-
2
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
R. Zoncu, A. Efeyan, D. M. Sabatini, mTOR: From growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35 (2011).
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
3
-
-
84856753762
-
The essence of yeast quiescence
-
C. De Virgilio, The essence of yeast quiescence. FEMS Microbiol. Rev. 36, 306-339 (2012).
-
(2012)
FEMS Microbiol. Rev.
, vol.36
, pp. 306-339
-
-
De Virgilio, C.1
-
4
-
-
83455177213
-
Target of rapamycin (TOR) in nutrient signaling and growth control
-
R. Loewith, M. N. Hall, Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 189, 1177-1201 (2011).
-
(2011)
Genetics
, vol.189
, pp. 1177-1201
-
-
Loewith, R.1
Hall, M.N.2
-
5
-
-
48649085816
-
Regulation of TORC1 by Rag GTPases in nutrient response
-
E. Kim, P. Goraksha-Hicks, L. Li, T. P. Neufeld, K. L. Guan, Regulation of TORC1 by Rag GTPases in nutrient response. Nat. Cell Biol. 10, 935-945 (2008).
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 935-945
-
-
Kim, E.1
Goraksha-Hicks, P.2
Li, L.3
Neufeld, T.P.4
Guan, K.L.5
-
6
-
-
69749113579
-
The Vam6 GEF controls TORC1 by activating the EGO complex
-
M. Binda, M. P. Péli-Gulli, G. Bonfils, N. Panchaud, J. Urban, T. W. Sturgill, R. Loewith, C. De Virgilio, The Vam6 GEF controls TORC1 by activating the EGO complex. Mol. Cell 35, 563-573 (2009).
-
(2009)
Mol. Cell
, vol.35
, pp. 563-573
-
-
Binda, M.1
Péli-Gulli, M.P.2
Bonfils, G.3
Panchaud, N.4
Urban, J.5
Sturgill, T.W.6
Loewith, R.7
De Virgilio, C.8
-
7
-
-
45849105156
-
The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
DOI 10.1126/science.1157535
-
Y. Sancak, T. R. Peterson, Y. D. Shaul, R. A. Lindquist, C. C. Thoreen, L. Bar-Peled, D. M. Sabatini, The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501 (2008). (Pubitemid 351929429)
-
(2008)
Science
, vol.320
, Issue.5882
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
9
-
-
84866431363
-
Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
-
L. Bar-Peled, L. D. Schweitzer, R. Zoncu, D. M. Sabatini, Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 150, 1196-1208 (2012).
-
(2012)
Cell
, vol.150
, pp. 1196-1208
-
-
Bar-Peled, L.1
Schweitzer, L.D.2
Zoncu, R.3
Sabatini, D.M.4
-
10
-
-
77951768486
-
Ragulator- Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
-
Y. Sancak, L. Bar-Peled, R. Zoncu, A. L. Markhard, S. Nada, D. M. Sabatini, Ragulator- Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 141, 290-303 (2010).
-
(2010)
Cell
, vol.141
, pp. 290-303
-
-
Sancak, Y.1
Bar-Peled, L.2
Zoncu, R.3
Markhard, A.L.4
Nada, S.5
Sabatini, D.M.6
-
11
-
-
84863110536
-
The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast
-
N. Valbuena, K. L. Guan, S. Moreno, The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast. J. Cell Sci. 125, 1920-1928 (2012).
-
(2012)
J. Cell Sci.
, vol.125
, pp. 1920-1928
-
-
Valbuena, N.1
Guan, K.L.2
Moreno, S.3
-
12
-
-
84859704385
-
Leucyl-tRNA synthetase controls TORC1 via the EGO complex
-
G. Bonfils, M. Jaquenoud, S. Bontron, C. Ostrowicz, C. Ungermann, C. De Virgilio, Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol. Cell 46, 105-110 (2012).
-
(2012)
Mol. Cell
, vol.46
, pp. 105-110
-
-
Bonfils, G.1
Jaquenoud, M.2
Bontron, S.3
Ostrowicz, C.4
Ungermann, C.5
De Virgilio, C.6
-
13
-
-
84862777407
-
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1- signaling pathway
-
J. M. Han, S. J. Jeong, M. C. Park, G. Kim, N. H. Kwon, H. K. Kim, S. H. Ha, S. H. Ryu, S. Kim, Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1- signaling pathway. Cell 149, 410-424 (2012).
