The logic and design of analog-sensitive kinases and their small molecule inhibitors

Methods in Enzymology

Volumn 548, Issue C, 2014, Pages 189-213

  Lopez, Michael S ^a   Kliegman, Joseph I ^a   Shokat, Kevan M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Analog sensitive; Chemical; Genetics; Kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; ALANINE; ANALOG SENSITIVE KINASE; ANALOG SENSITIVE KINASE INHIBITOR; CYSTEINE; GLYCINE; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PYRAZOLO[3,4 D]PYRIMIDINE INHIBITOR; STARALOG INHIBITOR; UNCLASSIFIED DRUG; VALINE; ADENOSINE TRIPHOSPHATE; LIGAND; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PURINE-ANALOG-SENSITIVE KINASE, HUMAN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; DOSE RESPONSE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME STRUCTURE; IC50; MAMMAL CELL; MUTATION; NONHUMAN; PHYLOGENETIC TREE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYME ACTIVE SITE; GENETICS; HUMAN; METABOLISM; PROTEIN ENGINEERING; SURFACE PROPERTY;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; DRUG DESIGN; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; PROTEIN ENGINEERING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; RECOMBINANT PROTEINS; SURFACE PROPERTIES;

EID: 84925382510     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-397918-6.00008-2     Document Type: Chapter

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