-
1
-
-
85047681190
-
Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture
-
Alessi DR (2001) Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem Soc Trans 29:1–14
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 1-14
-
-
Alessi, D.R.1
-
2
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541–6551
-
(1996)
EMBO J
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Jelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
3
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
-
Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol 7:261–269
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
4
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M, Cron P, Cohen P, Lucocq JM, Hemmings BA (1997) Role of translocation in the activation and function of protein kinase B. J Biol Chem 272:31515–31524
-
(1997)
J Biol Chem
, vol.272
, pp. 31515-31524
-
-
Andjelkovic, M.1
Alessi, D.R.2
Meier, R.3
Fernandez, A.4
Lamb, N.J.5
Frech, M.6
Cron, P.7
Cohen, P.8
Lucocq, J.M.9
Hemmings, B.A.10
-
5
-
-
0027432424
-
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
-
(Pt 2
-
Arcaro A, Wymann MP (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 296(Pt 2):297–301
-
(1993)
Biochem J
, vol.296
, pp. 297-301
-
-
Arcaro, A.1
Wymann, M.P.2
-
6
-
-
0024601010
-
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
-
Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC (1989) PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell 57:167–175
-
(1989)
Cell
, vol.57
, pp. 167-175
-
-
Auger, K.R.1
Serunian, L.A.2
Soltoff, S.P.3
Libby, P.4
Cantley, L.C.5
-
7
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serinethreonine kinase containing an SH2-like region
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN (1991) A retroviral oncogene, akt, encoding a serinethreonine kinase containing an SH2-like region. Science 254:274–277
-
(1991)
Science
, vol.254
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
8
-
-
0020636518
-
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol
-
Berridge MJ (1983) Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol. Biochem J 212:849–858
-
(1983)
Biochem J
, vol.212
, pp. 849-858
-
-
Berridge, M.J.1
-
9
-
-
0020595443
-
Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides
-
Berridge MJ, Dawson RM, Downes CP, Heslop JP, Irvine RF (1983) Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J 212:473–482
-
(1983)
Biochem J
, vol.212
, pp. 473-482
-
-
Berridge, M.J.1
Dawson, R.M.2
Downes, C.P.3
Heslop, J.P.4
Irvine, R.F.5
-
10
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
-
Bi L, Okabe I, Bernard DJ, Wynshaw-Boris A, Nussbaum RL (1999) Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase. J Biol Chem 274:10963–10968
-
(1999)
J Biol Chem
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Wynshaw-Boris, A.4
Nussbaum, R.L.5
-
11
-
-
0036185944
-
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
-
Bi L, Okabe I, Bernard DJ, Nussbaum RL (2002) Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome 13:169–172
-
(2002)
Mamm Genome
, vol.13
, pp. 169-172
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
Nussbaum, R.L.4
-
12
-
-
0029148577
-
Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells
-
Brown WJ, Dewald DB, Emr SD, Plutner H, Balch WE (1995) Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. J Cell Biol 130:781–796
-
(1995)
J Cell Biol
, vol.130
, pp. 781-796
-
-
Brown, W.J.1
Dewald, D.B.2
Emr, S.D.3
Plutner, H.4
Balch, W.E.5
-
13
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857–868
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Erson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
14
-
-
0037018148
-
14–3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
-
Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, Decaprio JA, Greenberg ME, Yaffe MB (2002) 14–3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol 156:817–828
-
(2002)
J Cell Biol
, vol.156
, pp. 817-828
-
-
Brunet, A.1
Kanai, F.2
Stehn, J.3
Xu, J.4
Sarbassova, D.5
Frangioni, J.V.6
Dalal, S.N.7
Decaprio, J.A.8
Greenberg, M.E.9
Yaffe, M.B.10
-
15
-
-
0029160069
-
Protein kinase B (C-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
Burgering BM, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599–602
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
16
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
Campbell IG, Russell SE, Choong DY, Montgomery KG, Ciavarella ML, Hooi CS, Cristiano BE, Pearson RB, Phillips WA (2004) Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 64:7678–7681