-
(2012)
Cell
, vol.149
, pp. 410-424
-
-
Han, J.M.1
Jeong, S.J.2
Park, M.C.3
Kim, G.4
Kwon, N.H.5
Kim, H.K.6
Ha, S.H.7
Ryu, S.H.8
Kim, S.9
-
14
-
-
67651235863
-
A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex
-
T. K. Neklesa, R. W. Davis, A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex. PLoS Genet. 5, e1000515 (2009).
-
(2009)
PLoS Genet.
, vol.5
-
-
Neklesa, T.K.1
Davis, R.W.2
-
15
-
-
79957971892
-
A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae
-
S. Dokudovskaya, F. Waharte, A. Schlessinger, U. Pieper, D. P. Devos, I. M. Cristea, R. Williams, J. Salamero, B. T. Chait, A. Sali, M. C. Field, M. P. Rout, C. Dargemont, A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol. Cell. Proteomics 10, M110.006478 (2011).
-
(2011)
Mol. Cell. Proteomics
, vol.10
-
-
Dokudovskaya, S.1
Waharte, F.2
Schlessinger, A.3
Pieper, U.4
Devos, D.P.5
Cristea, I.M.6
Williams, R.7
Salamero, J.8
Chait, B.T.9
Sali, A.10
Field, M.C.11
Rout, M.P.12
Dargemont, C.13
-
16
-
-
80655144720
-
Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation
-
X. Wu, B. P. Tu, Selective regulation of autophagy by the Iml1-Npr2-Npr3 complex in the absence of nitrogen starvation. Mol. Biol.Cell 22, 4124-4133 (2011).
-
(2011)
Mol. Biol.Cell
, vol.22
, pp. 4124-4133
-
-
Wu, X.1
Tu, B.P.2
-
17
-
-
27144510561
-
Translational regulation of GCN4 and the general amino acid control of yeast
-
DOI 10.1146/annurev.micro.59.031805.133833
-
A. G. Hinnebusch, Translational regulation of GCN4 and the general amino acid control of yeast. Annu. Rev. Microbiol. 59, 407-450 (2005). (Pubitemid 41507438)
-
(2005)
Annual Review of Microbiology
, vol.59
, pp. 407-450
-
-
Hinnebusch, A.G.1
-
18
-
-
21244448694
-
The TOR and EGO protein complexes orchestrate microautophagy in yeast
-
DOI 10.1016/j.molcel.2005.05.020, PII S109727650501347X
-
F. Dubouloz, O. Deloche, V. Wanke, E. Cameroni, C. De Virgilio, The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol. Cell 19, 15-26 (2005). (Pubitemid 40884654)
-
(2005)
Molecular Cell
, vol.19
, Issue.1
, pp. 15-26
-
-
Dubouloz, F.1
Deloche, O.2
Wanke, V.3
Cameroni, E.4
De Virgilio, C.5
-
19
-
-
79959393264
-
Structure-function relationships of the G domain, a canonical switch motif
-
A. Wittinghofer, I. R. Vetter, Structure-function relationships of the G domain, a canonical switch motif. Annu. Rev. Biochem. 80, 943-971 (2011).
