1NM-PP1 treatment of mice infected with Toxoplasma gondii

Journal of Veterinary Medical Science

Volumn 73, Issue 10, 2011, Pages 1377-1379

  Sugi, Tatsuki ^a   Kato, Kentaro ^a   Kobayashi, Kyousuke ^a   Kurokawa, Hitomi ^a   Takemae, Hitoshi ^a   Gong, Haiyan ^a   Recuenco, Frances C ^a   Iwanaga, Tatsuya ^a   Horimoto, Taisuke ^a   Akashi, Hiroomi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

1NM PP1; Bumped kinase inhibitor; Drug; Protein kinase; Toxoplasma gondii

Indexed keywords

1 TERT BUTYL 3 NAPHTHALEN 1 YLMETHYL 1H PYRAZOLO(3,4 D)PYRIMIDIN 4 YLEMINE; 1-TERT-BUTYL-3-NAPHTHALEN-1-YLMETHYL-1H-PYRAZOLO(3,4-D)PYRIMIDIN-4-YLEMINE; ANTIPROTOZOAL AGENT; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; BRAIN; DOSE RESPONSE; FEMALE; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LUNG; MORTALITY; MOUSE; ORAL DRUG ADMINISTRATION; PARASITE LOAD; PARASITOLOGY; SURVIVAL RATE; TOXOPLASMOSIS;

ADMINISTRATION, ORAL; ANIMALS; ANTIPROTOZOAL AGENTS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INJECTIONS, INTRAPERITONEAL; LIVER; LUNG; MICE; MICE, INBRED ICR; PARASITE LOAD; PROTEIN KINASE INHIBITORS; PYRAZOLES; PYRIMIDINES; SURVIVAL RATE; TOXOPLASMOSIS;

EUKARYOTA; MAMMALIA; MUS; TOXOPLASMA GONDII;

EID: 80055079601     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.11-0085     Document Type: Article

References (15)

1. Bishop, A. C., Ubersax, J. A., Petsch, D. T., Matheos, D. P., Gray, N. S., Blethrow, J., Shimizu, E., Tsien, J. Z., Schultz, P. G., Rose, M. D., Wood, J. L., Morgan, D. O. and Shokat, K. M. 2000. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407: 395-401.
2. Black, M. W. and Boothroyd, J. C. 2000. Lytic cycle of Toxoplasma gondii. Microbiol. Mol. Biol. Rev. 64: 607-623.
3. Huynh, M. H. and Carruthers, V. B. 2006. Toxoplasma MIC2 is a major determinant of invasion and virulence. PLoS Pathog. 2: e84.
4. Katlama, C., De Wit, S., O'Doherty, E., Van Glabeke, M. and Clumeck, N. 1996. Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. Clin. Infect. Dis. 22: 268-275.
5. Kieschnick, H., Wakefield, T., Narducci, C. A. and Beckers, C. 2001. Toxoplasma gondii attachment to host cells is regulated by a calmodulin-like domain protein kinase. J. Biol. Chem. 276: 12369-12377.
6. Lourido, S., Shuman, J., Zhang, C., Shokat, K. M., Hui, R. and Sibley, L. D. 2010. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature 465: 359-362.
7. Morgan, R. E., Evans, K. M., Patterson, S., Catti, F., Ward, G. E. and Westwood, N. J. 2007. Targeting invasion and egress: from tools to drugs? Curr. Drug Targets 8: 61-74.
8. Ojo, K. K., Larson, E. T., Keyloun, K. R., Castaneda, L. J., Derocher, A. E., Inampudi, K. K., Kim, J. E., Arakaki, T. L., Murphy, R. C., Zhang, L., Napuli, A. J., Maly, D. J., Verlinde, C. L., Buckner, F. S., Parsons, M., Hol, W. G., Merritt, E. A. and Van Voorhis, W. C. 2010. Toxoplasma gondii calciumdependent protein kinase 1 is a target for selective kinase inhibitors. Nat. Struct. Mol. Biol. 17: 602-607.
9. Pomel, S., Luk, F. C. and Beckers, C. J. 2008. Host cell egress and invasion induce marked relocations of glycolytic enzymes in Toxoplasma gondii tachyzoites. PLoS Pathog. 4: e1000188.
10. Reischl, U., Bretagne, S., Kruger, D., Ernault, P. and Costa, J. M. 2003. Comparison of two DNA targets for the diagnosis of Toxoplasmosis by real-time PCR using fluorescence resonance energy transfer hybridization probes. BMC Infect. Dis. 3: 7.
11. Sugi, T., Kato, K., Kobayashi, K., Pandey, K., Takemae, H., Kurokawa, H., Tohya, Y. and Akashi, H. 2009. Molecular analyses of Toxoplasma gondii calmodulin-like domain protein kinase isoform 3. Parasitol. Int. 58: 416-423.
12. Sugi, T., Kato, K., Kobayashi, K., Watanabe, S., Kurokawa, H., Gong, H., Pandey, K., Takemae, H. and Akashi, H. 2010. Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step. Eukaryot. Cell 9: 667-670.
13. Tenter, A. M., Heckeroth, A. R. and Weiss, L. M. 2000. Toxoplasma gondii: from animals to humans. Int. J. Parasitol. 30: 1217-1258.
14. Walling, J. 2006. From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates. Invest. New Drugs 24: 37-77.
15. Wang, H., Shimizu, E., Tang, Y. P., Cho, M., Kyin, M., Zuo, W., Robinson, D. A., Alaimo, P. J., Zhang, C., Morimoto, H., Zhuo, M., Feng, R., Shokat, K. M. and Tsien, J. Z. 2003. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc. Natl. Acad. Sci. U.S.A. 100: 4287-4292.