-
(2004)
Cancer Res
, vol.64
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.A.9
-
17
-
-
0025201426
-
Purification and characterization of phosphoinositide 3-kinase from rat liver
-
Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC (1990) Purification and characterization of phosphoinositide 3-kinase from rat liver. J Biol Chem 265:19704–19711
-
(1990)
J Biol Chem
, vol.265
, pp. 19704-19711
-
-
Carpenter, C.L.1
Duckworth, B.C.2
Auger, K.R.3
Cohen, B.4
Schaffhausen, B.S.5
Cantley, L.C.6
-
18
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, Uhlik M, Lin A, Du J, Qian YW, Zeckner DJ, Tucker-Kellogg G, Touchman J, Patel K, Mousses S, Bittner M, Schevitz R, Lai MH, Blanchard KL, Thomas JE (2007) A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448:439–444
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.H.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
19
-
-
0028178928
-
PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
-
Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J (1994) PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 370:71–75
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.C.2
Lemon, K.P.3
Kazlauskas, A.4
Blenis, J.5
-
20
-
-
0037119630
-
A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
-
Clayton E, Bardi G, Bell SE, Chantry D, Downes CP, Gray A, Humphries LA, Rawlings D, Reynolds H, Vigorito E, Turner M (2002) A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J Exp Med 196:753–763
-
(2002)
J Exp Med
, vol.196
, pp. 753-763
-
-
Clayton, E.1
Bardi, G.2
Bell, S.E.3
Chantry, D.4
Downes, C.P.5
Gray, A.6
Humphries, L.A.7
Rawlings, D.8
Reynolds, H.9
Vigorito, E.10
Turner, M.11
-
21
-
-
0023657043
-
Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation
-
Cocco L, Gilmour RS, Ognibene A, Letcher AJ, Manzoli FA, Irvine RF (1987) Synthesis of polyphosphoinositides in nuclei of Friend cells. Evidence for polyphosphoinositide metabolism inside the nucleus which changes with cell differentiation. Biochem J 248:765–770
-
(1987)
Biochem J
, vol.248
, pp. 765-770
-
-
Cocco, L.1
Gilmour, R.S.2
Ognibene, A.3
Letcher, A.J.4
Manzoli, F.A.5
Irvine, R.F.6
-
22
-
-
0026006501
-
Molecular cloning and characterisation of a novel putative proteinserine kinase related to the cAMP-dependent and protein kinase C families [published erratum appears in Eur J Biochem 1992 May 1;205(3):1217]
-
Coffer PJ, Woodgett JR (1991) Molecular cloning and characterisation of a novel putative proteinserine kinase related to the cAMP-dependent and protein kinase C families [published erratum appears in Eur J Biochem 1992 May 1;205(3):1217]. Eur J Biochem 201:475–481
-
(1991)
Eur J Biochem
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
23
-
-
18644372367
-
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
-
Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, Oliveira-Dos-Santos AJ, Benovic JL, Kahn CR, Izumo S, Steinberg SF, Wymann MP, Backx PH, Penninger JM (2002) Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110:737–749
-
(2002)
Cell
, vol.110
, pp. 737-749
-
-
Crackower, M.A.1
Oudit, G.Y.2
Kozieradzki, I.3
Sarao, R.4
Sun, H.5
Sasaki, T.6
Hirsch, E.7
Suzuki, A.8
Shioi, T.9
Irie-Sasaki, J.10
Sah, R.11
Cheng, H.Y.12
Rybin, V.O.13
Lembo, G.14
Fratta, L.15
Oliveira-Dos-Santos, A.J.16
Benovic, J.L.17
Kahn, C.R.18
Izumo, S.19
Steinberg, S.F.20
Wymann, M.P.21
Backx, P.H.22
Penninger, J.M.23
more..
-
24
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785–789
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Jelkovich, M.4
Hemmings, B.A.5
-
25
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231–241
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
Greenberg, M.E.7
-
27
-
-
0023497801
-
A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell
-
Declue JE, Sadowski I, Martin GS, Pawson T (1987) A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell. Proc Natl Acad Sci U S A 84:9064–9068
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 9064-9068
-
-
Declue, J.E.1
Sadowski, I.2
Martin, G.S.3
Pawson, T.4
-
28
-
-
0026040577
-
The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (For IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus
-
Divecha N, Banfic H, Irvine RF (1991) The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. EMBO J 10:3207–3214
-
(1991)
EMBO J
, vol.10
, pp. 3207-3214
-
-
Divecha, N.1
Banfic, H.2
Irvine, R.F.3
-
29
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661–665
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
30
