-
1
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144(5):646-74
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
0036782278
-
VEGF and the quest for tumour angiogenesis factors
-
DOI 10.1038/nrc909
-
Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2002;2(10):795-803 (Pubitemid 37328914)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.10
, pp. 795-803
-
-
Ferrara, N.1
-
3
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1(1):27-31
-
(1995)
Nat Med
, vol.1
, Issue.1
, pp. 27-31
-
-
Folkman, J.1
-
4
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8(4):299-309 (Pubitemid 41443415)
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
5
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
DOI 10.1172/JCI200317929
-
Bergers G, Song S, Meyer-Morse N, et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003;111(9):1287-95 (Pubitemid 36554699)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.9
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
7
-
-
26944437515
-
+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
-
DOI 10.1038/ncb1288, PII N1288
-
Song S, Ewald AJ, Stallcup W, et al. PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat Cell Biol 2005;7(9):870-9 (Pubitemid 41486287)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.9
, pp. 870-879
-
-
Song, S.1
Ewald, A.J.2
Stallcup, W.3
Werb, Z.4
Bergers, G.5
-
8
-
-
34547637867
-
Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
-
DOI 10.1158/0008-5472.CAN-07-0293
-
Sennino B, Falcon BL, McCauley D, et al. Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res 2007;67(15):7358-67 (Pubitemid 47206566)
-
(2007)
Cancer Research
, vol.67
, Issue.15
, pp. 7358-7367
-
-
Sennino, B.1
Falcon, B.L.2
McCauley, D.3
Le, T.4
McCauley, T.5
Kurz, J.C.6
Haskell, A.7
Epstein, D.M.8
McDonald, D.M.9
-
9
-
-
33745098620
-
Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248
-
DOI 10.1158/1535-7163.MCT-03-0156
-
Potapova O, Laird AD, Nannini MA, et al. Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248. Mol Cancer Ther 2006;5(5):1280-9 (Pubitemid 43881321)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.5
, pp. 1280-1289
-
-
Potapova, O.1
Laird, A.D.2
Nannini, M.A.3
Barone, A.4
Li, G.5
Moss, K.G.6
Cherrington, J.M.7
Mendel, D.B.8
-
10
-
-
34547662268
-
Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
-
DOI 10.1172/JCI31334
-
McCarty MF, Somcio RJ, Stoeltzing O, et al. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest 2007;117(8):2114-22 (Pubitemid 47219556)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.8
, pp. 2114-2122
-
-
McCarty, M.F.1
Somcio, R.J.2
Stoeltzing, O.3
Wey, J.4
Fan, F.5
Liu, W.6
Bucana, C.7
Ellis, L.M.8
-
11
-
-
20044396551
-
Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab′, leads to fluid accumulation and is associated with increased tumor vascularized volume
-
DOI 10.1200/JCO.2005.01.032
-
Jayson GC, Parker GJ, Mullamitha S, et al. Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume. J Clin Oncol 2005;23(5):973-81 (Pubitemid 46202317)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.5
, pp. 973-981
-
-
Jayson, G.C.1
Parker, G.J.M.2
Mullamitha, S.3
Valle, J.W.4
Saunders, M.5
Broughton, L.6
Lawrance, J.7
Carrington, B.8
Roberts, C.9
Issa, B.10
Buckley, D.L.11
Cheung, S.12
Davies, K.13
Watson, Y.14
Zinkewich-Peotti, K.15
Rolfe, L.16
Jackson, A.17
-
12
-
-
77953604802
-
Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models
-
Lu C, Shahzad MM, Moreno-Smith M, et al. Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models. Cancer Biol Ther 2010;9(3):176-82
-
(2010)
Cancer Biol Ther
, vol.9
, Issue.3
, pp. 176-182
-
-
Lu, C.1
Shahzad, M.M.2
Moreno-Smith, M.3
-
13
-
-
0035297541
-
Ihibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
-
Pietras K, Ostman A, Sjoquist M, et al. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res 2001;61(7):2929-34 (Pubitemid 32691937)
-
(2001)
Cancer Research
, vol.61
, Issue.7
, pp. 2929-2934
-
-
Pietras, K.1
Ostman, A.2
Sjoquist, M.3
Buchdunger, E.4
Reed, R.K.5
Heldin, C.-H.6
Rubin, K.7
-
14
-
-
61649100307
-
The FGF family: Biology, pathophysiology and therapy
-
Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 2009;8(3):235-53
-
(2009)
Nat Rev Drug Discov
, vol.8
, Issue.3
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
15
-
-
34948905351
-
Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis
-
DOI 10.1172/JCI32479
-
Nissen LJ, Cao R, Hedlund EM, et al. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest 2007;117(10):2766-77 (Pubitemid 47529608)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.10
, pp. 2766-2777
-
-
Nissen, L.J.1
Cao, R.2
Hedlund, E.-M.3
Wang, Z.4
Zhao, X.5
Wetterskog, D.6
Funa, K.7
Brakenhielm, E.8
Cao, Y.9
-
16
-
-
24944534593
-
VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRβ signaling
-
DOI 10.1242/jcs.02483
-
Kano MR, Morishita Y, Iwata C, et al. VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling. J Cell Sci 2005;118(Pt 16):3759-68 (Pubitemid 41309422)
-
(2005)
Journal of Cell Science
, vol.118
, Issue.16
, pp. 3759-3768
-
-
Kano, M.R.1
Morishita, Y.2
Iwata, C.3
Iwasaka, S.4
Watabe, T.5
Ouchi, Y.6
Miyazono, K.7
Miyazawa, K.8
-
17
-
-
81055124256
-
Targeting FGFR/PDGFR/VEGFR impairs tumor growth angiogenesis and metastasis by effects on tumor cells endothelial cells and pericytes in pancreatic cancer
-
Taeger J, Moser C, Hellerbrand C, et al. Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer. Mol Cancer Ther 2011;10(11):2157-67
-
(2011)
Mol Cancer Ther
, vol.10
, Issue.11
, pp. 2157-2167
-
-
Taeger, J.1
Moser, C.2
Hellerbrand, C.3
-
18
-
-
36749103151
-
Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein
-
Usui R, Shibuya M, Ishibashi S, Maru Y. Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein. EMBO Rep 2007;8(12):1155-561
-
(2007)
EMBO Rep
, vol.8
, Issue.12
, pp. 1155-561
-
-
Usui, R.1
Shibuya, M.2
Ishibashi, S.3
Maru, Y.4
-
19
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
DOI 10.1158/0008-5472.CAN-04-1443
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64(19):7099-109 (Pubitemid 39331023)
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
20
-
-
33846212284
-
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
-
DOI 10.1158/0008-5472.CAN-06-1377
-
Liu L, Cao Y, Chen C, et al. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res 2006;66(24):11851-8 (Pubitemid 46094197)
-
(2006)
Cancer Research
, vol.66
, Issue.24
, pp. 11851-11858
-
-
Liu, L.1
Cao, Y.2
Chen, C.3
Zhang, X.4
McNabola, A.5
Wilkie, D.6
Wilhelm, S.7
Lynch, M.8
Carter, C.9
-
21
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359(4):378-90
-
(2008)
N Engl J Med
, vol.359
, Issue.4
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
22
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007;356(2):125-34 (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
23
-
-
77954574658
-
Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203
-
Sun W, Powell M, O'Dwyer PJ, et al. Phase II study of sorafenib in combination with docetaxel and cisplatin in the treatment of metastatic or advanced gastric and gastroesophageal junction adenocarcinoma: ECOG 5203. J Clin Oncol 2010;28(18):2947-51
-
(2010)
J Clin Oncol
, vol.28
, Issue.18
, pp. 2947-2951
-
-
Sun, W.1
Powell, M.2
O'Dwyer, P.J.3
-
24
-
-
77952468875
-
Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer
-
Lam ET, Ringel MD, Kloos RT, et al. Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer. J Clin Oncol 2010;28(14):2323-30
-
(2010)
J Clin Oncol
, vol.28
, Issue.14
, pp. 2323-2330
-
-
Lam, E.T.1
Ringel, M.D.2
Kloos, R.T.3
-
25
-
-
70149087258
-
Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancer
-
Bianchi G, Loibl S, Zamagni C, et al. Phase II multicenter, uncontrolled trial of sorafenib in patients with metastatic breast cancer. Anticancer Drugs 2009;20(7):616-24
-
(2009)
Anticancer Drugs
, vol.20
, Issue.7
, pp. 616-624
-
-
Bianchi, G.1
Loibl, S.2
Zamagni, C.3
-
26
-
-
78650084078
-
A front-line window of opportunity phase 2 study of sorafenib in patients with advanced non-small cell lung cancer: North Central Cancer Treatment Group Study N0326
-
Dy GK, Hillman SL, Rowland KM Jr, et al. A front-line window of opportunity phase 2 study of sorafenib in patients with advanced non-small cell lung cancer: North Central Cancer Treatment Group Study N0326. Cancer 2010;116(24):5686-93
-
(2010)
Cancer
, vol.116
, Issue.24
, pp. 5686-5693
-
-
Dy, G.K.1
Hillman, S.L.2
Rowland Jr., K.M.3
-
27
-
-
79951988792
-
Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: A gynecologic oncology group trial
-
Matei D, Sill MW, Lankes HA, et al. Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial. J Clin Oncol 2011;29(1):69-75
-
(2011)
J Clin Oncol
, vol.29
, Issue.1
, pp. 69-75
-
-
Matei, D.1
Sill, M.W.2
Lankes, H.A.3
-
28
-
-
74249098818
-
Sorafenib in patients with advanced biliary tract carcinoma: A phase II trial
-
Bengala C, Bertolini F, Malavasi N, et al. Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial. Br J Cancer 2010;102(1):68-72
-
(2010)
Br J Cancer
, vol.102
, Issue.1
, pp. 68-72
-
-
Bengala, C.1
Bertolini, F.2
Malavasi, N.3
-
29
-
-
77954754601
-
Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group Study S0420
-
Williamson SK, Moon J, Huang CH, et al. Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: southwest Oncology Group Study S0420. J Clin Oncol 2010;28(20):3330-5
-
(2010)
J Clin Oncol
, vol.28
, Issue.20
, pp. 3330-5
-
-
Williamson, S.K.1
Moon, J.2
Huang, C.H.3
-
30
-
-
77949337347
-
A phase II study of sorafenib in advanced uterine carcinoma/ carcinosarcoma: A trial of the Chicago PMH and California Phase II Consortia
-
Nimeiri HS, Oza AM, Morgan RJ, et al. A phase II study of sorafenib in advanced uterine carcinoma/carcinosarcoma: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 2010;117(1):37-40
-
(2010)
Gynecol Oncol
, vol.117
, Issue.1
, pp. 37-40
-
-
Nimeiri, H.S.1
Oza, A.M.2
Morgan, R.J.3
-
31
-
-
78349298645
-
Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
-
Abou-Alfa GK, Johnson P, Knox JJ, et al. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA 2010;304(19):2154-60
-
(2010)
JAMA
, vol.304
, Issue.19
, pp. 2154-2160
-
-
Abou-Alfa, G.K.1
Johnson, P.2
Knox, J.J.3
-
32
-
-
79959306917
-
Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer
