-
1
-
-
36749045172
-
The molecular architecture of the nuclear pore complex
-
Alber, F., Dokudovskaya, S., Veenhoff, L. M., Zhang, W., Kipper, J., Devos, D., Suprapto, A., Karni-Schmidt, O., Williams, R., Chait, B. T. et al. (2007). The molecular architecture of the nuclear pore complex. Nature 450, 695-701.
-
(2007)
Nature
, vol.450
, pp. 695-701
-
-
Alber, F.1
Dokudovskaya, S.2
Veenhoff, L.M.3
Zhang, W.4
Kipper, J.5
Devos, D.6
Suprapto, A.7
Karni-Schmidt, O.8
Williams, R.9
Chait, B.T.10
-
2
-
-
47849125967
-
A multidimensional chromatography technology for in-depth phosphoproteome analysis
-
Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J. and Zhou, H. (2008). A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol. Cell. Proteomics 7, 1389-1396.
-
(2008)
Mol. Cell. Proteomics
, vol.7
, pp. 1389-1396
-
-
Albuquerque, C.P.1
Smolka, M.B.2
Payne, S.H.3
Bafna, V.4
Eng, J.5
Zhou, H.6
-
3
-
-
84864415940
-
The SEA complex-the beginning
-
Algret, R. and Dokudovskaya, S. (2012). The SEA complex-the beginning. Biopolym. Cell 28, 281-284.
-
(2012)
Biopolym. Cell
, vol.28
, pp. 281-284
-
-
Algret, R.1
Dokudovskaya, S.2
-
4
-
-
84910612231
-
Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway
-
Algret, R., Fernandez-Martinez, J., Shi, Y., Kim, S. J., Pellarin, R., Cimermancic, P., Cochet, E., Sali, A., Chait, B. T., Rout, M. P. et al. (2014). Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway. Mol. Cell. Proteomics 13, 2855-2870.
-
(2014)
Mol. Cell. Proteomics
, vol.13
, pp. 2855-2870
-
-
Algret, R.1
Fernandez-Martinez, J.2
Shi, Y.3
Kim, S.J.4
Pellarin, R.5
Cimermancic, P.6
Cochet, E.7
Sali, A.8
Chait, B.T.9
Rout, M.P.10
-
5
-
-
57749173112
-
Downregulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1, and HYAL2 in non-small cell lung cancer
-
Anedchenko, E. A., Dmitriev, A. A., Krasnov, G. S., Kondrat'eva, O. O., Kopantsev, E. P., Vinogradova, T. V., Zinov'eva, M. V., Zborovskaya, I. B., Polotsky, B. E., Sacharova, O. V. et al. (2008). Downregulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1, and HYAL2 in non-small cell lung cancer. Mol. Biol. 42, 859-869.
-
(2008)
Mol. Biol
, vol.42
, pp. 859-869
-
-
Anedchenko, E.A.1
Dmitriev, A.A.2
Krasnov, G.S.3
Kondrat'eva, O.O.4
Kopantsev, E.P.5
Vinogradova, T.V.6
Zinov'eva, M.V.7
Zborovskaya, I.B.8
Polotsky, B.E.9
Sacharova, O.V.10
-
6
-
-
84877886601
-
CORVET and HOPS tethering complexes-coordinators of endosome and lysosome fusion
-
Balderhaar, H. J. and Ungermann, C. (2013). CORVET and HOPS tethering complexes-coordinators of endosome and lysosome fusion. J. Cell Sci. 126, 1307-1316.
-
(2013)
J. Cell Sci
, vol.126
, pp. 1307-1316
-
-
Balderhaar, H.J.1
Ungermann, C.2
-
7
-
-
33748590520
-
DEP-domain-mediated regulation of GPCR signaling responses
-
Ballon, D. R., Flanary, P. L., Gladue, D. P., Konopka, J. B., Dohlman, H. G. and Thorner, J. (2006). DEP-domain-mediated regulation of GPCR signaling responses. Cell 126, 1079-1093.
-
(2006)
Cell
, vol.126
, pp. 1079-1093
-
-
Ballon, D.R.1
Flanary, P.L.2
Gladue, D.P.3
Konopka, J.B.4
Dohlman, H.G.5
Thorner, J.6
-
8
-
-
84903158167
-
Regulation of mTORC1 by amino acids
-
Bar-Peled, L. and Sabatini, D. M. (2014). Regulation of mTORC1 by amino acids. Trends Cell Biol. 24, 400-406.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 400-406
-
-
Bar-Peled, L.1
Sabatini, D.M.2
-
9
-
-
84866431363
-
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
-
Bar-Peled, L., Schweitzer, L. D., Zoncu, R. and Sabatini, D. M. (2012). Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150, 1196-1208.
-
(2012)
Cell
, vol.150
, pp. 1196-1208
-
-
Bar-Peled, L.1
Schweitzer, L.D.2
Zoncu, R.3
Sabatini, D.M.4
-
10
-
-
84878357685
-
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
-
Bar-Peled, L., Chantranupong, L., Cherniack, A. D., Chen, W. W., Ottina, K. A., Grabiner, B. C., Spear, E. D., Carter, S. L., Meyerson, M. and Sabatini, D. M. (2013). A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 340, 1100-1106.
-
(2013)
Science
, vol.340
, pp. 1100-1106
-
-
Bar-Peled, L.1
Chantranupong, L.2
Cherniack, A.D.3
Chen, W.W.4
Ottina, K.A.5
Grabiner, B.C.6
Spear, E.D.7
Carter, S.L.8
Meyerson, M.9
Sabatini, D.M.10
-
11
-
-
84925408245
-
Genetics advances in autosomal dominant focal epilepsies: focus on DEPDC5
-
Baulac, S. (2014). Genetics advances in autosomal dominant focal epilepsies: focus on DEPDC5. Prog. Brain Res. 213, 123-139.
-
(2014)
Prog. Brain Res
, vol.213
, pp. 123-139
-
-
Baulac, S.1
-
12
-
-
84890149646
-
Where is mTOR and what is it doing there?
-
Betz, C. and Hall, M. N. (2013). Where is mTOR and what is it doing there? J. Cell Biol. 203, 563-574.
-
(2013)
J. Cell Biol
, vol.203
, pp. 563-574
-
-
Betz, C.1
Hall, M.N.2
-
13
-
-
69749113579
-
The Vam6 GEF controls TORC1 by activating the EGO complex
-
Binda, M., Péli-Gulli, M. P., Bonfils, G., Panchaud, N., Urban, J., Sturgill, T. W., Loewith, R. and De Virgilio, C. (2009). The Vam6 GEF controls TORC1 by activating the EGO complex. Mol. Cell 35, 563-573.
-
(2009)
Mol. Cell
, vol.35
, pp. 563-573
-
-
Binda, M.1
Péli-Gulli, M.P.2
Bonfils, G.3
Panchaud, N.4
Urban, J.5
Sturgill, T.W.6
Loewith, R.7
De Virgilio, C.8
-
14
-
-
84859704385
-
Leucyl-tRNA synthetase controls TORC1 via the EGO complex
-
Bonfils, G., Jaquenoud, M., Bontron, S., Ostrowicz, C., Ungermann, C. and De Virgilio, C. (2012). Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol. Cell 46, 105-110.