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman JA (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9:550–562
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
31
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7:606–619
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
32
-
-
0026085468
-
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
-
Escobedo JA, Kaplan DR, Kavanaugh WM, Turck CW, Williams LT (1991) A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine. Mol Cell Biol 11:1125–1132
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1125-1132
-
-
Escobedo, J.A.1
Kaplan, D.R.2
Kavanaugh, W.M.3
Turck, C.W.4
Williams, L.T.5
-
33
-
-
69949170092
-
Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a
-
Fine B, Hodakoski C, Koujak S, Su T, Saal LH, Maurer M, Hopkins B, Keniry M, Sulis ML, Mense S, Hibshoosh H, Parsons R (2009) Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a. Science 325:1261–1265
-
(2009)
Science
, vol.325
, pp. 1261-1265
-
-
Fine, B.1
Hodakoski, C.2
Koujak, S.3
Su, T.4
Saal, L.H.5
Maurer, M.6
Hopkins, B.7
Keniry, M.8
Sulis, M.L.9
Mense, S.10
Hibshoosh, H.11
Parsons, R.12
-
34
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727–736
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
35
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
Franke TF, Kaplan DR, Cantley LC, Toker A (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275:665–668
-
(1997)
Science
, vol.275
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
36
-
-
0030991386
-
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
-
Frech M, Andjelkovic M, Ingley E, Reddy KK, Falck JR, Hemmings BA (1997) High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity. J Biol Chem 272:8474–8481
-
(1997)
J Biol Chem
, vol.272
, pp. 8474-8481
-
-
Frech, M.1
Jelkovic, M.2
Ingley, E.3
Reddy, K.K.4
Falck, J.R.5
Hemmings, B.A.6
-
37
-
-
0033757592
-
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha
-
Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT, Kahn CR, Cantley LC (2000) Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nat Genet 26:379–382
-
(2000)
Nat Genet
, vol.26
, pp. 379-382
-
-
Fruman, D.A.1
Mauvais-Jarvis, F.2
Pollard, D.A.3
Yballe, C.M.4
Brazil, D.5
Bronson, R.T.6
Kahn, C.R.7
Cantley, L.C.8
-
38
-
-
0037039320
-
Phosphoinositide 3-kinase and Bruton’s tyrosine kinase regulate overlapping sets of genes in B lymphocytes
-
Fruman DA, Ferl GZ, An SS, Donahue AC, Satterthwaite AB, Witte ON (2002) Phosphoinositide 3-kinase and Bruton’s tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc Natl Acad Sci U S A 99:359–364
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 359-364
-
-
Fruman, D.A.1
Ferl, G.Z.2
An, S.S.3
Donahue, A.C.4
Satterthwaite, A.B.5
Witte, O.N.6
-
39
-
-
0035858886
-
Role of phosphatidylinositol 3_ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium
-
Funamoto S, Milan K, Meili R, Firtel RA (2001) Role of phosphatidylinositol 3_ kinase and a downstream pleckstrin homology domain-containing protein in controlling chemotaxis in dictyostelium. J Cell Biol 153:795–810
-
(2001)
J Cell Biol
, vol.153
, pp. 795-810
-
-
Funamoto, S.1
Milan, K.2
Meili, R.3
Firtel, R.A.4
-
40
-
-
67651148274
-
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling
-
Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC (2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16:115–125
-
(2009)
Cancer Cell
, vol.16
, pp. 115-125
-
-
Gewinner, C.1
Wang, Z.C.2
Richardson, A.3
Teruya-Feldstein, J.4
Etemadmoghadam, D.5
Bowtell, D.6
Barretina, J.7
Lin, W.M.8
Rameh, L.9
Salmena, L.10
Pandolfi, P.P.11
Cantley, L.C.12
-
41
-
-
0028021882
-
Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate
-
Harlan JE, Hajduk PJ, Yoon HS, Fesik SW (1994) Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate. Nature 371:168–170
-
(1994)
Nature
, vol.371
, pp. 168-170
-
-
Harlan, J.E.1
Hajduk, P.J.2
Yoon, H.S.3
Fesik, S.W.4
-
43
-
-
0025200830
-
Characterization ofVPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
-
Herman PK, Emr SD (1990) Characterization ofVPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae. Mol Cell Biol 10:6742–6754
-
(1990)
Mol Cell Biol
, vol.10
, pp. 6742-6754
-
-
Herman, P.K.1
Emr, S.D.2
-
44
-
-
0026720350
-
Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit
-
Hiles ID, Otsu M, Volinia S, Fry MJ, Gout I, Dhand R, Panayotou G, Ruiz LF, Thompson A, Totty NF et al (1992) Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell 70:419–429
-
(1992)
Cell
, vol.70
, pp. 419-429
-
-
Hiles, I.D.1
Otsu, M.2