-
Spigel DR, Burris HA III, Greco FA, et al. Randomized, double-blind, placebo-controlled, phase II trial of sorafenib and erlotinib or erlotinib alone in previously treated advanced non-small-cell lung cancer. J Clin Oncol 2011;29(18):2582-9
-
(2011)
J Clin Oncol
, vol.29
, Issue.18
, pp. 2582-9
-
-
Spigel, D.R.1
Burris Iii, H.A.2
Greco, F.A.3
-
33
-
-
79959695837
-
Sorafenib in combination with erlotinib or with gemcitabine in elderly patients with advanced non-small-cell lung cancer: A randomized phase II study
-
Gridelli C, Morgillo F, Favaretto A, et al. Sorafenib in combination with erlotinib or with gemcitabine in elderly patients with advanced non-small-cell lung cancer: a randomized phase II study. Ann Oncol 2011;22(7):1528-34
-
(2011)
Ann Oncol
, vol.22
, Issue.7
, pp. 1528-1534
-
-
Gridelli, C.1
Morgillo, F.2
Favaretto, A.3
-
34
-
-
78651101402
-
Phase I/II study of sorafenib with anastrozole in patients with hormone receptor positive aromatase inhibitor resistant metastatic breast cancer
-
Isaacs C, Herbolsheimer P, Liu MC, et al. Phase I/II study of sorafenib with anastrozole in patients with hormone receptor positive aromatase inhibitor resistant metastatic breast cancer. Breast Cancer Res Treat 2011;125(1):137-43
-
(2011)
Breast Cancer Res Treat
, vol.125
, Issue.1
, pp. 137-143
-
-
Isaacs, C.1
Herbolsheimer, P.2
Liu, M.C.3
-
35
-
-
77951639655
-
Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer
-
Scagliotti G, Novello S, von Pawel J, et al. Phase III study of carboplatin and paclitaxel alone or with sorafenib in advanced non-small-cell lung cancer. J Clin Oncol 2010;28(11):1835-42
-
(2010)
J Clin Oncol
, vol.28
, Issue.11
, pp. 1835-1842
-
-
Scagliotti, G.1
Novello, S.2
Von Pawel, J.3
-
36
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003;9(1):327-37 (Pubitemid 36109749)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.I1
, pp. 327-337
-
-
Mendel, D.B.1
Douglas Laird, A.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
37
-
-
42949148257
-
Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
-
Burstein HJ, Elias AD, Rugo HS, et al. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. Clin Oncol 2008;26(11):1810-16
-
(2008)
Clin Oncol
, vol.26
, Issue.11
, pp. 1810-1816
-
-
Burstein, H.J.1
Elias, A.D.2
Rugo, H.S.3
-
38
-
-
84858175967
-
Phase I/II study of sunitinib in combination with metronomic dosing of cyclophosphamide and methotrexate in patients with metastatic breast cancer
-
abstract 1067
-
Chien AJ, Aicardi J, Melisko ME, et al. Phase I/II study of sunitinib in combination with metronomic dosing of cyclophosphamide and methotrexate in patients with metastatic breast cancer. J Clin Oncol 2010;28(15s Suppl):abstract 1067
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Chien, A.J.1
Aicardi, J.2
Melisko, M.E.3
-
39
-
-
77956187531
-
Multicenter phase II randomized trial evaluating antiangiogenic therapy with sunitinib as consolidation after objective response to taxane chemotherapy in women with HER2-negative metastatic breast cancer
-
Wildiers H, Fontaine C, Vuylsteke P, et al. Multicenter phase II randomized trial evaluating antiangiogenic therapy with sunitinib as consolidation after objective response to taxane chemotherapy in women with HER2-negative metastatic breast cancer. Breast Cancer Res Treat 2010;123(2):463-9
-
(2010)
Breast Cancer Res Treat
, vol.123
, Issue.2
, pp. 463-469
-
-
Wildiers, H.1
Fontaine, C.2
Vuylsteke, P.3
-
40
-
-
77951296573
-
Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer
-
Barrios CH, Liu MC, Lee SC, et al. Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer. Breast Cancer Res Treat 2010;121(1):121-31
-
(2010)
Breast Cancer Res Treat
, vol.121
, Issue.1
, pp. 121-131
-
-
Barrios, C.H.1
Liu, M.C.2
Lee, S.C.3
-
41
-
-
65549099731
-
Phase II study of sunitinib in men with advanced prostate cancer
-
Dror Michaelson M, Regan MM, Oh WK, et al. Phase II study of sunitinib in men with advanced prostate cancer. Ann Oncol 2009;20(5):913-20
-
(2009)
Ann Oncol
, vol.20
, Issue.5
, pp. 913-920
-
-
Dror Michaelson, M.1
Regan, M.M.2
Oh, W.K.3
-
42
-
-
77951887506
-
Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy
-
Sonpavde G, Periman PO, Bernold D, et al. Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy. Ann Oncol 2010;21(2):319-24
-
(2010)
Ann Oncol
, vol.21
, Issue.2
, pp. 319-324
-
-
Sonpavde, G.1
Periman, P.O.2
Bernold, D.3
-
43
-
-
36048992408
-
Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
-
DOI 10.1200/JCO.2007.12.8637
-
Saltz LB, Rosen LS, Marshall JL, et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007;25(30):4793-9 (Pubitemid 350086483)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.30
, pp. 4793-4799
-
-
Saltz, L.B.1
Rosen, L.S.2
Marshall, J.L.3
Belt, R.J.4
Hurwitz, H.I.5
Eckhardt, S.G.6
Bergsland, E.K.7
Haller, D.G.8
Lockhart, A.C.9
Rocha Lima, C.M.10
Huang, X.11
DePrimo, S.E.12
Chow-Maneval, E.13
Chao, R.C.14
Lenz, H.J.15
-
44
-
-
84858217359
-
A randomized, phase IIb study of sunitinib plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) versus bevacizumab plus mFOLFOX6 as first-line treatment for metastatic colorectal cancer: Interim results
-
abstract 3532
-
Hecht JR, Yoshino T, Mitchell EP, et al. A randomized, phase IIb study of sunitinib plus 5-fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) versus bevacizumab plus mFOLFOX6 as first-line treatment for metastatic colorectal cancer: interim results. J Clin Oncol 2010;28(15s Suppl):abstract 3532
-
(2010)
J Clin Oncol
, Issue.15 SUPPL.
, pp. 28
-
-
Hecht, J.R.1
Yoshino, T.2
Mitchell, E.P.3
-
45
-
-
39149120621
-
Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
-
Socinski MA, Novello S, Brahmer JR, et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J Clin Oncol 2008;26(4):650-66
-
(2008)
J Clin Oncol
, vol.26
, Issue.4
, pp. 650-666
-
-
Socinski, M.A.1
Novello, S.2
Brahmer, J.R.3
-
46
-
-
70350569370
-
Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma: A Gynecologic Oncology Group phase II study
-
Hensley ML, Sill MW, Scribner DR Jr, et al. Sunitinib malate in the treatment of recurrent or persistent uterine leiomyosarcoma: a Gynecologic Oncology Group phase II study. Gynecol Oncol 2009;115(3):460-5
-
(2009)
Gynecol Oncol
, vol.115
, Issue.3
, pp. 460-465
-
-
Hensley, M.L.1
Sill, M.W.2
Scribner Jr., D.R.3
-
47
-
-
79251585977
-
A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: An NCIC Clinical Trials Group Study
-
Biagi JJ, Oza AM, Chalchal HI, et al. A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study. Ann Oncol 2011;22(2):335-40
-
(2011)
Ann Oncol
, vol.22
, Issue.2
, pp. 335-340
-
-
Biagi, J.J.1
Oza, A.M.2
Chalchal, H.I.3
-
48
-
-
74249122456
-
A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184
-
Mackay HJ, Tinker A, Winquist E, et al. A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184. Gynecol Oncol 2010;116(2):163-7
-
(2010)
Gynecol Oncol
, vol.116
, Issue.2
, pp. 163-167
-
-
MacKay, H.J.1
Tinker, A.2
Winquist, E.3
-
49
-
-
73949143686
-
Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01
-
Machiels JP, Henry S, Zanetta S, et al. Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01. J Clin Oncol 2010;28(1):21-8
-
(2010)
J Clin Oncol
, vol.28
, Issue.1
, pp. 21-8
-
-
MacHiels, J.P.1
Henry, S.2
Zanetta, S.3
-
50
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood JM, Bold G, Buchdunger E, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res 2000;60(8):2178-89 (Pubitemid 30225181)
-
(2000)
Cancer Research
, vol.60
, Issue.8
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
Hofmann, F.7
Mestan, J.8
Mett, H.9
O'Reilly, T.10
Persohn, E.11
Rosel, J.12
Schnell, C.13
Stover, D.14
Theuer, A.15
Towbin, H.16
Wenger, F.17
Woods-Cook, K.18
Menrad, A.19
Siemeister, G.20
Schirner, M.21
Thierauch, K.-H.22
Schneider, M.R.23
Drevs, J.24
Martiny-Baron, G.25
Totzke, F.26
Marme, D.27
more..
-
51
-
-
79956297102
-
Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma
-
Van Cutsem E, Bajetta E, Valle J, et al. Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma. J Clin Oncol 2011;29(15):2004-10
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. 2004-2010
-
-
Van Cutsem, E.1
Bajetta, E.2
Valle, J.3
-
52
-
-
79956334386
-
Randomized, placebo-controlled, phase III study of first-line oxaliplatinbased chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma
-
Hecht JR, Trarbach T, Hainsworth JD, et al. Randomized, placebo-controlled, phase III study of first-line oxaliplatinbased chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. J Clin Oncol 2011;29(15):1997-2003
-
(2011)
J Clin Oncol
, vol.29
, Issue.15
, pp. 1997-2003
-
-
Hecht, J.R.1
Trarbach, T.2
Hainsworth, J.D.3
-
53
-
-
0038376002
-
Molecular regulation of vessel maturation
-
DOI 10.1038/nm0603-685
-
Jain RK. Molecular regulation of vessel maturation. Nat Med 2003;9(6):685-93 (Pubitemid 36749217)
-
(2003)
Nature Medicine
, vol.9
, Issue.6
, pp. 685-693
-
-
Jain, R.K.1
-
54
-
-
84857137458
-
Phase II trial of PTK787/ZK 222584 (vatalanib) administered orally once-daily or in two divided daily doses as second-line monotherapy in relapsed or progressing patients with stage IIIB/IV non-small-cell lung cancer (NSCLC)
-
[Epub ahead of print]
-
Gauler TC, Besse B, Mauguen A, et al. Phase II trial of PTK787/ZK 222584 (vatalanib) administered orally once-daily or in two divided daily doses as second-line monotherapy in relapsed or progressing patients with stage IIIB/IV non-small-cell lung cancer (NSCLC). Ann Oncol 2011; [Epub ahead of print]
-
(2011)
Ann Oncol
-
-
Gauler, T.C.1
Besse, B.2
Mauguen, A.3
-
55
-
-
33749000911
-
AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts
-
DOI 10.1158/0008-5472.CAN-05-4665
-
Polverino A, Coxon A, Starnes C, et al. AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and Kit receptors, potently inhibits angiogenesis and induces regression in tumor xenografts. Cancer Res 2006;66(17):8715-21 (Pubitemid 44449188)
-
(2006)
Cancer Research
, vol.66
, Issue.17
, pp. 8715-8721
-
-
Polverino, A.1
Coxon, A.2
Starnes, C.3
Diaz, Z.4
DeMelfi, T.5
Wang, L.6
Bready, J.7
Estrada, J.8
Cattley, R.9
Kaufman, S.10
Chen, D.11
Gan, Y.12
Kumar, G.13
Meyer, J.14
Neervannan, S.15
Alva, G.16
Talvenheimo, J.17
Montestruque, S.18
Tasker, A.19
Patel, V.20
Radinsky, R.21
Kendall, R.22
more..
