Potent and selective inhibitors of CDPK1 from T. Gondii and C. Parvum based on a 5-aminopyrazole-4-carboxamide scaffold

ACS Medicinal Chemistry Letters

Volumn 5, Issue 1, 2014, Pages 40-44

  Zhang, Zhongsheng ^a   Ojo, Kayode K ^a   Vidadala, Ramasubbarao ^b   Huang, Wenlin ^a   Geiger, Jennifer A ^c   Scheele, Suzanne ^c   Choi, Ryan ^a   Reid, Molly C ^a   Keyloun, Katelyn R ^a   Rivas, Kasey ^a   Kallur Siddaramaiah, Latha ^a   Comess, Kenneth M ^d   Robinson, Kenneth P ^d   Merta, Philip J ^d   Kifle, Lemma ^d   Hol, Wim G J ^a   Parsons, Marilyn ^c   Merritt, Ethan A ^a   Maly, Dustin J ^b   Verlinde, Christophe L M J ^a   Van Voorhis, Wesley C ^a   Fan, Erkang ^a   more..

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d ABBVIE INC   (United States)

Author keywords

calcium dependent protein kinase 1; Cryptosporidium parvum; enzyme inhibitor; selectivity; Toxoplasma gondii

Indexed keywords

5 AMINOPYRAZOLE 4 CARBOXAMIDE; CALCIUM DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PYRAZOLOPYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; MAMMAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

EID: 84892568278     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400315s     Document Type: Article

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