Volinia, S.3
Fry, M.J.4
Gout, I.5
Dhand, R.6
Panayotou, G.7
Ruiz, L.F.8
Thompson, A.9
Totty, N.F.10
-
45
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
-
Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, Sozzani S, Mantovani A, Altruda F, Wymann MP (2000) Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science 287:1049–1053
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
Silengo, L.6
Sozzani, S.7
Mantovani, A.8
Altruda, F.9
Wymann, M.P.10
-
46
-
-
50449116654
-
The incorporation of 32P into the nucleotides of ribonucleic acid in pigeon pancreas slices
-
Hokin LE, Hokin MR (1953) The incorporation of 32P into the nucleotides of ribonucleic acid in pigeon pancreas slices. Biochim Biophys Acta 11:591–592
-
(1953)
Biochim Biophys Acta
, vol.11
, pp. 591-592
-
-
Hokin, L.E.1
Hokin, M.R.2
-
47
-
-
0017716047
-
Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain
-
Inoue M, Kishimoto A, Takai Y, Nishizuka Y (1977) Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. J Biol Chem 252:7610–7616
-
(1977)
J Biol Chem
, vol.252
, pp. 7610-7616
-
-
Inoue, M.1
Kishimoto, A.2
Takai, Y.3
Nishizuka, Y.4
-
48
-
-
29144488505
-
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition
-
Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS (2005) Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol 171:1023–1034
-
(2005)
J Cell Biol
, vol.171
, pp. 1023-1034
-
-
Irie, H.Y.1
Pearline, R.V.2
Grueneberg, D.3
Hsia, M.4
Ravichandran, P.5
Kothari, N.6
Natesan, S.7
Brugge, J.S.8
-
49
-
-
0032530384
-
Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast
-
Isakoff SJ, Cardozo T, Andreev J, Li Z, Ferguson KM, Abagyan R, Lemmon MA, Aronheim A, Skolnik EY (1998) Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J 17:5374–5387
-
(1998)
EMBO J
, vol.17
, pp. 5374-5387
-
-
Isakoff, S.J.1
Cardozo, T.2
Reev, J.3
Li, Z.4
Ferguson, K.M.5
Abagyan, R.6
Lemmon, M.A.7
Aronheim, A.8
Skolnik, E.Y.9
-
50
-
-
70749140937
-
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation
-
Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, De Sauvage FJ, Backer JM, Seshagiri S (2009) Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell 16:463–474
-
(2009)
Cancer Cell
, vol.16
, pp. 463-474
-
-
Jaiswal, B.S.1
Janakiraman, V.2
Kljavin, N.M.3
Chaudhuri, S.4
Stern, H.M.5
Wang, W.6
Kan, Z.7
Dbouk, H.A.8
Peters, B.A.9
Waring, P.10
Dela Vega, T.11
Kenski, D.M.12
Bowman, K.K.13
Lorenzo, M.14
Li, H.15
Wu, J.16
Modrusan, Z.17
Stinson, J.18
Eby, M.19
Yue, P.20
Kaminker, J.S.21
De Sauvage, F.J.22
Backer, J.M.23
Seshagiri, S.24
more..
-
51
-
-
77952048131
-
Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits
-
Jiang X, Chen S, Asara JM, Balk SP (2010) Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits. J Biol Chem 285:14980–14989
-
(2010)
J Biol Chem
, vol.285
, pp. 14980-14989
-
-
Jiang, X.1
Chen, S.2
Asara, J.M.3
Balk, S.P.4
-
52
-
-
0025882091
-
Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily
-
Jones PF, Jakubowicz T, Pitossi FJ, Maurer F, Hemmings BA (1991) Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily. Proc Natl Acad Sci U S A 88:4171–4175
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 4171-4175
-
-
Jones, P.F.1
Jakubowicz, T.2
Pitossi, F.J.3
Maurer, F.4
Hemmings, B.A.5
-
53
-
-
0033587047
-
PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1
-
Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A (1999) PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol 9:512–521
-
(1999)
Curr Biol
, vol.9
, pp. 512-521
-
-
Jones, S.M.1
Klinghoffer, R.2
Prestwich, G.D.3
Toker, A.4
Kazlauskas, A.5
-
54
-
-
0037695593
-
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex
-
Jou ST, Carpino N, Takahashi Y, Piekorz R, Chao JR, Wang D, Ihle JN (2002) Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex. Mol Cell Biol 22:8580–8591
-
(2002)
Mol Cell Biol
, vol.22
, pp. 8580-8591
-
-
Jou, S.T.1
Carpino, N.2
Takahashi, Y.3
Piekorz, R.4
Chao, J.R.5
Wang, D.6
Ihle, J.N.7
-
55
-
-
0023665111
-
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
-
Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White M, Cantley L, Roberts TM (1987) Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell 50:1021–1029
-
(1987)
Cell
, vol.50
, pp. 1021-1029
-
-
Kaplan, D.R.1
Whitman, M.2
Schaffhausen, B.3
Pallas, D.C.4
White, M.5
Cantley, L.6
Roberts, T.M.7
-
56
-
-
0024434183
-
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
-
Kazlauskas A, Cooper JA (1989) Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell 58:1121–1133
-
(1989)
Cell
, vol.58