-
56
-
-
79953196070
-
Motesanib or open-label bevacizumab in combination with paclitaxel as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: A phase 2 randomised double-blind placebo-controlled study
-
Martin M, Roche H, Pinter T, et al. Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: a phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol 2011;12(4):369-76
-
(2011)
Lancet Oncol
, vol.12
, Issue.4
, pp. 369-376
-
-
Martin, M.1
Roche, H.2
Pinter, T.3
-
57
-
-
80054760826
-
An international, randomized, placebo-controlled, double-blind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel in patients with advanced non squamous non-small cell lung cancer
-
abstract LBA7512
-
Scagliotti G, Vynnychenko I, Ichinose Y, et al. An international, randomized, placebo-controlled, double-blind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel in patients with advanced non squamous non-small cell lung cancer. J Clin Oncol 2011;29(Suppl):abstract LBA7512
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Scagliotti, G.1
Vynnychenko, I.2
Ichinose, Y.3
-
58
-
-
68949108390
-
Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer
-
Schlumberger MJ, Elisei R, Bastholt L, et al. Phase II study of safety and efficacy of motesanib in patients with progressive or symptomatic, advanced or metastatic medullary thyroid cancer. J Clin Oncol 2009;27(23):3794-801
-
(2009)
J Clin Oncol
, vol.27
, Issue.23
, pp. 3794-801
-
-
Schlumberger, M.J.1
Elisei, R.2
Bastholt, L.3
-
59
-
-
34447322566
-
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
DOI 10.1158/1535-7163.MCT-07-0193
-
Kumar R, Knick VB, Rudolph SK, et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol Cancer Ther 2007;6(7):2012-21 (Pubitemid 47052491)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.7
, pp. 2012-2021
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
Johnson, J.H.4
Crosby, R.M.5
Crouthamel, M.-C.6
Hopper, T.M.7
Miller, C.G.8
Harrington, L.E.9
Onori, J.A.10
Mullin, R.J.11
Gilmer, T.M.12
Truesdale, A.T.13
Epperly, A.H.14
Boloor, A.15
Stafford, J.A.16
Luttrell, D.K.17
Cheung, M.18
-
60
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010;28(6):1061-8
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 1061-8
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
61
-
-
77957359933
-
Efficacy of pazopanib in progressive radioiodine-refractory metastatic differentiated thyroid cancers: Results of a phase 2 consortium study
-
Bible KC, Suman VJ, Molina JR, et al. Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study. Lancet Oncol 2010;11(10):962-72
-
(2010)
Lancet Oncol
, vol.11
, Issue.10
, pp. 962-972
-
-
Bible, K.C.1
Suman, V.J.2
Molina, J.R.3
-
62
-
-
77956842743
-
A phase II study of pazopanib in patients with recurrent or metastatic invasive breast carcinoma: A trial of the Princess Margaret Hospital phase II consortium
-
Taylor SK, Chia S, Dent S, et al. A phase II study of pazopanib in patients with recurrent or metastatic invasive breast carcinoma: a trial of the Princess Margaret Hospital phase II consortium. Oncologist 2010;15(8):810-18
-
(2010)
Oncologist
, vol.15
, Issue.8
, pp. 810-818
-
-
Taylor, S.K.1
Chia, S.2
Dent, S.3
-
63
-
-
77955874058
-
Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer
-
Monk BJ, Mas Lopez L, Zarba JJ, et al. Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer. J Clin Oncol 2010;28(22):3562-9
-
(2010)
J Clin Oncol
, vol.28
, Issue.22
, pp. 3562-9
-
-
Monk, B.J.1
Mas Lopez, L.2
Zarba, J.J.3
-
64
-
-
77956649079
-
A Phase II open-label study evaluating pazopanib in patients with recurrent ovarian cancer
-
Friedlander M, Hancock KC, Rischin D, et al. A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer. Gynecol Oncol 2010;119(1):32-7
-
(2010)
Gynecol Oncol
, vol.119
, Issue.1
, pp. 32-7
-
-
Friedlander, M.1
Hancock, K.C.2
Rischin, D.3
-
65
-
-
77955503066
-
Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non-small-cell lung cancer
-
Altorki N, Lane ME, Bauer T, et al. Phase II proof-of-concept study of pazopanib monotherapy in treatment-naive patients with stage I/II resectable non-small-cell lung cancer. J Clin Oncol 2010;28(19):3131-7
-
(2010)
J Clin Oncol
, vol.28
, Issue.19
, pp. 3131-7
-
-
Altorki, N.1
Lane, M.E.2
Bauer, T.3
-
66
-
-
67650337802
-
Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043)
-
Sleijfer S, Ray-Coquard I, Papai Z, et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the European organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol 2009;27(19):3126-32
-
(2009)
J Clin Oncol
, vol.27
, Issue.19
, pp. 3126-3132
-
-
Sleijfer, S.1
Ray-Coquard, I.2
Papai, Z.3
-
67
-
-
70249129087
-
Phase i dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
-
Eskens FA, Steeghs N, Verweij J, et al. Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors. J Clin Oncol 2009;27(25):4169-76
-
(2009)
J Clin Oncol
, vol.27
, Issue.25
, pp. 4169-4176
-
-
Eskens, F.A.1
Steeghs, N.2
Verweij, J.3
-
68
-
-
77950667446
-
Phase i evaluation of telatinib a vascular endothelial growth factor receptor tyrosine kinase inhibitor in combination with irinotecan and capecitabine in patients with advanced solid tumors
-
Langenberg MH, Witteveen PO, Roodhart JM, et al. Phase I evaluation of telatinib, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in combination with irinotecan and capecitabine in patients with advanced solid tumors. Clin Cancer Res 2010;16(7):2187-97
-
(2010)
Clin Cancer Res
, vol.16
, Issue.7
, pp. 2187-2197
-
-
Langenberg, M.H.1
Witteveen, P.O.2
Roodhart, J.M.3
-
69
-
-
80155170380
-
Phase i evaluation of telatinib a VEGF receptor tyrosine kinase inhibitor in combination with bevacizumab in subjects with advanced solid tumors
-
Langenberg MH, Witteveen PO, Roodhart J, et al. Phase I evaluation of telatinib, a VEGF receptor tyrosine kinase inhibitor, in combination with bevacizumab in subjects with advanced solid tumors. Ann Oncol 2011;22(11):2508-15
-
(2011)
Ann Oncol
, vol.22
, Issue.11
, pp. 2508-2515
-
-
Langenberg, M.H.1
Witteveen, P.O.2
Roodhart, J.3
-
70
-
-
33646586669
-
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
-
DOI 10.1158/1535-7163.MCT-05-0410
-
Albert DH, Tapang P, Magoc TJ, et al. Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther 2006;5(4):995-1006 (Pubitemid 43724600)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.4
, pp. 995-1006
-
-
Albert, D.H.1
Tapang, P.2
Magoc, T.J.3
Pease, L.J.4
Reuter, D.R.5
Wei, R.-Q.6
Li, J.7
Guo, J.8
Bousquet, P.F.9
Ghoreishi-Haack, N.S.10
Wang, B.11
Bukofzer, G.T.12
Wang, Y.-C.13
Stavropoulos, J.A.14
Hartandi, K.15
Niquette, A.L.16
Soni, N.17
Johnson, E.F.18
McCall, J.O.19
Bouska, J.J.20
Luo, Y.21
Donawho, C.K.22
Dai, Y.23
Marcotte, P.A.24
Glaser, K.B.25
Michaelides, M.R.26
Davidsen, S.K.27
more..
-
71
-
-
69249149754
-
A phase II study of ABT-869 in hepatocellular carcinoma (HCC): Interim analysis
-
abstract 4581
-
Toh H, Chen P, Carr BI, et al. A phase II study of ABT-869 in hepatocellular carcinoma (HCC): interim analysis. J Clin Oncol 2009;27(15s Suppl):abstract 4581
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Toh, H.1
Chen, P.2
Carr, B.I.3
-
72
-
-
58149175849
-
Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma
-
Huynh H, Ngo VC, Fargnoli J, et al. Brivanib alaninate, a dual inhibitor of vascular endothelial growth factor receptor and fibroblast growth factor receptor tyrosine kinases, induces growth inhibition in mouse models of human hepatocellular carcinoma. Clin Cancer Res 2008;14(19):6146-53
-
(2008)
Clin Cancer Res
, vol.14
, Issue.19
, pp. 6146-6153
-
-
Huynh, H.1
Ngo, V.C.2
Fargnoli, J.3
-
73
-
-
79953325932
-
Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma
-
Park JW, Finn RS, Kim JS, et al. Phase II, open-label study of brivanib as first-line therapy in patients with advanced hepatocellular carcinoma. Clin Cancer Res 2011;17(7):1973-83
-
(2011)
Clin Cancer Res
, vol.17
, Issue.7
, pp. 1973-1983
-
-
Park, J.W.1
Finn, R.S.2
Kim, J.S.3
-
74
-
-
79959699570
-
Phase i dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy
-
Garrett CR, Siu LL, El-Khoueiry A, et al. Phase I dose-escalation study to determine the safety, pharmacokinetics and pharmacodynamics of brivanib alaninate in combination with full-dose cetuximab in patients with advanced gastrointestinal malignancies who have failed prior therapy. Br J Cancer 2011;105(1):44-52
-
(2011)
Br J Cancer
, vol.105
, Issue.1
, pp. 44-52
-
-
Garrett, C.R.1
Siu, L.L.2
El-Khoueiry, A.3
-
75
-
-
49649123154
-
BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
-
Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008;68(12):4774-82
-
(2008)
Cancer Res
, vol.68
, Issue.12
, pp. 4774-4782
-
-
Hilberg, F.1
Roth, G.J.2
Krssak, M.3
-
76
-
-
77958038695
-
Phase i safety pharmacokinetic and biomarker study of BIBF 1120 an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors
-
Okamoto I, Kaneda H, Satoh T, et al. Phase I safety, pharmacokinetic, and biomarker study of BIBF 1120, an oral triple tyrosine kinase inhibitor in patients with advanced solid tumors. Mol Cancer Ther 2010;9(10):2825-33
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.10
, pp. 2825-2833
-
-
Okamoto, I.1
Kaneda, H.2
Satoh, T.3
-
77
-
-
80053561888
-
Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer
-
[Epub ahead of print]
-
Ledermann JA, Hackshaw A, Kaye S, et al. Randomized phase II placebo-controlled trial of maintenance therapy using the oral triple angiokinase inhibitor BIBF 1120 after chemotherapy for relapsed ovarian cancer. J Clin Oncol 2011; [Epub ahead of print]
-
(2011)
J Clin Oncol
-
-
Ledermann, J.A.1
Hackshaw, A.2
Kaye, S.3
-
78
-
-
79957452054
-
A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer
-
Reck M, Kaiser R, Eschbach C, et al. A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. Ann Oncol 2011;22(6):1374-81
-
(2011)
Ann Oncol
, vol.22
, Issue.6
, pp. 1374-1381
-
-
Reck, M.1
Kaiser, R.2
Eschbach, C.3
-
79
-
-
21044443128
-
In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
-
DOI 10.1158/1078-0432.CCR-04-2129
-
Lee SH, Lopes de Menezes D, Vora J, et al. In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 2005;11(10):3633-41 (Pubitemid 40685578)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.10
, pp. 3633-3641
-
-
Sang, H.L.1
De Menezes, D.L.2
Vora, J.3
Harris, A.4
Ye, H.5
Nordahl, L.6
Garrett, E.7
Samara, E.8
Aukerman, S.L.9
Gelb, A.B.10
Heise, C.11
-
80
-
-
84856199835
-
A phase II study of dovitinib (TKI258), an FGFR-and VEGFR-inhibitor, in patients with advanced or metastatic renal cell cancer (mRCC)
-
abstract 4551
-
Angevin E, Grunwald V, Ravaud A, et al. A phase II study of dovitinib (TKI258), an FGFR-and VEGFR-inhibitor, in patients with advanced or metastatic renal cell cancer (mRCC). J Clin Oncol 2011;29(Suppl):abstract 4551
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Angevin, E.1
Grunwald, V.2
Ravaud, A.3
-
81
-
-
84858173388
-
A multicenter, open-label phase II trial of dovitinib (TKI258) in advanced urothelial carcinoma patients with either mutated or wild-type FGFR3
-
Milowsky MI, Carlson GL, Shi MM, et al. A multicenter, open-label phase II trial of dovitinib (TKI258) in advanced urothelial carcinoma patients with either mutated or wild-type FGFR3. J Clin Oncol 2011;29(Suppl):TPS 186
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Milowsky, M.I.1
Carlson, G.L.2
Shi, M.M.3
-
82
-
-
84858210768
-
A multicenter, open-label phase II trial of dovitinib, an FGFR1 inhibitor, in FGFR1 amplified and non-amplified metastatic breast cancer
-
abstract 508
-
Andre F, Bachelot TD, Campone M, et al. A multicenter, open-label phase II trial of dovitinib, an FGFR1 inhibitor, in FGFR1 amplified and non-amplified metastatic breast cancer. J Clin Oncol 2011;29(Suppl):abstract 508
-
(2011)
J Clin Oncol
, Issue.SUPPL.