-
(2012)
Mol. Cell
, vol.46
, pp. 105-110
-
-
Bonfils, G.1
Jaquenoud, M.2
Bontron, S.3
Ostrowicz, C.4
Ungermann, C.5
De Virgilio, C.6
-
15
-
-
77953077420
-
A global protein kinase and phosphatase interaction network in yeast
-
Breitkreutz, A., Choi, H., Sharom, J. R., Boucher, L., Neduva, V., Larsen, B., Lin, Z. Y., Breitkreutz, B. J., Stark, C., Liu, G. et al. (2010). A global protein kinase and phosphatase interaction network in yeast. Science 328, 1043-1046.
-
(2010)
Science
, vol.328
, pp. 1043-1046
-
-
Breitkreutz, A.1
Choi, H.2
Sharom, J.R.3
Boucher, L.4
Neduva, V.5
Larsen, B.6
Lin, Z.Y.7
Breitkreutz, B.J.8
Stark, C.9
Liu, G.10
-
16
-
-
1842665662
-
Mitochondrial signaling: the retrograde response
-
Butow, R. A. and Avadhani, N. G. (2004). Mitochondrial signaling: the retrograde response. Mol. Cell 14, 1-15.
-
(2004)
Mol. Cell
, vol.14
, pp. 1-15
-
-
Butow, R.A.1
Avadhani, N.G.2
-
17
-
-
84907991157
-
The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1
-
Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P. and Sabatini, D. M. (2014). The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1. Cell Reports 9, 1-8.
-
(2014)
Cell Reports
, vol.9
, pp. 1-8
-
-
Chantranupong, L.1
Wolfson, R.L.2
Orozco, J.M.3
Saxton, R.A.4
Scaria, S.M.5
Bar-Peled, L.6
Spooner, E.7
Isasa, M.8
Gygi, S.P.9
Sabatini, D.M.10
-
18
-
-
75649111192
-
The genetic landscape of a cell
-
Costanzo, M., Baryshnikova, A., Bellay, J., Kim, Y., Spear, E. D., Sevier, C. S., Ding, H., Koh, J. L., Toufighi, K., Mostafavi, S. et al. (2010). The genetic landscape of a cell. Science 327, 425-431.
-
(2010)
Science
, vol.327
, pp. 425-431
-
-
Costanzo, M.1
Baryshnikova, A.2
Bellay, J.3
Kim, Y.4
Spear, E.D.5
Sevier, C.S.6
Ding, H.7
Koh, J.L.8
Toufighi, K.9
Mostafavi, S.10
-
19
-
-
46249109085
-
Focal brain malformations: a spectrum of disorders along the mTOR cascade
-
discussion 272-281
-
Crino, P. B. (2007). Focal brain malformations: a spectrum of disorders along the mTOR cascade. Novartis Found. Symp. 288, 260-272, discussion 272-281.
-
(2007)
Novartis Found. Symp
, vol.288
, pp. 260-272
-
-
Crino, P.B.1
-
20
-
-
84855958205
-
mTOR: A pathogenic signaling pathway in developmental brain malformations
-
Crino, P. B. (2011). mTOR: A pathogenic signaling pathway in developmental brain malformations. Trends Mol. Med. 17, 734-742.
-
(2011)
Trends Mol. Med
, vol.17
, pp. 734-742
-
-
Crino, P.B.1
-
21
-
-
9444273167
-
Components of coated vesicles and nuclear pore complexes share a common molecular architecture
-
Devos, D., Dokudovskaya, S., Alber, F., Williams, R., Chait, B. T., Sali, A. and Rout, M. P. (2004). Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol. 2, e380.
-
(2004)
PLoS Biol
, vol.2
-
-
Devos, D.1
Dokudovskaya, S.2
Alber, F.3
Williams, R.4
Chait, B.T.5
Sali, A.6
Rout, M.P.7
-
22
-
-
84878352545
-
Mutations in DEPDC5 cause familial focal epilepsy with variable foci
-
Dibbens, L. M., de Vries, B., Donatello, S., Heron, S. E., Hodgson, B. L., Chintawar, S., Crompton, D. E., Hughes, J. N., Bellows, S. T., Klein, K. M. et al. (2013). Mutations in DEPDC5 cause familial focal epilepsy with variable foci. Nat. Genet. 45, 546-551.
-
(2013)
Nat. Genet
, vol.45
, pp. 546-551
-
-
Dibbens, L.M.1
de Vries, B.2
Donatello, S.3
Heron, S.E.4
Hodgson, B.L.5
Chintawar, S.6
Crompton, D.E.7
Hughes, J.N.8
Bellows, S.T.9
Klein, K.M.10
-
23
-
-
84878532557
-
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
-
Dibble, C. C. and Manning, B. D. (2013). Signal integration by mTORC1 coordinates nutrient input with biosynthetic output. Nat. Cell Biol. 15, 555-564.
-
(2013)
Nat. Cell Biol
, vol.15
, pp. 555-564
-
-
Dibble, C.C.1
Manning, B.D.2
-
24
-
-
0036143156
-
Systematic identification of novel protein domain families associated with nuclear functions
-
Doerks, T., Copley, R. R., Schultz, J., Ponting, C. P. and Bork, P. (2002). Systematic identification of novel protein domain families associated with nuclear functions. Genome Res. 12, 47-56.
-
(2002)
Genome Res
, vol.12
, pp. 47-56
-
-
Doerks, T.1
Copley, R.R.2
Schultz, J.3
Ponting, C.P.4
Bork, P.5
-
25
-
-
80655124346
-
A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation
-
Dokudovskaya, S. and Rout, M. P. (2011). A novel coatomer-related SEA complex dynamically associates with the vacuole in yeast and is implicated in the response to nitrogen starvation. Autophagy 7, 1392-1393.
-
(2011)
Autophagy
, vol.7
, pp. 1392-1393
-
-
Dokudovskaya, S.1
Rout, M.P.2
-
26
-
-
79957971892
-
A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae
-
Dokudovskaya, S., Waharte, F., Schlessinger, A., Pieper, U., Devos, D. P., Cristea, I. M., Williams, R., Salamero, J., Chait, B. T., Sali, A. et al. (2011). A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol. Cell. Proteomics 10, M110 006478.
-
(2011)
Mol. Cell. Proteomics
, vol.10
-
-
Dokudovskaya, S.1
Waharte, F.2
Schlessinger, A.3
Pieper, U.4
Devos, D.P.5
Cristea, I.M.6
Williams, R.7
Salamero, J.8
Chait, B.T.9
Sali, A.10
-
27
-
-
84904270185
-
A dynamic interface between vacuoles and mitochondria in yeast
-
Elbaz-Alon, Y., Rosenfeld-Gur, E., Shinder, V., Futerman, A. H., Geiger, T. and Schuldiner, M. (2014). A dynamic interface between vacuoles and mitochondria in yeast. Dev. Cell 30, 95-102.
