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Volumn , Issue , 2014, Pages 209-228

Primary cilia and brain cancer

Author keywords

Cancer; Cell cycle; Hedgehog; NOTCH; Primary cilia; Receptor tyrosine kinase; WNT

Indexed keywords


EID: 84932177885     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-94-007-5808-7_8     Document Type: Chapter
Times cited : (1)

References (118)
  • 3
    • 79955789917 scopus 로고    scopus 로고
    • The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis
    • Bakircioglu M et al (2011) The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am J Hum Genet 88:523-535
    • (2011) Am J Hum Genet , vol.88 , pp. 523-535
    • Boca Raton Bakircioglu, M.1
  • 5
    • 80755139624 scopus 로고    scopus 로고
    • Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation
    • Berbari NF, Kin NW, Sharma N, Michaud EJ, Kesterson RA, Yoder BK (2011) Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation. Dev Biol 360:66-76
    • (2011) Dev Biol , vol.360 , pp. 66-76
    • Berbari, N.F.1    Kin, N.W.2    Sharma, N.3    Michaud, E.J.4    Kesterson, R.A.5    Yoder, B.K.6
  • 6
    • 69349094765 scopus 로고    scopus 로고
    • Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies
    • Bielas SL et al (2009) Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Nat Genet 41:1032-1036
    • (2009) Nat Genet , vol.41 , pp. 1032-1036
    • Bielas, S.L.1
  • 10
    • 4243144134 scopus 로고    scopus 로고
    • Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    • Cano DA, Murcia NS, Pazour GJ, Hebrok M (2004) Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131:3457-3467
    • (2004) Development , vol.131 , pp. 3457-3467
    • Cano, D.A.1    Murcia, N.S.2    Pazour, G.J.3    Hebrok, M.4
  • 11
    • 34247558062 scopus 로고    scopus 로고
    • The graded response to Sonic Hedgehog depends on cilia architecture
    • Caspary T, Larkins CE, Anderson KV (2007) The graded response to Sonic Hedgehog depends on cilia architecture. Dev Cell 12:767-778
    • (2007) Dev Cell , vol.12 , pp. 767-778
    • Caspary, T.1    Larkins, C.E.2    Anderson, K.V.3
  • 12
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    • Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev 23:1910-1928
    • (2009) Genes Dev , vol.23 , pp. 1910-1928
    • Chen, M.H.1    Wilson, C.W.2    Li, Y.J.3    Law, K.K.4    Lu, C.S.5    Gacayan, R.6    Zhang, X.7    Hui, C.C.8    Chuang, P.T.9
  • 13
    • 84859183715 scopus 로고    scopus 로고
    • Malignant glioma: Lessons from genomics, mouse models, and stem cells
    • Chen J, McKay RM, Parada LF (2012) Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell 149:36-47
    • (2012) Cell , vol.149 , pp. 36-47
    • Chen, J.1    McKay, R.M.2    Parada, L.F.3
  • 16
    • 82755161774 scopus 로고    scopus 로고
    • Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling
    • Christensen ST, Clement CA, Satir P, Pedersen LB (2012) Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling. J Pathol 226:172-184
    • (2012) J Pathol , vol.226 , pp. 172-184
    • Christensen, S.T.1    Clement, C.A.2    Satir, P.3    Pedersen, L.B.4
  • 17
    • 37249014359 scopus 로고    scopus 로고
    • Developmental signaling pathways in brain tumor-derived stem-like cells
    • Clark PA, Treisman DM, Ebben J, Kuo JS (2007) Developmental signaling pathways in brain tumor-derived stem-like cells. Dev Dyn 236:3297-3308
    • (2007) Dev Dyn , vol.236 , pp. 3297-3308
    • Clark, P.A.1    Treisman, D.M.2    Ebben, J.3    Kuo, J.S.4
  • 20
    • 58049208156 scopus 로고    scopus 로고
    • Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intra fl agellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    • Cortellino S, Wang C, Wang B, Bassi MR, Caretti E, Champeval D, Calmont A, Jarnik M, Burch J, Zaret KS, Larue L, Bellacosa A (2009) Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intra fl agellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev Biol 325:225-237
    • (2009) Dev Biol , vol.325 , pp. 225-237