, pp. 29
-
-
Andre, F.1
Bachelot, T.D.2
Campone, M.3
-
83
-
-
0027219258
-
A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor
-
Ponzetto C, Bardelli A, Maina F, et al. A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor. Mol Cell Biol 1993;13(8):4600-8 (Pubitemid 23220367)
-
(1993)
Molecular and Cellular Biology
, vol.13
, Issue.8
, pp. 4600-4608
-
-
Ponzetto, C.1
Bardelli, A.2
Maina, F.3
Longati, P.4
Panayotou, G.5
Dhand, R.6
Waterfield, M.D.7
Comoglio, P.M.8
-
84
-
-
0038115223
-
HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro
-
Ding S, Merkulova-Rainon T, Han ZC, Tobelem G. HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro. Blood 2003;101(12):4816-22 (Pubitemid 36857740)
-
(2003)
Blood
, vol.101
, Issue.12
, pp. 4816-4822
-
-
Ding, S.1
Merkulova-Rainon, T.2
Han, Z.C.3
Tobelem, G.4
-
85
-
-
0032900187
-
Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells
-
Wojta J, Kaun C, Breuss JM, et al. Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells. Lab Invest 1999;79(4):427-38 (Pubitemid 29190432)
-
(1999)
Laboratory Investigation
, vol.79
, Issue.4
, pp. 427-438
-
-
Wojta, J.1
Kaun, C.2
Breuss, J.M.3
Koshelnick, Y.4
Beckmann, R.5
Hattey, E.6
Mildner, M.7
Weninger, W.8
Nakamura, T.9
Tschachler, E.10
Binder, B.R.11
-
87
-
-
77953458271
-
ARQ 197 a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity
-
Munshi N, Jeay S, Li Y, et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther 2010;9(6):1544-53
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.6
, pp. 1544-1553
-
-
Munshi, N.1
Jeay, S.2
Li, Y.3
-
88
-
-
79953885749
-
Phase i trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies
-
Yap TA, Olmos D, Brunetto AT, et al. Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. J Clin Oncol 2011;29(10):1271-9
-
(2011)
J Clin Oncol
, vol.29
, Issue.10
, pp. 1271-9
-
-
Yap, T.A.1
Olmos, D.2
Brunetto, A.T.3
-
89
-
-
77957031745
-
Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
-
LBA 7502
-
Schiller JH, Akerley WL, Brugger W, et al. Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28(15s Suppl):LBA 7502
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Schiller, J.H.1
Akerley, W.L.2
Brugger, W.3
-
90
-
-
83355166909
-
Cabozantinib (XL184) a Novel MET and VEGFR2 inhibitor simultaneously suppresses metastasis angiogenesis and tumor growth
-
Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a Novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther 2011;10(12):2298-308
-
(2011)
Mol Cancer Ther
, vol.10
, Issue.12
, pp. 2298-308
-
-
Yakes, F.M.1
Chen, J.2
Tan, J.3
-
91
-
-
83255192931
-
Activity of cabozantinib (XL184) in advanced ovarian cancer patients (pts): Results from a phase II randomized discontinuation trial (RDT)
-
abstract 5008
-
Buckanovich RJ, Berger R, Sella A, et al. Activity of cabozantinib (XL184) in advanced ovarian cancer patients (pts): results from a phase II randomized discontinuation trial (RDT). J Clin Oncol 2011;29(Suppl):abstract 5008
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Buckanovich, R.J.1
Berger, R.2
Sella, A.3
-
92
-
-
79957495650
-
Phase II study of XL184 in a cohort of patients (pts) with castration-resistant prostate cancer (CRPC) and measurable soft tissue disease
-
abstract 127
-
Smith DC, Smith MR, Small EJ, et al. Phase II study of XL184 in a cohort of patients (pts) with castration-resistant prostate cancer (CRPC) and measurable soft tissue disease. J Clin Oncol 2011;29(Suppl):abstract 127
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Smith, D.C.1
Smith, M.R.2
Small, E.J.3
-
93
-
-
77956700164
-
Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB)
-
abstract 2006
-
Wen PY, Prados M, Schiff D, et al. Phase II study of XL184 (BMS 907351), an inhibitor of MET, VEGFR2, and RET, in patients (pts) with progressive glioblastoma (GB). J Clin Oncol 2010;28(15s Suppl):abstract 2006
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Wen, P.Y.1
Prados, M.2
Schiff, D.3
-
94
-
-
80052986157
-
Antitumor activity observed in a phase i drug-drug interaction study of cabozantinib (XL184) and rosiglitazone in patients (pts) with renal cell carcinoma (RCC) and differentiated thyroid cancer (DTC)
-
abstract e13042
-
Choueiri TK, Pal SK, Cabanillas ME, et al. Antitumor activity observed in a phase I drug-drug interaction study of cabozantinib (XL184) and rosiglitazone in patients (pts) with renal cell carcinoma (RCC) and differentiated thyroid cancer (DTC). J Clin Oncol 2011;29(Suppl):abstract e13042
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Choueiri, T.K.1
Pal, S.K.2
Cabanillas, M.E.3
-
95
-
-
78650377385
-
Long-term results in a cohort of medullary thyroid cancer (MTC) patients (pts) in a phase i study of XL184 (BMS 907351), an oral inhibitor of MET, VEGFR2, and RET
-
abstract 5502
-
Kurzrock R, Cohen EE, Sherman SI, et al. Long-term results in a cohort of medullary thyroid cancer (MTC) patients (pts) in a phase I study of XL184 (BMS 907351), an oral inhibitor of MET, VEGFR2, and RET. J Clin Oncol 2011;29(Suppl):abstract 5502
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Kurzrock, R.1
Cohen, E.E.2
Sherman, S.I.3
-
96
-
-
79959195227
-
A phase Ib/II study of XL184 (BMS 907351) with and without erlotinib (E) in patients (pts) with non-small cell lung cancer (NSCLC)
-
abstract 3017
-
Wakelee HA, Gettinger SN, Engelman JA, et al. A phase Ib/II study of XL184 (BMS 907351) with and without erlotinib (E) in patients (pts) with non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28(15s Suppl):abstract 3017
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Wakelee, H.A.1
Gettinger, S.N.2
Engelman, J.A.3
-
97
-
-
38049124932
-
Phase i experience with c-MET inhibitor XL880 administered orally to patients (pts) with solid tumors
-
abstract 3526
-
Eder JP, Heath E, Appleman L, et al. Phase I experience with c-MET inhibitor XL880 administered orally to patients (pts) with solid tumors. J Clin Oncol 2007;25:abstract 3526
-
(2007)
J Clin Oncol
, vol.25
-
-
Eder, J.P.1
Heath, E.2
Appleman, L.3
-
98
-
-
55349093866
-
A phase II study of the dual MET/VEGFR2 inhibitor XL880 in patients (pts) with papillary renal carcinoma (PRC)
-
abstract 5103
-
Srinivasan R, Choueiri TK, Vaishampayan U, et al. A phase II study of the dual MET/VEGFR2 inhibitor XL880 in patients (pts) with papillary renal carcinoma (PRC). J Clin Oncol 2008;26:abstract 5103
-
(2008)
J Clin Oncol
, vol.26
-
-
Srinivasan, R.1
Choueiri, T.K.2
Vaishampayan, U.3
-
99
-
-
23044508993
-
Angiopoietin 1 is mitogenic for cultured endothelial cells
-
DOI 10.1158/0008-5472.CAN-05-0522
-
Kanda S, Miyata Y, Mochizuki Y, et al. Angiopoietin 1 is mitogenic for cultured endothelial cells. Cancer Res 2005;65(15):6820-7 (Pubitemid 41060720)
-
(2005)
Cancer Research
, vol.65
, Issue.15
, pp. 6820-6827
-
-
Kanda, S.1
Miyata, Y.2
Mochizuki, Y.3
Matsuyama, T.4
Kanetake, H.5
-
100
-
-
0036112626
-
Activation of the Tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs sauamous cell carcinoma growth
-
Hawighorst T, Skobe M, Streit M, et al. Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol 2002;160(4):1381-92 (Pubitemid 34411642)
-
(2002)
American Journal of Pathology
, vol.160
, Issue.4
, pp. 1381-1392
-
-
Hawighorst, T.1
Skobe, M.2
Streit, M.3
Hong, Y.-K.4
Velasco, P.5
Brown, L.F.6
Riccardi, L.7
Lange-Asschenfeldt, B.8
Detmar, M.9
-
101
-
-
0035134082
-
Angiopoietin-2 is implicated in the regulation of tumor angiogenesis
-
Yu Q, Stamenkovic I. Angiopoietin-2 is implicated in the regulation of tumor angiogenesis. Am J Pathol 2001;158(2):563-70 (Pubitemid 32158617)
-
(2001)
American Journal of Pathology
, vol.158
, Issue.2
, pp. 563-570
-
-
Yu, Q.1
Stamenkovic, I.2
-
102
-
-
15144358851
-
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
DOI 10.1126/science.277.5322.55
-
Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997;277(5322):55-60 (Pubitemid 27450643)
-
(1997)
Science
, vol.277
, Issue.5322
, pp. 55-60
-
-
Maisonpierre, P.C.1
Suri, C.2
Jones, P.F.3
Bartunkova, S.4
Wiegand, S.J.5
Radziejewski, C.6
Compton, D.7
McClain, J.8
Aldrich, T.H.9
Papadopoulos, N.10
Daly, T.J.11
Davis, S.12
Sato, T.N.13
Yancopoulos, G.D.14
-
103
-
-
0030480322
-
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
-
DOI 10.1016/S0092-8674(00)81813-9
-
Suri C, Jones PF, Patan S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996;87(7):1171-80 (Pubitemid 27010101)
-
(1996)
Cell
, vol.87
, Issue.7
, pp. 1171-1180
-
-
Suri, C.1
Jones, P.F.2
Patan, S.3
Bartunkova, S.4
Maisonpierre, P.C.5
Davis, S.6
Sato, T.N.7
Yancopoulos, G.D.8
-
104
-
-
0344450778
-
Direct actions of angiopoietin-1 on human endothelium: Evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors
-
Papapetropoulos A, Garcia-Cardena G, Dengler TJ, et al. Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors. Lab Invest 1999;79(2):213-23 (Pubitemid 29110651)
-
(1999)
Laboratory Investigation
, vol.79
, Issue.2
, pp. 213-223
-
-
Papapetropoulos, A.1
Garcia-Cardena, G.2
Dengler, T.J.3
Maisonpierre, P.C.4
Yancopoulos, G.D.5
Sessa, W.C.6
-
105
-
-
0029001244
-
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
-
Sato TN, Tozawa Y, Deutsch U, et al. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation. Nature 1995;376(6535):70-4
-
(1995)
Nature
, vol.376
, Issue.6535
, pp. 70-4
-
-
Sato, T.N.1
Tozawa, Y.2
Deutsch, U.3
-
106
-
-
0038374813
-
Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma
-
DOI 10.1053/jhep.2003.50204
-
Mitsuhashi N, Shimizu H, Ohtsuka M, et al. Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma. Hepatology 2003;37(5):1105-13 (Pubitemid 36538687)
-
(2003)
Hepatology
, vol.37
, Issue.5
, pp. 1105-1113
-
-
Mitsuhashi, N.1
Shimizu, H.2
Ohtsuka, M.3
Wakabayashi, Y.4
Ito, H.5
Kimura, F.6
Yoshidome, H.7
Kato, A.8
Nukui, Y.9
Miyazaki, M.10
-
107
-
-
0035866389
-
The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer
-
Ahmad SA, Liu W, Jung YD, et al. The effects of angiopoietin-1 and-2 on tumor growth and angiogenesis in human colon cancer. Cancer Res 2001;61(4):1255-9 (Pubitemid 34292536)
-
(2001)
Cancer Research
, vol.61
, Issue.4
, pp. 1255-1259
-
-
Ahmad, S.A.1
Liu, W.2
Jung, Y.D.3
Fan, F.4
Wilson, M.5
Reinmuth, N.6
Shaheen, R.M.7
Bucana, C.D.8
Ellis, L.M.9
-
108
-
-
0037428670
-
Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival
-
DOI 10.1002/ijc.10851
-
Sfiligoi C, de Luca A, Cascone I, et al. Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival. Int. J Cancer 2003;103(4):466-74 (Pubitemid 36020220)
-
(2003)
International Journal of Cancer
, vol.103
, Issue.4
, pp. 466-474
-
-
Sfiligoi, C.1
De Luca, A.2
Cascone, I.3
Sorbello, V.4
Fuso, L.5
Ponzone, R.6
Biglia, N.7
Audero, E.8
Arisio, R.9
Bussolino, F.10
Sismonde, P.11
De Bortoli, M.12
-
109
-
-
0034045741
-
The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas
-
PII S0169500200001185
-
Wong MP, Chan SY, Fu KH, et al. The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas. Lung Cancer 2000;29(1):11-22 (Pubitemid 30398555)
-
(2000)
Lung Cancer
, vol.29
, Issue.1
, pp. 11-22
-
-
Wong, M.P.1
Chan, S.Y.2
Fu, K.H.3
Leung, S.Y.4
Cheung, N.5
Yuen, S.T.6
Chung, L.P.7
-
110
-
-
13544251726
-
Angiopoietin 2 expression is related to histological grade, vascular density, metastases., and outcome in prostate cancer
-
DOI 10.1002/pros.20163
-
Lind AJ, Wikstrom P, Granfors T, et al. Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer. Prostate 2005;62(4):394-9 (Pubitemid 40224144)
-
(2005)
Prostate
, vol.62
, Issue.4
, pp. 394-399
-
-
Lind, A.J.1
Wikstrom, P.2
Granfors, T.3
Egevad, L.4
Stattin, P.5
Bergh, A.6
-
111
-
-
1842582434
-
Expression of the angopoietin-1, angopoietin-2, Tie2, and vascular endothelial growth factor gene in epithelial ovarian cancer
-
DOI 10.1016/j.ygyno.2003.12.031, PII S0090825803009430
-
Hata K, Nakayama K, Fujiwaki R, et al. Expression of the angopoietin-1, angopoietin-2, Tie2, and vascular endothelial growth factor gene in epithelial ovarian cancer. Gynecol Oncol 2004;93(1):215-22 (Pubitemid 38429573)
-
(2004)
Gynecologic Oncology
, vol.93
, Issue.1
, pp. 215-222
-
-
Hata, K.1
Nakayama, K.2
Fujiwaki, R.3
Katabuchi, H.4
Okamura, H.5
Miyazaki, K.6
-
112
-
-
58149394474
-
Discontinued drugs in 2007 oncology drugs
-
Williams R. Discontinued drugs in 2007: oncology drugs. Expert Opin Investig Drugs 2008;17(3):1791-816
-
(2008)
Expert Opin Investig Drugs
, vol.17
, Issue.3
, pp. 1791-816
-
-
Williams, R.1
-
113
-
-
0033753903
-
Expression and function of angiopoietin-1 in breast cancer
-
Hayes AJ, Huang WQ, Yu J, et al. Expression and function of angiopoietin-1 in breast cancer. Br J Cancer 2000;83(9):1154-60
-
(2000)
Br J Cancer
, vol.83
, Issue.9
, pp. 1154-1160
-
-
Hayes, A.J.1
Huang, W.Q.2
Yu, J.3
-
114
-
-
0038407310
-
Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
-
Stoeltzing O, Ahmad SA, Liu W, et al. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res 2003;63(12):3370-7 (Pubitemid 36735897)
-
(2003)
Cancer Research
, vol.63
, Issue.12
, pp. 3370-3377
-
-
Stoeltzing, O.1
Ahmad, S.A.2
Liu, W.3
McCarty, M.F.4
Wey, J.S.5
Parikh, A.A.6
Fan, F.7
Reinmuth, N.8
Kawaguchi, M.9
Bucana, C.D.10
Ellis, L.M.11
-
115
-
-
0036112626
-
Activation of the Tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs sauamous cell carcinoma growth
-
Hawighorst T, Skobe M, Streit M, et al. Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth. Am J Pathol 2002;160(4):1381-92 (Pubitemid 34411642)
-
(2002)
American Journal of Pathology
, vol.160
, Issue.4
, pp. 1381-1392
-
-
Hawighorst, T.1
Skobe, M.2
Streit, M.3
Hong, Y.-K.4
Velasco, P.5
Brown, L.F.6
Riccardi, L.7
Lange-Asschenfeldt, B.8
Detmar, M.9
-
116
-
-
66349133061
-
Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment
-
Holopainen T, Huang H, Chen C, et al. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res 2009;69(11):4656-64
-
(2009)
Cancer Res
, vol.69
, Issue.11
, pp. 4656-4664
-
-
Holopainen, T.1
Huang, H.2
Chen, C.3
-
117
-
-
43049116169
-
Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1
-
DOI 10.1038/ncb1714, PII NCB1714
-
Fukuhara S, Sako K, Minami T, et al. Differential function of Tie2 at cellcell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol 2008;10(5):513-26 (Pubitemid 351627371)
-
(2008)
Nature Cell Biology
, vol.10
, Issue.5
, pp. 513-526
-
-
Fukuhara, S.1
Sako, K.2
Minami, T.3
Noda, K.4
Kim, H.Z.5
Kodama, T.6
Shibuya, M.7
Takakura, N.8
Koh, G.Y.9
Mochizuki, N.10
-
118
-
-
73649112748
-
Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
-
Falcon BL, Hashizume H, Koumoutsakos P, et al. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol 2009;175(5):2159-70
-
(2009)
Am J Pathol
, vol.175
, Issue.5
, pp. 2159-2170
-
-
Falcon, B.L.1
Hashizume, H.2
Koumoutsakos, P.3
-
119
-
-
77958042477
-
Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: Implications for AMG 386 an angiopoietin-1/2- neutralizing peptibody
-
Coxon A, Bready J, Min H, et al. Context-dependent role of angiopoietin-1 inhibition in the suppression of angiogenesis and tumor growth: implications for AMG 386, an angiopoietin-1/2-neutralizing peptibody. Mol Cancer Ther 2010;9(10):2641-51
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.10
, pp. 2641-2651
-
-
Coxon, A.1
Bready, J.2
Min, H.3
-
120
-
-
70249114453
-
Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
-
Herbst RS, Hong D, Chap L, et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009;27(21):3557-65
-
(2009)
J Clin Oncol
, vol.27
, Issue.21
, pp. 3557-3565
-
-
Herbst, R.S.1
Hong, D.2
Chap, L.3
-
121
-
-
77953097101
-
Phase 1 study of AMG 386 a selective angiopoietin 1/2-neutralizing peptibody in combination with chemotherapy in adults with advanced solid tumors
-
Mita AC, Takimoto CH, Mita M, et al. Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors. Clin Cancer Res 2010;16(11):3044-56
-
(2010)
Clin Cancer Res
, vol.16
, Issue.11
, pp. 3044-3056
-
-
Mita, A.C.1
Takimoto, C.H.2
Mita, M.3
-
122
-
-
77954522477
-
Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian carcinoma
-
abstract 5000
-
Karlan BY, Oza AM, Hansen VL, et al. Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian carcinoma. J Clin Oncol 2010;28(15s Suppl):abstract 5000
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Karlan, B.Y.1
Oza, A.M.2
Hansen, V.L.3
-
123
-
-
77955377518
-
Phase Ib study of AMG 386 combined with either pegylated liposomal doxorubicin or topotecan in patients with advanced ovarian cancer
-
abstract 5049
-
Wenham RM, Leach JW, Scudder SA, et al. Phase Ib study of AMG 386 combined with either pegylated liposomal doxorubicin or topotecan in patients with advanced ovarian cancer. J Clin Oncol 2010;28(15s Suppl):abstract 5049
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Wenham, R.M.1
Leach, J.W.2
Scudder, S.A.3
-
124
-
-
84865221683
-
A randomized, placebo-controlled phase II study of AMG 386 plus bevacizumab and paclitaxel or AMG 386 plus paclitaxel as first-line therapy in patients with HER2-negative, locally recurrent or metastatic breast cancer
-
abstract 544
-
Dieras V, Jassem J, Dirix LY, et al. A randomized, placebo-controlled phase II study of AMG 386 plus bevacizumab and paclitaxel or AMG 386 plus paclitaxel as first-line therapy in patients with HER2-negative, locally recurrent or metastatic breast cancer. J Clin Oncol 2011;29(Suppl):abstract 544
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL.