, pp. 1121-1133
-
-
Kazlauskas, A.1
Cooper, J.A.2
-
57
-
-
51849097348
-
The role of PTEN signaling perturbations in cancer and in targeted therapy
-
Keniry M, Parsons R (2008) The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene 27:5477–5485
-
(2008)
Oncogene
, vol.27
, pp. 5477-5485
-
-
Keniry, M.1
Parsons, R.2
-
58
-
-
0019819870
-
Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function
-
Kirk CJ, Creba JA, Downes CP, Michell RH (1981) Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function. Biochem Soc Trans 9:377–379
-
(1981)
Biochem Soc Trans
, vol.9
, pp. 377-379
-
-
Kirk, C.J.1
Creba, J.A.2
Downes, C.P.3
Michell, R.H.4
-
59
-
-
0033560896
-
Direct control of the Forkhead transcription factor AFX by protein kinase B
-
Kops GJ, De Ruiter ND, De Vries-Smits AM, Powell DR, Bos JL, Burgering BM (1999) Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 398:630–634
-
(1999)
Nature
, vol.398
, pp. 630-634
-
-
Kops, G.J.1
De Ruiter, N.D.2
De Vries-Smits, A.M.3
Powell, D.R.4
Bos, J.L.5
Burgering, B.M.6
-
60
-
-
0015593847
-
Amembrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, D-myoinositol 1:2-cyclic phosphate an D-myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex
-
Lapetina EG, Michell RH (1973) Amembrane-bound activity catalysing phosphatidylinositol breakdown to 1,2-diacylglycerol, D-myoinositol 1:2-cyclic phosphate an D-myoinositol 1-phosphate. Properties and subcellular distribution in rat cerebral cortex. Biochem J 131:433–442
-
(1973)
Biochem J
, vol.131
, pp. 433-442
-
-
Lapetina, E.G.1
Michell, R.H.2
-
61
-
-
0029830237
-
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth
-
Leevers SJ, Weinkove D, Macdougall LK, Hafen E, Waterfield MD (1996) The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J 15:6584–6594
-
(1996)
EMBO J
, vol.15
, pp. 6584-6594
-
-
Leevers, S.J.1
Weinkove, D.2
Macdougall, L.K.3
Hafen, E.4
Waterfield, M.D.5
-
62
-
-
38549092474
-
Membrane recognition by phospholipid-binding domains
-
Lemmon MA (2008) Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol 9:99–111
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 99-111
-
-
Lemmon, M.A.1
-
63
-
-
0030936323
-
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [see comments]
-
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer [see comments]. Science 275:1943–1947
-
(1997)
Science
, vol.275
, pp. 1943-1947
-
-
Li, J.1
Yen, C.2
Liaw, D.3
Podsypanina, K.4
Bose, S.5
Wang, S.I.6
Puc, J.7
Miliaresis, C.8
Rodgers, L.9
McCombie, R.10
Bigner, S.H.11
Giovanella, B.C.12
Ittmann, M.13
Tycko, B.14
Hibshoosh, H.15
Wigler, M.H.16
Parsons, R.17
-
64
-
-
0021221071
-
Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: Possible role in tumorigenesis
-
Macara IG, Marinetti GV, Balduzzi PC (1984) Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis. Proc Natl Acad Sci U S A 81:2728–2732
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 2728-2732
-
-
Macara, I.G.1
Marinetti, G.V.2
Balduzzi, P.C.3
-
65
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:13375–13378
-
(1998)
J Biol Chem
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
66
-
-
51049109033
-
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
-
Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, Brachmann S, Chene P, De Pover A, Schoemaker K, Fabbro D, Gabriel D, Simonen M, Murphy L, Finan P, Sellers W, Garcia-Echeverria C (2008) Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther 7:1851–1863
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 1851-1863
-
-
Maira, S.M.1
Stauffer, F.2
Brueggen, J.3
Furet, P.4
Schnell, C.5
Fritsch, C.6
Brachmann, S.7
Chene, P.8
De Pover, A.9
Schoemaker, K.10
Fabbro, D.11
Gabriel, D.12
Simonen, M.13
Murphy, L.14
Finan, P.15
Sellers, W.16
Garcia-Echeverria, C.17
-
67
-
-
33846416534
-
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu andMMTV-polyoma middle T transgenic mice
-
Maroulakou IG, Oemler W, Naber SP, Tsichlis PN (2007) Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu andMMTV-polyoma middle T transgenic mice. Cancer Res 67:167–177
-
(2007)
Cancer Res
, vol.67
, pp. 167-177
-
-
Maroulakou, I.G.1
Oemler, W.2
Naber, S.P.3
Tsichlis, P.N.4
-
68
-
-
0025298967
-
Binding of transforming protein p47gag-crk to a broad range of phosphotyrosine-containing proteins
-
Matsuda M, Mayer B, Fukui Y, Hanafusa H (1990) Binding of transforming protein p47gag-crk to a broad range of phosphotyrosine-containing proteins. Science 248:1537–1539
-
(1990)
Science
, vol.248
, pp. 1537-1539
-
-
Matsuda, M.1
Mayer, B.2
Fukui, Y.3