    • Cortellino, S.1    Wang, C.2    Wang, B.3    Bassi, M.R.4    Caretti, E.5    Champeval, D.6    Calmont, A.7    Jarnik, M.8    Burch, J.9    Zaret, K.S.10    Larue, L.11    Bellacosa, A.12
  • 21
    • 0032796826 scopus 로고    scopus 로고
    • Sonic hedgehog regulates the growth and patterning of the cerebellum
    • Dahmane N, Ruiz i Altaba A (1999) Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 126:3089-3100
    • (1999) Development , vol.126 , pp. 3089-3100
    • Dahmane, N.1    Ruizi Altaba, A.2
  • 22
    • 60549097297 scopus 로고    scopus 로고
    • Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone
    • Danilov AI, Gomes-Leal W, Ahlenius H, Kokaia Z, Carlemalm E, Lindvall O (2009) Ultrastructural and antigenic properties of neural stem cells and their progeny in adult rat subventricular zone. Glia 57:136-152
    • (2009) Glia , vol.57 , pp. 136-152
    • Danilov, A.I.1    Gomes-Leal, W.2    Ahlenius, H.3    Kokaia, Z.4    Carlemalm, E.5    Lindvall, O.6
  • 23
    • 58949085532 scopus 로고    scopus 로고
    • Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway
    • DiBella LM, Park A, Sun Z (2009) Zebrafish Tsc1 reveals functional interactions between the cilium and the TOR pathway. Hum Mol Genet 18:595-606
    • (2009) Hum Mol Genet , vol.18 , pp. 595-606
    • Dibella, L.M.1    Park, A.2    Sun, Z.3
  • 25
    • 79959653860 scopus 로고    scopus 로고
    • A role for the primary cilium in Notch signaling and epidermal differentiation during skin development
    • Ezratty EJ, Stokes N, Chai S, Shah AS, Williams SE, Fuchs E (2011) A role for the primary cilium in Notch signaling and epidermal differentiation during skin development. Cell 145:1129-1141
    • (2011) Cell , vol.145 , pp. 1129-1141
    • Ezratty, E.J.1    Stokes, N.2    Chai, S.3    Shah, A.S.4    Williams, S.E.5    Fuchs, E.6
  • 27
    • 5144222593 scopus 로고    scopus 로고
    • Mitotic spindle regulation by Nde1 controls cerebral cortical size
    • Feng Y, Walsh CA (2004) Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron 44:279-293
    • (2004) Neuron , vol.44 , pp. 279-293
    • Feng, Y.1    Walsh, C.A.2
  • 30
    • 78650811198 scopus 로고    scopus 로고
    • Subtypes of medulloblastoma have distinct developmental origins
    • Gibson P et al (2010) Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095-1099
    • (2010) Nature , vol.468 , pp. 1095-1099
    • Gibson, P.1
  • 31
    • 77951101203 scopus 로고    scopus 로고
    • The primary cilium: A signalling centre during vertebrate development
    • Goetz SC, Anderson KV (2010) The primary cilium: A signalling centre during vertebrate development. Nat Rev 11:331-344
    • (2010) Nat Rev , vol.11 , pp. 331-344
    • Goetz, S.C.1    Anderson, K.V.2
  • 35
    • 79952249809 scopus 로고    scopus 로고
    • Development and cancer of the cerebellum
    • Hatten ME, Roussel MF (2011) Development and cancer of the cerebellum. Trends Neurosci 34:134-142
    • (2011) Trends Neurosci , vol.34 , pp. 134-142
    • Hatten, M.E.1    Roussel, M.F.2
  • 36
    • 80054720490 scopus 로고    scopus 로고
    • Molecular genetic approaches and potential new therapeutic strategies for pediatric diffuse intrinsic pontine glioma
    • Hawkins CE, Bartels U, Bouffet E (2011) Molecular genetic approaches and potential new therapeutic strategies for pediatric diffuse intrinsic pontine glioma. J Clin Oncol 29:3956-3957
    • (2011) J Clin Oncol , vol.29 , pp. 3956-3957
    • Hawkins, C.E.1    Bartels, U.2    Bouffet, E.3
  • 37
    • 40749144679 scopus 로고    scopus 로고
    • Gli2 and Gli3 localize to cilia and require the intra fl agellar transport protein polaris for processing and function
    • Haycraft CJ, Banizs B, Aydin-Son Y, Zhang Q, Michaud EJ, Yoder BK (2005) Gli2 and Gli3 localize to cilia and require the intra fl agellar transport protein polaris for processing and function. PLoS Genet 1:e53
    • (2005) PLoS Genet , vol.1 , pp. e53
    • Haycraft, C.J.1    Banizs, B.2    Aydin-Son, Y.3    Zhang, Q.4    Michaud, E.J.5    Yoder, B.K.6
  • 38
    • 70349986352 scopus 로고    scopus 로고
    • Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia
    • Huang P, Schier AF (2009) Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development 136:3089-3098
    • (2009) Development , vol.136 , pp. 3089-3098
    • Huang, P.1    Schier, A.F.2
  • 39
    • 23844485210 scopus 로고    scopus 로고
    • Cilia and Hedgehog responsiveness in the mouse
    • Huangfu D, Anderson KV (2005) Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci USA 102:11325-11330
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 11325-11330
    • Huangfu, D.1    Anderson, K.V.2
  • 41
    • 77950463564 scopus 로고    scopus 로고
    • The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    • Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24:670-682
    • (2010) Genes Dev , vol.24 , pp. 670-682
    • Humke, E.W.1    Dorn, K.V.2    Milenkovic, L.3    Scott, M.P.4    Rohatgi, R.5
  • 43
    • 67349198593 scopus 로고    scopus 로고
    • Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia
    • Jia J, Kolterud A, Zeng H, Hoover A, Teglund S, Toftgard R, Liu A (2009) Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev Biol 330:452-460
    • (2009) Dev Biol , vol.330 , pp. 452-460
    • Jia, J.1    Kolterud, A.2    Zeng, H.3    Hoover, A.4    Teglund, S.5    Toftgard, R.6    Liu, A.7
  • 45
    • 56149097603 scopus 로고    scopus 로고
    • Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease
    • Jonassen JA, San Agustin J, Follit JA, Pazour GJ (2008) Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease. J Cell Biol 183:377-384
    • (2008) J Cell Biol , vol.183 , pp. 377-384
    • Jonassen, J.A.1    San Agustin, J.2    Follit, J.A.3    Pazour, G.J.4
  • 50
    • 80855139808 scopus 로고    scopus 로고
    • Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma
    • Kim J, Dabiri S, Seeley ES (2011a) Primary cilium depletion typifies cutaneous melanoma in situ and malignant melanoma. PLoS One 6:e27410
    • (2011) PLoS One , vol.6 , pp. e27410
    • Kim, J.1    Dabiri, S.2    Seeley, E.S.3
  • 53
    • 0037155228 scopus 로고    scopus 로고
    • Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death
    • Kisseleva MV, Cao L, Majerus PW (2002) Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death. J Biol Chem 277:6266-6272
    • (2002) J Biol Chem , vol.277 , pp. 6266-6272
    • Kisseleva, M.V.1    Cao, L.2    Majerus, P.W.3
  • 55
    • 76249112276 scopus 로고    scopus 로고
    • Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction
    • Ko HW, Norman RX, Tran J, Fuller KP, Fukuda M, Eggenschwiler JT (2010) Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction. Dev Cell 18:237-247
    • (2010) Dev Cell , vol.18 , pp. 237-247
    • Ko, H.W.1    Norman, R.X.2    Tran, J.3    Fuller, K.P.4    Fukuda, M.5    Eggenschwiler, J.T.6
  • 57
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: Unfolding the activation mechanism
    • Kopan R, Ilagan MX (2009) The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137:216-233
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 59
    • 79953305554 scopus 로고    scopus 로고
    • Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors
    • Li A, Saito M, Chuang JZ, Tseng YY, Dedesma C, Tomizawa K, Kaitsuka T, Sung CH (2011) Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors. Nat Cell Biol 13:402-411
    • (2011) Nat Cell Biol , vol.13 , pp. 402-411
    • Li, A.1    Saito, M.2    Chuang, J.Z.3    Tseng, Y.Y.4    Dedesma, C.5    Tomizawa, K.6    Kaitsuka, T.7    Sung, C.H.8
  • 60
    • 0037884961 scopus 로고    scopus 로고
    • Kidneyspecific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
    • Lin F, Hiesberger T, Cordes K, Sinclair AM, Goldstein LS, Somlo S, Igarashi P (2003) Kidneyspecific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease. Proc Natl Acad Sci USA 100:5286-5291
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5286-5291
    • Lin, F.1    Hiesberger, T.2    Cordes, K.3    Sinclair, A.M.4    Goldstein, L.S.5    Somlo, S.6    Igarashi, P.7
  • 61
    • 23144466931 scopus 로고    scopus 로고
    • Mouse intra fl agellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    • Liu A, Wang B, Niswander LA (2005) Mouse intra fl agellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132:3103-3111