-
-
Dieras, V.1
Jassem, J.2
Dirix, L.Y.3
-
125
-
-
80255135379
-
AMG 386 in combination with sorafenib in patients with metastatic renal cell cancer: A randomized, double-blind, placebo-controlled, phase II study
-
abstract 309
-
Rini BI, Szczylik C, Tannir NM, et al. AMG 386 in combination with sorafenib in patients with metastatic renal cell cancer: a randomized, double-blind, placebo-controlled, phase II study. J Clin Oncol 2011;29(Suppl 7):abstract 309
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 7
-
-
Rini, B.I.1
Szczylik, C.2
Tannir, N.M.3
-
126
-
-
84870632792
-
Randomized, double-blind, placebo-controlled phase II study of AMG 386 in combination with cisplatin and capecitabine in patients with metastatic gastroesophageal adenocarcinoma
-
abstract 66
-
Eatock MM, Szanto J, Tebbutt NC, et al. Randomized, double-blind, placebo-controlled phase II study of AMG 386 in combination with cisplatin and capecitabine in patients with metastatic gastroesophageal adenocarcinoma. J Clin Oncol 2011;29(Suppl 4):abstract 66
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 4
-
-
Eatock, M.M.1
Szanto, J.2
Tebbutt, N.C.3
-
127
-
-
79951930227
-
Exposure-response relationships of AMG 386 in combination with weekly paclitaxel in advanced ovarian cancer: Population pharmacokinetic/ pharmacodynamic modeling to facilitate phase III dose selection
-
abstract 5042
-
Lu J, Rasmussen E, Navale L, et al. Exposure-response relationships of AMG 386 in combination with weekly paclitaxel in advanced ovarian cancer: population pharmacokinetic/pharmacodynamic modeling to facilitate phase III dose selection. J Clin Oncol 2010;28(15s Suppl):abstract 5042
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Lu, J.1
Rasmussen, E.2
Navale, L.3
-
128
-
-
77954935349
-
First-in-human dose-escalation safety and PK trial of a novel intravenous humanized monoclonal CovX body inhibiting angiopoietin-2
-
abstract 2524
-
Rosen LS, Mendelson DS, Cohen RB, et al. First-in-human dose-escalation safety and PK trial of a novel intravenous humanized monoclonal CovX body inhibiting angiopoietin-2. J Clin Oncol 2010;28(15s Suppl):abstract 2524
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Rosen, L.S.1
Mendelson, D.S.2
Cohen, R.B.3
-
129
-
-
70349273685
-
The emerging role of TGF-beta superfamily coreceptors in cancer
-
Bernabeu C, Lopez-Novoa JM, Quintanilla M. The emerging role of TGF-beta superfamily coreceptors in cancer. Biochim Biophys Acta 2009;1792(10):954-73
-
(2009)
Biochim Biophys Acta
, vol.1792
, Issue.10
, pp. 954-973
-
-
Bernabeu, C.1
Lopez-Novoa, J.M.2
Quintanilla, M.3
-
130
-
-
0034785348
-
TGF-β signaling in tumor suppression and cancer progression
-
DOI 10.1038/ng1001-117
-
Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001;29(2):117-29; Erratum in: Nat Genet 2001;29(3):351 (Pubitemid 32952643)
-
(2001)
Nature Genetics
, vol.29
, Issue.2
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
131
-
-
0027332995
-
Cloning of a TGF beta type i receptor that forms a heteromeric complex with the TGF beta type II receptor
-
Franzen P, ten Dijke P, Ichijo H, et al. Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell 1993;75(4):681-92
-
(1993)
Cell
, vol.75
, Issue.4
, pp. 681-692
-
-
Franzen, P.1
Ten Dijke, P.2
Ichijo, H.3
-
132
-
-
0030768644
-
TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4
-
DOI 10.1093/emboj/16.17.5353
-
Nakao A, Imamura T, Souchelnytskyi S, et al. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 1997;16(17):5353-62 (Pubitemid 27380143)
-
(1997)
EMBO Journal
, vol.16
, Issue.17
, pp. 5353-5362
-
-
Nakao, A.1
Imamura, T.2
Souchelnytskyi, S.3
Kawabata, M.4
Ishisaki, A.5
Oeda, E.6
Tamaki, K.7
Hanai, J.-I.8
Heldin, C.-H.9
Miyazono, K.10
Ten Dijke, P.11
-
133
-
-
0037007226
-
Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
-
DOI 10.1093/emboj/21.7.1743
-
Goumans MJ, Valdimarsdottir G, Itoh S, et al. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J 2002;21(7):1743-53 (Pubitemid 34614630)
-
(2002)
EMBO Journal
, vol.21
, Issue.7
, pp. 1743-1753
-
-
Goumans, M.-J.1
Valdimarsdottir, G.2
Itoh, S.3
Rosendahl, A.4
Sideras, P.5
Ten Dijke, P.6
-
134
-
-
0037159280
-
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells
-
DOI 10.1161/01.CIR.0000033830.36431.46
-
Valdimarsdottir G, Goumans MJ, Rosendahl A, et al. Stimulation of id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells. Circulation 2002;106(17):2263-70 (Pubitemid 35222223)
-
(2002)
Circulation
, vol.106
, Issue.17
, pp. 2263-2270
-
-
Valdimarsdottir, G.1
Goumans, M.-J.2
Rosendahl, A.3
Brugman, M.4
Itoh, S.5
Lebrin, F.6
Sideras, P.7
Ten Dijke, P.8
-
135
-
-
0037114702
-
Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis
-
DOI 10.1182/blood.V100.13.4495
-
Lamouille S, Mallet C, Feige JJ, Bailly S. Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood 2002;100(13):4495-501 (Pubitemid 35429690)
-
(2002)
Blood
, vol.100
, Issue.13
, pp. 4495-4501
-
-
Lamouille, S.1
Mallet, C.2
Felge, J.-J.3
Bailly, S.4
-
136
-
-
38349173601
-
ALK5-and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2
-
Park SO, Lee YJ, Seki T, et al. ALK5-and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood 2008;111(2):633-42
-
(2008)
Blood
, vol.111
, Issue.2
, pp. 633-642
-
-
Park, S.O.1
Lee, Y.J.2
Seki, T.3
-
137
-
-
79959850956
-
ALK1 as an emerging target for antiangiogenic therapy of cancer
-
Cunha SI, Pietras K. ALK1 as an emerging target for antiangiogenic therapy of cancer. Blood 2011;117(26):6999-7006
-
(2011)
Blood
, vol.117
, Issue.26
, pp. 6999-7006
-
-
Cunha, S.I.1
Pietras, K.2
-
138
-
-
79951828866
-
Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies
-
Hu-Lowe DD, Chen E, Zhang L, et al. Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies. Cancer Res 2011;71(4):1362-73
-
(2011)
Cancer Res
, vol.71
, Issue.4
, pp. 1362-1373
-
-
Hu-Lowe, D.D.1
Chen, E.2
Zhang, L.3
-
139
-
-
76649106431
-
ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth
-
Mitchell D, Pobre EG, Mulivor AW, et al. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol Cancer Ther 2010;9(2):379-88
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.2
, pp. 379-388
-
-
Mitchell, D.1
Pobre, E.G.2
Mulivor, A.W.3
-
140
-
-
0025310515
-
Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
-
Gougos A, Letarte M. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J Biol Chem 1990;265(15):8361-4
-
(1990)
J Biol Chem
, vol.265
, Issue.15
, pp. 8361-4
-
-
Gougos, A.1
Letarte, M.2
-
141
-
-
0027096819
-
Molecular cloning and characterization of the human and porcine transforming growth factor-β type III receptors
-
DOI 10.1016/0006-291X(92)91566-9
-
Moren A, Ichijo H, Miyazono K. Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors. Biochem Biophys Res Commun 1992;189(1):356-62 (Pubitemid 23030049)
-
(1992)
Biochemical and Biophysical Research Communications
, vol.189
, Issue.1
, pp. 356-362
-
-
Moren, A.1
Ichijo, H.2
Miyazono, K.3
-
142
-
-
21644452716
-
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-β receptor complex
-
DOI 10.1002/jcp.20311
-
Blanco FJ, Santibanez JF, Guerrero-Esteo M, et al. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J Cell Physiol 2005;204(2):574-84 (Pubitemid 40934653)
-
(2005)
Journal of Cellular Physiology
, vol.204
, Issue.2
, pp. 574-584
-
-
Blanco, F.J.1
Santibanez, J.F.2
Guerrero-Esteo, M.3
Langa, C.4
Vary, C.P.H.5
Bernabeu, C.6
-
143
-
-
41049094560
-
Endoglin in angiogenesis and vascular diseases
-
ten Dijke P, Goumans MJ, Pardali E. Endoglin in angiogenesis and vascular diseases. Angiogenesis 2008;11(1):79-89
-
(2008)
Angiogenesis
, vol.11
, Issue.1
, pp. 79-89
-
-
Ten Dijke, P.1
Goumans, M.J.2
Pardali, E.3
-
144
-
-
84858250553
-
Phase i study of PF-03446962, a fully human mAb against ALK 1, a TGF{beta} receptor involved in tumor angiogenesis
-
abstract 3009
-
Goff LW, Cohen RB, Berlin J, et al. Phase I study of PF-03446962, a fully human mAb against ALK 1, a TGF{beta} receptor involved in tumor angiogenesis. J Clin Oncol 2011;29(Suppl 7):abstract 3009
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 7
-
-
Goff, L.W.1
Cohen, R.B.2
Berlin, J.3
-
145
-
-
79959833376
-
Phase i study of ACE-041, a novel inhibitor of vascular maturation, in patients with advanced solid tumors or relapsed/refractory multiple myeloma
-
TPS 179
-
Borgstein NG, Sharma S, Bendell JC, et al. Phase I study of ACE-041, a novel inhibitor of vascular maturation, in patients with advanced solid tumors or relapsed/refractory multiple myeloma. J Clin Oncol 2010;28(15s Suppl):TPS 179
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Borgstein, N.G.1
Sharma, S.2
Bendell, J.C.3
-
146
-
-
84858176365
-
A phase i study of TRC105 (anti-CD105 monoclonal antibody) in metastatic castration-resistant prostate cancer (mCRPC)
-
abstract e15070
-
Adelberg D, Apolo AB, Madan RA, et al. A phase I study of TRC105 (anti-CD105 monoclonal antibody) in metastatic castration-resistant prostate cancer (mCRPC). J Clin Oncol 2011;29(Suppl 7):abstract e15070
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 7
-
-
Adelberg, D.1
Apolo, A.B.2
Madan, R.A.3
-
147
-
-
84858224036
-
A phase i study of TRC105 (anti-CD105 antibody) in patients with advanced solid tumors
-
abstract 3073
-
Goldman JW, Gordon MS, Hurwitz H, et al. A phase I study of TRC105 (anti-CD105 antibody) in patients with advanced solid tumors. J Clin Oncol 2011;29(Suppl 7):abstract 3073
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 7
-
-
Goldman, J.W.1
Gordon, M.S.2
Hurwitz, H.3
-
148
-
-
0029116310
-
Endothelins
-
Levin ER. Endothelins. N Engl J Med 1995;333(6):356-63
-
(1995)
N Engl J Med
, vol.333
, Issue.6
, pp. 356-363
-
-
Levin, E.R.1
-
149
-
-
0037008695
-
Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1α in ovarian carcinoma cells
-
DOI 10.1074/jbc.M202421200
-
Spinella F, Rosano L, Di Castro V, et al. Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1alpha in ovarian carcinoma cells. J Biol Chem 2002;277(31):27850-5 (Pubitemid 34966730)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.31
, pp. 27850-27855
-
-
Spinella, F.1
Rosano, L.2
Di Castro, V.3
Natali, P.G.4
Bagnato, A.5
-
150
-
-
0038407691
-
Emerging role of endothelin-1 in tumor angiogenesis
-
DOI 10.1016/S1043-2760(02)00010-3, PII S1043276002000103
-
Bagnato A, Spinella F. Emerging role of endothelin-1 in tumor angiogenesis. Trends Endocrinol Metab 2003;14(1):44-50 (Pubitemid 36733931)
