Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by toxoplasma gondii

Journal of Medicinal Chemistry

Volumn 56, Issue 7, 2013, Pages 3068-3077

  Lourido, Sebastian ^a,c   Zhang, Chao ^b,d   Lopez, Michael S ^b   Tang, Keliang ^a   Barks, Jennifer ^a   Wang, Qiuling ^a   Wildman, Scott A ^a   Shokat, Kevan M ^b   Sibley, L David ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM DEPENDENT PROTEIN KINASE 1 INHIBITOR; MOLECULAR SCAFFOLD; PROTEIN SERINE THREONINE KINASE INHIBITOR; PYRAZOLO PYRIMIDINE INHIBITOR; PYRIMIDINE ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG HALF LIFE; ENZYME ACTIVITY; HOST CELL; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIPID MONOLAYER; MOUSE; NONHUMAN; RAT; SYNTHESIS; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; MICE; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; SMALL MOLECULE LIBRARIES; TOXOPLASMA; TOXOPLASMOSIS;

EID: 84876234812     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm4001314     Document Type: Article

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