Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans

Trends in Pharmacological Sciences

Volumn 36, Issue 7, 2015, Pages 452-460

  Hui, Raymond ^a,b   El Bakkouri, Majida ^a   Sibley, L David ^c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATP binding pocket; chemotherapy; gatekeeper; orthogonal inhibitors; parasites; serine threonine protein kinases

Indexed keywords

3 CLB PP1; 3 MB PP1; 317B; 317C; 3MA6; 3N51; 3NCG; 3SXF; 3T3U; 3T3V; 3UPZ; 3UQF; 3UQG; 3V51; 3V5P; 3V5T; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 4JBV; 5 AMINOPYRAZOLE 4 CARBOXAMIDE; ACYLBENZIMIDAZOLE; BKI 1; COMPOUND 1294; IMATINIB; IMIDAZOPYRIDAZINE; PP1 DERIVATIVE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PURFALCAMINE; PYRAZOLOPYRIMIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; CALCIUM BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTOZOAL PROTEIN;

APICOMPLEXA; CHEMOSENSITIVITY; CRYPTOSPORIDIOSIS; CYST; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; HUMAN; INFECTION; MALARIA; NONHUMAN; PARASITOSIS; PLASMODIUM; PRIORITY JOURNAL; REVIEW; STRUCTURE ANALYSIS; TOXOPLASMOSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; MOLECULAR MODEL; PHYLOGENY; PROTOZOAN INFECTIONS; STRUCTURE ACTIVITY RELATION;

APICOMPLEXA; CALCIUM-BINDING PROTEINS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHYLOGENY; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTOZOAN INFECTIONS; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84932194861     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2015.04.011     Document Type: Review

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