-
(2003)
Trends in Endocrinology and Metabolism
, vol.14
, Issue.1
, pp. 44-50
-
-
Bagnato, A.1
Spinella, F.2
-
151
-
-
34248667859
-
A Phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma
-
DOI 10.1007/s10637-006-9014-7
-
Kefford R, Beith JM, et al. A phase II study of bosentan, a dual endothelin receptor antagonist, as monotherapy in patients with stage IV metastatic melanoma. Invest New Drugs 2007;25(3):247-52 (Pubitemid 46774695)
-
(2007)
Investigational New Drugs
, vol.25
, Issue.3
, pp. 247-252
-
-
Kefford, R.1
Beith, J.M.2
Van Hazel, G.A.3
Millward, M.4
Trotter, J.M.5
Wyld, D.K.6
Kusic, R.7
Shreeniwas, R.8
Morganti, A.9
Ballmer, A.10
Segal, E.11
Nayler, O.12
Clozel, M.13
-
152
-
-
77950414996
-
A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy
-
Kefford RF, Clingan PR, Brady B, et al. A randomized, double-blind, placebo-controlled study of high-dose bosentan in patients with stage IV metastatic melanoma receiving first-line dacarbazine chemotherapy. Mol Cancer 2010;9:69
-
(2010)
Mol Cancer
, vol.9
, pp. 69
-
-
Kefford, R.F.1
Clingan, P.R.2
Brady, B.3
-
153
-
-
34250768913
-
Inhibitory effect of endothelin A receptor blockade on tumor growth and liver metastasis of a human gastric cancer cell line
-
DOI 10.1007/s10120-007-0421-z
-
Fukui R, Nishimori H, Hata F, et al. Inhibitory effect of endothelin A receptor blockade on tumor growth and liver metastasis of a human gastric cancer cell line. Gastric Cancer 2007;10(2):123-8 (Pubitemid 46955942)
-
(2007)
Gastric Cancer
, vol.10
, Issue.2
, pp. 123-128
-
-
Fukui, R.1
Nishimori, H.2
Hata, F.3
Yasoshima, T.4
Ohno, K.5
Yanai, Y.6
Kamiguchi, K.7
Denno, R.8
Sato, N.9
Hirata, K.10
-
154
-
-
0030047858
-
Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer
-
Nelson JB, Chan-Tack K, Hedican SP, et al. Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer. Cancer Res 1996;56(4):663-8 (Pubitemid 26059878)
-
(1996)
Cancer Research
, vol.56
, Issue.4
, pp. 663-668
-
-
Nelson, J.B.1
Chan-Tack, K.2
Hedican, S.P.3
Magnuson, S.R.4
Opgenorth, T.J.5
Bova, G.S.6
Simons, J.W.7
-
155
-
-
0037112435
-
Growth inhibition of cervix carcinoma cells in vivo by endothelin a receptor blockade
-
Bagnato A, Cirilli A, Salani D, et al. Growth inhibition of cervix carcinoma cell in vivo by endothelin A receptor blockade. Cancer Res 2002;62(22):6381-4 (Pubitemid 35364090)
-
(2002)
Cancer Research
, vol.62
, Issue.22
, pp. 6381-6384
-
-
Bagnato, A.1
Cirilli, A.2
Salani, D.3
Simeone, P.4
Muller, A.5
Nicotra, M.R.6
Natali, P.G.7
Venuti, A.8
-
156
-
-
0037441843
-
Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: A randomized, phase II, placebo-controlled trial
-
DOI 10.1200/JCO.2003.04.176
-
Carducci MA, Padley RJ, Breul J, et al. Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone refractory prostate cancer: a randomized, phase II, placebo controlled trial. J Clin Oncol 2003;21(4):679-89 (Pubitemid 46621903)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.4
, pp. 679-689
-
-
Carducci, M.A.1
Padley, R.J.2
Breul, J.3
Vogelzang, N.J.4
Zonnenberg, B.A.5
Daliani, D.D.6
Schulman, C.C.7
Nabulsi, A.A.8
Humerickhouse, R.A.9
Weinberg, M.A.10
Schmitt, J.L.11
Nelson, J.B.12
-
157
-
-
35648968713
-
A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer
-
DOI 10.1002/cncr.22996
-
Carducci MA, Saad F, Abrahamsson PA, et al. A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. Cancer 2007;110(9):1959-66 (Pubitemid 350036854)
-
(2007)
Cancer
, vol.110
, Issue.9
, pp. 1959-1966
-
-
Carducci, M.A.1
Saad, F.2
Abrahamsson, P.-A.3
Dearnaley, D.P.4
Schulman, C.C.5
North, S.A.6
Sleep, D.J.7
Isaacson, J.D.8
Nelson, J.B.9
-
158
-
-
40949108811
-
Phase I/II study of atrasentan, an endothelin A receptor antagonist, in combination with paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer
-
DOI 10.1158/1078-0432.CCR-07-1508
-
Chiappori AA, Haura E, Rodriguez FA, et al. Phase I/II study of atrasentan, an endothelin A receptor antagonist, in combination with paclitaxel and carboplatin as first-line therapy in advanced non-small cell lung cancer. Clin Cancer Res 2008;14(5):1464-9 (Pubitemid 351413930)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.5
, pp. 1464-1469
-
-
Chiappori, A.A.1
Haura, E.2
Rodriguez, F.A.3
Boulware, D.4
Kapoor, R.5
Neuger, A.M.6
Lush, R.7
Padilla, B.8
Burton, M.9
Williams, C.10
Simon, G.11
Antonia, S.12
Sullivan, D.M.13
Bepler, G.14
-
159
-
-
79954512364
-
Phase II ECOG trial of atrasentan in advanced renal cell carcinoma
-
abstract 5102
-
Manola J, Carducci M, Nair S, et al. Phase II ECOG trial of atrasentan in advanced renal cell carcinoma. J Clin Oncol 2007;25:abstract 5102
-
(2007)
J Clin Oncol
, vol.25
-
-
Manola, J.1
Carducci, M.2
Nair, S.3
-
160
-
-
59449108669
-
Preclinical anticancer activity of the specific endothelin A receptor antagonist ZD4054
-
Growcott JW. Preclinical anticancer activity of the specific endothelin A receptor antagonist ZD4054. Anticancer Drugs 2009;20(2):83-8
-
(2009)
Anticancer Drugs
, vol.20
, Issue.2
, pp. 83-8
-
-
Growcott, J.W.1
-
161
-
-
77956634017
-
Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: A double-blind placebo-controlled randomized Phase II trial
-
James ND, Caty A, Payne H, et al. Final safety and efficacy analysis of the specific endothelin A receptor antagonist zibotentan (ZD4054) in patients with metastatic castration resistant prostate cancer and bone metastases who were pain-free or mildly symptomatic for pain: a double-blind, placebo-controlled, randomized Phase II trial. BJU Int 2010;106(7):966-73
-
(2010)
BJU Int
, vol.106
, Issue.7
, pp. 966-973
-
-
James, N.D.1
Caty, A.2
Payne, H.3
-
162
-
-
79955835748
-
Phase III study of the efficacy and safety of zibotentan (ZD4054) in patients with bone metastatic castration-resistant prostate cancer
-
abstract 117
-
Nelson JB, Fizazi K, Miller K, et al. Phase III study of the efficacy and safety of zibotentan (ZD4054) in patients with bone metastatic castration-resistant prostate cancer. J Clin Oncol 2011;29(Suppl 7):abstract 117
-
(2011)
J Clin Oncol
, vol.29
, Issue.SUPPL. 7
-
-
Nelson, J.B.1
Fizazi, K.2
Miller, K.3
-
163
-
-
84858202642
-
Safety and efficacy of the specific endothelin A receptor antagonist zibotentan (ZD4054) plus docetaxel in patients with metastatic hormone-resistant prostate cancer: Results of a phase i study
-
abstract 4664
-
Trump DL, Payne H, Miller K, et al. Safety and efficacy of the specific endothelin A receptor antagonist zibotentan (ZD4054) plus docetaxel in patients with metastatic hormone-resistant prostate cancer: results of a phase I study. J Clin Oncol 2010;28(15s Suppl):abstract 4664
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Trump, D.L.1
Payne, H.2
Miller, K.3
-
164
-
-
0035266163
-
EphA2 overexpression causes tumorigenesis of mammary epithelial cells
-
Zelinski DP, Zantek ND, Stewart JC, et al. EphA2 overexpression causes tumorigenesis of mammary epithelial cells. Cancer Res 2001;61(5):2301-6 (Pubitemid 32692063)
-
(2001)
Cancer Research
, vol.61
, Issue.5
, pp. 2301-2306
-
-
Zelinski, D.P.1
Zantek, N.D.2
Stewart, J.C.3
Irizarry, A.R.4
Kinch, M.S.5
-
165
-
-
0032708010
-
Overexpression of the EphA2 tyrosine kinase in prostate cancer
-
Walker-Daniels J, Coffman K, Azimi M, et al. Overexpression of the EphA2 tyrosine kinase in prostate cancer. Prostate 1999;41(4):275-80
-
(1999)
Prostate
, vol.41
, Issue.4
, pp. 275-280
-
-
Walker-Daniels, J.1
Coffman, K.2
Azimi, M.3
-
166
-
-
0034779755
-
Predicting the sites of metastases from lung cancer using molecular biologic markers
-
DOI 10.1016/S0003-4975(01)02979-4, PII S0003497501029794
-
D'Amico TA, Aloia TA, Moore MB, et al. Predicting the sites of metastases from lung cancer using molecular biologic markers. Ann Thorac Surg 2001;72(4):1144-8 (Pubitemid 32937993)
-
(2001)
Annals of Thoracic Surgery
, vol.72
, Issue.4
, pp. 1144-1148
-
-
D'Amico, T.A.1
Aloia, T.A.2
Moore, M.-B.H.3
Conlon, D.H.4
Herndon II, J.E.5
Kinch, M.S.6
Harpole Jr., D.H.7
-
167
-
-
0034619758
-
The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
-
DOI 10.1038/sj.onc.1204004
-
Ogawa K, Pasqualini R, Lindberg RA, et al. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene 2000;19(52):6043-52 (Pubitemid 32039378)
-
(2000)
Oncogene
, vol.19
, Issue.52
, pp. 6043-6052
-
-
Ogawa, K.1
Pasqualini, R.2
Lindberg, R.A.3
Kain, R.4
Freeman, A.L.5
Pasquale, E.B.6
-
168
-
-
4143123295
-
EphA2 expression is associated with aggressive features in ovarian carcinoma
-
DOI 10.1158/1078-0432.CCR-03-0589
-
Thaker PH, Deavers M, Celestino J, et al. EphA2 expression is associated with aggressive features in ovarian carcinoma. Clin Cancer Res 2004;10(15):5145-50 (Pubitemid 39099789)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.15
, pp. 5145-5150
-
-
Thaker, P.H.1
Deavers, M.2
Celestino, J.3
Thornton, A.4
Fletcher, M.S.5
Landen, C.N.6
Kinch, M.S.7
Kiener, P.A.8
Sood, A.K.9
-
169
-
-
0344127552
-
C-Cbl-dependent EphA2 protein degradation is induced by ligand binding
-
Walker-Daniels J, Riese DJ II, Kinch MS. C-Cbl-dependent EphA2 protein degradation is induced by ligand binding. Mol Cancer Res 2002;1(1):79-87 (Pubitemid 36330213)
-
(2002)
Molecular Cancer Research
, vol.1
, Issue.1
, pp. 79-87
-
-
Walker-Daniels, J.1
Riese II, D.J.2
Kinch, M.S.3
-
170
-
-
0345269144
-
Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis
-
Cheng N, Brantley DM, Liu H, et al. Blockade of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol Cancer Res 2002;1(1):2-11 (Pubitemid 36330206)
-
(2002)
Molecular Cancer Research
, vol.1
, Issue.1
, pp. 2-11
-
-
Cheng, N.1
Brantley, D.M.2
Liu, H.3
Lin, Q.4
Enriquez, M.5
Gale, N.6
Yancopoulos, G.7
Cerretti, D.P.8
Daniel, T.O.9
Chen, J.10
-
171
-
-
0035870251
-
Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: Role of epithelial cell kinase (Eck/EphA2)
-
Hess AR, Seftor EA, Gardner LM, et al. Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/EphA2). Cancer Res 2001;61(8):3250-5 (Pubitemid 32695007)
-
(2001)
Cancer Research
, vol.61
, Issue.8
, pp. 3250-3255
-
-
Hess, A.R.1
Seftor, E.A.2
Gardner, L.M.G.3
Carles-Kinch, K.4
Schneider, G.B.5
Seftor, R.E.B.6
Kinch, M.S.7
Hendrix, M.J.C.8
-
172
-
-
33750581780
-
Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer
-
DOI 10.1093/jnci/djj414
-
