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Volumn 7, Issue 356, 2014, Pages

Npr2 inhibits TORC1 to prevent inappropriate utilization of glutamine for biosynthesis of nitrogen-containing metabolites

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; METHIONINE; NITROGEN; NPR2 PROTEIN; PROTEIN; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; AMMONIUM DERIVATIVE; NPR2 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SIGNAL PEPTIDE; TORC1 PROTEIN COMPLEX, S CEREVISIAE; TRANSCRIPTION FACTOR;

EID: 84919400169     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005948     Document Type: Article
Times cited : (39)

References (66)
  • 1
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • J. D. Rabinowitz, E. White, Autophagy and metabolism. Science 330, 1344-1348 (2010).
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 2
    • 84873469666 scopus 로고    scopus 로고
    • Nutrient sensing, metabolism, and cell growth control
    • H. X. Yuan, Y. Xiong, K. L. Guan, Nutrient sensing, metabolism, and cell growth control. Mol. Cell 49, 379-387 (2013).
    • (2013) Mol. Cell , vol.49 , pp. 379-387
    • Yuan, H.X.1    Xiong, Y.2    Guan, K.L.3
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D. Hanahan, R. A. Weinberg, Hallmarks of cancer: The next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • R. J. DeBerardinis, J. J. Lum, G. Hatzivassiliou, C. B. Thompson, The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 7, 11-20 (2008).
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 6
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • S. Wullschleger, R. Loewith, M. N. Hall, TOR signaling in growth and metabolism. Cell 124, 471-484 (2006).
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 7
    • 83455177213 scopus 로고    scopus 로고
    • Target of rapamycin TOR) in nutrient signaling and growth control
    • R. Loewith, M. N. Hall, Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 189, 1177-1201 (2011).
    • (2011) Genetics , vol.189 , pp. 1177-1201
    • Loewith, R.1    Hall, M.N.2
  • 8
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • X. M. Ma, J. Blenis, Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell. Biol. 10, 307-318 (2009).
    • (2009) Nat. Rev. Mol. Cell. Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 10
    • 84866076360 scopus 로고    scopus 로고
    • Nutritional control of growth and development in yeast
    • J. R. Broach, Nutritional control of growth and development in yeast. Genetics 192, 73-105 (2012).
    • (2012) Genetics , vol.192 , pp. 73-105
    • Broach, J.R.1
  • 11
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Y. Sancak, L. Bar-Peled, R. Zoncu, A. L. Markhard, S. Nada, D. M. Sabatini, Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303 (2010).
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 14
    • 67651235863 scopus 로고    scopus 로고
    • A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex
    • T. K. Neklesa, R. W. Davis, A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex. PLOS Genet. 5, e1000515 (2009).
    • (2009) PLOS Genet , vol.5 , pp. e1000515
    • Neklesa, T.K.1    Davis, R.W.2
  • 15
    • 77950523750 scopus 로고    scopus 로고
    • Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources
    • N. Spielewoy, M. Guaderrama, J. A. Wohlschlegel, M. Ashe, J. R. Yates III, C. Wittenberg, Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources. Eukaryot. Cell 9, 592-601 (2010).
    • (2010) Eukaryot. Cell , vol.9 , pp. 592-601
    • Spielewoy, N.1    Guaderrama, M.2    Wohlschlegel, J.A.3    Ashe, M.4    Yates, J.R.5    Wittenberg, C.6
  • 16
    • 0028840055 scopus 로고
    • A second nitrogen permease regulator in Saccharomyces cerevisiae
    • G. Rousselet, M. Simon, P. Ripoche, J. M. Buhler, A second nitrogen permease regulator in Saccharomyces cerevisiae. FEBS Lett. 359, 215-219 (1995).
    • (1995) FEBS Lett , vol.359 , pp. 215-219
    • Rousselet, G.1    Simon, M.2    Ripoche, P.3    Buhler, J.M.4
  • 18
    • 80655144720 scopus 로고    scopus 로고
    • Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
    • X. Wu, B. P. Tu, Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation. Mol. Biol. Cell 22, 4124-4133 (2011).
    • (2011) Mol. Biol. Cell , vol.22 , pp. 4124-4133
    • Wu, X.1    Tu, B.P.2
  • 19
    • 84878353147 scopus 로고    scopus 로고
    • Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1
    • N. Panchaud, M. P. Peli-Gulli, C. De Virgilio, Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Sci. Signal. 6, ra42 (2013).
    • (2013) Sci. Signal , vol.6 , pp. ra42
    • Panchaud, N.1    Peli-Gulli, M.P.2    De Virgilio, C.3
  • 21
    • 84880535847 scopus 로고    scopus 로고
    • Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A
    • B. M. Sutter, X. Wu, S. Laxman, B. P. Tu, Methionine inhibits autophagy and promotes growth by inducing the SAM-responsive methylation of PP2A. Cell 154, 403-415 (2013).
