Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 10, 2013, Pages 3064-3069

  Chapman, Timothy M ^a   Osborne, Simon A ^a   Bouloc, Nathalie ^a   Large, Jonathan M ^a   Wallace, Claire ^a   Birchall, Kristian ^a   Ansell, Keith H ^a   Jones, Hayley M ^a   Taylor, Debra ^a   Clough, Barbara ^b   Green, Judith L ^b   Holder, Anthony A ^b  

^a Centre for Therapeutics Discovery   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

Plasmodium falciparum Calcium dependent protein kinase 1 Malaria Imidazopyridazine SAR

Indexed keywords

ANTIPROTOZOAL AGENT; AURORA A KINASE; PHOSPHOTRANSFERASE; PROTOZOAL PROTEIN; PYRIDAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; IC 50; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIMALARIALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIGH-THROUGHPUT SCREENING ASSAYS; MALARIA; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTOZOAN PROTEINS; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

EID: 84876684325     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.017     Document Type: Article

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