-
(2014)
Dev. Cell
, vol.30
, pp. 95-102
-
-
Elbaz-Alon, Y.1
Rosenfeld-Gur, E.2
Shinder, V.3
Futerman, A.H.4
Geiger, T.5
Schuldiner, M.6
-
28
-
-
0037277456
-
Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae
-
Enyenihi, A. H. and Saunders, W. S. (2003). Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163, 47-54.
-
(2003)
Genetics
, vol.163
, pp. 47-54
-
-
Enyenihi, A.H.1
Saunders, W.S.2
-
29
-
-
34250745253
-
Structure and organization of coat proteins in the COPII cage
-
Fath, S., Mancias, J. D., Bi, X. and Goldberg, J. (2007). Structure and organization of coat proteins in the COPII cage. Cell 129, 1325-1336.
-
(2007)
Cell
, vol.129
, pp. 1325-1336
-
-
Fath, S.1
Mancias, J.D.2
Bi, X.3
Goldberg, J.4
-
30
-
-
79959413234
-
Evolution: On a bender-BARs, ESCRTs, COPs, and finally getting your coat
-
Field, M. C., Sali, A. and Rout, M. P. (2011). Evolution: On a bender-BARs, ESCRTs, COPs, and finally getting your coat. J. Cell Biol. 193, 963-972.
-
(2011)
J. Cell Biol
, vol.193
, pp. 963-972
-
-
Field, M.C.1
Sali, A.2
Rout, M.P.3
-
31
-
-
84859771379
-
Molecular mechanisms of cisplatin resistance
-
Galluzzi, L., Senovilla, L., Vitale, I., Michels, J., Martins, I., Kepp, O., Castedo, M. and Kroemer, G. (2012). Molecular mechanisms of cisplatin resistance. Oncogene 31, 1869-1883.
-
(2012)
Oncogene
, vol.31
, pp. 1869-1883
-
-
Galluzzi, L.1
Senovilla, L.2
Vitale, I.3
Michels, J.4
Martins, I.5
Kepp, O.6
Castedo, M.7
Kroemer, G.8
-
32
-
-
34147208413
-
Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiae
-
Godard, P., Urrestarazu, A., Vissers, S., Kontos, K., Bontempi, G., van Helden, J. and André, B. (2007). Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 27, 3065-3086.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 3065-3086
-
-
Godard, P.1
Urrestarazu, A.2
Vissers, S.3
Kontos, K.4
Bontempi, G.5
van Helden, J.6
André, B.7
-
33
-
-
79957923566
-
Mitochondria regulate autophagy by conserved signalling pathways
-
Graef, M. and Nunnari, J. (2011). Mitochondria regulate autophagy by conserved signalling pathways. EMBO J. 30, 2101-2114.
-
(2011)
EMBO J
, vol.30
, pp. 2101-2114
-
-
Graef, M.1
Nunnari, J.2
-
34
-
-
77952876927
-
New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients
-
Granados-Principal, S., Quiles, J. L., Ramirez-Tortosa, C. L., Sanchez-Rovira, P. and Ramirez-Tortosa, M. C. (2010). New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients. Food Chem. Toxicol. 48, 1425-1438.
-
(2010)
Food Chem. Toxicol
, vol.48
, pp. 1425-1438
-
-
Granados-Principal, S.1
Quiles, J.L.2
Ramirez-Tortosa, C.L.3
Sanchez-Rovira, P.4
Ramirez-Tortosa, M.C.5
-
35
-
-
84880523573
-
Talks about TORCs: recent advancesin target of rapamycin signalling
-
Hall, M. N. (2013). Talks about TORCs: recent advancesin target of rapamycin signalling. On mTOR nomenclature. Biochem. Soc. Trans. 41, 887-888.
-
(2013)
On mTOR nomenclature. Biochem. Soc. Trans
, vol.41
, pp. 887-888
-
-
Hall, M.N.1
-
36
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
-
Han, J. M., Jeong, S. J., Park, M. C., Kim, G., Kwon, N. H., Kim, H. K., Ha, S. H., Ryu, S. H. and Kim, S. (2012). Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 149, 410-424.
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
Ha, S.H.7
Ryu, S.H.8
Kim, S.9
-
37
-
-
42349100173
-
The chemical genomic portrait of yeast: uncovering a phenotype for all genes
-
Hillenmeyer, M. E., Fung, E., Wildenhain, J., Pierce, S. E., Hoon, S., Lee, W., Proctor, M., St Onge, R. P., Tyers, M., Koller, D. et al. (2008). The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science 320, 362-365.
-
(2008)
Science
, vol.320
, pp. 362-365
-
-
Hillenmeyer, M.E.1
Fung, E.2
Wildenhain, J.3
Pierce, S.E.4
Hoon, S.5
Lee, W.6
Proctor, M.7
St Onge, R.P.8
Tyers, M.9
Koller, D.10
-
38
-
-
0242300110
-
A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery
-
Hitchcock, A. L., Auld, K., Gygi, S. P. and Silver, P. A. (2003). A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc. Natl. Acad. Sci. USA 100, 12735-12740.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12735-12740
-
-
Hitchcock, A.L.1
Auld, K.2
Gygi, S.P.3
Silver, P.A.4
-
39
-
-
84908031923
-
State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae
-
Hughes Hallett, J. E., Luo, X. and Capaldi, A. P. (2014). State transitions in the TORC1 signaling pathway and information processing in Saccharomyces cerevisiae. Genetics 198, 773-786.
-
(2014)
Genetics
, vol.198
, pp. 773-786
-
-
Hughes Hallett, J.E.1
Luo, X.2
Capaldi, A.P.3
-
40
-
-
84905264803
-
Convergence of ubiquitylation and phosphorylation signaling in rapamycin-treated yeast cells
-
Iesmantavicius, V., Weinert, B. T. and Choudhary, C. (2014). Convergence of ubiquitylation and phosphorylation signaling in rapamycin-treated yeast cells. Mol. Cell. Proteomics 13, 1979-1992.
-
(2014)
Mol. Cell. Proteomics
, vol.13
, pp. 1979-1992
-
-
Iesmantavicius, V.1
Weinert, B.T.2
Choudhary, C.3
-
41
-
-
1642277028
-
missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila
-
Iida, T. and Lilly, M. A. (2004). missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila. Development 131, 1029-1039.
-
(2004)
Development
, vol.131
, pp. 1029-1039
-
-
Iida, T.1
Lilly, M.A.2
-
42
-
-
84878366242
-
Mutations of DEPDC5 cause autosomal dominant focal epilepsies
-
Ishida, S., Picard, F., Rudolf, G., Noé, E., Achaz, G., Thomas, P., Genton, P., Mundwiller, E., Wolff, M., Marescaux, C. et al. (2013). Mutations of DEPDC5 cause autosomal dominant focal epilepsies. Nat. Genet. 45, 552-555.