    • (2013) Cell , vol.154 , pp. 403-415
    • Sutter, B.M.1    Wu, X.2    Laxman, S.3    Tu, B.P.4
  • 23
    • 0037037787 scopus 로고    scopus 로고
    • Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
    • E. R. Zabarovsky, M. I. Lerman, J. D. Minna, Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers. Oncogene 21, 6915-6935 (2002).
    • (2002) Oncogene , vol.21 , pp. 6915-6935
    • Zabarovsky, E.R.1    Lerman, M.I.2    Minna, J.D.3
  • 24
    • 0042844651 scopus 로고    scopus 로고
    • Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: A novel component involved in cisplatin-and doxorubicinprovoked cell kill
    • P. W. Schenk, M. Brok, A. W. Boersma, J. A. Brandsma, H. Den Dulk, H. Burger, G. Stoter, J. Brouwer, K. Nooter, Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: A novel component involved in cisplatin-and doxorubicinprovoked cell kill. Mol. Pharmacol. 64, 259-268 (2003).
    • (2003) Mol. Pharmacol , vol.64 , pp. 259-268
    • Schenk, P.W.1    Brok, M.2    Boersma, A.W.3    Brandsma, J.A.4    Den Dulk, H.5    Burger, H.6    Stoter, G.7    Brouwer, J.8    Nooter, K.9
  • 25
    • 0019750424 scopus 로고
    • Regulation of glucose metabolism in growing yeast cells
    • A. Fiechter, G. F. Fuhrmann, O. Käppeli, Regulation of glucose metabolism in growing yeast cells. Adv. Microb. Physiol. 22, 123-183 (1981).
    • (1981) Adv. Microb. Physiol , vol.22 , pp. 123-183
    • Fiechter, A.1    Fuhrmann, G.F.2    Käppeli, O.3
  • 26
    • 0022989417 scopus 로고
    • Regulation of carbon metabolism in Saccharomyces cerevisiae and related yeasts
    • O. Käppeli, Regulation of carbon metabolism in Saccharomyces cerevisiae and related yeasts. Adv. Microb. Physiol. 28, 181-209 (1986).
    • (1986) Adv. Microb. Physiol , vol.28 , pp. 181-209
    • Käppeli, O.1
  • 28
    • 75149148563 scopus 로고    scopus 로고
    • Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer
    • R. J. DeBerardinis, T. Cheng, Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 29, 313-324 (2010).
    • (2010) Oncogene , vol.29 , pp. 313-324
    • Deberardinis, R.J.1    Cheng, T.2
  • 29
    • 0025882878 scopus 로고
    • Physiological and genetic analysis of the carbon regulation of the NAD-dependent glutamate dehydrogenase of Saccharomyces cerevisiae
    • P. W. Coschigano, S. M. Miller, B. Magasanik, Physiological and genetic analysis of the carbon regulation of the NAD-dependent glutamate dehydrogenase of Saccharomyces cerevisiae. Mol. Cell. Biol. 11, 4455-4465 (1991).
    • (1991) Mol. Cell. Biol , vol.11 , pp. 4455-4465
    • Coschigano, P.W.1    Miller, S.M.2    Magasanik, B.3
  • 30
    • 84858183302 scopus 로고    scopus 로고
    • Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae
    • P. O. Ljungdahl, B. Daignan-Fornier, Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae. Genetics 190, 885-929 (2012).
    • (2012) Genetics , vol.190 , pp. 885-929
    • Ljungdahl, P.O.1    Daignan-Fornier, B.2
  • 32
    • 0042377362 scopus 로고    scopus 로고
    • Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase
    • P. Bieganowski, H. C. Pace, C. Brenner, Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase. J. Biol. Chem. 278, 33049-33055 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 33049-33055
    • Bieganowski, P.1    Pace, H.C.2    Brenner, C.3
  • 33
    • 0034617076 scopus 로고    scopus 로고
    • Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae
    • A. S. Tibbetts, D. R. Appling, Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae. J. Biol. Chem. 275, 20920-20927 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 20920-20927
    • Tibbetts, A.S.1    Appling, D.R.2
  • 34
    • 0142153893 scopus 로고    scopus 로고
    • Ammonia assimilation by Saccharomyces cerevisiae
    • B. Magasanik, Ammonia assimilation by Saccharomyces cerevisiae. Eukaryot. Cell 2, 827-829 (2003).