Hanafusa, H.4
-
69
-
-
1342342993
-
PDK1, the master regulator of AGC kinase signal transduction
-
Mora A, Komander D, Van Aalten DM, Alessi DR (2004) PDK1, the master regulator of AGC kinase signal transduction. Semin Cell Dev Biol 15:161–170
-
(2004)
Semin Cell Dev Biol
, vol.15
, pp. 161-170
-
-
Mora, A.1
Komander, D.2
Van Aalten, D.M.3
Alessi, D.R.4
-
70
-
-
0025119824
-
Src homology region 2 domains direct protein-protein interactions in signal transduction
-
Moran MF, Koch CA, Anderson D, Ellis C, England L, Martin GS, Pawson T (1990) Src homology region 2 domains direct protein-protein interactions in signal transduction. Proc Natl Acad Sci U S A 87:8622–8626
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 8622-8626
-
-
Moran, M.F.1
Koch, C.A.2
Erson, D.3
Ellis, C.4
England, L.5
Martin, G.S.6
Pawson, T.7
-
71
-
-
0029768753
-
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
-
Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382:536–539
-
(1996)
Nature
, vol.382
, pp. 536-539
-
-
Morris, J.Z.1
Tissenbaum, H.A.2
Ruvkun, G.3
-
72
-
-
0025345747
-
Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain
-
O’Brien MC, Fukui Y, Hanafusa H (1990) Activation of the proto-oncogene p60c-src by point mutations in the SH2 domain. Mol Cell Biol 10:2855–2862
-
(1990)
Mol Cell Biol
, vol.10
, pp. 2855-2862
-
-
O’Brien, M.C.1
Fukui, Y.2
Hanafusa, H.3
-
73
-
-
0030659557
-
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. Elegans
-
Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389:994–999
-
(1997)
Nature
, vol.389
, pp. 994-999
-
-
Ogg, S.1
Paradis, S.2
Gottlieb, S.3
Patterson, G.I.4
Lee, L.5
Tissenbaum, H.A.6
Ruvkun, G.7
-
74
-
-
32944457518
-
MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O’Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N (2006) mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66:1500–1508
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O’Reilly, K.E.1
Rojo, F.2
She, Q.B.3
Solit, D.4
Mills, G.B.5
Smith, D.6
Lane, H.7
Hofmann, F.8
Hicklin, D.J.9
Ludwig, D.L.10
Baselga, J.11
Rosen, N.12
-
75
-
-
0025755422
-
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
-
Otsu M, Hiles I, Gout I, Fry MJ, Ruiz LF, Panayotou G, Thompson A, Dhand R, Hsuan J, Totty N, et al (1991) Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell 65:91–104
-
(1991)
Cell
, vol.65
, pp. 91-104
-
-
Otsu, M.1
Hiles, I.2
Gout, I.3
Fry, M.J.4
Ruiz, L.F.5
Panayotou, G.6
Thompson, A.7
Dhand, R.8
Hsuan, J.9
Totty, N.10
-
76
-
-
0033151613
-
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
-
Paradis S, Ailion M, Toker A, Thomas JH, Ruvkun G (1999) A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13:1438–1452
-
(1999)
Genes Dev
, vol.13
, pp. 1438-1452
-
-
Paradis, S.1
Ailion, M.2
Toker, A.3
Thomas, J.H.4
Ruvkun, G.5
-
77
-
-
0032529189
-
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
-
Paradis S, Ruvkun G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev 12:2488–2498
-
(1998)
Genes Dev
, vol.12
, pp. 2488-2498
-
-
Paradis, S.1
Ruvkun, G.2
-
78
-
-
4344714889
-
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects
-
Patrucco E, Notte A, Barberis L, Selvetella G, Maffei A, Brancaccio M, Marengo S, Russo G, Azzolino O, Rybalkin SD, Silengo L, Altruda F, Wetzker R, Wymann MP, Lembo G, Hirsch E (2004) PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118:375–387
-
(2004)
Cell
, vol.118
, pp. 375-387
-
-
Patrucco, E.1
Notte, A.2
Barberis, L.3
Selvetella, G.4
Maffei, A.5
Brancaccio, M.6
Marengo, S.7
Russo, G.8
Azzolino, O.9
Rybalkin, S.D.10
Silengo, L.11
Altruda, F.12
Wetzker, R.13
Wymann, M.P.14
Lembo, G.15
Hirsch, E.16
-
79
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez VP, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfield MD, Downward J (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370:527–532
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez, V.P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
80
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (2004) High frequency of mutations of the PIK3CA gene in human cancers. Science 304:554
-
(2004)
Science
, vol.304
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
81
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098–1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
82
-
-
0027905021
-
Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting
-
Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD (1993) Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260:88–91
-
(1993)
Science
, vol.260
, pp. 88-91