-
(2013)
Nat. Genet
, vol.45
, pp. 552-555
-
-
Ishida, S.1
Picard, F.2
Rudolf, G.3
Noé, E.4
Achaz, G.5
Thomas, P.6
Genton, P.7
Mundwiller, E.8
Wolff, M.9
Marescaux, C.10
-
43
-
-
77957814634
-
NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway
-
Jayachandran, G., Ueda, K., Wang, B., Roth, J. A. and Ji, L. (2010). NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. PLoS ONE 5, e11994.
-
(2010)
PLoS ONE
, vol.5
-
-
Jayachandran, G.1
Ueda, K.2
Wang, B.3
Roth, J.A.4
Ji, L.5
-
44
-
-
84866409979
-
The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction
-
Jazwinski, S. M. and Kriete, A. (2012). The yeast retrograde response as a model of intracellular signaling of mitochondrial dysfunction. Front. Physiol. 3, 139.
-
(2012)
Front. Physiol
, vol.3
, pp. 139
-
-
Jazwinski, S.M.1
Kriete, A.2
-
45
-
-
84922727084
-
Metabolism. Differential regulation of mTORC1 by leucine and glutamine
-
Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F. X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S. and Guan, K. L. (2015). Metabolism. Differential regulation of mTORC1 by leucine and glutamine. Science 347, 194-198.
-
(2015)
Science
, vol.347
, pp. 194-198
-
-
Jewell, J.L.1
Kim, Y.C.2
Russell, R.C.3
Yu, F.X.4
Park, H.W.5
Plouffe, S.W.6
Tagliabracci, V.S.7
Guan, K.L.8
-
46
-
-
0036569946
-
Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo
-
Ji, L., Nishizaki, M., Gao, B., Burbee, D., Kondo, M., Kamibayashi, C., Xu, K., Yen, N., Atkinson, E. N., Fang, B. et al. (2002). Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Cancer Res. 62, 2715-2720.
-
(2002)
Cancer Res
, vol.62
, pp. 2715-2720
-
-
Ji, L.1
Nishizaki, M.2
Gao, B.3
Burbee, D.4
Kondo, M.5
Kamibayashi, C.6
Xu, K.7
Yen, N.8
Atkinson, E.N.9
Fang, B.10
-
47
-
-
80053440197
-
Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae
-
Kawai, S., Urban, J., Piccolis, M., Panchaud, N., De Virgilio, C. and Loewith, R. (2011). Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae. Eukaryot. Cell 10, 1367-1369.
-
(2011)
Eukaryot. Cell
, vol.10
, pp. 1367-1369
-
-
Kawai, S.1
Urban, J.2
Piccolis, M.3
Panchaud, N.4
De Virgilio, C.5
Loewith, R.6
-
48
-
-
84863009605
-
SH3BP4 is a negative regulator of amino acid-Rag GTPasemTORC1 signaling
-
Kim, Y. M., Stone, M., Hwang, T. H., Kim, Y. G., Dunlevy, J. R., Griffin, T. J. and Kim, D. H. (2012). SH3BP4 is a negative regulator of amino acid-Rag GTPasemTORC1 signaling. Mol. Cell 46, 833-846.
-
(2012)
Mol. Cell
, vol.46
, pp. 833-846
-
-
Kim, Y.M.1
Stone, M.2
Hwang, T.H.3
Kim, Y.G.4
Dunlevy, J.R.5
Griffin, T.J.6
Kim, D.H.7
-
49
-
-
84907178314
-
Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy
-
Kira, S., Tabata, K., Shirahama-Noda, K., Nozoe, A., Yoshimori, T. and Noda, T. (2014). Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy. Autophagy 10, 1565-1578.
-
(2014)
Autophagy
, vol.10
, pp. 1565-1578
-
-
Kira, S.1
Tabata, K.2
Shirahama-Noda, K.3
Nozoe, A.4
Yoshimori, T.5
Noda, T.6
-
50
-
-
84865125882
-
Nprl3 is required for normal development of the cardiovascular system
-
Kowalczyk, M. S., Hughes, J. R., Babbs, C., Sanchez-Pulido, L., Szumska, D., Sharpe, J. A., Sloane-Stanley, J. A., Morriss-Kay, G. M., Smoot, L. B., Roberts, A. E. et al. (2012a). Nprl3 is required for normal development of the cardiovascular system. Mamm. Genome 23, 404-415.
-
(2012)
Mamm. Genome
, vol.23
, pp. 404-415
-
-
Kowalczyk, M.S.1
Hughes, J.R.2
Babbs, C.3
Sanchez-Pulido, L.4
Szumska, D.5
Sharpe, J.A.6
Sloane-Stanley, J.A.7
Morriss-Kay, G.M.8
Smoot, L.B.9
Roberts, A.E.10
-
51
-
-
84862778066
-
Intragenic enhancers act as alternative promoters
-
Kowalczyk, M. S., Hughes, J. R., Garrick, D., Lynch, M. D., Sharpe, J. A., Sloane-Stanley, J. A., McGowan, S. J., De Gobbi, M., Hosseini, M., Vernimmen, D. et al. (2012b). Intragenic enhancers act as alternative promoters. Mol. Cell 45, 447-458.
-
(2012)
Mol. Cell
, vol.45
, pp. 447-458
-
-
Kowalczyk, M.S.1
Hughes, J.R.2
Garrick, D.3
Lynch, M.D.4
Sharpe, J.A.5
Sloane-Stanley, J.A.6
McGowan, S.J.7
De Gobbi, M.8
Hosseini, M.9
Vernimmen, D.10
-
52
-
-
50149086076
-
TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling
-
Kurata, A., Katayama, R., Watanabe, T., Tsuruo, T. and Fujita, N. (2008). TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. Cancer Sci. 99, 1827-1834.
-
(2008)
Cancer Sci
, vol.99
, pp. 1827-1834
-
-
Kurata, A.1
Katayama, R.2
Watanabe, T.3
Tsuruo, T.4
Fujita, N.5
-
53
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante, M. and Sabatini, D. M. (2012). mTOR signaling in growth control and disease. Cell 149, 274-293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
54
-
-
84880536607
-
Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation
-
Laxman, S., Sutter, B. M., Wu, X., Kumar, S., Guo, X., Trudgian, D. C., Mirzaei, H. and Tu, B. P. (2013). Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation. Cell 154, 416-429.
-
(2013)
Cell
, vol.154
, pp. 416-429
-
-
Laxman, S.1
Sutter, B.M.2
Wu, X.3
Kumar, S.4
Guo, X.5
Trudgian, D.C.6
Mirzaei, H.7
Tu, B.P.8
-
55
-
-
84919400169
-
Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogencontaining metabolites
-
Laxman, S., Sutter, B. M., Shi, L. and Tu, B. P. (2014). Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogencontaining metabolites. Sci. Signal. 7, ra120.