Landen CN Jr, Lu C, Han LY, et al. Efficacy and antivascular effects of EphA2 reduction with an agonistic antibody in ovarian cancer. J Natl Cancer Inst 2006;98(21):1558-70 (Pubitemid 44680907)
-
(2006)
Journal of the National Cancer Institute
, vol.98
, Issue.21
, pp. 1558-1570
-
-
Landen, C.N.1
Lu, C.2
Han, L.Y.3
Coffman, K.T.4
Bruckheimer, E.5
Halder, J.6
Mangala, L.S.7
Merritt, W.M.8
Lin, Y.G.9
Gao, C.10
Schmandt, R.11
Kamat, A.A.12
Li, Y.13
Thaker, P.14
Gershenson, D.M.15
Parikh, N.U.16
Gallick, G.E.17
Kinch, M.S.18
Sood, A.K.19
-
173
-
-
0036337787
-
Cardiovascular ephrinB2 function is essential for embryonic angiogenesis
-
Gerety SS, Anderson DJ. Cardiovascular ephrinB2 function is essential for embryonic angiogenesis. Development 2002;129(6):1397-410 (Pubitemid 34874161)
-
(2002)
Development
, vol.129
, Issue.6
, pp. 1397-1410
-
-
Gerety, S.S.1
Anderson, D.J.2
-
174
-
-
52249094928
-
The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma
-
Yavrouian EJ, Sinha UK, Rice DH, et al. The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2008;134(9):985-91
-
(2008)
Arch Otolaryngol Head Neck Surg
, vol.134
, Issue.9
, pp. 985-991
-
-
Yavrouian, E.J.1
Sinha, U.K.2
Rice, D.H.3
-
175
-
-
79952442827
-
Over-expression of Ephb4 is associated with carcinogenesis of gastric cancer
-
Li M, Zhao ZW, Zhang Y, Xin Y. Over-expression of Ephb4 is associated with carcinogenesis of gastric cancer. Dig Dis Sci 2011;56(3):698-706
-
(2011)
Dig Dis Sci
, vol.56
, Issue.3
, pp. 698-706
-
-
Li, M.1
Zhao, Z.W.2
Zhang, Y.3
Xin, Y.4
-
176
-
-
77955484001
-
Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinoma
-
Spannuth WA, Mangala LS, Stone RL, et al. Converging evidence for efficacy from parallel EphB4-targeted approaches in ovarian carcinoma. Mol Cancer Ther 2010;9(8):2377-88
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.8
, pp. 2377-2388
-
-
Spannuth, W.A.1
Mangala, L.S.2
Stone, R.L.3
-
177
-
-
67349089517
-
Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers
-
Alam SM, Fujimoto J, Jahan I, et al. Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers. Gynecol Oncol 2009;114(1):84-8
-
(2009)
Gynecol Oncol
, vol.114
, Issue.1
, pp. 84-8
-
-
Alam, S.M.1
Fujimoto, J.2
Jahan, I.3
-
178
-
-
33847640650
-
Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers
-
DOI 10.1093/annonc/mdl414
-
Alam SM, Fujimoto J, Jahan I, et al. Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers. Ann Oncol 2007;18(3):485-90 (Pubitemid 46359627)
-
(2007)
Annals of Oncology
, vol.18
, Issue.3
, pp. 485-490
-
-
Alam, S.M.1
Fujimoto, J.2
Jahan, I.3
Sato, E.4
Tamaya, T.5
-
179
-
-
33746646032
-
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway
-
DOI 10.1038/ncb1438, PII NCB1438
-
Noren NK, Foos G, Hauser CA, Pasquale EB. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 2006;8(8):815-25 (Pubitemid 44151584)
-
(2006)
Nature Cell Biology
, vol.8
, Issue.8
, pp. 815-825
-
-
Noren, N.K.1
Foos, G.2
Hauser, C.A.3
Pasquale, E.B.4
-
180
-
-
70349747006
-
The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis
-
Dopeso H, Mateo-Lozano S, Mazzolini R, et al. The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Res 2009;69(18):7430-8
-
(2009)
Cancer Res
, vol.69
, Issue.18
, pp. 7430-8
-
-
Dopeso, H.1
Mateo-Lozano, S.2
Mazzolini, R.3
-
181
-
-
78549253191
-
Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis
-
Djokovic D, Trindade A, Gigante J, et al. Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer 2010;10:641
-
(2010)
BMC Cancer
, vol.10
, pp. 641
-
-
Djokovic, D.1
Trindade, A.2
Gigante, J.3
-
182
-
-
33644783643
-
The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth
-
DOI 10.1182/blood-2005-04-1655
-
Kertesz N, Krasnoperov V, Reddy R, et al. The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. Blood 2006;107(6):2330-8 (Pubitemid 43345552)
-
(2006)
Blood
, vol.107
, Issue.6
, pp. 2330-2338
-
-
Kertesz, N.1
Krasnoperov, V.2
Reddy, R.3
Leshanski, L.4
Kumar, S.R.5
Zozulya, S.6
Gill, P.S.7
-
183
-
-
59449103839
-
The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade
-
Scehnet JS, Ley EJ, Krasnoperov V, et al. The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. Blood 2009;113(1):254-63
-
(2009)
Blood
, vol.113
, Issue.1
, pp. 254-263
-
-
Scehnet, J.S.1
Ley, E.J.2
Krasnoperov, V.3
-
184
-
-
77950577414
-
Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth
-
Krasnoperov V, Kumar SR, Ley E, et al. Novel EphB4 monoclonal antibodies modulate angiogenesis and inhibit tumor growth. Am J Pathol 2010;176(4):2029-38
-
(2010)
Am J Pathol
, vol.176
, Issue.4
, pp. 2029-2038
-
-
Krasnoperov, V.1
Kumar, S.R.2
Ley, E.3
-
185
-
-
84858201044
-
A drug-drug interaction study of everolimus (an mTOR inhibitor) and JI-101, an orally active inhibitor of VEGF 2, PDGF, and EphB4 receptors, in patients with advanced urologic tumors
-
abstract e15077
-
Agarwal N, Sahu M, Abhyankar DJ, et al. A drug-drug interaction study of everolimus (an mTOR inhibitor) and JI-101, an orally active inhibitor of VEGF 2, PDGF, and EphB4 receptors, in patients with advanced urologic tumors. J Clin Oncol 2011;29:abstract e15077
-
(2011)
J Clin Oncol
, vol.29
-
-
Agarwal, N.1
Sahu, M.2
Abhyankar, D.J.3
-
186
-
-
33846236394
-
The multifaceted role of Notch in cancer
-
DOI 10.1016/j.gde.2006.12.001, PII S0959437X0600236X, Genetic and Cellular mechanisms of oncogenesis
-
Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Curr Opin Genet Dev 2007;17(1):52-9 (Pubitemid 46109291)
-
(2007)
Current Opinion in Genetics and Development
, vol.17
, Issue.1
, pp. 52-59
-
-
Roy, M.1
Pear, W.S.2
Aster, J.C.3
-
187
-
-
34548535783
-
Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis?
-
DOI 10.1016/j.molmed.2007.07.002, PII S1471491407001487
-
Sainson RC, Harris AL. Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends Mol Med 2007;13(9):389-95 (Pubitemid 47385383)
-
(2007)
Trends in Molecular Medicine
, vol.13
, Issue.9
, pp. 389-395
-
-
Sainson, R.C.A.1
Harris, A.L.2
-
188
-
-
33845877157
-
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
-
DOI 10.1038/nature05355, PII NATURE05355
-
Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006;444(7122):1032-7 (Pubitemid 46018516)
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1032-1037
-
-
Noguera-Troise, I.1
Daly, C.2
Papadopoulos, N.J.3
Coetzee, S.4
Boland, P.5
Gale, N.W.6
Chieh Lin, H.7
Yancopoulos, G.D.8
Thurston, G.9
-
189
-
-
33748359703
-
Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer
-
DOI 10.1158/1078-0432.CCR-06-0285
-
Patel NS, Dobbie MS, Rochester M, et al. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res 2006;12(16):4836-44 (Pubitemid 44338568)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.16
, pp. 4836-4844
-
-
Patel, N.S.1
Dobbie, M.S.2
Rochester, M.3
Steers, G.4
Poulsom, R.5
Le Monnier, K.6
Cranston, D.W.7
Li, J.-L.8
Harris, A.L.9
-
190
-
-
84858233031
-
Biologic role of tumor and endothelial delta-like ligand 4 in ovarian cancer
-
Hu W, Lu C, Stone RL, et al. Biologic role of tumor and endothelial delta-like ligand 4 in ovarian cancer. Gynecol Oncol 2011;120:S35-6
-
(2011)
Gynecol Oncol
, vol.120
-
-
Hu, W.1
Lu, C.2
Stone, R.L.3
-
191
-
-
33947214529
-
Notch signaling, gamma-secretase inhibitors, and cancer therapy
-
Shih Ie M, Wang TL. Notch signaling, gamma-secretase inhibitors, and cancer therapy. Cancer Res 2007;67(5):1879-82
-
(2007)
Cancer Res
, vol.67
, Issue.5
, pp. 1879-1882
-
-
Shih Ie, M.1
Wang, T.L.2
-
192
-
-
0034782184
-
Liver metastases from colorectal denocarcinomas grow in three patterns with different angiogenesis and esmoplasia
-
Vermeulen PB, Colpaert C, Salgado R, et al. Liver metastases from colorectal denocarcinomas grow in three patterns with different angiogenesis and esmoplasia. J Pathol 2001;195(3):336-42
-
(2001)
J Pathol
, vol.195
, Issue.3
, pp. 336-342
-
-
Vermeulen, P.B.1
Colpaert, C.2
Salgado, R.3
-
193
-
-
0030722076
-
Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis
-
Pezzella F, Pastorino U, Tagliabue E, et al. Non-small-cell lung carcinoma tumor growth without morphological evidence of neo-angiogenesis. Am J Pathol 1997;151(5):1417-23 (Pubitemid 27479772)
-
(1997)
American Journal of Pathology
, vol.151
, Issue.5
, pp. 1417-1423
-
-
Pezzella, F.1
Pastorino, U.2
Tagliabue, E.3
Andreola, S.4
Sozzi, G.5
Gasparini, G.6
Menard, S.7
Gatter, K.C.8
Harris, A.L.9
Fox, S.10
Buyse, M.11
Pilotti, S.12
Pierotti, M.13
Rilke, F.14
-
194
-
-
0032887340
-
Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry
-
Maniotis AJ, Folberg R, Hess A, et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. Am J Pathol 1999;155(3):739-52 (Pubitemid 29426820)
-
(1999)
American Journal of Pathology
, vol.155
, Issue.3
, pp. 739-752
-
-
Maniotis, A.J.1
Folberg, R.2
Hess, A.3
Seftor, E.A.4
Gardner, L.M.G.5
Pe'er, J.6
Trent, J.M.7
Meltzer, P.S.8
Hendrix, M.J.C.9
-
195
-
-
0038143145
-
Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma
-
DOI 10.1038/nrc1092
-
Hendrix MJ, Seftor EA, Hess AR, Seftor RE. Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma. Nat Rev Cancer 2003;3(6):411-21 (Pubitemid 37328845)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.6
, pp. 411-421
-
-
Hendrix, M.J.C.1
Seftor, E.A.2
Hess, A.R.3
Seftor, R.E.B.4
-
196
-
-
33847048710
-
Alternative vascularization mechanisms in cancer: Pathology and therapeutic implications
-
DOI 10.2353/ajpath.2007.060302
-
Dome B, Hendrix MJ, Paku S, et al. Alternative vascularisation mechanisms in cancer: pathology and therapeutic implications. Am J Pathol 2007;170(1):1-15 (Pubitemid 47339184)
-
(2007)
American Journal of Pathology
, vol.170
, Issue.1
, pp. 1-15
-
-
Dome, B.1
Hendrix, M.J.C.2
Paku, S.3
Tovari, J.4
Timar, J.5
-
197
-
-
78650153633
-
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
-
Ricci-Vitiani L, Pallini R, Biffoni M, et al. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 2010;468(7325):824-8
-
(2010)
Nature
, vol.468
, Issue.7325
, pp. 824-828
-
-
Ricci-Vitiani, L.1
Pallini, R.2
Biffoni, M.3
-
198
-
-
30944446883
-
Lessons from phase III clinical trials on anti-VEGF therapy for cancer
-
DOI 10.1038/ncponc0403, PII N0403
-
Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006;3(1):24-40 (Pubitemid 43108832)
-
(2006)
Nature Clinical Practice Oncology
, vol.3
, Issue.1
, pp. 24-40
-
-
Jain, R.K.1
Duda, D.G.2
Clark, J.W.3
Loeffler, J.S.4
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