    • (2005) Development , vol.132 , pp. 3103-3111
    • Liu, A.1    Wang, B.2    Niswander, L.A.3
  • 62
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • Logan CY, Nusse R (2004) The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 20:781-810
    • (2004) Annu Rev Cell Dev Biol , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 63
    • 24344482068 scopus 로고    scopus 로고
    • PKD2 functions as an epidermal growth factor-activated plasma membrane channel
    • Ma R, Li WP, Rundle D, Kong J, Akbarali HI, Tsiokas L (2005) PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol Cell Biol 25:8285-8298
    • (2005) Mol Cell Biol , vol.25 , pp. 8285-8298
    • Ma, R.1    Li, W.P.2    Rundle, D.3    Kong, J.4    Akbarali, H.I.5    Tsiokas, L.6
  • 65
    • 27744484694 scopus 로고    scopus 로고
    • Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli
    • May SR, Ashique AM, Karlen M, Wang B, Shen Y, Zarbalis K, Reiter J, Ericson J, Peterson AS (2005) Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol 287:378-389
    • (2005) Dev Biol , vol.287 , pp. 378-389
    • May, S.R.1    Ashique, A.M.2    Karlen, M.3    Wang, B.4    Shen, Y.5    Zarbalis, K.6    Reiter, J.7    Ericson, J.8    Peterson, A.S.9
  • 67
    • 74549177523 scopus 로고    scopus 로고
    • Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells
    • Moser JJ, Fritzler MJ, Rattner JB (2009) Primary ciliogenesis defects are associated with human astrocytoma/glioblastoma cells. BMC Cancer 9:448
    • (2009) BMC Cancer , vol.9 , pp. 448
    • Moser, J.J.1    Fritzler, M.J.2    Rattner, J.B.3
  • 70
    • 69949120070 scopus 로고    scopus 로고
    • Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo
    • Ocbina PJ, Tuson M, Anderson KV (2009) Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. PLoS One 4:e6839
    • (2009) PLoS One , vol.4 , pp. e6839
    • Ocbina, P.J.1    Tuson, M.2    Anderson, K.V.3
  • 71
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW et al (2008) An integrated genomic analysis of human glioblastoma multiforme. Science (NY) 321:1807-1812
    • (2008) Science (NY) , vol.321 , pp. 1807-1812
    • Parsons, D.W.1
  • 75
    • 34250758641 scopus 로고    scopus 로고
    • HEF1-dependent Aurora A activation induces disassembly of the primary cilium
    • Pugacheva EN, Jablonski SA, Hartman TR, Henske EP, Golemis EA (2007) HEF1-dependent Aurora A activation induces disassembly of the primary cilium. Cell 129:1351-1363
    • (2007) Cell , vol.129 , pp. 1351-1363
    • Pugacheva, E.N.1    Jablonski, S.A.2    Hartman, T.R.3    Henske, E.P.4    Golemis, E.A.5
  • 76
    • 0018694416 scopus 로고
    • The resorption of primary cilia during mitosis in a vertebrate (PtK1) cell line
    • Rieder CL, Jensen CG, Jensen LC (1979) The resorption of primary cilia during mitosis in a vertebrate (PtK1) cell line. J Ultrastruct Res 68:173-185
    • (1979) J Ultrastruct Res , vol.68 , pp. 173-185
    • Rieder, C.L.1    Jensen, C.G.2    Jensen, L.C.3
  • 77
    • 26444577884 scopus 로고    scopus 로고
    • A previously unidentified amino-terminal domain regulates transcriptional activity of wildtype and disease-associated human GLI2
    • Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, Dlugosz AA, Muenke M (2005) A previously unidentified amino-terminal domain regulates transcriptional activity of wildtype and disease-associated human GLI2. Hum Mol Genet 14:2181-2188
    • (2005) Hum Mol Genet , vol.14 , pp. 2181-2188
    • Roessler, E.1    Ermilov, A.N.2    Grange, D.K.3    Wang, A.4    Grachtchouk, M.5    Dlugosz, A.A.6    Muenke, M.7
  • 78
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science (NY) 317:372-376
    • (2007) Science (NY) , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 80
    • 27144460671 scopus 로고    scopus 로고
    • Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates
    • Ross AJ et al (2005) Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet 37:1135-1140
    • (2005) Nat Genet , vol.37 , pp. 1135-1140