-
(2014)
Sci. Signal
, vol.7
-
-
Laxman, S.1
Sutter, B.M.2
Shi, L.3
Tu, B.P.4
-
56
-
-
77954310096
-
Structure of coatomer cage proteins and the relationship among COPI, COPII, and clathrin vesicle coats
-
Lee, C. and Goldberg, J. (2010). Structure of coatomer cage proteins and the relationship among COPI, COPII, and clathrin vesicle coats. Cell 142, 123-132.
-
(2010)
Cell
, vol.142
, pp. 123-132
-
-
Lee, C.1
Goldberg, J.2
-
57
-
-
33847638535
-
AWD40 repeat protein, Arabidopsis Sec13 homolog 1, may play a role in vacuolar trafficking by controlling the membrane association of AtDRP2A
-
Lee, M. H., Lee, S. H., Kim, H., Jin, J. B., Kim, D. H. and Hwang, I. (2006). AWD40 repeat protein, Arabidopsis Sec13 homolog 1, may play a role in vacuolar trafficking by controlling the membrane association of AtDRP2A. Mol. Cells 22, 210-219.
-
(2006)
Mol. Cells
, vol.22
, pp. 210-219
-
-
Lee, M.H.1
Lee, S.H.2
Kim, H.3
Jin, J.B.4
Kim, D.H.5
Hwang, I.6
-
58
-
-
0034327412
-
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor gene. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
-
Lerman, M. I. and Minna, J. D. (2000). The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Cancer Res. 60, 6116-6133.
-
(2000)
Cancer Res
, vol.60
, pp. 6116-6133
-
-
Lerman, M.I.1
Minna, J.D.2
-
59
-
-
84876431000
-
Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II
-
Levine, T. P., Daniels, R. D., Wong, L. H., Gatta, A. T., Gerondopoulos, A. and Barr, F. A. (2013). Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II. Small GTPases 4, 62-69.
-
(2013)
Small GTPases
, vol.4
, pp. 62-69
-
-
Levine, T.P.1
Daniels, R.D.2
Wong, L.H.3
Gatta, A.T.4
Gerondopoulos, A.5
Barr, F.A.6
-
60
-
-
62949218373
-
The yeast lysosome-like vacuole: endpoint and crossroads
-
Li, S. C. and Kane, P. M. (2009). The yeast lysosome-like vacuole: endpoint and crossroads. Biochim. Biophys. Acta 1793, 650-663.
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 650-663
-
-
Li, S.C.1
Kane, P.M.2
-
61
-
-
4644279735
-
Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C
-
Li, J., Wang, F., Haraldson, K., Protopopov, A., Duh, F. M., Geil, L., Kuzmin, I., Minna, J. D., Stanbridge, E., Braga, E. et al. (2004). Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C. Cancer Res. 64, 6438-6443.
-
(2004)
Cancer Res
, vol.64
, pp. 6438-6443
-
-
Li, J.1
Wang, F.2
Haraldson, K.3
Protopopov, A.4
Duh, F.M.5
Geil, L.6
Kuzmin, I.7
Minna, J.D.8
Stanbridge, E.9
Braga, E.10
-
62
-
-
84884171372
-
Focal malformations of cortical development: new vistas for molecular pathogenesis
-
Lim, K. C. and Crino, P. B. (2013). Focal malformations of cortical development: new vistas for molecular pathogenesis. Neuroscience 252, 262-276.
-
(2013)
Neuroscience
, vol.252
, pp. 262-276
-
-
Lim, K.C.1
Crino, P.B.2
-
63
-
-
84899823395
-
Relationship between tumor and peripheral blood NPRL2 mRNA levels in patients with colorectal adenoma and colorectal cancer
-
Liu, A. Y., Liu, D. G., Du, Y. J., Pei, F. H., Yang, G., Liu, B. R., Zhang, H. T., Wang, X. H., Fan, Y. J., Chen, Y. Z. et al. (2014). Relationship between tumor and peripheral blood NPRL2 mRNA levels in patients with colorectal adenoma and colorectal cancer. Cancer Biol. Ther. 15, 489-495.
-
(2014)
Cancer Biol. Ther
, vol.15
, pp. 489-495
-
-
Liu, A.Y.1
Liu, D.G.2
Du, Y.J.3
Pei, F.H.4
Yang, G.5
Liu, B.R.6
Zhang, H.T.7
Wang, X.H.8
Fan, Y.J.9
Chen, Y.Z.10
-
64
-
-
84858183302
-
Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae
-
Ljungdahl, P. O. and Daignan-Fornier, B. (2012). Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae. Genetics 190, 885-929.
-
(2012)
Genetics
, vol.190
, pp. 885-929
-
-
Ljungdahl, P.O.1
Daignan-Fornier, B.2
-
65
-
-
83455177213
-
Target of rapamycin (TOR) in nutrient signaling and growth control
-
Loewith, R. and Hall, M. N. (2011). Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 189, 1177-1201.
-
(2011)
Genetics
, vol.189
, pp. 1177-1201
-
-
Loewith, R.1
Hall, M.N.2
-
66
-
-
69249205372
-
The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73
-
Lunardi, A., Chiacchiera, F., D'Este, E., Carotti, M., Dal Ferro, M., Di Minin, G., Del Sal, G. and Collavin, L. (2009). The evolutionary conserved gene C16orf35 encodes a nucleo-cytoplasmic protein that interacts with p73. Biochem. Biophys. Res. Commun. 388, 428-433.
-
(2009)
Biochem. Biophys. Res. Commun
, vol.388
, pp. 428-433
-
-
Lunardi, A.1
Chiacchiera, F.2
D'Este, E.3
Carotti, M.4
Dal Ferro, M.5
Di Minin, G.6
Del Sal, G.7
Collavin, L.8
-
67
-
-
34547134198
-
Lysosomes: fusion and function
-
Luzio, J. P., Pryor, P. R. and Bright, N. A. (2007). Lysosomes: fusion and function. Nat. Rev. Mol. Cell Biol. 8, 622-632.
-
(2007)
Nat. Rev. Mol. Cell Biol
, vol.8
, pp. 622-632
-
-
Luzio, J.P.1
Pryor, P.R.2
Bright, N.A.3
-
68
-
-
84884966776
-
TORC1 signaling is governed by two negative regulators in fission yeast
-
Ma, N., Liu, Q., Zhang, L., Henske, E. P. and Ma, Y. (2013). TORC1 signaling is governed by two negative regulators in fission yeast. Genetics 195, 457-468.
-
(2013)
Genetics
, vol.195
, pp. 457-468
-
-
Ma, N.1
Liu, Q.2
Zhang, L.3
Henske, E.P.4
Ma, Y.5
-
69
-
-
84857859388
-
Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1
-
Michaillat, L., Baars, T. L. and Mayer, A. (2012). Cell-free reconstitution of vacuole membrane fragmentation reveals regulation of vacuole size and number by TORC1. Mol. Biol. Cell 23, 881-895.