-
-
Schu, P.V.1
Takegawa, K.2
Fry, M.J.3
Stack, J.H.4
Waterfield, M.D.5
Emr, S.D.6
-
84
-
-
0025921611
-
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
-
Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J (1991) Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell 65:83–90
-
(1991)
Cell
, vol.65
, pp. 83-90
-
-
Skolnik, E.Y.1
Margolis, B.2
Mohammadi, M.3
Lowenstein, E.4
Fischer, R.5
Drepps, A.6
Ullrich, A.7
Schlessinger, J.8
-
85
-
-
78650235523
-
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer
-
Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG (2010) Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer. Mol Cell 40:877–892
-
(2010)
Mol Cell
, vol.40
, pp. 877-892
-
-
Sosa, M.S.1
Lopez-Haber, C.2
Yang, C.3
Wang, H.4
Lemmon, M.A.5
Busillo, J.M.6
Luo, J.7
Benovic, J.L.8
Klein-Szanto, A.9
Yagi, H.10
Gutkind, J.S.11
Parsons, R.E.12
Kazanietz, M.G.13
-
86
-
-
17144436629
-
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
-
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV (1997) Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15:356–362
-
(1997)
Nat Genet
, vol.15
, pp. 356-362
-
-
Steck, P.A.1
Pershouse, M.A.2
Jasser, S.A.3
Yung, W.K.4
Lin, H.5
Ligon, A.H.6
Langford, L.A.7
Baumgard, M.L.8
Hattier, T.9
Davis, T.10
Frye, C.11
Hu, R.12
Swedlund, B.13
Teng, D.H.14
Tavtigian, S.V.15
-
87
-
-
0024599049
-
Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate
-
Stephens L, Hawkins PT, Downes CP (1989) Metabolic and structural evidence for the existence of a third species of polyphosphoinositide in cells: D-phosphatidyl-myo-inositol 3-phosphate. Biochem J 259:267–276
-
(1989)
Biochem J
, vol.259
, pp. 267-276
-
-
Stephens, L.1
Hawkins, P.T.2
Downes, C.P.3
-
88
-
-
0025731596
-
Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils
-
Stephens LR, Hughes KT, Irvine RF (1991) Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils. Nature 351:33–39
-
(1991)
Nature
, vol.351
, pp. 33-39
-
-
Stephens, L.R.1
Hughes, K.T.2
Irvine, R.F.3
-
89
-
-
0030799706
-
Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
-
Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT (1997) Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science 277:567–570
-
(1997)
Science
, vol.277
, pp. 567-570
-
-
Stokoe, D.1
Stephens, L.R.2
Copeland, T.3
Gaffney, P.R.4
Reese, C.B.5
Painter, G.F.6
Holmes, A.B.7
McCormick, F.8
Hawkins, P.T.9
-
90
-
-
0020643801
-
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
-
Streb H, Irvine RF, Berridge MJ, Schulz I (1983) Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306:67–69
-
(1983)
Nature
, vol.306
, pp. 67-69
-
-
Streb, H.1
Irvine, R.F.2
Berridge, M.J.3
Schulz, I.4
-
91
-
-
0011168670
-
Evidence that the Rous sarcoma transforming gene product phosphorylates phosphatidylinositol and diacylglycerol
-
Sugimoto Y, Whitman M, Cantley LC, Erikson RL (1984) Evidence that the Rous sarcoma transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. Proc Natl Acad Sci U S A 81:2117–2121
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 2117-2121
-
-
Sugimoto, Y.1
Whitman, M.2
Cantley, L.C.3
Erikson, R.L.4
-
92
-
-
0017379059
-
A proenzyme of cyclic nucleotide-independent protein kinase and its activation by calcium-dependent neutral protease from rat liver
-
Takai Y, Yamamoto M, Inoue M, Kishimoto A, Nishizuka Y (1977) A proenzyme of cyclic nucleotide-independent protein kinase and its activation by calcium-dependent neutral protease from rat liver. Biochem Biophys Res Commun 77:542–550
-
(1977)
Biochem Biophys Res Commun
, vol.77
, pp. 542-550
-
-
Takai, Y.1
Yamamoto, M.2
Inoue, M.3
Kishimoto, A.4
Nishizuka, Y.5
-
93
-
-
0032909703
-
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
-
Terauchi Y, Tsuji Y, Satoh S, Minoura H, Murakami K, Okuno A, Inukai K, Asano T, Kaburagi Y, Ueki K, Nakajima H, Hanafusa T, Matsuzawa Y, Sekihara H, Yin Y, Barrett JC, Oda H, Ishikawa T, Akanuma Y, Komuro I, Suzuki M, Yamamura K, Kodama T, Suzuki H, Koyasu S, Aizawa S, Tobe K, Fukui Y, Yazaki Y, Kadowaki T (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21:230–235
-
(1999)
Nat Genet
, vol.21
, pp. 230-235
-
-
Terauchi, Y.1
Tsuji, Y.2
Satoh, S.3
Minoura, H.4
Murakami, K.5
Okuno, A.6
Inukai, K.7
Asano, T.8
Kaburagi, Y.9
Ueki, K.10
Nakajima, H.11
Hanafusa, T.12
Matsuzawa, Y.13
Sekihara, H.14
Yin, Y.15
Barrett, J.C.16
Oda, H.17
Ishikawa, T.18
Akanuma, Y.19
Komuro, I.20
Suzuki, M.21
Yamamura, K.22
Kodama, T.23
Suzuki, H.24
Koyasu, S.25
Aizawa, S.26
Tobe, K.27
Fukui, Y.28
Yazaki, Y.29
Kadowaki, T.30
more..
