.K.1
  • 152
    • 84884211491 scopus 로고    scopus 로고
    • Macrophage cathepsin K promotes prostate tumor progression in bone
    • Herroon, M.K. et al. (2013) Macrophage cathepsin K promotes prostate tumor progression in bone. Oncogene 32, 1580-1593
    • (2013) Oncogene , vol.32 , pp. 1580-1593
    • Herroon, M.K.1
  • 153
    • 80355146399 scopus 로고    scopus 로고
    • Transcriptional regulation of macrophage polarization: Enabling diversity with identity
    • Lawrence, T. and Natoli, G. (2011) Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat. Rev. Immunol. 11, 750-761
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 750-761
    • Lawrence, T.1    Natoli, G.2
  • 154
    • 84893655060 scopus 로고    scopus 로고
    • A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients
    • Zhang, M. et al. (2014) A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients. J. Ovarian Res. 7, 19
    • (2014) J. Ovarian Res. , vol.7 , pp. 19
    • Zhang, M.1
  • 155
    • 84899753746 scopus 로고    scopus 로고
    • Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo
    • Joshi, S. et al. (2014) Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo. PLoS ONE 9, e95893
    • (2014) PLoS ONE , vol.9 , pp. e95893
    • Joshi, S.1
  • 156
    • 49749146393 scopus 로고    scopus 로고
    • Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/ macrophages
    • Hiraoka, K. et al. (2008) Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/ macrophages. Cancer Sci. 99, 1595-1602
    • (2008) Cancer Sci. , vol.99 , pp. 1595-1602
    • Hiraoka, K.1
  • 157
    • 84883362872 scopus 로고    scopus 로고
    • Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts
    • Fend, L. et al. (2013) Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts. PLoS ONE 8, e73310
    • (2013) PLoS ONE , vol.8 , pp. e73310
    • Fend, L.1
  • 158
    • 84862909092 scopus 로고    scopus 로고
    • Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells
    • Okuda, H. et al. (2012) Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells. Cancer Res. 72, 537-547
    • (2012) Cancer Res. , vol.72 , pp. 537-547
    • Okuda, H.1
  • 159
    • 0032768313 scopus 로고    scopus 로고
    • A novel orthotopic model of breast cancer metastasis to bone
    • Lelekakis, M. et al. (1999) A novel orthotopic model of breast cancer metastasis to bone. Clin. Exp. Metastasis 17, 163-170
    • (1999) Clin. Exp. Metastasis , vol.17 , pp. 163-170
    • Lelekakis, M.1
  • 160
    • 46949091216 scopus 로고    scopus 로고
    • APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice
    • Uluckan, O. et al. (2008) APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice. J. Cell. Biochem. 104, 1311-1323
    • (2008) J. Cell. Biochem. , vol.104 , pp. 1311-1323
    • Uluckan, O.1
  • 161
    • 23944525065 scopus 로고    scopus 로고
    • Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder
    • Chaffer, C.L. et al. (2005) Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder. Clin. Exp. Metastasis 22, 115-125
    • (2005) Clin. Exp. Metastasis , vol.22 , pp. 115-125
    • Chaffer, C.L.1
  • 162
    • 0032188762 scopus 로고    scopus 로고
    • Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression
    • Yang, M. et al. (1998) Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression. Cancer Res. 58, 4217-4221
    • (1998) Cancer Res. , vol.58 , pp. 4217-4221
    • Yang, M.1
  • 163
    • 0033557967 scopus 로고    scopus 로고
    • A fluorescent orthotopic bone metastasis model of human prostate cancer
    • Yang, M. et al. (1999) A fluorescent orthotopic bone metastasis model of human prostate cancer. Cancer Res. 59, 781-786
    • (1999) Cancer Res. , vol.59 , pp. 781-786
    • Yang, M.1
  • 164
    • 0032733840 scopus 로고    scopus 로고
    • Genetically fluorescent melanoma bone and organ metastasis models
    • Yang, M. et al. (1999) Genetically fluorescent melanoma bone and organ metastasis models. Clin. Cancer Res. 5, 3549-3559
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3549-3559
    • Yang, M.1
  • 165
    • 84907065343 scopus 로고    scopus 로고
    • Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice
    • Miwa, S. et al. (2014) Tumor-targeting Salmonella typhimurium A1-R prevents experimental human breast cancer bone metastasis in nude mice. Oncotarget 5, 7119-7125
    • (2014) Oncotarget , vol.5 , pp. 7119-7125
    • Miwa, S.1
  • 166
    • 84921748715 scopus 로고    scopus 로고
    • Fluorescence-guided surgery of prostate cancer bone metastasis
    • Miwa, S. et al. (2014) Fluorescence-guided surgery of prostate cancer bone metastasis. J. Surg. Res. 192, 124-133
    • (2014) J. Surg. Res. , vol.192 , pp. 124-133
    • Miwa, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.