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 881-895
-
-
Michaillat, L.1
Baars, T.L.2
Mayer, A.3
-
70
-
-
3342991427
-
Solution structure of the RWD domain of the mouse GCN2 protein
-
Nameki, N., Yoneyama, M., Koshiba, S., Tochio, N., Inoue, M., Seki, E., Matsuda, T., Tomo, Y., Harada, T., Saito, K. et al. (2004). Solution structure of the RWD domain of the mouse GCN2 protein. Protein Sci. 13, 2089-2100.
-
(2004)
Protein Sci
, vol.13
, pp. 2089-2100
-
-
Nameki, N.1
Yoneyama, M.2
Koshiba, S.3
Tochio, N.4
Inoue, M.5
Seki, E.6
Matsuda, T.7
Tomo, Y.8
Harada, T.9
Saito, K.10
-
71
-
-
0034973590
-
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast
-
Natarajan, K., Meyer, M. R., Jackson, B. M., Slade, D., Roberts, C., Hinnebusch, A. G. and Marton, M. J. (2001). Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol. Cell. Biol. 21, 4347-4368.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 4347-4368
-
-
Natarajan, K.1
Meyer, M.R.2
Jackson, B.M.3
Slade, D.4
Roberts, C.5
Hinnebusch, A.G.6
Marton, M.J.7
-
72
-
-
67651235863
-
A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex
-
Neklesa, T. K. and Davis, R. W. (2009). A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex. PLoS Genet. 5, e1000515.
-
(2009)
PLoS Genet
, vol.5
-
-
Neklesa, T.K.1
Davis, R.W.2
-
73
-
-
67949091245
-
Vps-C complexes: gatekeepers of endolysosomal traffic
-
Nickerson, D. P., Brett, C. L. and Merz, A. J. (2009). Vps-C complexes: gatekeepers of endolysosomal traffic. Curr. Opin. Cell Biol. 21, 543-551.
-
(2009)
Curr. Opin. Cell Biol
, vol.21
, pp. 543-551
-
-
Nickerson, D.P.1
Brett, C.L.2
Merz, A.J.3
-
74
-
-
84870859143
-
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer
-
Nookala, R. K., Langemeyer, L., Pacitto, A., Ochoa-Montaño, B., Donaldson, J. C., Blaszczyk, B. K., Chirgadze, D. Y., Barr, F. A., Bazan, J. F. and Blundell, T. L. (2012). Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer. Open Biol. 2, 120071.
-
(2012)
Open Biol
, vol.2
-
-
Nookala, R.K.1
Langemeyer, L.2
Pacitto, A.3
Ochoa-Montaño, B.4
Donaldson, J.C.5
Blaszczyk, B.K.6
Chirgadze, D.Y.7
Barr, F.A.8
Bazan, J.F.9
Blundell, T.L.10
-
75
-
-
84893477830
-
Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging
-
Oshiro, N., Rapley, J. and Avruch, J. (2014). Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J. Biol. Chem. 289, 2658-2674.
-
(2014)
J. Biol. Chem
, vol.289
, pp. 2658-2674
-
-
Oshiro, N.1
Rapley, J.2
Avruch, J.3
-
76
-
-
70349260217
-
The tumor suppressor NPRL2 in hepatocellular carcinoma plays an important role in progression and can be served as an independent prognostic factor
-
Otani, S., Takeda, S., Yamada, S., Sakakima, Y., Sugimoto, H., Nomoto, S., Kasuya, H., Kanazumi, N., Nagasaka, T. and Nakao, A. (2009). The tumor suppressor NPRL2 in hepatocellular carcinoma plays an important role in progression and can be served as an independent prognostic factor. J. Surg. Oncol. 100, 358-363.
-
(2009)
J. Surg. Oncol
, vol.100
, pp. 358-363
-
-
Otani, S.1
Takeda, S.2
Yamada, S.3
Sakakima, Y.4
Sugimoto, H.5
Nomoto, S.6
Kasuya, H.7
Kanazumi, N.8
Nagasaka, T.9
Nakao, A.10
-
77
-
-
84878353147
-
Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1
-
Panchaud, N., Péli-Gulli, M. P. and De Virgilio, C. (2013a). Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Sci. Signal. 6, ra42.
-
(2013)
Sci. Signal
, vol.6
-
-
Panchaud, N.1
Péli-Gulli, M.P.2
De Virgilio, C.3
-
78
-
-
84884889883
-
SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation
-
Panchaud, N., Péli-Gulli, M. P. and De Virgilio, C. (2013b). SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation. Cell Cycle 12, 2948-2952.
-
(2013)
Cell Cycle
, vol.12
, pp. 2948-2952
-
-
Panchaud, N.1
Péli-Gulli, M.P.2
De Virgilio, C.3
-
79
-
-
84912128530
-
Sestrins inhibit mTORC1 kinase activation through the GATOR complex
-
Parmigiani, A., Nourbakhsh, A., Ding, B., Wang, W., Kim, Y. C., Akopiants, K., Guan, K. L., Karin, M. and Budanov, A. V. (2014). Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Reports 9, 1281-1291.
-
(2014)
Cell Reports
, vol.9
, pp. 1281-1291
-
-
Parmigiani, A.1
Nourbakhsh, A.2
Ding, B.3
Wang, W.4
Kim, Y.C.5
Akopiants, K.6
Guan, K.L.7
Karin, M.8
Budanov, A.V.9
-
80
-
-
0032031607
-
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast
-
Patton, E. E., Willems, A. R., Sa, D., Kuras, L., Thomas, D., Craig, K. L. and Tyers, M. (1998). Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast. Genes Dev. 12, 692-705.
-
(1998)
Genes Dev
, vol.12
, pp. 692-705
-
-
Patton, E.E.1
Willems, A.R.2
Sa, D.3
Kuras, L.4
Thomas, D.5
Craig, K.L.6
Tyers, M.7
-
81
-
-
84907525131
-
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling
-
Peng, M., Yin, N. and Li, M. O. (2014). Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling. Cell 159, 122-133.
-
(2014)
Cell
, vol.159
, pp. 122-133
-
-
Peng, M.1
Yin, N.2
Li, M.O.3
-
82
-
-
84886871016
-
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
-
Petit, C. S., Roczniak-Ferguson, A. and Ferguson, S. M. (2013). Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases. J. Cell Biol. 202, 1107-1122.
-
(2013)
J. Cell Biol
, vol.202
, pp. 1107-1122
-
-
Petit, C.S.1
Roczniak-Ferguson, A.2
Ferguson, S.M.3
-
83
-
-
84925777835
-
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
-
[Epub ahead of print]
-
Rebsamen, M., Pochini, L., Stasyk, T., de Araujo, M. E., Galluccio, M., Kandasamy, R. K., Snijder, B., Fauster, A., Rudashevskaya, E. L., Bruckner, M. et al. (2015). SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature [Epub ahead of print] .