    • Ross, A.J.1
  • 84
    • 58149159900 scopus 로고    scopus 로고
    • Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia
    • Schraml P, Frew IJ, Thoma CR, Boysen G, Struckmann K, Krek W, Moch H (2009) Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia. Mod Pathol 22:31-36
    • (2009) Mod Pathol , vol.22 , pp. 31-36
    • Schraml, P.1    Frew, I.J.2    Thoma, C.R.3    Boysen, G.4    Struckmann, K.5    Krek, W.6    Moch, H.7
  • 86
    • 58349099851 scopus 로고    scopus 로고
    • Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia
    • Seeley ES, Carriere C, Goetze T, Longnecker DS, Korc M (2009) Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia. Cancer Res 69:422-430
    • (2009) Cancer Res , vol.69 , pp. 422-430
    • Seeley, E.S.1    Carriere, C.2    Goetze, T.3    Longnecker, D.S.4    Korc, M.5
  • 90
    • 34547939469 scopus 로고    scopus 로고
    • Cep97 and CP110 suppress a cilia assembly program
    • Spektor A, Tsang WY, Khoo D, Dynlacht BD (2007) Cep97 and CP110 suppress a cilia assembly program. Cell 130:678-690
    • (2007) Cell , vol.130 , pp. 678-690
    • Spektor, A.1    Tsang, W.Y.2    Khoo, D.3    Dynlacht, B.D.4
  • 91
    • 79551600015 scopus 로고    scopus 로고
    • Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways
    • Takebe N, Harris PJ, Warren RQ, Ivy SP (2011) Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways. Nat Rev Clin Oncol 8:97-106
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 97-106
    • Takebe, N.1    Harris, P.J.2    Warren, R.Q.3    Ivy, S.P.4
  • 93
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • TCGA
    • TCGA (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455:1061-1068
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 94
    • 22144493761 scopus 로고    scopus 로고
    • Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs
    • Teilmann SC, Christensen ST (2005) Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs. Cell Biol Int 29:340-346
    • (2005) Cell Biol Int , vol.29 , pp. 340-346
    • Teilmann, S.C.1    Christensen, S.T.2
  • 95
    • 77956841203 scopus 로고    scopus 로고
    • Transcriptional control of genes involved in ciliogenesis: Afirst step in making cilia
    • Thomas J, Morle L, Soulavie F, Laurencon A, Sagnol S, Durand B (2010) Transcriptional control of genes involved in ciliogenesis: Afirst step in making cilia. Biol Cell 102:499-513
    • (2010) Biol Cell , vol.102 , pp. 499-513
    • Thomas, J.1    Morle, L.2    Soulavie, F.3    Laurencon, A.4    Sagnol, S.5    Durand, B.6
  • 98
    • 0018287375 scopus 로고
    • Centriole ciliation is related to quiescence and DNA synthesis in 3 T3 cells
    • Tucker RW, Pardee AB, Fujiwara K (1979) Centriole ciliation is related to quiescence and DNA synthesis in 3 T3 cells. Cell 17:527-535
    • (1979) Cell , vol.17 , pp. 527-535
    • Tucker, R.W.1    Pardee, A.B.2    Fujiwara, K.3
  • 99
    • 77958508124 scopus 로고    scopus 로고
    • A mechanism for vertebrate Hedgehog signaling: Recruitment to cilia and dissociation of SuFu-Gli protein complexes
    • Tukachinsky H, Lopez LV, Salic A (2010) A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol 191:415-428
    • (2010) J Cell Biol , vol.191 , pp. 415-428
    • Tukachinsky, H.1    Lopez, L.V.2    Salic, A.3
  • 100
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG et al (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17:98-110
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1
  • 101
    • 79951670174 scopus 로고    scopus 로고
    • Gene expression profiling of gliomas: Merging genomic and histopathological classification for personalised therapy
    • Vitucci M, Hayes DN, Miller CR (2011) Gene expression profiling of gliomas: merging genomic and histopathological classification for personalised therapy. Br J Cancer 104:545-553
    • (2011) Br J Cancer , vol.104 , pp. 545-553
    • Vitucci, M.1    Hayes, D.N.2    Miller, C.R.3
  • 102
    • 0033594537 scopus 로고    scopus 로고
    • Purkinje-cell-derived Sonic Hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum
    • Wallace VA (1999) Purkinje-cell-derived Sonic Hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Curr Biol 9:445-448
    • (1999) Curr Biol , vol.9 , pp. 445-448
    • Wallace, V.A.1
  • 103
    • 77957222648 scopus 로고    scopus 로고
    • Planar cell polarity signaling, cilia and polarized ciliary beating
    • Wallingford JB (2010) Planar cell polarity signaling, cilia and polarized ciliary beating. Curr Opin Cell Biol 22:597-604
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 597-604
    • Wallingford, J.B.1
  • 104
    • 79551587194 scopus 로고    scopus 로고
    • Strange as it may seem: The many links between Wnt signaling, planar cell polarity, and cilia
    • Wallingford JB, Mitchell B (2011) Strange as it may seem: The many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev 25:201-213
    • (2011) Genes Dev , vol.25 , pp. 201-213
    • Wallingford, J.B.1    Mitchell, B.2
  • 105
    • 70350380859 scopus 로고    scopus 로고
    • Regulation of primary cilia formation by ceramide
    • Wang G, Krishnamurthy K, Bieberich E (2009) Regulation of primary cilia formation by ceramide. J Lipid Res 50:2103-2110
    • (2009) J Lipid Res , vol.50 , pp. 2103-2110
    • Wang, G.1    Krishnamurthy, K.2    Bieberich, E.3
  • 106
    • 0032959871 scopus 로고    scopus 로고
    • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    • Wechsler-Reya RJ, Scott MP (1999) Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22:103-114
    • (1999) Neuron , vol.22 , pp. 103-114
    • Wechsler-Reya, R.J.1    Scott, M.P.2
  • 110
    • 68849099883 scopus 로고    scopus 로고
    • Characterization of primary cilia in human airway smooth muscle cells
    • Wu J, Du H, Wang X, Mei C, Sieck GC, Qian Q (2009) Characterization of primary cilia in human airway smooth muscle cells. Chest 136:561-570
    • (2009) Chest , vol.136 , pp. 561-570
    • Wu, J.1    Du, H.2    Wang, X.3    Mei, C.4    Sieck, G.C.5    Qian, Q.6
  • 113
  • 114
    • 84863116083 scopus 로고    scopus 로고
    • Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation
    • Yuan S, Li J, Diener DR, Choma MA, Rosenbaum JL, Sun Z (2012) Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proc Natl Acad Sci USA 109:2021-2026
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 2021-2026
    • Yuan, S.1    Li, J.2    Diener, D.R.3    Choma, M.A.4    Rosenbaum, J.L.5    Sun, Z.6
  • 115
    • 77950487385 scopus 로고    scopus 로고
    • Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets
    • Zarghooni M, Bartels U, Lee E, Buczkowicz P, Morrison A, Huang A, Bouffet E, Hawkins C (2010) Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor alpha and poly (ADP-ribose) polymerase as potential therapeutic targets. J Clin Oncol 28:1337-1344
    • (2010) J Clin Oncol , vol.28 , pp. 1337-1344
    • Zarghooni, M.1    Bartels, U.2    Lee, E.3    Buczkowicz, P.4    Morrison, A.5    Huang, A.6    Bouffet, E.7    Hawkins, C.8
  • 116
    • 78650808301 scopus 로고    scopus 로고
    • Coordinated translocation of mammalian Gli proteins and suppressor offused to the primary cilium
    • Zeng H, Jia J, Liu A (2010) Coordinated translocation of mammalian Gli proteins and suppressor offused to the primary cilium. PLoS One 5:e15900
    • (2010) PLoS One , vol.5 , pp. e15900
    • Zeng, H.1    Jia, J.2    Liu, A.3
  • 117
    • 69549110419 scopus 로고    scopus 로고
    • Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3 T3-L1 preadipocytes
    • Zhu D, Shi S, Wang H, Liao K (2009) Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3 T3-L1 preadipocytes. J Cell Sci 122:2760-2768
    • (2009) J Cell Sci , vol.122 , pp. 2760-2768
    • Zhu, D.1    Shi, S.2    Wang, H.3    Liao, K.4
  • 118
    • 66249115336 scopus 로고    scopus 로고
    • The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro
    • Zuo X, Guo W, Lipschutz JH (2009) The exocyst protein Sec10 is necessary for primary ciliogenesis and cystogenesis in vitro. Mol Biol Cell 20:2522-2529
    • (2009) Mol Biol Cell , vol.20 , pp. 2522-2529
    • Zuo, X.1    Guo, W.2    Lipschutz, J.H.3


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