    • (2003) Eukaryot. Cell , vol.2 , pp. 827-829
    • Magasanik, B.1
  • 35
    • 0035941209 scopus 로고    scopus 로고
    • NADP-glutamate dehydrogenase isoenzymes of Saccharomyces cerevisiae Purification, kinetic properties, and physiological roles
    • A. DeLuna, A. Avendano, L. Riego, A. Gonzalez, NADP-glutamate dehydrogenase isoenzymes of Saccharomyces cerevisiae. Purification, kinetic properties, and physiological roles. J. Biol. Chem. 276, 43775-43783 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 43775-43783
    • Deluna, A.1    Avendano, A.2    Riego, L.3    Gonzalez, A.4
  • 36
    • 0025063371 scopus 로고
    • Role of NAD-linked glutamate dehydrogenase in nitrogen metabolism in Saccharomyces cerevisiae
    • S. M. Miller, B. Magasanik, Role of NAD-linked glutamate dehydrogenase in nitrogen metabolism in Saccharomyces cerevisiae. J. Bacteriol. 172, 4927-4935 (1990).
    • (1990) J. Bacteriol , vol.172 , pp. 4927-4935
    • Miller, S.M.1    Magasanik, B.2
  • 37
    • 0028925047 scopus 로고
    • Saccharomyces cerevisiae has a single glutamate synthase gene coding for a plant-like high-molecular-weight polypeptide
    • C. Cogoni, L. Valenzuela, D. González-Halphen, H. Olivera, G. Macino, P. Ballario, A. González, Saccharomyces cerevisiae has a single glutamate synthase gene coding for a plant-like high-molecular-weight polypeptide. J. Bacteriol. 177, 792-798 (1995).
    • (1995) J. Bacteriol , vol.177 , pp. 792-798
    • Cogoni, C.1    Valenzuela, L.2    González-Halphen, D.3    Olivera, H.4    Macino, G.5    Ballario, P.6    González, A.7
  • 38
    • 0001840999 scopus 로고
    • Nitrogen metabolism in Saccharomyces cerevisiae
    • J. N. Strathern, E. W. Jones, J. R. Broach, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
    • T. G. Cooper, Nitrogen metabolism in Saccharomyces cerevisiae, in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, J. N. Strathern, E. W. Jones, J. R. Broach, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1982), pp. 39-99.
    • (1982) The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression , pp. 39-99
    • Cooper, T.G.1
  • 39
    • 0037094434 scopus 로고    scopus 로고
    • Nitrogen regulation in Saccharomyces cerevisiae
    • B. Magasanik, C. A. Kaiser, Nitrogen regulation in Saccharomyces cerevisiae. Gene 290, 1-18 (2002).
    • (2002) Gene , vol.290 , pp. 1-18
    • Magasanik, B.1    Kaiser, C.A.2
  • 40
    • 0036024577 scopus 로고    scopus 로고
    • Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: Connecting the dots
    • T. G. Cooper, Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: Connecting the dots. FEMS Microbiol. Rev. 26, 223-238 (2002).
    • (2002) FEMS Microbiol. Rev , vol.26 , pp. 223-238
    • Cooper, T.G.1
  • 41
    • 84884544927 scopus 로고    scopus 로고
    • Five conditions commonly used to down-regulate tor complex 1 generate different physiological situations exhibiting distinct requirements and outcomes
    • J. J. Tate, T. G. Cooper, Five conditions commonly used to down-regulate tor complex 1 generate different physiological situations exhibiting distinct requirements and outcomes. J. Biol. Chem. 288, 27243-27262 (2013).
    • (2013) J. Biol. Chem , vol.288 , pp. 27243-27262
    • Tate, J.J.1    Cooper, T.G.2
  • 42
    • 0033540030 scopus 로고    scopus 로고
    • The TOR signalling pathway controls nuclear localization of nutrientregulated transcription factors
    • T. Beck, M. N. Hall, The TOR signalling pathway controls nuclear localization of nutrientregulated transcription factors. Nature 402, 689-692 (1999).
    • (1999) Nature , vol.402 , pp. 689-692
    • Beck, T.1    Hall, M.N.2
  • 43
    • 33748767906 scopus 로고    scopus 로고
    • Ammonia-specific regulation of Gln3 localization in Saccharomyces cerevisiae by protein kinase Npr1
    • J. J. Tate, R. Rai, T. G. Cooper, Ammonia-specific regulation of Gln3 localization in Saccharomyces cerevisiae by protein kinase Npr1. J. Biol. Chem. 281, 28460-28469 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 28460-28469
    • Tate, J.J.1    Rai, R.2    Cooper, T.G.3
  • 44
    • 34547121478 scopus 로고    scopus 로고
    • Stress-responsive Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation
    • J. J. Tate, T. G. Cooper, Stress-responsive Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation. J. Biol. Chem. 282, 18467-18480 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 18467-18480
    • Tate, J.J.1    Cooper, T.G.2
  • 45
    • 73449118235 scopus 로고    scopus 로고
    • Monitoring mitophagy in yeast: The Om45-GFP processing assay
    • T. Kanki, D. Kang, D. J. Klionsky, Monitoring mitophagy in yeast: The Om45-GFP processing assay. Autophagy 5, 1186-1189 (2009).