-
(2015)
Nature
-
-
Rebsamen, M.1
Pochini, L.2
Stasyk, T.3
de Araujo, M.E.4
Galluccio, M.5
Kandasamy, R.K.6
Snijder, B.7
Fauster, A.8
Rudashevskaya, E.L.9
Bruckner, M.10
-
84
-
-
0028840055
-
A second nitrogen permease regulator in Saccharomyces cerevisiae
-
Rousselet, G., Simon, M., Ripoche, P. and Buhler, J. M. (1995). A second nitrogen permease regulator in Saccharomyces cerevisiae. FEBS Lett. 359, 215-219.
-
(1995)
FEBS Lett
, vol.359
, pp. 215-219
-
-
Rousselet, G.1
Simon, M.2
Ripoche, P.3
Buhler, J.M.4
-
85
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L. and Sabatini, D. M. (2008). The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
86
-
-
77951768486
-
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S. and Sabatini, D. M. (2010). Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303.
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
87
-
-
84902281810
-
Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations
-
Scheffer, I. E., Heron, S. E., Regan, B. M., Mandelstam, S., Crompton, D. E., Hodgson, B. L., Licchetta, L., Provini, F., Bisulli, F., Vadlamudi, L. et al. (2014). Mutations in mammalian target of rapamycin regulator DEPDC5 cause focal epilepsy with brain malformations. Ann. Neurol. 75, 782-787.
-
(2014)
Ann. Neurol
, vol.75
, pp. 782-787
-
-
Scheffer, I.E.1
Heron, S.E.2
Regan, B.M.3
Mandelstam, S.4
Crompton, D.E.5
Hodgson, B.L.6
Licchetta, L.7
Provini, F.8
Bisulli, F.9
Vadlamudi, L.10
-
88
-
-
0042844651
-
Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin-and doxorubicin-provoked cell kill
-
Schenk, P.W., Brok, M., Boersma, A.W., Brandsma, J. A., Den Dulk, H., Burger, H., Stoter, G., Brouwer, J. and Nooter, K. (2003). Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin-and doxorubicin-provoked cell kill. Mol. Pharmacol. 64, 259-268.
-
(2003)
Mol. Pharmacol
, vol.64
, pp. 259-268
-
-
Schenk, P.W.1
Brok, M.2
Boersma, A.W.3
Brandsma, J.A.4
Den Dulk, H.5
Burger, H.6
Stoter, G.7
Brouwer, J.8
Nooter, K.9
-
89
-
-
35948985511
-
Integral and associated lysosomal membrane proteins
-
Schröder, B., Wrocklage, C., Pan, C., Jäger, R., Kösters, B., Schäfer, H., Elsässer, H. P., Mann, M. and Hasilik, A. (2007). Integral and associated lysosomal membrane proteins. Traffic 8, 1676-1686.
-
(2007)
Traffic
, vol.8
, pp. 1676-1686
-
-
Schröder, B.1
Wrocklage, C.2
Pan, C.3
Jäger, R.4
Kösters, B.5
Schäfer, H.6
Elsässer, H.P.7
Mann, M.8
Hasilik, A.9
-
90
-
-
0031931222
-
Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor
-
Schuldiner, O., Yanover, C. and Benvenisty, N. (1998). Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor. Curr. Genet. 33, 16-20.
-
(1998)
Curr. Genet
, vol.33
, pp. 16-20
-
-
Schuldiner, O.1
Yanover, C.2
Benvenisty, N.3
-
91
-
-
79955567724
-
The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis
-
Senger, S., Csokmay, J., Akbar, T., Jones, T. I., Sengupta, P. and Lilly, M. A. (2011). The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. Development 138, 2133-2142.
-
(2011)
Development
, vol.138
, pp. 2133-2142
-
-
Senger, S.1
Csokmay, J.2
Akbar, T.3
Jones, T.I.4
Sengupta, P.5
Lilly, M.A.6
-
92
-
-
0034599816
-
Structure and assembly of the Nup84p complex
-
Siniossoglou, S., Lutzmann, M., Santos-Rosa, H., Leonard, K., Mueller, S., Aebi, U. and Hurt, E. (2000). Structure and assembly of the Nup84p complex. J. Cell Biol. 149, 41-54.
-
(2000)
J. Cell Biol
, vol.149
, pp. 41-54
-
-
Siniossoglou, S.1
Lutzmann, M.2
Santos-Rosa, H.3
Leonard, K.4
Mueller, S.5
Aebi, U.6
Hurt, E.7
-
93
-
-
77950523750
-
Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources
-
Spielewoy, N., Guaderrama, M., Wohlschlegel, J. A., Ashe, M., Yates, J. R., 3rd and Wittenberg, C. (2010). Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources. Eukaryot. Cell 9, 592-601.
-
(2010)
Eukaryot. Cell
, vol.9
, pp. 592-601
-
-
Spielewoy, N.1
Guaderrama, M.2
Wohlschlegel, J.A.3
Ashe, M.4
Yates, J.R.5
Wittenberg, C.6
-
94
-
-
30544436808
-
Structure of the Sec13/31 COPII coat cage
-
Stagg, S. M., Gürkan, C., Fowler, D. M., LaPointe, P., Foss, T. R., Potter, C. S., Carragher, B. and Balch, W. E. (2006). Structure of the Sec13/31 COPII coat cage. Nature 439, 234-238.
-
(2006)
Nature
, vol.439
, pp. 234-238
-
-
Stagg, S.M.1
Gürkan, C.2
Fowler, D.M.3
LaPointe, P.4
Foss, T.R.5
Potter, C.S.6
Carragher, B.7
Balch, W.E.8
-
95
-
-
48649098177
-
Structural basis for cargo regulation of COPII coat assembly
-
Stagg, S. M., LaPointe, P., Razvi, A., Gürkan, C., Potter, C. S., Carragher, B. and Balch, W. E. (2008). Structural basis for cargo regulation of COPII coat assembly. Cell 134, 474-484.
-
(2008)
Cell
, vol.134
, pp. 474-484
-
-
Stagg, S.M.1
LaPointe, P.2
Razvi, A.3
Gürkan, C.4
Potter, C.S.5
Carragher, B.6
Balch, W.E.7
-
96
-
-
84880535847
-
Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A
-
Sutter, B. M., Wu, X., Laxman, S. and Tu, B. P. (2013). Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A. Cell 154, 403-415.
-
(2013)
Cell
, vol.154
, pp. 403-415
-
-
Sutter, B.M.1
Wu, X.2
Laxman, S.3
Tu, B.P.4
-
97
-
-
84936074487
-
Decreased expression of NPRL2 in renal cancer cells is associated with unfavourable pathological, proliferation and apoptotic features
-
Tang, Y., Jiang, L. and Tang, W. (2014). Decreased expression of NPRL2 in renal cancer cells is associated with unfavourable pathological, proliferation and apoptotic features. Pathol. Oncol. Res. 20, 829-837.
-
(2014)
Pathol. Oncol. Res
, vol.20
, pp. 829-837
-
-
Tang, Y.1
Jiang, L.2
Tang, W.3
-
98
-
-
84912068759
-
Rab1A is an mTORC1 activator and a colorectal oncogene
-
Thomas, J. D., Zhang, Y. J., Wei, Y. H., Cho, J. H., Morris, L. E., Wang, H. Y. and Zheng, X. F. (2014). Rab1A is an mTORC1 activator and a colorectal oncogene. Cancer Cell 26, 754-769.
