Platelet-Derived Nucleotides Promote Tumor-Cell Transendothelial Migration and Metastasis via P2Y2 Receptor

Cancer Cell

Volumn 24, Issue 1, 2013, Pages 130-137

  Schumacher, Dagmar ^a   Strilic, Boris ^a   Sivaraj, KishorKumar ^a   Wettschureck, Nina ^a,b   Offermanns, Stefan ^a,b  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE; PURINERGIC P2Y2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GRANULE; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG TARGETING; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; METASTASIS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE RELEASE REACTION; TUMOR CELL;

MUS;

EID: 84880008122     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccr.2013.05.008     Document Type: Article

References (34)

1. Abbracchio M.P., Burnstock G., Boeynaems J.M., Barnard E.A., Boyer J.L., Kennedy C., Knight G.E., Fumagalli M., Gachet C., Jacobson K.A., Weisman G.A. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 2006, 58:281-341.
2. Borsig L., Wong R., Feramisco J., Nadeau D.R., Varki N.M., Varki A. Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc. Natl. Acad. Sci. USA 2001, 98:3352-3357.
3. Boucharaba A., Serre C.M., Grès S., Saulnier-Blache J.S., Bordet J.C., Guglielmi J., Clézardin P., Peyruchaud O. Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J.Clin. Invest. 2004, 114:1714-1725.
4. Camerer E., Qazi A.A., Duong D.N., Cornelissen I., Advincula R., Coughlin S.R. Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood 2004, 104:397-401.
5. Chaffer C.L., Weinberg R.A. A perspective on cancer cell metastasis. Science 2011, 331:1559-1564.
6. Crissman J.D., Hatfield J.S., Menter D.G., Sloane B., Honn K.V. Morphological study of the interaction of intravascular tumor cells with endothelial cells and subendothelial matrix. Cancer Res. 1988, 48:4065-4072.
7. Crozat K., Hoebe K., Ugolini S., Hong N.A., Janssen E., Rutschmann S., Mudd S., Sovath S., Vivier E., Beutler B. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J.Exp. Med. 2007, 204:853-863.
8. Diacovo T.G., Puri K.D., Warnock R.A., Springer T.A., von Andrian U.H. Platelet-mediated lymphocyte delivery to high endothelial venules. Science 1996, 273:252-255.
9. Erpenbeck L., Schön M.P. Deadly allies: the fatal interplay between platelets and metastasizing cancer cells. Blood 2010, 115:3427-3436.
10. Gavard J., Gutkind J.S. Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha 12/13 and Galpha 11/q. J.Biol. Chem. 2008, 283:29888-29896.
11. Gay L.J., Felding-Habermann B. Contribution of platelets to tumour metastasis. Nat. Rev. Cancer 2011, 11:123-134.
12. Honn K.V., Tang D.G., Chen Y.Q. Platelets and cancer metastasis: more than an epiphenomenon. Semin. Thromb. Hemost. 1992, 18:392-415.
13. Honn K.V., Tang D.G., Grossi I.M., Renaud C., Duniec Z.M., Johnson C.R., Diglio C.A. Enhanced endothelial cell retraction mediated by 12(S)-HETE: a proposed mechanism for the role of platelets in tumor cell metastasis. Exp. Cell Res. 1994, 210:1-9.
14. Im J.H., Fu W., Wang H., Bhatia S.K., Hammer D.A., Kowalska M.A., Muschel R.J. Coagulation facilitates tumor cell spreading in the pulmonary vasculature during early metastatic colony formation. Cancer Res. 2004, 64:8613-8619.
15. Italiano J.E., Richardson J.L., Patel-Hett S., Battinelli E., Zaslavsky A., Short S., Ryeom S., Folkman J., Klement G.L. Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate plateletalpha granules and differentially released. Blood 2008, 111:1227-1233.
16. Jain S., Harris J., Ware J. Platelets: linking hemostasis and cancer. Arterioscler. Thromb. Vasc. Biol. 2010, 30:2362-2367.
17. Joyce J.A., Pollard J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 2009, 9:239-252.
18. Knezevic N., Tauseef M., Thennes T., Mehta D. The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin. J.Exp. Med. 2009, 206:2761-2777.
19. Korhonen H., Fisslthaler B., Moers A., Wirth A., Habermehl D., Wieland T., Schütz G., Wettschureck N., Fleming I., Offermanns S. Anaphylactic shock depends on endothelial Gq/G11. J.Exp. Med. 2009, 206:411-420.
20. Kramer R.H., Nicolson G.L. Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion. Proc. Natl. Acad. Sci. USA 1979, 76:5704-5708.
21. Kukulski F., Ben Yebdri F., Bahrami F., Fausther M., Tremblay A., Sévigny J. Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration invitro. Mol. Immunol. 2010, 47:991-999.
22. Labelle M., Hynes R.O. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discov. 2012, 2:1091-1099.
23. Labelle M., Begum S., Hynes R.O. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 2011, 20:576-590.
24. Nguyen D.X., Bos P.D., Massagué J. Metastasis: from dissemination to organ-specific colonization. Nat. Rev. Cancer 2009, 9:274-284.
25. Nierodzik M.L., Karpatkin S. Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype. Cancer Cell 2006, 10:355-362.
26. Nieswandt B., Hafner M., Echtenacher B., Männel D.N. Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res. 1999, 59:1295-1300.
27. Palumbo J.S., Talmage K.E., Massari J.V., La Jeunesse C.M., Flick M.J., Kombrinck K.W., Jirousková M., Degen J.L. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 2005, 105:178-185.
28. Pearlstein E., Ambrogio C., Karpatkin S. Effect of antiplatelet antibody on the development of pulmonary metastases following injection of CT26 colon adenocarcinoma, Lewis lung carcinoma, and B16 amelanotic melanoma tumor cells into mice. Cancer Res. 1984, 44:3884-3887.
29. Petri B., Broermann A., Li H., Khandoga A.G., Zarbock A., Krombach F., Goerge T., Schneider S.W., Jones C., Nieswandt B., et al. vonWillebrand factor promotes leukocyte extravasation. Blood 2010, 116:4712-4719.
30. Reed G.L. Platelet secretory mechanisms. Semin. Thromb. Hemost. 2004, 30:441-450.
31. Ren Q., Ye S., Whiteheart S.W. The platelet release reaction: just when you thought platelet secretion was simple. Curr. Opin. Hematol. 2008, 15:537-541.
32. Ren Q., Wimmer C., Chicka M.C., Ye S., Ren Y., Hughson F.M., Whiteheart S.W. Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. Blood 2010, 116:869-877.
33. Rothwell P.M., Wilson M., Price J.F., Belch J.F., Meade T.W., Mehta Z. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet 2012, 379:1591-1601.
34. Ruf W., Mueller B.M. Thrombin generation and the pathogenesis of cancer. Semin. Thromb. Hemost. 2006, 32(Suppl 1):61-68.