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 943-971
-
-
Wittinghofer, A.1
Vetter, I.R.2
-
20
-
-
0032127912
-
GTPase-activating proteins: Helping hands to complement an active site
-
DOI 10.1016/S0968-0004(98)01224-9, PII S0968000498012249
-
K. Scheffzek, M. R. Ahmadian, A. Wittinghofer, GTPase-activating proteins: Helping hands to complement an active site. Trends Biochem. Sci. 23, 257-262 (1998). (Pubitemid 28343370)
-
(1998)
Trends in Biochemical Sciences
, vol.23
, Issue.7
, pp. 257-262
-
-
Scheffzek, K.1
Ahmadian, M.R.2
Wittinghofer, A.3
-
21
-
-
4644279735
-
Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C
-
DOI 10.1158/0008-5472.CAN-03-3869
-
J. Li, F. Wang, K. Haraldson, A. Protopopov, F. M. Duh, L. Geil, I. Kuzmin, J. D. Minna, E. Stanbridge, E. Braga, V. I. Kashuba, G. Klein, M. I. Lerman, E. R. Zabarovsky, Functional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.3C. Cancer Res. 64, 6438-6443 (2004). (Pubitemid 39297898)
-
(2004)
Cancer Research
, vol.64
, Issue.18
, pp. 6438-6443
-
-
Li, J.1
Wang, F.2
Haraldson, K.3
Protopopov, A.4
Duh, F.-M.5
Geil, L.6
Kuzmin, I.7
Minna, J.D.8
Stanbridge, E.9
Braga, E.10
Kashuba, V.I.11
Klein, G.12
Lerman, M.I.13
Zabarovsky, E.R.14
-
22
-
-
0036569946
-
Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo
-
L. Ji, M. Nishizaki, B. Gao, D. Burbee, M. Kondo, C. Kamibayashi, K. Xu, N. Yen, E. N. Atkinson, B. Fang, M. I. Lerman, J. A. Roth, J. D. Minna, Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo. Cancer Res. 62, 2715-2720 (2002). (Pubitemid 34462757)
-
(2002)
Cancer Research
, vol.62
, Issue.9
, pp. 2715-2720
-
-
Ji, L.1
Nishizaki, M.2
Gao, B.3
Burbee, D.4
Kondo, M.5
Kamibayashi, C.6
Xu, K.7
Yen, N.8
Atkinson, E.N.9
Fang, B.10
Lerman, M.I.11
Roth, J.A.12
Minna, J.D.13
-
23
-
-
0034327412
-
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes
-
The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
-
M. I. Lerman, J. D. Minna, The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Cancer Res. 60, 6116-6133 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 6116-6133
-
-
Lerman, M.I.1
Minna, J.D.2
-
24
-
-
17644428035
-
Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis
-
DOI 10.1002/gcc.20181
-
T. J. Seng, K. Ichimura, L. Liu, O. Tingby, D. M. Pearson, V. P. Collins, Complex chromosome 22 rearrangements in astrocytic tumors identified using microsatellite and chromosome 22 tile path array analysis. Genes Chromosomes Cancer 43, 181-193 (2005). (Pubitemid 40570738)
-
(2005)
Genes Chromosomes and Cancer
, vol.43
, Issue.2
, pp. 181-193
-
-
Tzer, J.S.1
Ichimura, K.2
Liu, L.3
Tingby, O.4
Pearson, D.M.5
Collins, V.P.6
-
25
-
-
34249813098
-
Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae
-
DOI 10.1016/j.molcel.2007.04.020, PII S1097276507002560
-
J. Urban, A. Soulard, A. Huber, S. Lippman, D. Mukhopadhyay, O. Deloche, V. Wanke, D. Anrather, G. Ammerer, H. Riezman, J. R. Broach, C. De Virgilio, M. N. Hall, R. Loewith, Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol. Cell 26, 663-674 (2007). (Pubitemid 46856238)
-
(2007)
Molecular Cell
, vol.26
, Issue.5
, pp. 663-674
-
-
Urban, J.1
Soulard, A.2
Huber, A.3
Lippman, S.4
Mukhopadhyay, D.5
Deloche, O.6
Wanke, V.7
Anrather, D.8
Ammerer, G.9
Riezman, H.10
Broach, J.R.11
De Virgilio, C.12
Hall, M.N.13
Loewith, R.14
-
26
-
-
84864308260
-
Transient sequestration of TORC1 into stress granules during heat stress
-
T. Takahara, T. Maeda, Transient sequestration of TORC1 into stress granules during heat stress. Mol. Cell 47, 242-252 (2012).