-
(2014)
Cancer Cell
, vol.26
, pp. 754-769
-
-
Thomas, J.D.1
Zhang, Y.J.2
Wei, Y.H.3
Cho, J.H.4
Morris, L.E.5
Wang, H.Y.6
Zheng, X.F.7
-
99
-
-
10744230485
-
Global mapping of the yeast genetic interaction network
-
Tong, A. H., Lesage, G., Bader, G. D., Ding, H., Xu, H., Xin, X., Young, J., Berriz, G. F., Brost, R. L., Chang, M. et al. (2004). Global mapping of the yeast genetic interaction network. Science 303, 808-813.
-
(2004)
Science
, vol.303
, pp. 808-813
-
-
Tong, A.H.1
Lesage, G.2
Bader, G.D.3
Ding, H.4
Xu, H.5
Xin, X.6
Young, J.7
Berriz, G.F.8
Brost, R.L.9
Chang, M.10
-
100
-
-
84888200442
-
The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1
-
Tsun, Z. Y., Bar-Peled, L., Chantranupong, L., Zoncu, R., Wang, T., Kim, C., Spooner, E. and Sabatini, D. M. (2013). The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1. Mol. Cell 52, 495-505.
-
(2013)
Mol. Cell
, vol.52
, pp. 495-505
-
-
Tsun, Z.Y.1
Bar-Peled, L.2
Chantranupong, L.3
Zoncu, R.4
Wang, T.5
Kim, C.6
Spooner, E.7
Sabatini, D.M.8
-
101
-
-
33750330930
-
The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells
-
Ueda, K., Kawashima, H., Ohtani, S., Deng, W. G., Ravoori, M., Bankson, J., Gao, B., Girard, L., Minna, J. D., Roth, J. A. et al. (2006). The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells. Cancer Res. 66, 9682-9690.
-
(2006)
Cancer Res
, vol.66
, pp. 9682-9690
-
-
Ueda, K.1
Kawashima, H.2
Ohtani, S.3
Deng, W.G.4
Ravoori, M.5
Bankson, J.6
Gao, B.7
Girard, L.8
Minna, J.D.9
Roth, J.A.10
-
102
-
-
84922018584
-
Preliminary functional assessment and classification of DEPDC5 variants associated with focal epilepsy
-
van Kranenburg, M., Hoogeveen-Westerveld, M. and Nellist, M. (2015). Preliminary functional assessment and classification of DEPDC5 variants associated with focal epilepsy. Hum. Mutat. 36, 200-209.
-
(2015)
Hum. Mutat
, vol.36
, pp. 200-209
-
-
van Kranenburg, M.1
Hoogeveen-Westerveld, M.2
Nellist, M.3
-
103
-
-
84922743269
-
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
-
Wang, S., Tsun, Z. Y., Wolfson, R. L., Shen, K., Wyant, G. A., Plovanich, M. E., Yuan, E. D., Jones, T. D., Chantranupong, L., Comb, W. et al. (2015). Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science 347, 188-194.
-
(2015)
Science
, vol.347
, pp. 188-194
-
-
Wang, S.1
Tsun, Z.Y.2
Wolfson, R.L.3
Shen, K.4
Wyant, G.A.5
Plovanich, M.E.6
Yuan, E.D.7
Jones, T.D.8
Chantranupong, L.9
Comb, W.10
-
104
-
-
84905908848
-
The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila
-
Wei, Y. and Lilly, M. A. (2014). The TORC1 inhibitors Nprl2 and Nprl3 mediate an adaptive response to amino-acid starvation in Drosophila. Cell Death Differ. 21, 1460-1468.
-
(2014)
Cell Death Differ
, vol.21
, pp. 1460-1468
-
-
Wei, Y.1
Lilly, M.A.2
-
105
-
-
84924296523
-
TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila
-
Wei, Y., Reveal, B., Reich, J., Laursen, W. J., Senger, S., Akbar, T., Iida-Jones, T., Cai, W., Jarnik, M. and Lilly, M. A. (2014). TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. Proc. Natl. Acad. Sci. USA 111, E5670-E5677.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E5670-E5677
-
-
Wei, Y.1
Reveal, B.2
Reich, J.3
Laursen, W.J.4
Senger, S.5
Akbar, T.6
Iida-Jones, T.7
Cai, W.8
Jarnik, M.9
Lilly, M.A.10
-
106
-
-
80655144720
-
Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
-
Wu, X. and Tu, B. P. (2011). Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation. Mol. Biol. Cell 22, 4124-4133.
-
(2011)
Mol. Biol. Cell
, vol.22
, pp. 4124-4133
-
-
Wu, X.1
Tu, B.P.2
-
107
-
-
74949090299
-
An overview of the molecular mechanism of autophagy
-
Yang, Z. and Klionsky, D. J. (2009). An overview of the molecular mechanism of autophagy. Curr. Top. Microbiol. Immunol. 335, 1-32.
-
(2009)
Curr. Top. Microbiol. Immunol
, vol.335
, pp. 1-32
-
-
Yang, Z.1
Klionsky, D.J.2
-
108
-
-
84879993307
-
NPRL2 gene expression in the progression of colon tumors
-
Yogurtcu, B., Hatemi, I., Aydin, I. and Buyru, N. (2012). NPRL2 gene expression in the progression of colon tumors. Genet. Mol. Res. 11, 4810-4816.
-
(2012)
Genet. Mol. Res
, vol.11
, pp. 4810-4816
-
-
Yogurtcu, B.1
Hatemi, I.2
Aydin, I.3
Buyru, N.4
-
109
-
-
84874266850
-
Discovery of novel DENN proteins: implications for the evolution of eukaryotic intracellular membrane structures and human disease
-
Zhang, D., Iyer, L. M., He, F. and Aravind, L. (2012). Discovery of novel DENN proteins: implications for the evolution of eukaryotic intracellular membrane structures and human disease. Front. Genet. 3, 283.
-
(2012)
Front. Genet
, vol.3
, pp. 283
-
-
Zhang, D.1
Iyer, L.M.2
He, F.3
Aravind, L.4
-
110
-
-
84879046486
-
A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans
-
Zhu, H., Shen, H., Sewell, A. K., Kniazeva, M. and Han, M. (2013). A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans. eLife 2, e00429.
-
(2013)
eLife
, vol.2
-
-
Zhu, H.1
Shen, H.2
Sewell, A.K.3
Kniazeva, M.4
Han, M.5
-
111
-
-
80555143078
-
mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
-
Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y. and Sabatini, D. M. (2011). mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 334, 678-683.
-
(2011)
Science
, vol.334
, pp. 678-683
-
-
Zoncu, R.1
Bar-Peled, L.2
Efeyan, A.3
Wang, S.4
Sancak, Y.5
Sabatini, D.M.6
|