    • (2009) Autophagy , vol.5 , pp. 1186-1189
    • Kanki, T.1    Kang, D.2    Klionsky, D.J.3
  • 46
    • 0035890316 scopus 로고    scopus 로고
    • Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast
    • H. R. Kalhor, K. Luk, A. Ramos, P. Zobel-Thropp, S. Clarke, Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. Arch. Biochem. Biophys. 395, 239-245 (2001).
    • (2001) Arch. Biochem. Biophys , vol.395 , pp. 239-245
    • Kalhor, H.R.1    Luk, K.2    Ramos, A.3    Zobel-Thropp, P.4    Clarke, S.5
  • 47
    • 0032771639 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p
    • N. Nakashima, E. Noguchi, T. Nishimoto, Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152, 853-867 (1999).
    • (1999) Genetics , vol.152 , pp. 853-867
    • Nakashima, N.1    Noguchi, E.2    Nishimoto, T.3
  • 50
    • 84880536607 scopus 로고    scopus 로고
    • Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation
    • S. Laxman, B. M. Sutter, X. Wu, S. Kumar, X. Guo, D. C. Trudgian, H. Mirzaei, B. P. Tu, Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation. Cell 154, 416-429 (2013).
    • (2013) Cell , vol.154 , pp. 416-429
    • Laxman, S.1    Sutter, B.M.2    Wu, X.3    Kumar, S.4    Guo, X.5    Trudgian, D.C.6    Mirzaei, H.7    Tu, B.P.8
  • 51
    • 84906971940 scopus 로고    scopus 로고
    • Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins
    • D. Stracka, S. Jozefczuk, F. Rudroff, U. Sauer, M. N. Hall, Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins. J. Biol. Chem. 289, 25010-25020 (2014).
    • (2014) J. Biol. Chem , vol.289 , pp. 25010-25020
    • Stracka, D.1    Jozefczuk, S.2    Rudroff, F.3    Sauer, U.4    Hall, M.N.5
  • 52
    • 0025942492 scopus 로고
    • GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats
    • J. S. Flick, M. Johnston, GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats. Mol. Cell. Biol. 11, 5101-5112 (1991).
    • (1991) Mol. Cell. Biol , vol.11 , pp. 5101-5112
    • Flick, J.S.1    Johnston, M.2
  • 53
    • 0028230982 scopus 로고
    • Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae
    • M. Johnston, J. S. Flick, T. Pexton, Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae. Mol. Cell. Biol. 14, 3834-3841 (1994).
    • (1994) Mol. Cell. Biol , vol.14 , pp. 3834-3841
    • Johnston, M.1    Flick, J.S.2    Pexton, T.3
  • 58
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • R. J. DeBerardinis, A. Mancuso, E. Daikhin, I. Nissim, M. Yudkoff, S.Wehrli, C. B. Thompson, Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc. Natl. Acad. Sci. U.S.A. 104, 19345-19350 (2007).
    • (2007) Proc. Natl. Acad. Sci. U.S.A , vol.104 , pp. 19345-19350
    • Deberardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 59
    • 84883497454 scopus 로고    scopus 로고
    • Glutamine and cancer: Cell biology, physiology, and clinical opportunities
    • C. T. Hensley, A. T. Wasti, R. J. DeBerardinis, Glutamine and cancer: Cell biology, physiology, and clinical opportunities. J. Clin. Invest. 123, 3678-3684 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 3678-3684
    • Hensley, C.T.1    Wasti, A.T.2    Deberardinis, R.J.3
  • 60
    • 0034856827 scopus 로고    scopus 로고
    • Glutamine and cancer
    • discussion 2550S-2551S
    • M. A. Medina, Glutamine and cancer. J. Nutr. 131, 2539S-2542S; discussion 2550S-2551S (2001).
    • (2001) J. Nutr , vol.131 , pp. 2539S-2542S
    • Medina, M.A.1
  • 61
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • M. S. Longtine, A. McKenzie III, D. J. Demarini, N. G. Shah, A. Wach, A. Brachat, P. Philippsen, J. R. Pringle, Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14, 953-961 (1998).
    • (1998) Yeast , vol.14 , pp. 953-961
    • Longtine, M.S.1    McKenzie, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Philippsen, P.7    Pringle, J.R.8


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