-
(2012)
Mol. Cell
, vol.47
, pp. 242-252
-
-
Takahara, T.1
Maeda, T.2
-
27
-
-
32344453787
-
Assay and stimulation of the Rab5 GTPase by the p85α subunit of phosphatidylinositol 3-kinase
-
DOI 10.1016/S0076-6879(05)03048-X, PII S007668790503048X, 48, GTPases Regulating Membrane Targeting and Fusion
-
D. H. Anderson, M. D. Chamberlain, Assay and stimulation of the Rab5 GTPase by the p85a subunit of phosphatidylinositol 3-kinase. Methods Enzymol. 403, 552-561 (2005). (Pubitemid 43216939)
-
(2005)
Methods in Enzymology
, vol.403
, pp. 552-561
-
-
Anderson, D.H.1
Chamberlain, M.D.2
-
28
-
-
10344232033
-
The p85α subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
-
DOI 10.1074/jbc.M409769200
-
M. D. Chamberlain, T. R. Berry, M. C. Pastor, D. H. Anderson, The p85a subunit of phosphatidylinositol 3′-kinase binds to and stimulates the GTPase activity of Rab proteins. J. Biol. Chem. 279, 48607-48614 (2004). (Pubitemid 39625735)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.47
, pp. 48607-48614
-
-
Chamberlain, M.D.1
Berry, T.R.2
Pastor, M.C.3
Anderson, D.H.4
-
29
-
-
34548680957
-
Bimolecular fluorescence complementation analysis system for in vivo detection of protein-protein interaction in Saccharomyces cerevisiae
-
M. K. Sung, W. K. Huh, Bimolecular fluorescence complementation analysis system for in vivo detection of protein-protein interaction in Saccharomyces cerevisiae. Yeast 24, 767-775 (2007).
-
(2007)
Yeast
, vol.24
, pp. 767-775
-
-
Sung, M.K.1
Huh, W.K.2
-
30
-
-
0348047591
-
TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0
-
DOI 10.1016/S1097-2765(03)00485-4
-
I. Pedruzzi, F. Dubouloz, E. Cameroni, V. Wanke, J. Roosen, J. Winderickx, C. De Virgilio, TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0. Mol. Cell 12, 1607-1613 (2003). (Pubitemid 38037027)
-
(2003)
Molecular Cell
, vol.12
, Issue.6
, pp. 1607-1613
-
-
Pedruzzi, I.1
Dubouloz, F.2
Cameroni, E.3
Wanke, V.4
Roosen, J.5
Winderickx, J.6
De Virgilio, C.7
-
31
-
-
0032579440
-
Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications
-
DOI 10.1002/(SICI)1097-0061(19980130)14:2<115::AID-YEA204>3.0.CO;2- 2
-
C. B. Brachmann, A. Davies, G. J. Cost, E. Caputo, J. Li, P. Hieter, J. D. Boeke, Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14, 115-132 (1998). (Pubitemid 28062863)
-
(1998)
Yeast
, vol.14
, Issue.2
, pp. 115-132
-
-
Brachmann, C.B.1
Davies, A.2
Cost, G.J.3
Caputo, E.4
Li, J.5
Hieter, P.6
Boeke, J.D.7
-
32
-
-
0024266139
-
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
-
DOI 10.1016/0378-1119(88)90185-0
-
R. D. Gietz, A. Sugino, New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74, 527-534 (1988). (Pubitemid 19060666)
-
(1988)
Gene
, vol.74
, Issue.2
, pp. 527-534
-
-
Gietz, R.D.1
Sugino, A.2
-
33
-
-
84868223667
-
Synchronizing nuclear import of ribosomal proteins with ribosome assembly
-
D. Kressler, G. Bange, Y. Ogawa, G. Stjepanovic, B. Bradatsch, D. Pratte, S. Amlacher, D. Strauß, Y. Yoneda, J. Katahira, I. Sinning, E. Hurt, Synchronizing nuclear import of ribosomal proteins with ribosome assembly. Science 338, 666-671 (2012).
-
(2012)
Science
, vol.338
, pp. 666-671
-
-
Kressler, D.1
Bange, G.2
Ogawa, Y.3
Stjepanovic, G.4
Bradatsch, B.5
Pratte, D.6
Amlacher, S.7
Strauß, D.8
Yoneda, Y.9
Katahira, J.10
Sinning, I.11
Hurt, E.12
-
34
-
-
0026512939
-
Multifunctional yeast high-copy-number shuttle vectors
-
T. W. Christianson, R. S. Sikorski, M. Dante, J. H. Shero, P. Hieter, Multifunctional yeast high-copy-number shuttle vectors. Gene 110, 119-122 (1992).
-
(1992)
Gene
, vol.110
, pp. 119-122
-
-
Christianson, T.W.1
Sikorski, R.S.2
Dante, M.3
Shero, J.H.4
Hieter, P.5
|