-
94
-
-
0023810588
-
An inositol tetrakisphosphate-containing phospholipid in activated neutrophils
-
Traynor-Kaplan AE, Harris AL, Thompson BL, Taylor P, Sklar LA (1988) An inositol tetrakisphosphate-containing phospholipid in activated neutrophils. Nature 334:353–356
-
(1988)
Nature
, vol.334
, pp. 353-356
-
-
Traynor-Kaplan, A.E.1
Harris, A.L.2
Thompson, B.L.3
Taylor, P.4
Sklar, L.A.5
-
95
-
-
0037039317
-
Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase
-
Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC (2002) Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 99:419–424
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 419-424
-
-
Ueki, K.1
Yballe, C.M.2
Brachmann, S.M.3
Vicent, D.4
Watt, J.M.5
Kahn, C.R.6
Cantley, L.C.7
-
96
-
-
0027211693
-
Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor’s mitogenic signal
-
Valius M, Kazlauskas A (1993) Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor’s mitogenic signal. Cell 73:321–334
-
(1993)
Cell
, vol.73
, pp. 321-334
-
-
Valius, M.1
Kazlauskas, A.2
-
98
-
-
67649382929
-
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer
-
Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA (2009) AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell 16:21–32
-
(2009)
Cancer Cell
, vol.16
, pp. 21-32
-
-
Vasudevan, K.M.1
Barbie, D.A.2
Davies, M.A.3
Rabinovsky, R.4
McNear, C.J.5
Kim, J.J.6
Hennessy, B.T.7
Tseng, H.8
Pochanard, P.9
Kim, S.Y.10
Dunn, I.F.11
Schinzel, A.C.12
Sandy, P.13
Hoersch, S.14
Sheng, Q.15
Gupta, P.B.16
Boehm, J.S.17
Reiling, J.H.18
Silver, S.19
Lu, Y.20
Stemke-Hale, K.21
Dutta, B.22
Joy, C.23
Sahin, A.A.24
Gonzalez-Angulo, A.M.25
Lluch, A.26
Rameh, L.E.27
Jacks, T.28
Root, D.E.29
Lander, E.S.30
Mills, G.B.31
Hahn, W.C.32
Sellers, W.R.33
Garraway, L.A.34
more..
-
99
-
-
0028170210
-
Phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos CJ, Matter WF, Hui KY, Brown RF (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4- morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J Biol Chem 269:5241–5248
-
(1994)
J Biol Chem
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
101
-
-
0028429961
-
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
-
Wennstrom S, Hawkins P, Cooke F, Hara K, Yonezawa K, Kasuga M, Jackson T, Claesson-Welsh L, Stephens L (1994) Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr Biol 4:385–393
-
(1994)
Curr Biol
, vol.4
, pp. 385-393
-
-
Wennstrom, S.1
Hawkins, P.2
Cooke, F.3
Hara, K.4
Yonezawa, K.5
Kasuga, M.6
Jackson, T.7
Claesson-Welsh, L.8
Stephens, L.9
-
102
-
-
0023897684
-
Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
-
Whitman M, Downes CP, Keeler M, Keller T, Cantley L (1988) Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644–646
-
(1988)
Nature
, vol.332
, pp. 644-646
-
-
Whitman, M.1
Downes, C.P.2
Keeler, M.3
Keller, T.4
Cantley, L.5
-
103
-
-
0027374488
-
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
-
Yano H, Nakanishi S, Kimura K, Hanai N, Saitoh Y, Fukui Y, Nonomura Y, Matsuda Y (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 268:25846–25856
-
(1993)
J Biol Chem
, vol.268
, pp. 25846-25856
-
-
Yano, H.1
Nakanishi, S.2
Kimura, K.3
Hanai, N.4
Saitoh, Y.5
Fukui, Y.6
Nonomura, Y.7
Matsuda, Y.8
-
104
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
Yao R, Cooper GM (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003–2006
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.M.2
-
105
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A (2005) Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 20:539–550
-
(2005)
Mol Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
106
-
-
29444449785
-
The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells
-
Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM (2005) The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A 102:18443–18448
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 18443-18448
-
-
Zhao, J.J.1
Liu, Z.2
Wang, L.3
Shin, E.4
Loda, M.F.5
Roberts, T.M.6
-
107
-
-
0027403027
-
SH2 domains recognize specific phosphopeptide sequences
-
Zhou S, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ et al (1993) SH2 domains recognize specific phosphopeptide sequences. Cell 72:767–778
-
(1993)
Cell
, vol.72
, pp. 767-778
-
-
Zhou, S.1
Shoelson, S.E.2
Chaudhuri, M.3
Gish, G.4
Pawson, T.5
Haser, W.G.6
King, F.7
Roberts, T.8
Ratnofsky, S.9
Lechleider, R.J.10
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